Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

Aging Cell

Volumn 12, Issue 4, 2013, Pages 645-651

  Mercken, Evi M ^a   Crosby, Seth D ^b   Lamming, Dudley W ^c,d,e   Jebailey, Lellean ^f   Krzysik Walker, Susan ^a   Villareal, Dennis T ^b   Capri, Miriam ^g   Franceschi, Claudio ^g   Zhang, Yongqing ^a   Becker, Kevin ^a   Sabatini, David M ^c,d,e   de Cabo, Rafael ^a   Fontana, Luigi ^b,h,i  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^f GeneGo bioinformatics software Inc   (United States)

^g UNIVERSITY OF BOLOGNA   (Italy)

^h UNIVERSITY OF SALERNO   (Italy)

ⁱ CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

Caloric restriction; Human; Insulin IGF 1 signaling; Skeletal muscle

Indexed keywords

INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN C; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; TRANSCRIPTOME;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CALORIC RESTRICTION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GROUPS BY AGE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INFLAMMATION; LONGEVITY; MALE; MUSCLE METABOLISM; MUSCLE MITOCHONDRION; NONHUMAN; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; ADIPOSE TISSUE; AGING; ANIMAL; CYTOLOGY; GENETICS; KAPLAN MEIER METHOD; METABOLISM; MITOCHONDRIAL DYNAMICS; PRINCIPAL COMPONENT ANALYSIS; QUADRICEPS FEMORIS MUSCLE; SIGNAL TRANSDUCTION;

RATTUS;

ADIPOSE TISSUE; ADULT; AGING; ANIMALS; CALORIC RESTRICTION; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; KAPLAN-MEIER ESTIMATE; MALE; MITOCHONDRIAL TURNOVER; PHOSPHATIDYLINOSITOL 3-KINASES; PRINCIPAL COMPONENT ANALYSIS; QUADRICEPS MUSCLE; RATS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSCRIPTOME;

EID: 84880509894     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12088     Document Type: Article

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