Longevity and skeletal muscle mass: The role of IGF signalling, the sirtuins, dietary restriction and protein intake

Aging Cell

Volumn 14, Issue 4, 2015, Pages 511-523

  Sharples, Adam P ^a   Hughes, David C ^a,b   Deane, Colleen S ^c,d   Saini, Amarjit ^e   Selman, Colin ^f   Stewart, Claire E ^a  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^d BOURNEMOUTH UNIVERSITY   (United Kingdom)

^e KAROLINSKA INSTITUTE   (Sweden)

^f UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

AKT; AMPK; cachexia; Calorie restriction; FOXO; high protein diets; IGF I; IRS 1; lifespan; longevity; MAFBx; MTOR; MURF; Regeneration; Sarcopenia; Satellite cells; SIRT; SkM; TSC

Indexed keywords

AMINO ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MAMMALIAN TARGET OF RAPAMYCIN; S6 KINASE; SIRTUIN; SIRTUIN 1; SOMATOMEDIN; TRANSCRIPTION FACTOR FOXO; TUBERIN; MTOR PROTEIN, HUMAN; PROTEIN INTAKE; SOMATOMEDIN C; TARGET OF RAPAMYCIN KINASE;

AGING; ARTICLE; CATABOLISM; CELL DIFFERENTIATION; CELL ENERGY; CELL SURVIVAL; DEMOGRAPHY; DIET RESTRICTION; ENERGY METABOLISM; GENE OVEREXPRESSION; HUMAN; LIFESPAN; LONGEVITY; MOLECULAR BIOLOGY; MORBIDITY; MORTALITY; MUSCLE FUNCTION; MUSCLE MASS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTAKE; QUALITY OF LIFE; REGULATORY MECHANISM; SARCOPENIA; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SOCIOECONOMICS; TISSUE REGENERATION; ADMINISTRATION AND DOSAGE; ANIMAL; ANTAGONISTS AND INHIBITORS; CALORIC RESTRICTION; DIET; DRUG EFFECTS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE;

AGING; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CALORIC RESTRICTION; DIET; DIETARY PROTEINS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LONGEVITY; MICE; MUSCLE, SKELETAL; SIGNAL TRANSDUCTION; SIRTUINS; TOR SERINE-THREONINE KINASES;

EID: 84958060584     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12342     Document Type: Article

References (219)

1. Adamo ML, Farrar RP (2006) Resistance training, and IGF involvement in the maintenance of muscle mass during the aging process. Ageing Res. Rev. 5, 310-331.
2. Aguilar V, Alliouachene S, Sotiropoulos A, Sobering A, Athea Y, Djouadi F, Miraux S, Thiaudiere E, Foretz M, Viollet B, Diolez P, Bastin J, Benit P, Rustin P, Carling D, Sandri M, Ventura-Clapier R, Pende M (2007) S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase. Cell Metab. 5, 476-487.
3. Alic N, Tullet JM, Niccoli T, Broughton S, Hoddinott MP, Slack C, Gems D, Partridge L (2014) Cell-nonautonomous effects of dFOXO/DAF-16 in aging. Cell Rep. 6, 608-616.
4. Al-Shanti N, Stewart CE (2011) Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation of SOCS-3. J. Cell. Biochem. 113, 923-933.
5. Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML, Yurova MN, Antoch MP, Blagosklonny MV (2010) Rapamycin extends maximal lifespan in cancer-prone mice. Am. J. Pathol. 176, 2092-2097.
6. Anversa P (2005) Aging and longevity: the IGF-1 enigma. Circ. Res. 97, 411-414.
7. Aspnes LE, Lee CM, Weindruch R, Chung SS, Roecker EB, Aiken JM (1997) Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle. FASEB J. 11, 573-581.
8. Atherton PJ, Smith K, Etheridge T, Rankin D, Rennie MJ (2010) Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells. Amino Acids 38, 1533-1539.
9. Barbieri M, Bonafe M, Franceschi C, Paolisso G (2003) Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am. J. Physiol. Endocrinol. Metab. 285, E1064-E1071.
10. Barger JL, Walford RL, Weindruch R (2003) The retardation of aging by caloric restriction: its significance in the transgenic era. Exp. Gerontol. 38, 1343-1351.
11. Bartke A (2005) Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology 146, 3718-3723.
12. Bartke A, Brown-Borg H (2004) Life extension in the dwarf mouse. Curr. Top. Dev. Biol. 63, 189-225.
13. Bates PC, Holder AT (1988) The anabolic actions of growth hormone and thyroxine on protein metabolism in Snell dwarf and normal mice. J. Endocrinol. 119, 31-41.
14. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337-342.
15. Beccafico S, Riuzzi F, Puglielli C, Mancinelli R, Fulle S, Sorci G, Donato R (2010) Human muscle satellite cells show age-related differential expression of S100B protein and RAGE. Age (Dordr) 33 (4), 523-541.
16. Beharry AW, Sandesara PB, Roberts BM, Ferreira LF, Senf SM, Judge AR (2014) HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy. J. Cell Sci. 127, 1441-1453.
17. Benbassat CA, Maki KC, Unterman TG (1997) Circulating levels of insulin-like growth factor (IGF) binding protein-1 and -3 in aging men: relationships to insulin, glucose, IGF, and dehydroepiandrosterone sulfate levels and anthropometric measures. J. Clin. Endocrinol. Metab. 82, 1484-1491.
18. Bigot A, Jacquemin V, Debacq-Chainiaux F, Butler-Browne GS, Toussaint O, Furling D, Mouly V (2008) Replicative aging down-regulates the myogenic regulatory factors in human myoblasts. Biol. Cell 100, 189-199.
19. Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A, Partridge L (2010) Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab. 11, 35-46.
20. Bjornsti MA, Houghton PJ (2004) The TOR pathway: a target for cancer therapy. Nat. Rev. Cancer 4, 335-348.
21. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-2015.
22. Bruunsgaard H, Pedersen BK (2003) Age-related inflammatory cytokines and disease. Immunol. Allergy Clin. North Am. 23, 15-39.
23. Bruunsgaard H, Andersen-Ranberg K, Hjelmborg JB, Pedersen BK, Jeune B (2003a) Elevated levels of tumor necrosis factor alpha and mortality in centenarians. Am. J. Med. 115, 278-283.
24. Bruunsgaard H, Ladelund S, Pedersen AN, Schroll M, Jorgensen T, Pedersen BK (2003b) Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people. Clin. Exp. Immunol. 132, 24-31.
25. Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvari M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D (2011) Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 477, 482-485.
26. Ceda GP, Dall'Aglio E, Maggio M, Lauretani F, Bandinelli S, Falzoi C, Grimaldi W, Ceresini G, Corradi F, Ferrucci L, Valenti G, Hoffman AR (2005) Clinical implications of the reduced activity of the GH-IGF-I axis in older men. J. Endocrinol. Invest. 28, 96-100.
27. Cerletti M, Jang YC, Finley LW, Haigis MC, Wagers AJ (2012) Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell 10, 515-519.
28. Cermak NM, Res PT, de Groot LC, Saris WH, van Loon LJ (2012) Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis. Am. J. Clin. Nutr. 96, 1454-1464.
29. Churchward-Venne TA, Burd NA, Mitchell CJ, West DW, Philp A, Marcotte GR, Baker SK, Baar K, Phillips SM (2012) Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men. J. Physiol. 590, 2751-2765.
30. Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L (2001) Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104-106.
31. Collins CA, Zammit PS, Ruiz AP, Morgan JE, Partridge TA (2007) A population of myogenic stem cells that survives skeletal muscle aging. Stem Cells 25, 885-894.
32. Cracknell R (2013). The Ageing Populationed [WWW document]. URL http:// www.parliament.uk/business/publications/research/key-issues-for-the-new-parliament/ value-for-money-in-public-services/the-ageing-population/ [accessed on 2010].
33. Cruz-Jentoft AJ, Landi F, Topinkova E, Michel JP (2010) Understanding sarcopenia as a geriatric syndrome. Curr. Opin. Clin. Nutr. Metab. Care 13, 1-7. Cuthbertson D, Smith K, Babraj J, Leese G, Waddell T, Atherton P, Wackerhage H
34. Taylor PM, Rennie MJ (2005) Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J. 19, 422-424.
35. Deane CS, Hughes DC, Sculthorpe N, Lewis MP, Stewart CE, Sharples AP (2013) Impaired hypertrophy in myoblasts is improved with testosterone administration. J. Steroid Biochem. Mol. Biol. 138C, 152-161.
36. Donmez G, Outeiro TF (2013) SIRT1 and SIRT2: emerging targets in neurodegeneration. EMBO Mol. Med. 5, 344-352.
37. Drummond MJ, Fry CS, Glynn EL, Dreyer HC, Dhanani S, Timmerman KL, Volpi E, Rasmussen BB (2009) Rapamycin administration in humans blocks the contraction- induced increase in skeletal muscle protein synthesis. J. Physiol. 587, 1535-1546.
38. Dumke CL, Wetter AC, Arias EB, Kahn CR, Cartee GD (2001) Absence of insulin receptor substrate-1 expression does not alter GLUT1 or GLUT4 abundance or contraction-stimulated glucose uptake by mouse skeletal muscle. Horm. Metab. Res. 33, 696-700.
39. Edstrom E, Altun M, Hagglund M, Ulfhake B (2006) Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle. J. Gerontol. A Biol. Sci. Med. Sci. 61, 663-674.
40. Emran S, Yang M, He X, Zandveld J, Piper MD (2014) Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration. Aging (Albany NY) 6, 390-398.
41. Foulstone EJ, Meadows KA, Holly JM, Stewart CE (2001) Insulin-like growth factors (IGF-I and IGF-II) inhibit C2 skeletal myoblast differentiation and enhance TNF alpha-induced apoptosis. J. Cell. Physiol. 189, 207-215.
42. Foulstone EJ, Savage PB, Crown AL, Holly JM, Stewart CE (2003a) Adaptations of the IGF system during malignancy: human skeletal muscle versus the systemic environment. Horm. Metab. Res. 35, 667-674.
43. Foulstone EJ, Savage PB, Crown AL, Holly JM, Stewart CE (2003b) Role of insulinlike growth factor binding protein-3 (IGFBP-3) in the differentiation of primary human adult skeletal myoblasts. J. Cell. Physiol. 195, 70-79.
44. Foulstone EJ, Huser C, Crown AL, Holly JM, Stewart CE (2004) Differential signalling mechanisms predisposing primary human skeletal muscle cells to altered proliferation and differentiation: roles of IGF-I and TNFalpha. Exp. Cell Res. 294, 223-235.
45. Fry CS, Drummond MJ, Glynn EL, Dickinson JM, Gundermann DM, Timmerman KL, Walker DK, Dhanani S, Volpi E, Rasmussen BB (2011) Aging impairs contractioninduced human skeletal muscle mTORC1 signaling and protein synthesis. Skelet. Muscle 1, 11.
46. Fujita S, Dreyer HC, Drummond MJ, Glynn EL, Cadenas JG, Yoshizawa F, Volpi E, Rasmussen BB (2007) Nutrient signalling in the regulation of human muscle protein synthesis. J. Physiol. 582, 813-823.
