HMB attenuates muscle loss during sustained energy deficit induced by calorie restriction and endurance exercise

Metabolism: Clinical and Experimental

Volumn 62, Issue 12, 2013, Pages 1718-1729

  Park, Bong Sup ^a   Henning, Paul C ^a,c   Grant, Samuel C ^b   Lee, Won Jun ^a,d   Lee, Sang Rok ^a   Arjmandi, Bahram H ^a   Kim, Jeong Su ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

^b FAMU FSU COLLEGE OF ENGINEERING   (United States)

^c U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

^d Ewha Womans University   (South Korea)

Author keywords

Body composition; Catabolic; Functionality; Mice; Protein degradation

Indexed keywords

ATROGIN 1; BETA HYDROXY BETA METHYLBUTYRATE; BRANCHED CHAIN AMINO ACID; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; CALORIC RESTRICTION; CONTROLLED STUDY; DRUG EFFICACY; ENDURANCE TRAINING; ENERGY BALANCE; GASTROCNEMIUS MUSCLE; GENE EXPRESSION; GRIP STRENGTH; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MUSCLE ATROPHY; MUSCLE MASS; NONHUMAN; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SENSORIMOTOR FUNCTION;

Β-HYDROXY-Β-METHYLBUTYRATE; AD LIBITUM-TRAINED; AD LIBITUM-TRAINED+HMB; ALT; ALTH; B; BASELINE; BASELINE+HMB; BH; BODY COMPOSITION; C; CALORIC RESTRICTED+TRAINED; CALORIC RESTRICTED+TRAINED+HMB; CATABOLIC; CH; CROSS-SECTIONAL AREA; CSA; DUAL ENERGY X-RAY ABSORPTIOMETRY; DXA; FUNCTIONALITY; GAPDH; GLYCERALDEHYDES 3-PHOSPHATE DEHYDROGENASE; HMB; LBM; LEAN BODY MASS; MICE; NATIONAL HIGH MAGNETIC FIELD LABORATORY; NHMFL; PROTEIN DEGRADATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RT-PCR; SUSOPS; SUSTAINED OPERATIONS; TB; TRUE BASELINE;

ANATOMY, CROSS-SECTIONAL; ANIMALS; BLOTTING, WESTERN; BODY COMPOSITION; CALORIC RESTRICTION; DIET; ENERGY METABOLISM; HAND STRENGTH; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, MUSCLE; MUSCLE FIBERS, SKELETAL; MUSCLE PROTEINS; MUSCLE STRENGTH; MUSCLE, SKELETAL; NEURAL CONDUCTION; ORGAN SIZE; PHYSICAL CONDITIONING, ANIMAL; PHYSICAL ENDURANCE; REAL-TIME POLYMERASE CHAIN REACTION; SKP CULLIN F-BOX PROTEIN LIGASES; UBIQUITIN-PROTEIN LIGASES; VALERATES;

EID: 84888007754     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2013.06.005     Document Type: Article

References (35)

