SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

Aging Cell

Volumn 13, Issue 5, 2014, Pages 787-796

  Mercken, Evi M ^a   Mitchell, Sarah J ^a,b,c   Martin Montalvo, Alejandro ^a   Minor, Robin K ^a   Almeida, Maria ^d   Gomes, Ana P ^e   Scheibye Knudsen, Morten ^a   Palacios, Hector H ^a   Licata, Jordan J ^a   Zhang, Yongqing ^a   Becker, Kevin G ^a   Khraiwesh, Husam ^f   González Reyes, José A ^f   Villalba, José M ^f   Baur, Joseph A ^g   Elliott, Peter ^h   Westphal, Christoph ^h   Vlasuk, George P ^h   Ellis, James L ^h   Sinclair, David A ^e   Bernier, Michel ^a   de Cabo, Rafael ^a   more..

^a NATIONAL INSTITUTE ON AGING   (United States)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF CÓRDOBA   (Spain)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

^h GLAXOSMITHKLINE   (United States)

Author keywords

Healthspan; Inflammation; Lifespan; Muscle wasting; Osteoporosis; Sirtuins

Indexed keywords

AGENTS AFFECTING METABOLISM; ALKALINE PHOSPHATASE; CITRATE SYNTHASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SIRTUIN 1; SRT 2104; SUPPRESSOR OF CYTOKINE SIGNALING 2; TAMOXIFEN CITRATE; UNCLASSIFIED DRUG; FUSED HETEROCYCLIC RINGS; SRT2104;

ADENOVIRUS INFECTION; ADULT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY COMPOSITION; BONE DENSITY; BONE MASS; DIET SUPPLEMENTATION; DRUG EFFECT; GENE SILENCING; IMMOBILIZATION; INFLAMMATION; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIFESPAN; LONGEVITY; MALE; MITOCHONDRIAL RESPIRATION; MOTOR COORDINATION; MOTOR PERFORMANCE; MOUSE; MUSCLE ATROPHY; MUSCLE MASS; MUSCLE METABOLISM; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OSTEOCLASTOGENESIS; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHORT COURSE THERAPY; SURVIVAL; TREATMENT DURATION; AGING; ANIMAL; BODY MASS; BONE; C57BL MOUSE; DIET; DRUG EFFECTS; HUMAN; KAPLAN MEIER METHOD; METABOLISM;

MAMMALIA; MUS;

AGING; ANIMALS; BODY COMPOSITION; BODY MASS INDEX; BONE AND BONES; DIET; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MICE; MICE, INBRED C57BL; SURVIVAL ANALYSIS;

EID: 84924866970     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12220     Document Type: Article

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