Growth, differentiation, and survival: Multiple physiological functions for insulin-like growth factors

Physiological Reviews

Volumn 76, Issue 4, 1996, Pages 1005-1026

  Stewart, Claire E H ^a   Rotwein, Peter ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; EMBRYO DEVELOPMENT; FETUS DEVELOPMENT; GROWTH REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS REGULATION; RAT; RECEPTOR BINDING;

EID: 0029973924     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.1996.76.4.1005     Document Type: Article

References (232)

1. ABBOTT, A. M., R. BUENO, M. T. PEDRINI, J. M. MURRAY, AND R. J. SMITH. Insulin-like growth factor I receptor gene structure. J. Biol. Chem. 267: 10759-10763, 1992.
2. ADASHI, E. Y. Growth factors and ovarian function: the IGF-I paradigm. Horm. Res. 42: 44-48, 1994.
3. ALEXANDRIDES, T. K., AND R. J. SMITH. A novel fetal insulin-like growth factor (IGF) I receptor. J. Biol. Chem. 264: 12922-12930, 1989.
4. ALLANDER, S. V., C. LARSSON, E. EHRENBORG, A. SUWANICHKUL, G. WEBER, S. L. MORRIS, S. BAJALICA, M. C. KEIFER, H. LUTHMAN, AND D. R. POWELL. Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5. J. Biol. Chem. 269: 10891-10898, 1994.
5. ANDERSEN, A. S., T. KJELDSEN, F. C. WIBERG, P. M. CHRISTENSEN, J. S. RASMUSSEN, K. NORRIS, K. B. MOLLER, AND N. P. H. MOLLER. Changing the insulin receptor to possess insulin-like growth factor I ligand specificity. Biochemistry 29: 7363-7366, 1990.
6. APPELL, K. C., I. A. SIMPSON, AND S. W. CUSHMAN. Characterization of the stimulatory action of insulin on insulin-like growth factor II binding to rat adipose cells. Differences in the mechanism of insulin action on insulin-like growth factor II receptors and glucose transporters. J. Biol. Chem. 263: 10824-10829, 1988.
7. ARAKI, E., M. A. LIPES, M.-E. PATTI, J. C. BRUNING, B. HAAG III, R. S. JOHNSON, AND C. R. KAHN. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature Lond. 372: 186-190, 1994.
8. BACH, L. A., S. HSIEH, A. L. BROWN, AND M. M. RECHLER. Recombinant human insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced differentiation of L6A1 myoblasts. Endocrinology 135: 2168-2176, 1994.
9. BACH, L. A., AND M. M. RECHLER. Insulin-like growth factor binding proteins. Diabetes Rev. 3: 38-61, 1995.
10. BAKER, J., J.-P. LIU, E. J. ROBERTSON, AND A. EFSTRATIADIS. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75: 73-82, 1993.
11. BARLOW, D. P. Gametic imprinting in mammals. Science Wash. DC 270: 1610-1613, 1995.
12. BARLOW, D. P., R. STOGER, B. G. HERRMANN, K. SAITO, AND N. SCHWEIFER. The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus. Nature Lond. 349: 84-87, 1991.
13. BARRECA, A., M. DE LUCA, P. DEL MONTE, S. BONDANZA, G. DAMONTE, G. CARIOLA, E. DI MARCO, G. GIORDANO, R. CANCEDDA, AND F. MINUTO. In vitro paracrine regulation of human keratinocyte growth by fibroblast-derived insulin-like growth factors. J. Cell. Physiol. 151: 262-268, 1992.
14. BARRES, B. A., I. K. HART, H. S. R. COLES, J. F. BURNE, J. T. VOYVODIC, W. D. RICHARDSON, AND M. C. RAFF. Cell death and control of cell survival in the oligodendrocyte lineage. Cell 70: 31-46, 1992.
15. BASERGA, R. Oncogenes and the strategy of growth factors. Cell 79: 927-930, 1994.
16. BASERGA, R., AND R. RUBIN. Cell cycle and growth control. Crit. Rev. Eukaryotic Gene Expression 3: 47-61, 1993.
17. BAXTER, R. C. Circulating binding proteins for the insulinlike growth factors. Trends Endocrinol. Metab. 4: 91-96, 1993.