47. Fulco M, Schiltz RL, Iezzi S, King MT, Zhao P, Kashiwaya Y, Hoffman E, Veech RL, Sartorelli V (2003) Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol. Cell 12, 51-62.
48. Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA, Sartorelli V (2008) Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev. Cell 14, 661-673.
49. Garcia AM, Busuttil RA, Calder RB, Dolle ME, Diaz V, McMahan CA, Bartke A, Nelson J, Reddick R, Vijg J (2008) Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues. Mech. Ageing Dev. 129, 528-533.
50. Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, Mullenders LH, van der Horst GT, Bruning JC, Niessen CM, Hoeijmakers JH, Schumacher B (2009) Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity. Nat. Cell Biol. 11, 604-615.
51. Garthe I, Raastad T, Refsnes PE, Koivisto A, Sundgot-Borgen J (2011) Effect of two different weight-loss rates on body composition and strength and power-related performance in elite athletes. Int. J. Sport Nutr. Exerc. Metab. 21, 97-104.
52. Geusens PP, Boonen S (2002) Osteoporosis and the growth hormone-insulin-like growth factor axis. Horm. Res. 58(Suppl 3), 49-55.
53. Ghosh HS, McBurney M, Robbins PD (2010) SIRT1 negatively regulates the mammalian target of rapamycin. PLoS One 5, e9199.
54. Giannakou ME, Partridge L (2007) Role of insulin-like signalling in Drosophila lifespan. Trends Biochem. Sci. 32, 180-188.
55. Giannakou ME, Goss M, Junger MA, Hafen E, Leevers SJ, Partridge L (2004) Longlived Drosophila with overexpressed dFOXO in adult fat body. Science 305, 361.
56. Giovannucci E, Pollak M, Liu Y, Platz EA, Majeed N, Rimm EB, Willett WC (2003) Nutritional predictors of insulin-like growth factor I and their relationships to cancer in men. Cancer Epidemiol. Biomarkers Prev. 12, 84-89.
57. Gong Z, Kennedy O, Sun H, Wu Y, Williams GA, Klein L, Cardoso L, Matheny RW Jr, Hubbard GB, Ikeno Y, Farrar RP, Schaffler MB, Adamo ML, Muzumdar RH, Yakar S (2014) Reductions in serum IGF-1 during aging impair health span. Aging Cell 13, 408-418.
58. Goodman CA, Frey JW, Mabrey DM, Jacobs BL, Lincoln HC, You JS, Hornberger TA (2011) The role of skeletal muscle mTOR in the regulation of mechanical loadinduced growth. J. Physiol. 589, 5485-5501.
59. Greer EL, Brunet A (2005) FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24, 7410-7425.
60. Greiwe JS, Cheng B, Rubin DC, Yarasheski KE, Semenkovich CF (2001) Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans. FASEB J. 15, 475-482
61. Grohmann M, Sabin M, Holly J, Shield J, Crowne E, Stewart C (2005) Characterization of differentiated subcutaneous and visceral adipose tissue from children the influences of TNF-a and IGF-I. J. Lipid Res. 46, 93-103.
62. Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD (2011) Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci. Transl. Med. 3, 70ra13.
63. Hamilton DL, Philp A, MacKenzie MG, Patton A, Towler MC, Gallagher IJ, Bodine SC, Baar K (2014) Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation. Am. J. Physiol. Endocrinol. Metab. 307, E365-373.
64. Hankinson SE, Willett WC, Colditz GA, Hunter DJ, Michaud DS, Deroo B, Rosner B, Speizer FE, Pollak M (1998) Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 351, 1393-1396.
65. Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon C (2007) Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6, 95-110.
66. Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392-395.
67. Hepple RT, Qin M, Nakamoto H, Goto S (2008) Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: implications for sarcopenia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295, R1231-R1237.
68. Herranz D, Munoz-Martin M, Canamero M, Mulero F, Martinez-Pastor B, Fernandez-Capetillo O, Serrano M (2010) Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat. Commun. 1, 3.
69. Hidestrand M, Richards-Malcolm S, Gurley CM, Nolen G, Grimes B, Waterstrat A, Zant GV, Peterson CA (2008) Sca-1-expressing nonmyogenic cells contribute to fibrosis in aged skeletal muscle. J. Gerontol. A Biol. Sci. Med. Sci. 63, 566-579.
70. Holly JM, Perks CM, Stewart CE (2000) Overview of insulin-like growth factor physiology. Growth Horm. IGF Res. 10 (Suppl A), S8-S9.
71. Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, Cervera P, Le Bouc Y (2002) IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421, 182-187.
72. Hong S, Zhao B, Lombard DB, Fingar DC, Inoki K (2014) Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation. J. Biol. Chem. 289, 13132-13141.
73. Hughes VA, Frontera WR, Wood M, Evans WJ, Dallal GE, Roubenoff R, Fiatarone Singh MA (2001) Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity, and health. J. Gerontol. A Biol. Sci. Med. Sci. 56, B209-B217.
74. Hunter RB, Kandarian SC (2004) Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy. J. Clin. Invest. 114, 1504-1511.
75. Hursting SD, Smith SM, Lashinger LM, Harvey AE, Perkins SN (2010) Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research. Carcinogenesis 31, 83-89.
76. Inoki K, Zhu T, Guan KL (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590.
77. Jacobs KM, Pennington JD, Bisht KS, Aykin-Burns N, Kim H-S, Mishra M, Sun L, Nguyen P, Ahn B-H, Leclerc J (2008) SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int. J. Biol. Sci. 4, 291.
78. Jacobs BL, You JS, Frey JW, Goodman CA, Gundermann DM, Hornberger TA (2013) Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome. J. Physiol. 591, 4611-4620.
