Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men

Journal of Physiology

Volumn 587, Issue 1, 2009, Pages 211-217

  Kumar, Vinod ^a   Selby, Anna ^a   Rankin, Debbie ^a   Patel, Rekha ^a   Atherton, Philip ^a   Hildebrandt, Wulf ^a   Williams, John ^b   Smith, Kenneth ^a   Seynnes, Olivier ^c   Hiscock, Natalie ^d   Rennie, Michael J ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b DERBY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c MANCHESTER METROPOLITAN UNIVERSITY   (United Kingdom)

^d UNILEVER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOISOCAPROIC ACID; INITIATION FACTOR 4E BINDING PROTEIN 1; LEUCINE; MUSCLE PROTEIN; S6 KINASE;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; COMBUSTION; CONTROLLED STUDY; EXERCISE INTENSITY; EXERCISE PHYSIOLOGY; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; VASTUS LATERALIS MUSCLE; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; AGING; EXERCISE; HUMANS; MALE; MUSCLE FIBERS, SKELETAL; MUSCLE PROTEINS; MUSCLE, SKELETAL; MYOFIBRILS; PHOSPHOPROTEINS; PHOSPHORYLATION; RESISTANCE TRAINING; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 58149307453     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2008.164483     Document Type: Article

References (29)

1. Baar K & Esser K (1999). Phosphorylation of p70 (S6k) correlates with increased skeletal muscle mass following resistance exercise. Am J Physiol Cell Physiol 276, C120-C127.
2. Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, Garry PJ & Lindeman RD (1998). Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147, 755-763.
3. Biolo G, Maggi SP, Williams BD, Tipton KD & Wolfe RR (1995). Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. Am J Physiol Endocrinol Metab 268, E514-E520.
4. Bowtell JL, Park DM, Smith K, Cuthbertson DJR, Waddell T & Rennie MJ (2003). Stimulation of human quadriceps protein synthesis after strenous exercise: No effects of varying intensity between 60 and 90% of one repetition maximum (1RM). J Physiol 547.P, P16.
5. Chesley A, MacDougall JD, Tarnopolsky MA, Atkinson SA & Smith K (1992). Changes in human muscle protein synthesis after resistance exercise. J Appl Physiol 73, 1383-1388.
6. Cuthbertson D, Smith K, Babraj J, Leese G, Waddell T, Atherton P, Wackerhage H, Taylor PM & Rennie MJ (2005). Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J 19, 422-424.
7. Cuthbertson DJ, Babraj JA, Smith K, Wilkes E, Fedele MJ, Esser K & Rennie MJ (2006). Anabolic signalling and protein synthesis in human skeletal muscle after dynamic shortening or lengthening exercise. Am J Physiol Endocrinol Metab 290, E731-E738.
8. Deldicque L, Theisen D & Francaux M (2005). Regulation of mTOR by amino acids and resistance exercise in skeletal muscle. Eur J Appl Physiol 94, 1-10.
9. Dreyer HC, Fujita S, Cadenas JG, Chinkes DL, Volpi E & Rasmussen BB (2006). Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J Physiol 576, 613-624.
10. Drummond MJ, Dreyer HC, Pennings B, Fry CS, Dhanani S, Dillon EL, Sheffield-Moore M, Volpi E & Rasmussen BB (2008). Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. J Appl Physiol 104, 1452-1461.
11. Fiatarone MA, Marks EC, Ryan ND, Meredith CN, Lipsitz LA & Evans WJ (1990). High-intensity strength training in nonagenarians. Effects on skeletal muscle. JAMA 263, 3029-3034.
12. Frontera WR, Hughes VA, Fielding RA, Fiatarone MA, Evans WJ & Roubenoff R (2000). Aging of skeletal muscle: A 12-yr longitudinal study. J Appl Physiol 88, 1321-1326.