18. BAXTER, R. C., AND W. H. DAUGHADAY. Impaired formation of the ternary insulin-like growth factor-binding protein complex in patients with hypoglycemia due to nonislet cell tumors. J. Clin. Endocrinol. Metab. 73: 696-702, 1991.
19. r 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: determination by reconstitution and affinity-labeling. Proc. Natl. Acad. Sci. USA 86: 6898-6902, 1989.
20. BEHRINGER, R. R., T. M. LEWIN, C. J. QUAIFE, R. D. PALMITER, R. L. BRINSTER, AND A. J. D'ERCOLE. Expression of insulin-like growth factor I stimulates normal somatic growth in growth hormone-deficient transgenic mice. Endocrinology 127: 1033-1040, 1990.
21. BLAKESLEY, V. A., T. KALEBIC, L. J. HELMAN, B. STANNARD, T. N. FARIA, C. T. ROBERTS, JR., AND D. LEROITH. Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor. Endocrinology 137: 410-417, 1996.
22. BLAT, C., J. DELBE, J. VILLAUDY, G. CHATELAIN, A. GOLDE, AND L. HAREL. Inhibitory diffusible factor 45 bifunctional activity. J. Biol. Chem. 264: 12449-12454, 1989.
23. BOBEK, G., C. D. SCOTT, AND R. C. BAXTER. Secretion of soluble insulin-like growth factor-II/mannose 6-phosphate receptor by rat tissues in culture. Endocrinology 128: 2204-2206, 1991.
24. BRAULKE, T., S. TIPPMER, E. NEHER, AND K. VON FIGURA. Regulation of the mannose 6-phosphate/IGF II receptor expression at the cell surface by mannose 6-phosphate, insulin like growth factors and epidermal growth factor. EMBO J. 8: 681-686, 1989.
25. BUCKBINDER, L., R. TALBOTT, S. VELASCO-MIGUEL, I. TAKENAKA, B. FAHA, B. R. SELZINGER, AND N. KLEY. Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature Lond. 377: 646-649, 1995.
26. CAMACHO-HUBNER, C., D. R. CLEMMONS, AND A. J. D'ERCOLE. Regulation of insulin-like growth factor (IGF) binding proteins in transgenic mice with altered expression of growth hormone and IGF-1. Endocrinology 129: 1201-1206, 1991.
27. CANFIELD, W. M., AND S. KORNFELD. The chicken liver cation-independent mannose 6-phosphate receptor lacks the high affinity binding site for insulin-like growth factor II. J. Biol. Chem. 264: 7100-7103, 1989.
28. CARONI, P., AND P. GRANDES. Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors. J. Cell Biol. 110: 1307-1317, 1990.
29. CARONI, P., AND C. SCHNEIDER. Signaling by insulin-like growth factors in paralyzed skeletal muscle: rapid induction of IGF1 expression in muscle fibers and prevention of interstitial cell proliferation by IGF-BP5 and IGF-BP4. J. Neurosci. 14: 3378-3388, 1994.
30. CARONI, P., C. SCHNEIDER, M. C. KIEFER, AND J. ZAPF. Role of muscle insulin-like growth factors in nerve sprouting: suppression of terminal sprouting in paralyzed muscle by IGF-binding protein 4. J. Cell Biol. 125: 893-902, 1994.
31. CHEATHAM, B., AND C. R. KAHN. Insulin action and the insulin signaling network. Endocr. Rev. 16: 117-142, 1995.
32. S6k. Proc. Natl. Acad. Sci. USA 92: 1696-11700, 1995.
33. CHRISTOFORI, G., P. NAIK, AND D. HANAHAN. Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during β-cell tumorigenesis. Nature Genet. 10: 196-201, 1995.
34. CHRISTOFORI, G., P. NAIK, AND D. HANAHAN. A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature Lond. 369: 414-417, 1994.
35. CHUN, S.-Y., H. BILLIG, J. L. TILLY, I. FURUTA, A. TSAFRIRI, AND A. J. W. HSUEH. Gonadotropin suppression of apoptosis in cultured preovulatory follicles: mediatory role of endogenous insulin-like growth factor I. Endocrinology 135: 1845-1853, 1994.
36. CLAIRMONT, K. B., AND M. P. CZECH. Chicken and Xenopus mannose 6-phosphate receptors fail to bind insulin-like growth factor II. J. Biol. Chem. 264: 16390-16392, 1989.
