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Volumn 146, Issue 9, 2005, Pages 3718-3723

Role of the growth hormone/insulin-like growth factor system in mammalian aging

Author keywords

Aging; Growth hormone; IGF 1; Insulin sensitivity; Mice

Indexed keywords

GROWTH HORMONE; INSULIN; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN; SOMATOMEDIN C;

EID: 23844551318     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2005-0411     Document Type: Short Survey
Times cited : (255)

References (77)
  • 5
    • 0034455827 scopus 로고    scopus 로고
    • Assessment of growth parameters and life span of GHR/BP gene-disrupted mice
    • Coschigano KT, Clemmons D, Bellush LL, Kopchick JJ 2000 Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology 141:2608-2613
    • (2000) Endocrinology , vol.141 , pp. 2608-2613
    • Coschigano, K.T.1    Clemmons, D.2    Bellush, L.L.3    Kopchick, J.J.4
  • 6
    • 0035811073 scopus 로고    scopus 로고
    • Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
    • Flurkey K, Papaconstantinou J, Miller RA, Harrison DE 2001 Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Nat Acad Sci USA 98:6736-6741
    • (2001) Proc Nat Acad Sci USA , vol.98 , pp. 6736-6741
    • Flurkey, K.1    Papaconstantinou, J.2    Miller, R.A.3    Harrison, D.E.4
  • 10
    • 0001560622 scopus 로고
    • Dwarf, a new mendelian recessive character of the house mouse
    • Snell GD 1929 Dwarf, a new mendelian recessive character of the house mouse. Proc Natl Acad Sci USA 15:733-734
    • (1929) Proc Natl Acad Sci USA , vol.15 , pp. 733-734
    • Snell, G.D.1
  • 11
    • 0017078016 scopus 로고
    • Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6
    • Eicher EM, Beamer WG 1976 Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6. J Hered 67:87-91
    • (1976) J Hered , vol.67 , pp. 87-91
    • Eicher, E.M.1    Beamer, W.G.2
  • 13
    • 0041419437 scopus 로고    scopus 로고
    • Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span
    • Coschigano KT, Holland AN, Riders ME, List EO, Flyvbjerg A, Kopchick JJ 2003 Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology 144:3799-3810
    • (2003) Endocrinology , vol.144 , pp. 3799-3810
    • Coschigano, K.T.1    Holland, A.N.2    Riders, M.E.3    List, E.O.4    Flyvbjerg, A.5    Kopchick, J.J.6
  • 16
    • 0028788807 scopus 로고
    • Assessment of the primary adrenal cortical and pancreatic hormone basal levels in relation to plasma glucose and age in the unstressed Ames dwarf mouse
    • Borg KE, Brown-Borg HM, Bartke A 1995 Assessment of the primary adrenal cortical and pancreatic hormone basal levels in relation to plasma glucose and age in the unstressed Ames dwarf mouse. Proc Soc Exp Biol Med 210:126-133
    • (1995) Proc Soc Exp Biol Med , vol.210 , pp. 126-133
    • Borg, K.E.1    Brown-Borg, H.M.2    Bartke, A.3
  • 18
    • 0036237480 scopus 로고    scopus 로고
    • Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-I and IRS-2 in liver of Ames dwarf mice
    • Dominici FP, Hauck S, Argentino DP, Bartke A, Turyn D 2002 Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-I and IRS-2 in liver of Ames dwarf mice. J Endocrinol 173:81-94
    • (2002) J Endocrinol , vol.173 , pp. 81-94
    • Dominici, F.P.1    Hauck, S.2    Argentino, D.P.3    Bartke, A.4    Turyn, D.5
  • 19
    • 0036103401 scopus 로고    scopus 로고
    • Implications of the insulin signaling pathway in Snell dwarf mouse longevity: A similarity with the C. elegans longevity paradigm