79. James PL, Stewart CE, Rotwein P (1996) Insulin-like growth factor binding protein- 5 modulates muscle differentiation through an insulin-like growth factordependent mechanism. J. Cell Biol. 133, 683-693.
80. Johnson SC, Martin GM, Rabinovitch PS, Kaeberlein M (2013a) Preserving youth: does rapamycin deliver? Sci. Transl. Med. 5, 211 fs240.
81. Johnson SC, Rabinovitch PS, Kaeberlein M (2013b) mTOR is a key modulator of ageing and age-related disease. Nature 493, 338-345.
82. Josse AR, Atkinson SA, Tarnopolsky MA, Phillips SM (2011) Increased consumption of dairy foods and protein during diet- and exercise-induced weight loss promotes fat mass loss and lean mass gain in overweight and obese premenopausal women. J. Nutr. 141, 1626-1634.
83. Kaaks R, Lukanova A, Sommersberg B (2000) Plasma androgens, IGF-1, body size, and prostate cancer risk: a synthetic review. Prostate Cancer Prostatic Dis. 3, 157-172.
84. Kaeberlein M, McVey M, Guarente L (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13, 2570-2580.
85. Kaeberlein M, Powers RW 3rd, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK (2005) Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 1193-1196.
86. Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, Bar-Joseph Z, Cohen HY (2012a) The sirtuin SIRT6 regulates lifespan in male mice. Nature 483, 218-221.
87. Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, Bar-Joseph Z, Cohen HY (2012b) The sirtuin SIRT6 regulates lifespan in male mice. Nature 483, 218-221.
88. Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S (2004) Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr. Biol. 14, 885-890.
89. Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KC, Boxer LD, Chang HY (2009) SIRT6 links histone H3 lysine 9 deacetylation to NF-jB-dependent gene expression and organismal life span. Cell 136, 62-74.
90. Kenyon C (2011) The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing. Philos. Trans. R. Soc. Lond. B Biol. Sci. 366, 9-16.
91. Krieger JW, Sitren HS, Daniels MJ, Langkamp-Henken B (2006) Effects of variation in protein and carbohydrate intake on body mass and composition during energy restriction: a meta-regression 1. Am. J. Clin. Nutr. 83, 260-274.
92. Kumar V, Selby A, Rankin D, Patel R, Atherton P, Hildebrandt W, Williams J, Smith K, Seynnes O, Hiscock N, Rennie MJ (2009) Age-related differences in the doseresponse relationship of muscle protein synthesis to resistance exercise in young and old men. J. Physiol. 587, 211-217.
93. Langen RC, Schols AM, Kelders MC, Wouters EF, Janssen-Heininger YM (2001) Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB. FASEB J. 15, 1169-1180.
94. Lashinger LM, Malone LM, McArthur MJ, Goldberg JA, Daniels EA, Pavone A, Colby JK, Smith NC, Perkins SN, Fischer SM, Hursting SD (2011) Genetic reduction of insulin-like growth factor-1 mimics the anticancer effects of calorie restriction on cyclooxygenase-2-driven pancreatic neoplasia. Cancer Prev. Res. (Phila.) 4, 1030-1040.
95. Lau MM, Stewart CE, Liu Z, Bhatt H, Rotwein P, Stewart CL (1994) Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Genes Dev. 8, 2953-2963.
96. Lee D, Goldberg AL (2013) SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth. J. Biol. Chem. 288, 30515-30526.
97. Leger B, Derave W, De Bock K, Hespel P, Russell AP (2008) Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation. Rejuvenation Res. 11 (1), 163-175B.
98. Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD (2014) Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab. 19, 407-417.
99. Li YP, Reid MB (2000) NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279, R1165-R1170.
100. Li YP, Chen Y, John J, Moylan J, Jin B, Mann DL, Reid MB (2005) TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle. FASEB J. 19, 362-370.
101. Liu M, Wilk SA, Wang A, Zhou L, Wang RH, Ogawa W, Deng C, Dong LQ, Liu F (2010) Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR. J. Biol. Chem. 285, 36387-36394.
102. Liu KA, Lashinger LM, Rasmussen AJ, Hursting SD (2014) Leucine supplementation differentially enhances pancreatic cancer growth in lean and overweight mice. Cancer Metab. 2, 6.
103. Lu A, Proto JD, Guo L, Tang Y, Lavasani M, Tilstra JS, Niedernhofer LJ, Wang B, Guttridge DC, Robbins PD, Huard J (2012) NF-kappaB negatively impacts the myogenic potential of muscle-derived stem cells. Mol. Ther. 20, 661-668.
104. Maestu J, Eliakim A, Jurimae J, Valter I, Jurimae T (2010) Anabolic and catabolic hormones and energy balance of the male bodybuilders during the preparation for the competition. J. Strength Cond. Res. 24, 1074-1081.
105. Mair W, Dillin A (2008) Aging and survival: the genetics of life span extension by dietary restriction. Annu. Rev. Biochem. 77, 727-754.
106. Masoro EJ, Yu BP, Bertrand HA (1982) Action of food restriction in delaying the aging process. Proc. Natl Acad. Sci. USA 79, 4239-4241.
107. Masternak MM, Panici JA, Bonkowski MS, Hughes LF, Bartke A (2009) Insulin sensitivity as a key mediator of growth hormone actions on longevity. J. Gerontol. A Biol. Sci. Med. Sci. 64, 516-521.
108. Matheny RW, Merritt E, Zannikos SV, Farrar RP, Adamo ML (2009) Serum IGF-Ideficiency does not prevent compensatory skeletal muscle hypertrophy in resistance exercise. Exp. Biol. Med. (Maywood) 234, 164-170.
