NF-κB inhibition delays DNA damage - Induced senescence and aging in mice

Journal of Clinical Investigation

Volumn 122, Issue 7, 2012, Pages 2601-2612

  Tilstra, Jeremy S ^a   Robinson, Andria R ^b,c   Wang, Jin ^d   Gregg, Siobhán Q ^a,c   Clauson, Cheryl L ^a   Reay, Daniel P ^a   Nasto, Luigi A ^a   St Croix, Claudette M ^a   Usas, Arvydas ^a   Vo, Nam ^a   Huard, Johnny ^a   Clemens, Paula R ^a   Stolz, Donna B ^a   Guttridge, Denis C ^e   Watkins, Simon C ^a   Garinis, George A ^f   Wang, Yinsheng ^d   Niedernhofer, Laura J ^a,c,g   Robbins, Paul D ^a,g  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e OHIO STATE UNIVERSITY   (United States)

^f INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY   (Greece)

^g SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOFUSCIN; SOMATOMEDIN C; TRANSCRIPTION FACTOR RELA;

AGING; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL DAMAGE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CYTOPLASM; DEGENERATIVE DISEASE; DNA BINDING; DNA DAMAGE; EMBRYO; GENE EXPRESSION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SENESCENCE; SYMPTOM;

AGING; ANIMALS; CELL AGING; CELL NUCLEUS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA DAMAGE; DNA-BINDING PROTEINS; ENDONUCLEASES; GENE EXPRESSION REGULATION; HEPATOCYTES; I-KAPPA B KINASE; MICE; MICE, TRANSGENIC; OXIDATIVE STRESS; PEPTIDES; PHOSPHORYLATION; PROGERIA; PROTEIN BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TRANSCRIPTIONAL ACTIVATION;

EID: 84863550186     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI45785     Document Type: Article

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