    • Hsieh C-C, DeFord JH, Flurkey K, Harrison DE, Papaconstantinou J 2002 Implications of the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm. Mech Ageing Dev 123:1229-1243
    • (2002) Mech Ageing Dev , vol.123 , pp. 1229-1243
    • Hsieh, C.-C.1    DeFord, J.H.2    Flurkey, K.3    Harrison, D.E.4    Papaconstantinou, J.5
  • 21
    • 0002950745 scopus 로고
    • Influence of luteotrophin on fertility of dwarf mice
    • Bartke A 1965 Influence of luteotrophin on fertility of dwarf mice. J Reprod Fertil 10:93-103
    • (1965) J Reprod Fertil , vol.10 , pp. 93-103
    • Bartke, A.1
  • 23
    • 13744258936 scopus 로고    scopus 로고
    • The influence of genes on the aging process of mice: A statistical assessment of the genetics of aging
    • de Magalhaes JP, Cabral J, Magalhaes D 2005 The influence of genes on the aging process of mice: A statistical assessment of the genetics of aging. Genetics 169:265-274
    • (2005) Genetics , vol.169 , pp. 265-274
    • De Magalhaes, J.P.1    Cabral, J.2    Magalhaes, D.3
  • 24
    • 0345237923 scopus 로고    scopus 로고
    • Delayed occurrence of fatal neoplastic diseases in Ames dwarf mice: Correlation to extended longevity
    • Ikeno Y, Bronson, RT, Hubbard, GB, Lee, S, Bartke, A. 2003 Delayed occurrence of fatal neoplastic diseases in Ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci 58A:291-296
    • (2003) J Gerontol A Biol Sci Med Sci , vol.58 A , pp. 291-296
    • Ikeno, Y.1    Bronson, R.T.2    Hubbard, G.B.3    Lee, S.4    Bartke, A.5
  • 25
    • 0034966342 scopus 로고    scopus 로고
    • Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters
    • Kinney BA, Meliska CJ, Steger RW, Bartke A 2001 Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters. Horm Behav 39:277-284
    • (2001) Horm Behav , vol.39 , pp. 277-284
    • Kinney, B.A.1    Meliska, C.J.2    Steger, R.W.3    Bartke, A.4
  • 26
    • 0035051811 scopus 로고    scopus 로고
    • Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice
    • Kinney BA, Coschigano KT, Kopchick JJ, Bartke A 2001 Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice. Physiol Behav 72:653-660
    • (2001) Physiol Behav , vol.72 , pp. 653-660
    • Kinney, B.A.1    Coschigano, K.T.2    Kopchick, J.J.3    Bartke, A.4
  • 27
    • 0015466216 scopus 로고
    • Articular aging and osteoarthrosis in dwarf mice
    • Silberberg R 1972 Articular aging and osteoarthrosis in dwarf mice. Path Microbiol 38:417-430
    • (1972) Path Microbiol , vol.38 , pp. 417-430
    • Silberberg, R.1
  • 28
    • 0000457407 scopus 로고
    • La production de chaleur de la souris. Etude de plusieurs races de souris
    • Benedict FG, Lee RC 1936 La production de chaleur de la souris. Etude de plusieurs races de souris. Ann Physiol Physicochim Biol 12:983-1064
    • (1936) Ann Physiol Physicochim Biol , vol.12 , pp. 983-1064
    • Benedict, F.G.1    Lee, R.C.2
  • 29
    • 0034993409 scopus 로고    scopus 로고
    • Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in the growth hormone receptor/binding protein knockout mouse
    • Hauck SJ, Hunter WS, Danilovich N, Kopchick JJ, Bartke A 2001 Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in the growth hormone receptor/binding protein knockout mouse. Exp Biol Med 226:552-558
    • (2001) Exp Biol Med , vol.226 , pp. 552-558
    • Hauck, S.J.1    Hunter, W.S.2    Danilovich, N.3    Kopchick, J.J.4    Bartke, A.5
  • 30
    • 0035728328 scopus 로고    scopus 로고