109. Matthews L, Hammer R, Behringer R, D'Ercole A, Bell G, Brinster R, Palmiter R (1988) Growth, enhancement of transgenic mice expressing human insulin-like growth factor-I. Endocrinology 123, 2827-2833.
110. Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R (2012) Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 489, 318-321.
111. McKiernan SH, Colman RJ, Lopez M, Beasley TM, Aiken JM, Anderson RM, Weindruch R (2011) Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle. Exp. Gerontol. 46, 23-29.
112. McKiernan SH, Colman RJ, Aiken E, Evans TD, Beasley TM, Aiken JM, Weindruch R, Anderson RM (2012) Cellular adaptation contributes to calorie restrictioninduced preservation of skeletal muscle in aged rhesus monkeys. Exp. Gerontol. 47, 229-236.
113. Meadows KA, Holly JM, Stewart CE (2000) Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts. J. Cell. Physiol. 183, 330-337.
114. Mercken EM, Crosby SD, Lamming DW, JeBailey L, Krzysik-Walker S, Villareal DT, Capri M, Franceschi C, Zhang Y, Becker K, Sabatini DM, de Cabo R, Fontana L (2013) Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell 12, 645-651.
115. Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, Gonzalez-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R (2014) SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell 13, 787-796.
116. Miller RA, Buehner G, Chang Y, Harper JM, Sigler R, Smith-Wheelock M (2005) Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell 4, 119-125.
117. Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R (2011) Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J. Gerontol. A Biol. Sci. Med. Sci. 66, 191-201.
118. Min KJ, Yamamoto R, Buch S, Pankratz M, Tatar M (2008) Drosophila lifespan control by dietary restriction independent of insulin-like signaling. Aging Cell 7, 199-206.
119. Miyazaki M, McCarthy JJ, Fedele MJ, Esser KA (2011) Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling. J. Physiol. 589, 1831-1846.
120. Mojtahedi MC, Thorpe MP, Karampinos DC, Johnson CL, Layman DK, Georgiadis JG, Evans EM (2011) The effects of a higher protein intake during energy restriction on changes in body composition and physical function in older women. J. Gerontol. A Biol. Sci. Med. Sci. 66, 1218-1225.
121. Moore DR, Robinson MJ, Fry JL, Tang JE, Glover EI, Wilkinson SB, Prior T, Tarnopolsky MA, Phillips SM (2009) Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. Am. J. Clin. Nutr. 89, 161-168.
122. Morris BJ (2013) Seven sirtuins for seven deadly diseases of aging. Free Radic. Biol. Med. 56, 133-171.
123. Morris RT, Spangenburg EE, Booth FW (2004) Responsiveness of cell signaling pathways during the failed 15-day regrowth of aged skeletal muscle. J. Appl. Physiol. 96, 398-404.
124. Morse CI, Thom JM, Mian OS, Muirhead A, Birch KM, Narici MV (2005a) Muscle strength, volume and activation following 12-month resistance training in 70- year-old males. Eur. J. Appl. Physiol. 95, 197-204.
125. Morse CI, Thom JM, Reeves ND, Birch KM, Narici MV (2005b) In vivo physiological cross-sectional area and specific force are reduced in the gastrocnemius of elderly men. J. Appl. Physiol. 99, 1050-1055.
126. Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW (2006) Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124, 315-329.
127. Mourier A, Bigard AX, Legrand H, Guezennec CY, De Kerviler E, Roger B (1997) Combined effects of caloric restriction and branched-chain amino acid supplementation on body composition and exercise performance in elite wrestlers. Int. J. Sports Med. 18, 47-55.
128. Nabeshima Y, Hanaoka K, Hayasaka M, Esumi E, Li S, Nonaka I, Nabeshima Y (1993) Myogenin gene disruption results in perinatal lethality because of severe muscle defect. Nature 364, 532-535.
129. Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schroder S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Garrett L (2013) Rapamycin extends murine lifespan but has limited effects on aging. J. Clin. Invest. 123, 3272.
130. O'Connor MS, Carlson ME, Conboy IM (2009) Differentiation rather than aging of muscle stem cells abolishes their telomerase activity. Biotechnol. Prog. 25, 1130-1137.
131. Ohanna M, Sobering AK, Lapointe T, Lorenzo L, Praud C, Petroulakis E, Sonenberg N, Kelly PA, Sotiropoulos A, Pende M (2005) Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nat. Cell Biol. 7, 286-294.
132. Page MM, Salmon AB, Leiser SF, Robb EL, Brown MF, Miller RA, Stuart JA (2009) Mechanisms of stress resistance in Snell dwarf mouse fibroblasts: enhanced antioxidant and DNA base excision repair capacity, but no differences in mitochondrial metabolism. Free Radic. Biol. Med. 46, 1109-1118.
133. Pallafacchina G, Calabria E, Serrano AL, Kalhovde JM, Schiaffino S (2002) A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification. Proc. Natl Acad. Sci. USA 99, 9213-9218.
134. Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown AL, Kim MK, Beaven MA, Burgin AB, Manganiello V, Chung JH (2012) Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 148, 421-433.
135. Park BS, Henning PC, Grant SC, Lee WJ, Lee SR, Arjmandi BH, Kim JS (2013) HMB attenuates muscle loss during sustained energy deficit induced by calorie restriction and endurance exercise. Metabolism 62, 1718-1729.
136. Parkington JD, LeBrasseur NK, Siebert AP, Fielding RA (2004) Contractionmediated mTOR, p70S6k, and ERK1/2 phosphorylation in aged skeletal muscle. J. Appl. Physiol. 97, 243-248.
137. Passtoors WM, Beekman M, Deelen J, van der Breggen R, Maier AB, Guigas B, Derhovanessian E, van Heemst D, de Craen AJ, Gunn DA, Pawelec G, Slagboom PE (2013) Gene expression analysis of mTOR pathway: association with human longevity. Aging Cell 12, 24-31.
138. Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R (2008) Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 8, 157-168.
139. Pell JM, Bates PC (1992) Differential actions of growth hormone and insulin-like growth factor-I on tissue protein metabolism in dwarf mice. Endocrinology 130, 1942-1950.
140. Pete G, Fuller CR, Oldham JM, Smith DR, D'Ercole AJ, Kahn CR, Lund PK (1999) Postnatal growth responses to insulin-like growth factor I in insulin receptor substrate-1-deficient mice. Endocrinology 140, 5478-5487.
141. Phillips SM (2014) A brief review of critical processes in exercise-induced muscular hypertrophy. Sports Med. 44 (Suppl 1), S71-S77. Phillips T, Leeuwenburgh C (2005) Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction. FASEB J. 19, 668-670.
142. Philp A, Hamilton DL, Baar K (2011) Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1. J. Appl. Physiol. 110, 561-568.
143. Pietrangelo T, Puglielli C, Mancinelli R, Beccafico S, Fano G, Fulle S (2009) Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation. Exp. Gerontol. 44, 523-531.
144. Pimentel GD, Rosa JC, Lira FS, Zanchi NE, Ropelle ER, Oyama LM, Oller do Nascimento CM, de Mello MT, Tufik S, Santos RV (2011) beta-Hydroxy-betamethylbutyrate (HMbeta) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway. Nutr. Metab. (Lond) 8, 11.
145. Piper MD, Selman C, McElwee JJ, Partridge L (2008) Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice? J. Intern. Med. 263, 179-191.
146. Player DJ, Martin NR, Passey SL, Sharples AP, Mudera V, Lewis MP (2014) Acute mechanical overload increases IGF-I and MMP-9 mRNA in 3D tissue-engineered skeletal muscle. Biotechnol. Lett. 36, 1113-1124.
147. Pollak MN, Schernhammer ES, Hankinson SE (2004) Insulin-like growth factors and neoplasia. Nat. Rev. Cancer 4, 505-518.
148. Porter MM, Vandervoort AA, Lexell J (1995) Aging of human muscle: structure, function and adaptability. Scand. J. Med. Sci. Sports 5, 129-142.
149. Powers RW 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S (2006) Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 20, 174-184.
150. Rantanen T, Volpato S, Ferrucci L, Heikkinen E, Fried LP, Guralnik JM (2003) Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism. J. Am. Geriatr. Soc. 51, 636-641.
151. Rathbone CR, Booth FW, Lees SJ (2009) Sirt1 increases skeletal muscle precursor cell proliferation. Eur. J. Cell Biol. 88, 35-44.
152. Renault V, Thornell LE, Eriksson PO, Butler-Browne G, Mouly V (2002) Regenerative potential of human skeletal muscle during aging. Aging Cell 1, 132-139.
153. Renehan AG, Zwahlen M, Minder C, O'Dwyer ST, Shalet SM, Egger M (2004) Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet 363, 1346-1353.
154. Richie JP Jr, Leutzinger Y, Parthasarathy S, Malloy V, Orentreich N, Zimmerman JA (1994) Methionine restriction increases blood glutathione and longevity in F344 rats. FASEB J. 8, 1302-1307.
155. Risson V, Mazelin L, Roceri M, Sanchez H, Moncollin V, Corneloup C, Richard- Bulteau H, Vignaud A, Baas D, Defour A, Freyssenet D, Tanti JF, Le-Marchand- Brustel Y, Ferrier B, Conjard-Duplany A, Romanino K, Bauche S, Hantai D, Mueller M, Kozma SC, Thomas G, Ruegg MA, Ferry A, Pende M, Bigard X, Koulmann N, Schaeffer L, Gangloff YG (2009) Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy. J. Cell Biol. 187, 859-874.
156. Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK (2012) TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15, 713-724.
157. Rodriguez RM, Fraga MF (2010) Aging and cancer: are sirtuins the link? Future Oncol. 6, 905-915.
158. Rosenberg IH (1997) Sarcopenia: origins and clinical relevance. J. Nutr. 127 (5 Suppl), 990S-991S.
159. Rossi P, Marzani B, Giardina S, Negro M, Marzatico F (2008) Human skeletal muscle aging and the oxidative system: cellular events. Curr. Aging Sci. 1, 182-191.
160. Sacks FM, Bray GA, Carey VJ, Smith SR, Ryan DH, Anton SD, McManus K, Champagne CM, Bishop LM, Laranjo N, Leboff MS, Rood JC, de Jonge L, Greenway FL, Loria CM, Obarzanek E, Williamson DA (2009) Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N. Engl. J. Med. 360, 859-873.
161. Saini A, Al-Shanti N, Stewart CE (2006) Waste management -cytokines, growth factors and cachexia. Cytokine Growth Factor Rev. 17, 475-486.
162. Saini A, Al-Shanti N, Faulkner SH, Stewart CE (2008) Pro- and anti-apoptotic roles for IGF-I in TNF-alpha-induced apoptosis: a MAP kinase mediated mechanism. Growth Factors 26, 239-253.
163. Saini A, Al-Shanti N, Stewart C (2010) C2 skeletal myoblast survival, death, proliferation and differentiation: regulation by Adra1d. Cell. Physiol. Biochem. 25, 253-262.
164. Saini A, Al-Shanti N, Sharples AP, Stewart CE (2012) Sirtuin 1 regulates skeletal myoblast survival and enhances differentiation in the presence of resveratrol. Exp. Physiol. 97, 400-418.
