Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

Cell

Volumn 117, Issue 3, 2004, Pages 399-412

  Sandri, Marco ^a   Sandri, Claudia ^b   Gilbert, Alex ^c   Skurk, Carsten ^d   Calabria, Elisa ^b   Picard, Anne ^b   Walsh, Kenneth ^d   Schiaffino, Stefano ^b   Lecker, Stewart H ^c   Goldberg, Alfred L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; PROTEIN KINASE B; SOMATOMEDIN C; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; MUSCLE ATROPHY; MUSCLE CELL; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SKELETAL MUSCLE; STARVATION;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 11144356337     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(04)00400-3     Document Type: Article

References (41)

1. Bodine S.C., Latres E., Baumhueter S., Lai V.K., Nunez L., Clarke B.A., Poueymirou W.T., Panaro F.J., Na E., Dharmarajan K., et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science. 294:2001;1704-1708. a
2. Bodine S.C., Stitt T.N., Gonzalez M., Kline W.O., Stover G.L., Bauerlein R., Zlotchenko E., Scrimgeour A., Lawrence J.C., Glass D.J., Yancopoulos G.D. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat. Cell Biol. 3:2001;1014-1019. b
3. Bois P.R., Grosveld G.C. Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors. EMBO J. 22:2003;1147-1157
4. Brummelkamp T.R., Bernards R., Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science. 296:2002;550-553
5. Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., Anderson M.J., Arden K.C., Blenis J., Greenberg M.E. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 96:1999;857-868
6. Furuyama T., Nakazawa T., Nakano I., Mori N. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem. J. 349:2000;629-634
7. Furuyama T., Kitayama K., Yamashita H., Mori N. Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation. Biochem. J. 375:2003;365-371
8. Gilley J., Coffer P.J., Ham J. FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J. Cell Biol. 162:2003;613-622
9. Gomes M.D., Lecker S.H., Jagoe R.T., Navon A., Goldberg A.L. Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc. Natl. Acad. Sci. USA. 98:2001;14440-14445
10. Guttridge D.C., Mayo M.W., Madrid L.V., Wang C.Y., Baldwin A.S. Jr. NF-κB-induced loss of MyoD messenger RNA. possible role in muscle decay and cachexia Science. 289:2000;2363-2366
11. Hasselgren P.O. Glucocorticoids and muscle catabolism. Curr. Opin. Clin. Nutr. Metab. Care. 2:1999;201-205
12. Hribal M.L., Nakae J., Kitamura T., Shutter J.R., Accili D. Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors. J. Cell Biol. 162:2003;535-541
13. Imae M., Fu Z., Yoshida A., Noguchi T., Kato H. Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16. J. Mol. Endocrinol. 30:2003;253-262
14. Israel A. The IKK complex. an integrator of all signals that activate NF-κB? Trends Cell Biol. 10:2000;129-133
15. Jagoe R.T., Goldberg A.L. What do we really know about the ubiquitin-proteasome pathway in muscle atrophy? Curr. Opin Clin. Nutr. Metab. Care. 4:2001;183-190
16. Jagoe R.T., Lecker S.H., Gomes M., Goldberg A.L. Patterns of gene expression in atrophying skeletal muscles. the response to food deprivation FASEB J. 16:2002;1697-1712
17. Kim H.S., Skurk C., Thomas S.R., Bialik A., Suhara T., Kureishi Y., Birnbaum M., Keaney J.F. Jr., Walsh K. Regulation of angiogenesis by glycogen synthase kinase-3β J. Biol. Chem. 277:2002;41888-41896
18. Kim D.H., Sarbassov dos D., Ali S.M., Latek R.R., Guntur K.V., Erdjument-Bromage H., Tempst P., Sabatini D.M. GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol. Cell. 11:2003;895-904
19. Kramer J.M., Davidge J.T., Lockyer J.M., Staveley B.E. Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev. Biol. 3:2003;5
20. Lecker S.H., Solomon V., Mitch W.E., Goldberg A.L. Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states. J. Nutr. 129:1999;227S-237S