    • Mitochondrial oxidant generation and oxidative damage in Ames dwarf and GH transgenic mice
    • Brown-Borg H, Johnson W, Rakoczy S, Romanick M 2001 Mitochondrial oxidant generation and oxidative damage in Ames dwarf and GH transgenic mice. Amer Aging Assoc 24:85-96
    • (2001) Amer Aging Assoc , vol.24 , pp. 85-96
    • Brown-Borg, H.1    Johnson, W.2    Rakoczy, S.3    Romanick, M.4
  • 31
    • 0032751474 scopus 로고    scopus 로고
    • Antioxidative mechanisms and plasma growth hormone levels
    • Brown-Borg HM, Bode AM, Bartke A 1999 Antioxidative mechanisms and plasma growth hormone levels. Endocrine 11:41-48
    • (1999) Endocrine , vol.11 , pp. 41-48
    • Brown-Borg, H.M.1    Bode, A.M.2    Bartke, A.3
  • 32
    • 0034027841 scopus 로고    scopus 로고
    • Catalase expression in delayed and premature aging mouse models
    • Brown-Borg H, Rakoczy S 2000 Catalase expression in delayed and premature aging mouse models. Exp Gerontol 35:199-212
    • (2000) Exp Gerontol , vol.35 , pp. 199-212
    • Brown-Borg, H.1    Rakoczy, S.2
  • 33
    • 0034653367 scopus 로고    scopus 로고
    • Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase
    • Hauck S, Bartke A 2000 Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase. Free Rad Biol & Med 28:970-978
    • (2000) Free Rad Biol & Med , vol.28 , pp. 970-978
    • Hauck, S.1    Bartke, A.2
  • 34
    • 12344305246 scopus 로고    scopus 로고
    • Glutathione metabolism in long-living Ames dwarf mice
    • Brown-Borg HM, Rakoczy SG 2005 Glutathione metabolism in long-living Ames dwarf mice. Exp Gerontol 40:115-20
    • (2005) Exp Gerontol , vol.40 , pp. 115-120
    • Brown-Borg, H.M.1    Rakoczy, S.G.2
  • 35
    • 0036665932 scopus 로고    scopus 로고
    • Long-lived Ames dwarf mice: Oxidative damage to mitochondrial DNA in heart and brain
    • Sanz A, Bartke A, Barja G 2002 Long-lived Ames dwarf mice: oxidative damage to mitochondrial DNA in heart and brain. J Am Aging Assoc 25:119-122
    • (2002) J Am Aging Assoc , vol.25 , pp. 119-122
    • Sanz, A.1    Bartke, A.2    Barja, G.3
  • 36
    • 0042203536 scopus 로고    scopus 로고
    • Multiplex stress resistance in cells from long-lived dwarf mice
    • Murakami S, Salmon A, Miller R 2003 Multiplex stress resistance in cells from long-lived dwarf mice. FASEB 17:1565-6
    • (2003) FASEB , vol.17 , pp. 1565-1566
    • Murakami, S.1    Salmon, A.2    Miller, R.3
  • 38
    • 0030292450 scopus 로고    scopus 로고
    • Hypothesis: Interventions that increase the response to stress offer the potential for effective life prolongation and increased health
    • Johnson TE, Lithgow GJ, Murakami S 1996 Hypothesis: interventions that increase the response to stress offer the potential for effective life prolongation and increased health. J Gerontol A Biol Sci Med Sci 51:B392-5
    • (1996) J Gerontol A Biol Sci Med Sci , vol.51
    • Johnson, T.E.1    Lithgow, G.J.2    Murakami, S.3
  • 39
    • 0003069083 scopus 로고    scopus 로고
    • Dietary Restriction: An Experimental Approach to the Study of the Biology of Aging
    • Masoro EJ, Austad SN (eds) Academic Press, San Diego
    • Masoro EJ 2001 Dietary Restriction: An Experimental Approach to the Study of the Biology of Aging. In: Masoro EJ, Austad SN (eds) Handbook of The Biology of Aging (Fifth Edition). Academic Press, San Diego, pp 396-420
    • (2001) Handbook of the Biology of Aging (Fifth Edition) , pp. 396-420
    • Masoro, E.J.1
  • 40
    • 0028985830 scopus 로고