165. Salles J, Chanet A, Giraudet C, Patrac V, Pierre P, Jourdan M, Luiking YC, Verlaan S, Migne C, Boirie Y (2013) 1, 25 (OH) 2-vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes. Mol. Nutr. Food Res. 57, 2137-2146.
166. Sandri M (2008) Signaling in muscle atrophy and hypertrophy. Physiology 23, 160-170.
167. Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL (2004) Foxo transcription factors induce the atrophyrelated ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 117, 399-412.
168. Sansone L, Reali V, Pellegrini L, Villanova L, Aventaggiato M, Marfe G, Rosa R, Nebbioso M, Tafani M, Fini M, Russo MA, Pucci B (2013) SIRT1 silencing confers neuroprotection through IGF-1 pathway activation. J. Cell. Physiol. 228, 1754-1761.
169. Sartorelli V, Caretti G (2005) Mechanisms underlying the transcriptional regulation of skeletal myogenesis. Curr. Opin. Genet. Dev. 15, 528-535.
170. Satoh A, Brace CS, Rensing N, Cliften P, Wozniak DF, Herzog ED, Yamada KA, Imai S (2013) Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Cell Metab. 18, 416-430.
171. Schiaffino S, Dyar KA, Ciciliot S, Blaauw B, Sandri M (2013) Mechanisms regulating skeletal muscle growth and atrophy. FEBS J. 280, 4294-4314.
172. Schug TT, Li X (2011) Sirtuin 1 in lipid metabolism and obesity. Ann. Med. 43, 198-211
173. Scime A, Rudnicki MA (2006) Anabolic potential and regulation of the skeletal muscle satellite cell populations. Curr. Opin. Clin. Nutr. Metab. Care 9, 214-219.
174. Selman C (2014) Dietary restriction and the pursuit of effective mimetics. Proc. Nutr. Soc. 73, 260-270.
175. Selman C, Phillips T, Staib JL, Duncan JS, Leeuwenburgh C, Speakman JR (2005) Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition. Mech. Ageing Dev. 126, 783-793.
176. Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson IC, Thornton JM, Gems D, Partridge L, Withers DJ (2008) Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J. 22, 807-818.
177. Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ (2009) Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326, 140-144.
178. Selman C, Partridge L, Withers DJ (2011) Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1. PLoS One 6, e16144.
179. Selman C, Withers DJ (2011) Mammalian models of extended healthy lifespan. Philos. Trans. R. Soc. Lond. B Biol. Sci. 366, 99-107.
180. Sharples AP, Stewart CE (2011) Myoblast models of skeletal muscle hypertrophy and atrophy. Curr. Opin. Clin. Nutr. Metab. Care 14, 230-236.
181. Sharples AP, Al-Shanti N, Stewart CE (2010) C2 and C2C12 murine skeletal myoblast models of atrophic and hypertrophic potential: relevance to disease and ageing? J. Cell. Physiol. 225, 240-250.
182. Sharples AP, Al-Shanti N, Lewis MP, Stewart CE (2011) Reduction of myoblast differentiation following multiple population doublings in mouse C(2) C(12) cells: a model to investigate ageing? J. Cell. Biochem. 112, 3773-3785.
183. Sharples AP, Player DJ, Martin NR, Mudera V, Stewart CE, Lewis MP (2012) Modelling in-vivo skeletal muscle ageing in-vitro using three dimensional bioengineered constructs. Aging Cell 8, 1474-9726.
184. Sharples AP, Al-Shanti N, Hughes DC, Lewis MP, Stewart CE (2013) The role of insulin-like-growth factor binding protein 2 (IGFBP2) and phosphatase and tensin homologue (PTEN) in the regulation of myoblast differentiation and hypertrophy. Growth Horm. IGF Res. 23, 53-61.
185. Sinha R, Cooper TK, Rogers CJ, Sinha I, Turbitt WJ, Calcagnotto A, Perrone CE, Richie JP Jr (2014) Dietary methionine restriction inhibits prostatic intraepithelial neoplasia in TRAMP mice. Prostate 74, 1663-1673.
186. Slagboom PE, Beekman M, Passtoors WM, Deelen J, Vaarhorst AA, Boer JM, van den Akker EB, van Heemst D, de Craen AJ, Maier AB, Rozing M, Mooijaart SP, Heijmans BT, Westendorp RG (2011) Genomics of human longevity. Philos. Trans. R. Soc. Lond. B Biol. Sci. 366, 35-42.
187. Solon-Biet SM, McMahon AC, Ballard JW, Ruohonen K, Wu LE, Cogger VC, Warren A, Huang X, Pichaud N, Melvin RG, Gokarn R, Khalil M, Turner N, Cooney GJ, Sinclair DA, Raubenheimer D, Le Couteur DG, Simpson SJ (2014) The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metab. 19, 418-430.
188. SommerM, Poliak N, Upadhyay S, Ratovitski E, Nelkin BD, Donehower LA, Sidransky D (2006) DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse. Cell Cycle 5, 2005-2011.
189. de Souza RJ, Bray GA, Carey VJ, Hall KD, LeBoff MS, Loria CM, Laranjo NM, Sacks FM, Smith SR (2012) Effects of 4 weight-loss diets differing in fat, protein, and carbohydrate on fat mass, lean mass, visceral adipose tissue, and hepatic fat: results from the POUNDS LOST trial. Am. J. Clin. Nutr. 95, 614-625.
190. Speakman JR, Selman C (2011) The free-radical damage theory: accumulating evidence against a simple link of oxidative stress to ageing and lifespan. BioEssays 33, 255-259.
191. Stewart CE, Pell JM (2010) Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. Point: IGF is the major physiological regulator of muscle mass. J. Appl. Physiol. 108, 1820-1821; discussion 1823-1824; author reply 1832.