13. Fujita S, Dreyer HC, Drummond MJ, Glynn EL, Volpi E & Rasmussen BB (2008). Essential amino acid and carbohydrate ingestion prior to resistance exercise does not enhance post-exercise muscle protein synthesis. J Appl Physiol (in press).
14. Greenhaff PL, Karagounis LG, Peirce N, Simpson EJ, Hazell M, Layfield R, Wackerhage H, Smith K, Atherton P, Selby A & Rennie MJ (2008). Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle. Am J Physiol Endocrinol Metab 295, E595-E604.
15. Koopman R, Zorenc AH, Gransier RJ, Cameron-Smith D & van Loon LJ (2006). Increase in S6K1 phosphorylation in human skeletal muscle following resistance exercise occurs mainly in type II muscle fibers. Am J Physiol Endocrinol Metab 290, E1245-E1252.
16. Kosek DJ, Kim JS, Petrella JK, Cross JM & Bamman MM (2006). Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults. J Appl Physiol 101, 531-544.
17. Larsson L (1983). Histochemical characteristics of human skeletal muscle during aging. Acta Physiol Scand 117, 469-471.
18. Miller BF, Olesen JL, Hansen M, Dossing S, Crameri RM, Welling RJ, Langberg H, Flyvbjerg A, Kjaer M, Babraj JA, Smith K & Rennie MJ (2005). Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise. J Physiol 567, 1021-1033.
19. Mittendorfer B, Andersen JL, Plomgaard P, Saltin B, Babraj JA, Smith K & Rennie MJ (2005). Protein synthesis rates in human muscles: neither anatomical location nor fibre-type composition are major determinants. J Physiol 563, 203-211.
20. Narici MV & Maganaris CN (2006). Adaptability of elderly human muscles and tendons to increased loading. J Anat 208, 433-443.
21. Phillips SM, Tipton KD, Aarsland A, Wolf SE & Wolfe RR (1997). Mixed muscle protein synthesis and breakdown after resistance exercise in humans. Am J Physiol Endocrinol Metab 273, E99-E107.
22. Porter MM, Vandervoort AA & Lexell J (1995). Aging of human muscle: structure, function and adaptability. Scand J Med Sci Sports 5, 129-142.
23. Raguso CA, Kyle U, Kossovsky MP, Roynette C, Paoloni-Giacobino A, Hans D, Genton L & Pichard C (2006). A 3-year longitudinal study on body composition changes in the elderly: Role of physical exercise. Clin Nutr 25, 573-580.
24. Sheffield-Moore M, Paddon-Jones D, Sanford AP, Rosenblatt JI, Matlock AG, Cree MG & Wolfe RR (2005). Mixed muscle and hepatic derived plasma protein metabolism is differentially regulated in older and younger men following resistance exercise. Am J Physiol Endocrinol Metab 288, E922-E929.
25. Smith GI, Atherton P, Villareal DT, Frimel TN, Rankin D, Rennie MJ & Mittendorfer B (2008). Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women. PLoS ONE 3, e1875.
26. Spiering BA, Kraemer WJ, Anderson JM, Armstrong LE, Nindl BC, Volek JS & Maresh CM (2008). Resistance exercise biology: Manipulation of resistance exercise programme variables determines the responses of cellular and molecular signalling pathways. Sports Med 38, 527-540.
27. Terzis G, Georgiadis G, Stratakos G, Vogiatzis I, Kavouras S, Manta P, Mascher H & Blomstrand E (2008). Resistance exercise-induced increase in muscle mass correlates with p70S6 kinase phosphorylation in human subjects. Eur J Appl Physiol 102, 145-152.
28. Watt PW, Lindsay Y, Scrimgeour CM, Chien PA, Gibson JN, Taylor DJ & Rennie MJ (1991). Isolation of aminoacyl- tRNA and its labelling with stable-isotope tracers: Use in studies of human tissue protein synthesis. Proc Natl Acad Sci U S A 88, 5892-5896.
29. Wilkinson SB, Phillips SM, Atherton PJ, Patel R, Yarasheski KE, Tarnopolsky MA & Rennie MJ (2008). Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle. J Physiol 586, 3701-3717.