37. CLAIRMONT, K. B., AND M. P. CZECH. Extracellular release as the major degradative pathway of the insulin-like growth factor II/ mannose 6-phosphate receptor. J. Biol. Chem. 266: 12131-12134, 1991.
38. COHEN, G. B., R. REN, AND D. BALTIMORE. Modular binding domains in signal transduction proteins. Cell 80: 237-248, 1995.
39. COHEN, P., G. LAMSON, T. OKAJIMA, AND R. G. ROSENFELD. Transfection of the human insulin-like growth factor binding protein-3 gene into Balb/c fibroblasts inhibits cellular growth. Mol. Endocrinol. 7: 380-386, 1993.
40. COHICK, W. S., AND D. R. CLEMMONS. The insulin-like growth factors. Annu. Rev. Physiol. 55: 131-153, 1993.
41. COLEMAN, M. E., F. DEMAYO, K. C. YIN, H. M. LEE, R. GESKE, C. MONTGOMERY, AND R. J. SCHWARTZ. Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice. J. Biol. Chem. 270: 12109-12116, 1995.
42. CONDORELLI, G., R. BUENO, AND R. J. SMITH. Two alternatively spliced forms of the human insulin-like growth factor I receptor have distinct biological activities and internalization kinetics. J. Biol. Chem. 269: 8510-8516, 1994.
43. COPPOLA, D., A. FERBER, M. MIURA, C. SELL, C. D'AMBROSIO, R. RUBIN, AND R. BASERGA. A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor. Mol. Cell. Biol. 14: 4588-4595, 1994.
44. DAHMS, N. M., P. A. ROSE, J. D. MOLKENTIN, Y. ZHANG, AND M. A. BRZYCKI. The bovine mannose 6-phosphate/insulin-like growth factor II receptor. The role of arginine residues in mannose 6-phosphate binding. J. Biol. Chem. 268: 5457-5463, 1993.
45. DAHMS, N. M., D. A. WICK, AND M. A. BRZYCKI-WESSELL. The bovine mannose 6-phosphate/insulin-like growth factor II receptor, Localization of the insulin-like growth factor II binding site to domains 5-11. J. Biol. Chem. 269: 3802-3809, 1994.
46. DAI, J., AND R. C. BAXTER. Regulation in vivo of the acid-labile subunit of the rat serum insulin-like growth factor-binding protein complex. Endocrinology 135: 2335-2341, 1994.
47. DAUGHADAY, W. H., AND T. F. DEUEL. Tumor secretion of growth factors. Endocrinol. Metab. Clin. N. Am. 20: 539-563, 1991.
48. DAUGHADAY, W. H., K. HALL, M. S. RABEN, W. D. SALMON, JR., J. L. VAN DEN BRANDE, AND J. J. VAN WYK. Somatomedin: proposed designation for sulphation factor. Nature Lond. 235: 107, 1972.
49. DAUGHADAY, W. H., K. A. PARKER, S. BOROWSKY, B. TRIVEDI, AND M. KAPADIA. Measurement of somatomedin-related peptides in fetal, neonatal, and maternal rat serum by insulin-like growth factor (IGF) I radioimmunosassay, IGF-II radioreceptor assay (RRA), and multiplication-stimulating activity RRA after acid-ethanol extraction. Endocrinology 110: 575-581, 1982.
50. DAVIS, R. J. MAPKs: new JNK expands the group. Trends Biochem. Sci. 19: 470-473, 1994.
51. D'ERCOLE, A. J. Expression of insulin-like growth factor-I in transgenic mice. Ann. NY Acad. Sci. 692: 149-160, 1993.
52. DEANGELIS, T., A. FERBER, AND R. BASERGA. Insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the platelet-derived growth factor receptor. J. Cell. Physiol. 164: 214-221, 1995.
53. DECHIARA, T. M., A. EFSTRATIADIS, AND E. J. ROBERTSON. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature Lond. 345: 78-80, 1990.
54. DECHIARA, T. M., E. J. ROBERTSON, AND A. EFSTRATIADIS. Parental imprinting of the mouse insulin-like growth factor II gene. Cell 64: 849-859, 1991.
55. DELAFONTAINE, P., A. ANWAR, H. LOU, AND L. KU. G-protein coupled and tyrosine kinase receptors: evidence that activation of the insulin-like growth factor I receptor is required for thrombin-induced mitogenesis of rat aortic smooth muscle cells. J. Clin. Invest. 97: 139-145, 1996.
