Rapamycin extends murine lifespan but has limited effects on aging

Journal of Clinical Investigation

Volumn 123, Issue 8, 2013, Pages 3272-3291

  Neff, Frauke ^a,b   Flores Dominguez, Diana ^c   Ryan, Devon P ^c   Horsch, Marion ^b   Schröder, Susanne ^c   Adler, Thure ^b,d   Afonso, Luciana Caminha ^b   Aguilar Pimentel, Juan Antonio ^b,e   Becker, Lore ^b,f   Garrett, Lillian ^b   Hans, Wolfgang ^b   Hettich, Moritz M ^c   Holtmeier, Richard ^g   Hölter, Sabine M ^b   Moreth, Kristin ^b   Prehn, Cornelia ^b   Puk, Oliver ^b   Rácz, Ildikó ^h   Rathkolb, Birgit ^b,i   Rozman, Jan ^b,e   Naton, Beatrix ^b   Ordemann, Rainer ^j   Adamski, Jerzy ^b,e   Beckers, Johannes ^b,e   Bekeredjian, Raffi ^k   Busch, Dirk H ^d   Ehninger, Gerhard ^j   Graw, Jochen ^b   Höfler, Heinz ^a,e   Klingenspor, Martin ^e   Klopstock, Thomas ^c,f   Ollert, Markus ^e   Stypmann, Jörg ^g   Wolf, Eckhard ⁱ   Wurst, Wolfgang ^b,c,l   Zimmer, Andreas ^h   Fuchs, Helmut ^b   Gailus Durner, Valérie ^b   De Angelis, Martin Hrabe ^b,e,f,m   Ehninger, Dan ^c   more..

^a Institute of Pathology   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^d Institute for Medical Microbiology   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^g UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^h UNIVERSITY OF BONN   (Germany)

ⁱ UNIVERSITY OF MUNICH   (Germany)

^j UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^k UNIVERSITY OF HEIDELBERG   (Germany)

^l MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^m GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

RAPAMYCIN;

AGING; ANIMAL EXPERIMENT; ARTICLE; CARCINOGENESIS; CARDIOVASCULAR SYSTEM; COGNITION; CONTROLLED STUDY; DRUG EFFECT; EXPLORATORY BEHAVIOR; GRIP STRENGTH; LIFESPAN; LONGEVITY; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; THYROID FOLLICLE;

AGING; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; DRUG EVALUATION, PRECLINICAL; GRANULOMA; IMMUNOGLOBULINS; LEUKOCYTE COUNT; LIVER; LIVER CIRRHOSIS; LONGEVITY; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; MUSCLE STRENGTH; OXYGEN CONSUMPTION; PHENOTYPE; PLATELET COUNT; PSYCHOMOTOR PERFORMANCE; SIROLIMUS; SURVIVAL ANALYSIS; T-LYMPHOCYTES; THYROID GLAND; TOR SERINE-THREONINE KINASES;

EID: 84881247539     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI67674     Document Type: Article

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