21. Lecker S.H., Jagoe R.T., Gilbert A., Gomes M., Baracos V., Bailey J., Price S.R., Mitch W.E., Goldberg A.L. Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J. 18:2004;39-51
22. Li Y.P., Lecker S.H., Chen Y., Waddell I.D., Goldberg A.L., Reid M.B. TNFα increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k. FASEB J. 17:2003;1048-1057
23. Mitch W.E., Bailey J.L., Wang X., Jurkovitz C., Newby D., Price S.R. Evaluation of signals activating ubiquitin-proteasome proteolysis in a model of muscle wasting. Am. J. Physiol. 276:1999;C1132-C1138
24. Murgia M., Serrano A.L., Calabria E., Pallafacchina G., Lomo T., Schiaffino S. Ras is involved in nerve-activity-dependent regulation of muscle genes. Nat. Cell Biol. 2:2000;142-147
25. Musaro A., McCullagh K.J., Naya F.J., Olson E.N., Rosenthal N. IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1. Nature. 400:1999;581-585
26. Nakae J., Kitamura T., Silver D.L., Accili D. The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J. Clin. Invest. 108:2001;1359-1367
27. Nakae J., Biggs W.H., Kitamura T., Cavenee W.K., Wright C.V., Arden K.C., Accili D. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat. Genet. 32:2002;245-253
28. Nakae J., Kitamura T., Kitamura Y., Biggs W.H. 3rd, Arden K.C., Accili D. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev. Cell. 4:2003;119-129
29. Nasrin N., Ogg S., Cahill C.M., Biggs W., Nui S., Dore J., Calvo D., Shi Y., Ruvkun G., Alexander-Bridges M.C. DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc. Natl. Acad. Sci. USA. 97:2000;10412-10417
30. Pallafacchina G., Calabria E., Serrano A.L., Kalhovde J.M., Schiaffino S. A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification. Proc. Natl. Acad. Sci. USA. 99:2002;9213-9218
31. Peng X.D., Xu P.Z., Chen M.L., Hahn-Windgassen A., Skeen J., Jacobs J., Sundararajan D., Chen W.S., Crawford S.E., Coleman K.G., Hay N. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev. 17:2003;1352-1365
32. Puig O., Marr M.T., Ruhf M.L., Tjian R. Control of cell number by Drosophila FOXO. downstream and feedback regulation of the insulin receptor pathway Genes Dev. 17:2003;2006-2020
33. Puigserver P., Rhee J., Donovan J., Walkey C.J., Yoon J.C., Oriente F., Kitamura Y., Altomonte J., Dong H., Accili D., Spiegelman B.M. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction. Nature. 423:2003;550-555
34. Ramaswamy S., Nakamura N., Sansal I., Bergeron L., Sellers W.R. A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell. 2:2002;81-91
35. Rommel C., Bodine S.C., Clarke B.A., Rossman R., Nunez L., Stitt T.N., Yancopoulos G.D., Glass D.J. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat. Cell Biol. 3:2001;1009-1013
36. Rubinson D.A., Dillon C.P., Kwiatkowski A.V., Sievers C., Yang L., Kopinja J., Rooney D.L., Ihrig M.M., McManus M.T., Gertler F.B., et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat. Genet. 33:2003;401-406
37. Sacheck J., Ohtsuka A., McLary C., Goldberg A.L. IGF-1 stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin-ligases, atrogin-1 and MuRF1. Am. J. Physiol. in press:2004
38. Skurk C., Maatz H., Kim H.S., Yang J., Abid M.R., Aird W.C., Walsh K. The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J. Biol. Chem. 279:2004;1513-1525
39. Stitt, T.N., Drujan, D., Clarke, B.A., Panaro, F., Timofeyva, Y., Kline, W.O., Gonzalez, M., Yancopoulos, G.D., and Glass, D.J. (2004). The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol. Cell., in press. Published online April 30, 2004. 10.1016/S1097276504002114
40. Tran, H., Brunet, A., Griffith, E.C., and Greenberg, M.E. (2003). The many forks in FOXO's road. Science's STKE, 10.1126/stke.2003.172.re5.
41. Verdu J., Buratovich M.A., Wilder E.L., Birnbaum M.J. Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nat. Cell Biol. 1:1999;500-506