56. DELANY, A. M., J. M. PASH, AND E. CANALIS. Cellular and clinical perspectives on skeletal insulin-like growth factor I. J. Cell. Biochem. 55: 328-333, 1994.
57. DE SOUZA, A. T., G. R. HANKINS, M. K. WASHINGTON, R. L. FINE, T. C. ORTON, AND R. L. JIRTLE. Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors. Oncogene 10: 1725-1729, 1995.
58. DE SOUZA, A. T., G. R. HANKINS, M. K. WASHINGTON, T. C. ORTON, AND R. L. JIRTLE. M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nature Genet. 11: 447-449, 1995.
59. DEVOL, D. L., P. ROTWEIN, J. L. SADOW, J. NOVAKOFSKI, AND P. J. BECHTEL. Activation of insulin-like growth factor gene expression during work-induced skeletal muscle growth. Am. J. Physiol. 259 (Endocrinol. Metab. 22): E89-E95, 1990.
60. DICICCO-BLOOM, E., AND I. B. BLACK. Insulin growth factors regulate the mitotic cycle in cultured rat sympathetic neuroblasts. Proc. Natl. Acad. Sci. USA 85: 4066-4070, 1988.
61. 61a. D'MELLO, S. R., C. GALLI, T. CIOTTI, AND P. CAUSSANO. Induction of apoptosis in cerebellar granule neurons by low potassium: inhibiton of death by insulin-like growth factor I and cAMP. Proc. Natl. Acad. Sci. USA 90: 10989-10993, 1993.
62. DRAGO, J., M. MURPHY, S. M. CARROIX, R. P. HARVEY, AND P. F. BARTLETT. Fibroblast growth factor-mediated proliferation of central nervous system precursors depends on endogenous production of insulin-like growth factor I. Proc. Natl. Acad. Sci. USA 88: 2199-2203, 1991.
63. DUGUAY, S. J., S. J. CHAN, T. P. MOMMSEN, AND D. F. STEINER. Divergence of insulin-like growth factors I and II in the elasmo-branch, Squalus acanthias. FEBS Lett. 371: 69-72, 1995.
64. EDWALL, D., M. SCHALLING, E. JENNISCHE, AND G. NORSTEDT. Induction of insulin-like growth factor I messenger ribonucleic acid during regeneration of rat skeletal muscle. Endocrinology 124: 820-825, 1989.
65. EFSTRATIADIS, A. Parental imprinting of autosomal mammalian genes. Curr. Opin. Genet. Dev. 4: 265-280, 1994.
66. EHRENBORG, E., C. LARSSON, I. STERN, M. JANSON, D. R. POWELL, AND H. LUTHMAN. Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7. Genomics 12: 497-502, 1992.
67. EKSTROM, T. J., H. CUI, X. LI, AND R. OHLSSON. Promoter-specific IGF2 imprinting status and its plasticity during human liver development. Development 121: 309-316, 1995.
68. EWTON, D. Z., S. L. FALEN, AND J. R. FLORINI. The type II insulin-like growth factor (IGF) receptor has low affinity for IGF-I analogs: pleiotypic actions of IGFs on myoblasts are apparently mediated by the type I receptor. Endocrinology 120: 115-123, 1987.
69. FARIA, T. N., V. A. BLAKESLEY, H. KATO, B. STANNARD, D. LEROITH, AND C. T. ROBERTS, JR. Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function. J. Biol. Chem. 269: 13922-13928, 1994.
70. FILSON, A. J., A. LOUVI, A. EFSTRATIADIS, AND E. J. ROBERTSON. Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes. Development 118: 731-736, 1993.
71. FLAUMENHAFT, R., S. KOJIMA, M. ABE, AND D. B. RIFKIN. Activation of latent transforming growth factor β. Adv. Pharmacol. 24: 51-76, 1993.
72. FLORINI, J. R., D. Z. EWTON, AND F. J. MCWADE. IGFs, muscle growth, and myogenesis. Diabetes Rev. 3: 73-92, 1995.
73. FLORINI, J. R., D. Z. EWTON, AND S. L. ROOF. Insulin-like growth factor-I stimulates terminal myogenic differentiation by induction of myogenin gene expression. Mol. Endocrinol. 5: 718-724, 1991.