    • Number and size of islets of langerhans in pregnant, human growth hormone-expressing transgenic, and pituitary dwarf mice: Effect of lactogenic hormones
    • Parsons JA, Bartke A, Sorenson RL 1995 Number and size of islets of langerhans in pregnant, human growth hormone-expressing transgenic, and pituitary dwarf mice: Effect of lactogenic hormones. Endocrinology 136:2013-2021
    • (1995) Endocrinology , vol.136 , pp. 2013-2021
    • Parsons, J.A.1    Bartke, A.2    Sorenson, R.L.3
  • 41
    • 12344335482 scopus 로고    scopus 로고
    • Long-lived growth hormone receptor knockout mice: Interaction of reduced insulin-like growth factor 1/insulin signaling and caloric restriction
    • Al-Regaiey KA, Masternak MM, Bonkowski M, Sun L, Bartke A 2005 Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor 1/insulin signaling and caloric restriction. Endocrinology 146:851-60
    • (2005) Endocrinology , vol.146 , pp. 851-860
    • Al-Regaiey, K.A.1    Masternak, M.M.2    Bonkowski, M.3    Sun, L.4    Bartke, A.5
  • 42
  • 44
    • 0034626747 scopus 로고    scopus 로고
    • Genetic pathways that regulate ageing in model organisms
    • Guarente L, Kenyon C 2000 Genetic pathways that regulate ageing in model organisms. Nature 408:255-262
    • (2000) Nature , vol.408 , pp. 255-262
    • Guarente, L.1    Kenyon, C.2
  • 45
    • 0037470501 scopus 로고    scopus 로고
    • The endocrine regulation of aging by insulin-like signals
    • Tatar M, Bartke A, Antebi A 2003 The endocrine regulation of aging by insulin-like signals. Science 299:1346-1351
    • (2003) Science , vol.299 , pp. 1346-1351
    • Tatar, M.1    Bartke, A.2    Antebi, A.3
  • 47
    • 9644270707 scopus 로고    scopus 로고
    • Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways
    • Kojima T, Kamei H, Aizu T, Arai Y, Takayama M, Nakazawa S, Ebihara Y, Inagaki H, Masui Y, Gondo Y 2004 Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways. Exp Gerontol 39:1595-1598
    • (2004) Exp Gerontol , vol.39 , pp. 1595-1598
    • Kojima, T.1    Kamei, H.2    Aizu, T.3    Arai, Y.4    Takayama, M.5    Nakazawa, S.6    Ebihara, Y.7    Inagaki, H.8    Masui, Y.9    Gondo, Y.10
  • 49
    • 11144242821 scopus 로고    scopus 로고
    • Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: Studies of a novel mouse model combining lactogen resistance and growth hormone deficiency
    • Fleenor D, Oden J, Kelly PA, Mohan S, Alliouachene S, Pende M, Wentz S, Kerr J, Freemark M 2005 Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: Studies of a novel mouse model combining lactogen resistance and growth hormone deficiency. Endocrinology 146:103-112
    • (2005) Endocrinology , vol.146 , pp. 103-112
    • Fleenor, D.1    Oden, J.2    Kelly, P.A.3    Mohan, S.4    Alliouachene, S.5    Pende, M.6    Wentz, S.7    Kerr, J.8    Freemark, M.9
  • 50
    • 0032958139 scopus 로고    scopus 로고
    • Pituitary and testicular function in growth hormone receptor gene knockout mice
    • Chandrashekar V, Bartke A, Coschigano KT, Kopchick JJ 1999 Pituitary and testicular function in growth hormone receptor gene knockout mice. Endocrinology 140:1082-1088
    • (1999) Endocrinology , vol.140 , pp. 1082-1088
    • Chandrashekar, V.1    Bartke, A.2    Coschigano, K.T.3    Kopchick, J.J.4
  • 51
    • 0036358167 scopus 로고    scopus 로고
    • Growth negatively impacts the life span of mammals
    • Rollo CD 2002 Growth negatively impacts the life span of mammals. Evol. Dev. 4:55-61
