Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome

Journal of Physiology

Volumn 591, Issue 18, 2013, Pages 4611-4620

  Jacobs, Brittany L ^a   You, Jae Sung ^a   Frey, John W ^a   Goodman, Craig A ^a   Gundermann, David M ^a   Hornberger, Troy A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; TUBERIN;

ANIMAL EXPERIMENT; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; ECCENTRIC MUSCLE CONTRACTION; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LYSOSOME; MALE; MECHANICAL STIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SKELETAL MUSCLE; WESTERN BLOTTING;

AMINO ACID MOTIFS; ANIMALS; CELL LINE; LYSOSOMES; MALE; MICE; MICE, INBRED C57BL; MUSCLE CONTRACTION; MUSCLE, SKELETAL; PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 84884254389     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2013.256339     Document Type: Article

References (23)

1. Bodine SC, Stitt TN, Gonzalez M, Kline WO, Stover GL, Bauerlein R, Zlotchenko E, Scrimgeour A, Lawrence JC, Glass DJ & Yancopoulos GD (2001). Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol 3, 1014-1019.
2. Cai SL, Tee AR, Short JD, Bergeron JM, Kim J, Shen J, Guo R, Johnson CL, Kiguchi K & Walker CL (2006). Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. J Cell Biol 173, 279-289.
3. Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC, Nellist M, Yeung RS, Halley DJ, Nicosia SV, Pledger WJ & Cheng JQ (2002). Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J Biol Chem 277, 35364-35370.
4. Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO & Manning BD (2012). TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell 47, 535-546.
5. Drummond GB (2009). Reporting ethical matters in The Journal of Physiology: standards and advice. J Physiol 587, 713-719.
6. Eskelinen EL (2006). Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. Mol Aspects Med 27, 495-502.
7. Goldberg AL, Etlinger JD, Goldspink DF & Jablecki C (1975). Mechanism of work-induced hypertrophy of skeletal muscle. Med Sci Sports 7, 185-198.
8. Goodman CA, Frey JW, Mabrey DM, Jacobs BL, Lincoln HC, You JS & Hornberger TA (2011). The role of skeletal muscle mTOR in the regulation of mechanical load-induced growth. J Physiol 589, 5485-5501.
9. Goodman CA, Miu MH, Frey JW, Mabrey DM, Lincoln HC, Ge Y, Chen J & Hornberger TA (2010). A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signalling is sufficient to induce skeletal muscle hypertrophy. Mol Biol Cell 21, 3258-3268.
10. Hornberger TA, Stuppard R, Conley KE, Fedele MJ, Fiorotto ML, Chin ER & Esser KA (2004). Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism. Biochem J 380, 795-804.
11. Huang J & Manning BD (2008). The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J 412, 179-190.
12. Miyazaki M, McCarthy JJ & Esser KA (2010). Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes. FEBS J 277, 2180-2191.
13. O'Neil TK, Duffy LR, Frey JW & Hornberger TA (2009). The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions. J Physiol 587, 3691-3701.
14. Pearce LR, Komander D & Alessi DR (2010). The nuts and bolts of AGC protein kinases. Nat Rev Mol Cell Biol 11, 9-22.
15. Saito K, Araki Y, Kontani K, Nishina H & Katada T (2005). Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin. J Biochem 137, 423-430.
16. Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S & Sabatini DM (2010). Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141, 290-303.
17. Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA & Sabatini DM (2007). PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell 25, 903-915.
18. Seguin R & Nelson ME (2003). The benefits of strength training for older adults. Am J Prev Med 25, 141-149.
19. Sengupta S, Peterson TR & Sabatini DM (2010). Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 40, 310-322.
20. Tomasoni R & Mondino A (2011). The tuberous sclerosis complex: balancing proliferation and survival. Biochem Soc Trans 39, 466-471.
21. Yoon MS, Du G, Backer JM, Frohman MA & Chen J (2011). Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. J Cell Biol 195, 435-447.
22. You JS, Frey JW & Hornberger TA (2012). Mechanical stimulation iInduces mTOR signaling via an ERK-independent mechanism: Implications for a direct activation of mTOR by phosphatidic acid. PLoS One 7, e47258.
23. Zhao K, Zhou H, Zhao X, Wolff DW, Tu Y, Liu H, Wei T & Yang F (2012). Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis. J Lipid Res 53, 2102-2114.