192. Stewart CE, Rotwein P (1996a) Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. Physiol. Rev. 76, 1005-1026.
193. Stewart CE, Rotwein P (1996b) Insulin-like growth factor-II is an autocrine survival factor for differentiating myoblasts. J. Biol. Chem. 271, 11330-11338.
194. Stewart CE, Bates PC, Calder TA, Woodall SM, Pell JM (1993) Potentiation of insulin-like growth factor-I (IGF-I) activity by an antibody: supportive evidence for enhancement of IGF-I bioavailability in vivo by IGF binding proteins. Endocrinology 133, 1462-1465.
195. Stewart CE, James PL, Fant ME, Rotwein P (1996) Overexpression of insulin-like growth factor-II induces accelerated myoblast differentiation. J. Cell. Physiol. 169, 23-32.
196. Stewart CE, Mihai R, Holly JM (1999a) Increased tyrosine kinase activity but not calcium mobilization is required for ceramide-induced apoptosis. Exp. Cell Res. 250, 329-338.
197. Stewart CE, Newcomb PV, Savage PB, Dickens M, Tavare J, Holly JM (1999b) Increased, not decreased activation of the insulin-like growth factor (IGF) receptor signalling pathway during ceramide-induced apoptosis. Growth Horm. IGF Res. 9, 131-142.
198. Stewart CE, Newcomb PV, Holly JM (2004) Multifaceted roles of TNF-alpha in myoblast destruction: a multitude of signal transduction pathways. J. Cell. Physiol. 198, 237-247.
199. Sundaresan NR, Pillai VB, Wolfgeher D, Samant S, Vasudevan P, Parekh V, Raghuraman H, Cunningham JM, Gupta M, Gupta MP (2011) The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy. Sci. Signal. 4, ra46.
200. Tatar M, Bartke A, Antebi A (2003) The endocrine regulation of aging by insulinlike signals. Science 299, 1346-1351.
201. Taylor C, Bartlett JD, van de Graaf CS, Louhelainen J, Coyne V, Iqbal Z, Maclaren DP, Gregson W, Close GL, Morton JP (2013) Protein ingestion does not impair exercise-induced AMPK signalling when in a glycogen-depleted state: implications for train-low compete-high. Eur. J. Appl. Physiol. 113, 1457-1468.
202. Terada N, Patel HR, Takase K, Kohno K, Nairn AC, Gelfand EW (1994) Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc. Natl Acad. Sci. USA 91, 11477-11481.
203. Tilstra JS, Robinson AR, Wang J, Gregg SQ, Clauson CL, Reay DP, Nasto LA, St Croix CM, Usas A, Vo N (2012) NF-jB inhibition delays DNA damage-induced senescence and aging in mice. J. Clin. Invest. 122, 2601.
204. Tran D, Bergholz J, Zhang H, He H, Wang Y, Zhang Y, Li Q, Kirkland JL, Xiao Z-X (2014) Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence. Aging Cell 13, 669-678.
205. Vallejo AN, Michel JJ, Bale LK, Lemster BH, Borghesi L, Conover CA (2009) Resistance to age-dependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A. Proc. Natl Acad. Sci. USA 106, 11252-11257.
206. Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Muller F (2003) Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426, 620.
207. Viswanathan M, Guarente L (2011) Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature 477, E1-E2.
208. Wall BT, van Loon LJ (2013) Nutritional strategies to attenuate muscle disuse atrophy. Nutr. Rev. 71, 195-208.
209. Wang F, Nguyen M, Qin F, Tong Q (2007) SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 6, 505-514.
210. Wang DT, Yin Y, Yang YJ, Lv PJ, Shi Y, Lu L, Wei LB (2014) Resveratrol prevents TNF-alpha-induced muscle atrophy via regulation of Akt/mTOR/FoxO1 signaling in C2C12 myotubes. Int. Immunopharmacol. 19, 206-213.
211. Welsh GI, Stokes CM, Wang X, Sakaue H, Ogawa W, Kasuga M, Proud CG (1997) Activation of translation initiation factor eIF2B by insulin requires phosphatidyl inositol 3-kinase. FEBS Lett. 410, 418-422.
212. Wilkinson JE, Burmeister L, Brooks SV, Chan CC, Friedline S, Harrison DE, Hejtmancik JF, Nadon N, Strong R, Wood LK, Woodward MA, Miller RA (2012) Rapamycin slows aging in mice. Aging Cell 11, 675-682.
213. Willett M, Cowan JL, Vlasak M, Coldwell MJ, Morley SJ (2009) Inhibition of mammalian target of rapamycin (mTOR) signalling in C2C12 myoblasts prevents myogenic differentiation without affecting the hyperphosphorylation of 4E-BP1. Cell. Signal. 21, 1504-1512.
214. Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF (1998) Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391, 900-904.
215. Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, White MF (1999) Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat. Genet. 23, 32-40.
216. Yang J, Anzo M, Cohen P (2005) Control of aging and longevity by IGF-I signaling. Exp. Gerontol. 40, 867-872.
217. Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW (2004) Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23, 2369-2380.
218. Yuan R, Tsaih SW, Petkova SB, Marin de Evsikova C, Xing S, Marion MA, Bogue MA, Mills KD, Peters LL, Bult CJ, Rosen CJ, Sundberg JP, Harrison DE, Churchill GA, Paigen B (2009) Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell 8, 277-287.
219. Zhang Y, Bokov A, Gelfond J, Soto V, Ikeno Y, Hubbard G, Diaz V, Sloane L, Maslin K, Treaster S, Rendon S, van Remmen H, Ward W, Javors M, Richardson A, Austad SN, Fischer K (2014) Rapamycin extends life and health in C57BL/6 mice. J. Gerontol. A Biol. Sci. Med. Sci. 69, 119-130.