    • (2002) Evol. Dev. , vol.4 , pp. 55-61
    • Rollo, C.D.1
  • 52
    • 0013056730 scopus 로고    scopus 로고
    • Big mice die young: Early life body weight predicts longevity in genetically heterogeneous mice
    • Miller RA, Harper JM, Galecki A, Burke DT 2002 Big mice die young: Early life body weight predicts longevity in genetically heterogeneous mice. Aging Cell 1:22-29
    • (2002) Aging Cell , vol.1 , pp. 22-29
    • Miller, R.A.1    Harper, J.M.2    Galecki, A.3    Burke, D.T.4
  • 53
    • 0023899013 scopus 로고
    • Insulin-like growth factor I levels in proportionate dogs, chondrodystrophic dogs and in giant dogs
    • Eigenmann JE, Amador A, Patterson DF 1988 Insulin-like growth factor I levels in proportionate dogs, chondrodystrophic dogs and in giant dogs. Acta Endocrinol 118:105-108
    • (1988) Acta Endocrinol , vol.118 , pp. 105-108
    • Eigenmann, J.E.1    Amador, A.2    Patterson, D.F.3
  • 54
    • 0030992739 scopus 로고    scopus 로고
    • Comparative longevity of pet dogs and humans: Implications for gerontology research
    • Patronek GJ, Waters DJ, Glickman LT 1997 Comparative longevity of pet dogs and humans: Implications for gerontology research. J Gerontol 52A:B171-B178
    • (1997) J Gerontol , vol.52 A
    • Patronek, G.J.1    Waters, D.J.2    Glickman, L.T.3
  • 56
    • 13944282128 scopus 로고    scopus 로고
    • Sex and death: What is the connection?
    • Partridge L, Gems D, Withers DJ 2005 Sex and death: What is the connection? Cell 120:461-472
    • (2005) Cell , vol.120 , pp. 461-472
    • Partridge, L.1    Gems, D.2    Withers, D.J.3
  • 58
    • 0036843071 scopus 로고    scopus 로고
    • Gene expression patterns in calorically restricted mice: Partial overlap with long-lived mutant mice
    • Miller RA, Chang Y, Galecki AT, Al-Regaiey K, Kopchick JJ, Bartke A 2002 Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice. Mol Endocrinol 16:2657-2666
    • (2002) Mol Endocrinol , vol.16 , pp. 2657-2666
    • Miller, R.A.1    Chang, Y.2    Galecki, A.T.3    Al-Regaiey, K.4    Kopchick, J.J.5    Bartke, A.6
  • 60
    • 0037322925 scopus 로고    scopus 로고
    • Body composition of prolactin-, growth hormone-, and thyrotropin- deficient Ames dwarf mice
    • Heiman M, Tinsley F, Mattison J, Hauck S, Bartke A 2003 Body composition of prolactin-, growth hormone-, and thyrotropin-deficient Ames dwarf mice. Endocrine 20:149-154
    • (2003) Endocrine , vol.20 , pp. 149-154
    • Heiman, M.1    Tinsley, F.2    Mattison, J.3    Hauck, S.4    Bartke, A.5
  • 62
    • 13844277026 scopus 로고    scopus 로고
    • Local Expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived Mice
    • Sun LY, Al-Regaiey K, Masternak MM, Wang J, Bartke A 2005 Local Expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived Mice. Neurobiol Aging 26:929-937
    • (2005) Neurobiol Aging , vol.26 , pp. 929-937
    • Sun, L.Y.1    Al-Regaiey, K.2    Masternak, M.M.3    Wang, J.4    Bartke, A.5
  • 63
    • 14244266395 scopus 로고    scopus 로고
    • Increased neurogenesis in dentate gyrus of long-lived Ames dwarf mice
    • Sun LY, Evans MS, Hsieh J, Panici J, Bartke A 2005 Increased neurogenesis in dentate gyrus of long-lived Ames dwarf mice. Endocrinology 146:1138-1144
    • (2005) Endocrinology , vol.146 , pp. 1138-1144
    • Sun, L.Y.1    Evans, M.S.2    Hsieh, J.3    Panici, J.4    Bartke, A.5
  • 64
    • 1242292288 scopus 로고    scopus 로고
    • Could a deficiency in growth hormone signaling be beneficial to the aging brain?