1. B.C. Nindl, C.D. Leone, and W.J. Tharion Physical performance responses during 72 h of military operational stress Med Sci Sports Exerc 34 11 2002 1814 1822
2. B.C. Nindl, B.R. Barnes, and J.A. Alemany Physiological consequences of U.S. Army Ranger training Med Sci Sports Exerc 39 8 2007 1380 1387
3. L.B. Panton, J.A. Rathmacher, and S. Baier Nutritional supplementation of the leucine metabolite beta-hydroxy-beta-methylbutyrate (HMB) during resistance training Nutrition 16 9 2000 734 739
4. V.E. Baracos Management of muscle wasting in cancer-associated cachexia: understanding gained from experimental studies Cancer 92 6 Suppl 2001 1669 1677
5. H.J. Smith, P. Mukerji, and M.J. Tisdale Attenuation of proteasome-induced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}- methylbutyrate in cancer-induced muscle loss Cancer Res 65 1 2005 277 283
6. G.D. Pimentel, J.C. Rosa, and F.S. Lira beta-Hydroxy-beta-methylbutyrate (HMbeta) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway Nutr Metab (Lond) 8 1 2011 11
7. R. Kornasio, I. Riederer, and G. Butler-Browne beta-hydroxy-beta- methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3K/Akt pathways Biochim Biophys Acta 1793 5 2009 755 763
8. C.J. Rogers, D. Berrigan, and D.A. Zaharoff Energy restriction and exercise differentially enhance components of systemic and mucosal immunity in mice J Nutr 138 1 2008 115 122
9. J.H. Baxter, J.L. Carlos, and J. Thurmond Dietary toxicity of calcium beta-hydroxy-beta-methyl butyrate (CaHMB) Food Chem Toxicol 43 12 2005 1731 1741
10. J.-S. Kim, Y.-M Park, and S.-R. Lee β-hydroxy-β-methylbutyrate did not enhance high intensity resistance training-induced improvements in myofiber dimensions and myogenic capacity in aged female rats Mol Cells 3 2012 439 448
11. V. Navarro, A. Fernandez-Quintela, and I. Churruca The body fat-lowering effect of conjugated linoleic acid: a comparison between animal and human studies J Physiol Biochem 62 2 2006 137 147
12. Y. Torii, N. Kiyota, and N. Sugimoto Comparison of effects of botulinum toxin subtype A1 and A2 using twitch tension assay and rat grip strength test Toxicon 57 1 2011 93 99
13. O.A. Meyer, H.A. Tilson, and W.C. Byrd A method for the routine assessment of fore- and hindlimb grip strength of rats and mice Neurobehav Toxicol 1 3 1979 233 236
14. M.P. Murphy, J.T. Rick, and N.W. Milgram A simple and rapid test of sensorimotor function in the aged rat Neurobiol Learn Mem 64 2 1995 181 186
15. C.E. Bailey, D.W. Hammers, and J.H. Deford Ischemia-reperfusion enhances GAPDH nitration in aging skeletal muscle Aging (Albany NY) 3 10 2011 1003 1017
16. K. Ma, C. Mallidis, and S. Bhasin Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression Am J Physiol Endocrinol Metab 285 2 2003 E363 E371
17. S. Reisz-Porszasz, S. Bhasin, and J.N. Artaza Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin Am J Physiol Endocrinol Metab 285 4 2003 E876 E888
18. S.A. Parsons, D.P. Millay, and B.J. Wilkins Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy J Biol Chem 279 25 2004 26192 26200
19. T.R. Magee, J.N. Artaza, and M.G. Ferrini Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass J Gene Med 8 9 2006 1171 1181
20. A. Csibi, M.P. Leibovitch, and K. Cornille MAFbx/Atrogin-1 controls the activity of the initiation factor eIF3-f in skeletal muscle atrophy by targeting multiple C-terminal lysines J Biol Chem 284 7 2009 4413 4421
21. L.A. Gilliam, J.S. Moylan, and E.W. Patterson Doxorubicin acts via mitochondrial ROS to stimulate catabolism in C2C12 myotubes Am J Physiol Cell Physiol 302 1 2012 C195 C202
22. J.S. Kim, J.M. Cross, and M.M. Bamman Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women Am J Physiol Endocrinol Metab 288 6 2005 E1110 E1119
23. J.J. Widrick, G.F. Maddalozzo, and D. Lewis Morphological and functional characteristics of skeletal muscle fibers from hormone-replaced and nonreplaced postmenopausal women J Gerontol A Biol Sci Med Sci 58 1 2003 3 10
24. M.B. Cooke, E. Rybalka, and C.G. Stathis Whey protein isolate attenuates strength decline after eccentrically-induced muscle damage in healthy individuals J Int Soc Sports Nutr 7 2010 30
25. S.M. Firth, and R.C. Baxter Cellular actions of the insulin-like growth factor binding proteins Endocr Rev 23 6 2002 824 854
26. V.G. Coffey, D.R. Moore, and N.A. Burd Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints Eur J Appl Physiol 111 7 2011 1473 1483
27. S.C. Bodine, E. Latres, and S. Baumhueter Identification of ubiquitin ligases required for skeletal muscle atrophy Science 294 5547 2001 1704 1708
28. H.L. Katzeff, K.M. Ojamaa, and I. Klein The effects of long-term aerobic exercise and energy restriction on protein synthesis Metabolism 44 2 1995 188 192
29. R.G. Pedrosa, J. Donato, and I.S. Pires Leucine supplementation favors liver protein status but does not reduce body fat in rats during 1 week of food restriction Appl Physiol Nutr Metab 35 2 2010 180 183
30. J. Knapik, C. Meredith, and B. Jones Leucine metabolism during fasting and exercise J Appl Physiol 70 1 1991 43 47
31. E. Tsalikian, C. Howard, and J.E. Gerich Increased leucine flux in short-term fasted human subjects: evidence for increased proteolysis Am J Physiol 247 3 1984 E323 E327
32. H. Hayashi, H. Yamaza, and T. Komatsu Calorie restriction minimizes activation of insulin signaling in response to glucose: potential involvement of the growth hormone-insulin-like growth factor 1 axis Exp Gerontol 43 9 2008 827 832
33. S. Wullschleger, R. Loewith, and M.N. Hall TOR signaling in growth and metabolism Cell 124 3 2006 471 484
34. D.T. Villareal, G.I. Smith, and K. Shah Effect of weight loss on the rate of muscle protein synthesis during fasted and fed conditions in obese older adults Obesity 20 9 2012 1780 1786
35. M.D. Gomes, S.H. Lecker, and R.T. Jagoe Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy Proc Natl Acad Sci U S A 98 25 2001 14440 14445