    • Kinney-Forshee B, Kinney N, Steger R, Bartke A 2004 Could a deficiency in growth hormone signaling be beneficial to the aging brain? Physiol Behav 80:589-94
    • (2004) Physiol Behav , vol.80 , pp. 589-594
    • Kinney-Forshee, B.1    Kinney, N.2    Steger, R.3    Bartke, A.4
  • 65
    • 0032483062 scopus 로고    scopus 로고
    • Insulin-like growth factor-I (IGF-I) ameliorates age-related behavioral deficits
    • Markowska AL, Mooney M, Sonntag WE 1998 Insulin-like growth factor-I (IGF-I) ameliorates age-related behavioral deficits. Neuroscience 87:559-569
    • (1998) Neuroscience , vol.87 , pp. 559-569
    • Markowska, A.L.1    Mooney, M.2    Sonntag, W.E.3
  • 67
    • 0036086818 scopus 로고    scopus 로고
    • Lifespan extension by reduction of the growth hormone-insulin-like growth factor-1 axis: Relation to caloric restriction
    • Shimokawa I, Higami Y, Utsuyama M, Tuchiya T, Komatsu T, Chiba T, Yamaza H 2002 Lifespan extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction. Am J Pathol 160:2259-2265
    • (2002) Am J Pathol , vol.160 , pp. 2259-2265
    • Shimokawa, I.1    Higami, Y.2    Utsuyama, M.3    Tuchiya, T.4    Komatsu, T.5    Chiba, T.6    Yamaza, H.7
  • 69
    • 13444311915 scopus 로고    scopus 로고
    • Plasma and hypothalamic peptide-hormone levels regulating somatotroph function and energy balance in fed and fasted states: A comparative study in four strains of rats
    • Kappeler L, Zizzari P, Grouselle D, Epelbaum J, Bluet-Pajot MT 2004 Plasma and hypothalamic peptide-hormone levels regulating somatotroph function and energy balance in fed and fasted states: A comparative study in four strains of rats. J Neuroendocrinol 16:980-988
    • (2004) J Neuroendocrinol , vol.16 , pp. 980-988
    • Kappeler, L.1    Zizzari, P.2    Grouselle, D.3    Epelbaum, J.4    Bluet-Pajot, M.T.5
  • 71
    • 11044228316 scopus 로고    scopus 로고
    • Do deficiencies in growth hormone and insulin-like growth factor-1 (IGF-1) shorten or prolong longevity?
    • Laron Z 2005 Do deficiencies in growth hormone and insulin-like growth factor-1 (IGF-1) shorten or prolong longevity? Mech Ageing Dev 126:305-307
    • (2005) Mech Ageing Dev , vol.126 , pp. 305-307
    • Laron, Z.1
  • 75
    • 0242490056 scopus 로고    scopus 로고
    • Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice
    • Bartke A 2003 Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice. Neuroendocrinology 78:210-216
    • (2003) Neuroendocrinology , vol.78 , pp. 210-216
    • Bartke, A.1
  • 77
    • 0038637217 scopus 로고    scopus 로고
    • Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: Cues for an evolutionarily conserved mechanism of life span control
    • Jul
    • Bonafe M, Barbieri M, Marchegiani F, Olivieri F, Ragno E, Giampieri C, Mugianesi E, Centurelli M, Franceschi C, Paolisso Gl 2003 Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. J Clin Endocrinol Metab Jul;88:3299-304
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3299-3304
    • Bonafe, M.1    Barbieri, M.2    Marchegiani, F.3    Olivieri, F.4    Ragno, E.5    Giampieri, C.6    Mugianesi, E.7    Centurelli, M.8    Franceschi, C.9    Paolisso, Gl.10


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