74. FRATTALI, A L, AND J. E. PESSIN. Relationship between α subunit ligand occupancy and β subunit autophosphorylation in insulin/ insulin-like growth factor-1 hybrid receptors. J. Biol. Chem. 268: 7393-7400, 1993.
75. FRODIN, M., AND S. GAMMELTOFT. Insulin-like growth factors act synergistically with basic fibroblast growth factor and nerve growth factor to promote chromaffin cell proliferation. Proc. Natl. Acad. Sci. USA 91: 1771-1775, 1994.
76. FROESCH, E. R., H. BURGI, E. B. RAMSEIER, P, BALLY, AND A. LABHART. Antibody-suppressible and nonsuppressible insulin-like activities in human serum and their physiologic significance. An insulin assay with adipose tissue of increased precision and specificity. J. Clin. Invest. 42: 1816-1834, 1963.
77. GARMROUDI, F., AND R. G. MACDONALD. Localization of the insulin-like growth factor II (IGF-II) binding/cross-linking site of the IGF-II/mannose 6-phosphate receptor to extracellular repeats 10-11. J. Biol. Chem. 269: 26944-26952, 1994.
78. GIANNOUKAKIS, N., C. DEAL, J. PAQUETTE, C. G. GOODYER, AND C. POLYCHRONAKOS. Parental genomic imprinting of the human IGF2 gene. Nature Genet. 4: 98-101, 1993.
79. GIUDICE, L. C. The insulin-like growth factor system in normal and abnormal human ovarian follicle development. Am. J. Med. 98, Suppl.: 48S-54S, 1995.
80. GLASSCOCK, G. F., A. N. HEIN, J. A. MILLER, R. L. HINTZ, AND R. G. ROSENFELD. Effects of continuous infusion of insulin-like growth factor I and II, alone and in combination with thyroxine or growth hormone, on the neonatal hypophysectomized rat. Endocrinology 130: 203-210, 1992.
81. GRONBORG, M., B. S. WULFF, J. S. RASMUSSEN, T. KJELDSEN, AND S. GAMMELTOFT. Structure-function relationship of the insulin-like growth factor-I receptor tyrosine kinase. J. Biol. Chem. 268: 23435-23440, 1993.
82. GULER, H.-P., J. ZAPF, E. SCHEIWILLER, AND E. R. FROESCH. Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats. Proc. Natl. Acad. Sci. USA 85: 4889-4893, 1988.
83. GUSTAFSON, T. A., AND W. J. RUTTER. The cysteine-rich domains of the insulin and insulin-like growth factor I receptors are primary determinants of hormone binding specificity. J. Biol. Chem. 265: 18663-18667, 1990.
84. HARI, J., S. B. PIERCE, D. O. MORGAN, V. SARA, M. C. SMITH, AND R. A. ROTH. The receptor for insulin-like growth factor II mediates an insulin-tike response. EMBO J. 6: 3367-3371, 1987.
85. HARRINGTON, E. A., M. R. BENNETT, A. FANIDI, AND G. I. EVAN. c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J. 13: 3286-3295, 1994.
86. HERNANDEZ-SANCHEZ, C., V. BLAKESLEY, T. KALEBIC, L. HELMAN, AND D. LEROITH. The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis. J. Biol. Chem. 270: 29176-29181, 1995.
87. HERZOG, V., W. NEUMULLER, AND B. HOTZMANN. Thyroglobulin, the major and obligatory exportable protein of thyroid follicle cells, carries the lysosomal recognition marker mannose-6-phosphate. EMBO J. 6: 555-560, 1987.
88. HSU, D., P. E. KNUDSON, A. ZAPF, G. C. ROLBAND, AND J. M. OLEFSKY. NPXY motif in the insulin-like growth factor-I receptor is required for efficient ligand-mediated receptor internalization and biological signaling. Endocrinology 134: 744-750, 1994.
89. IKEZU, T., T. OKAMOTO, U. GIAMBARELLA, T. YOKOTA, AND I. NISHIMOTO. In vivo coupling of insulin-like growth factor II/mannose 6-phosphate receptor to heteromeric G proteins. J. Biol. Chem. 270: 29224-29228, 1995.
90. ISHII, D. N. Relationship of insulin-like growth factor II gene expression in muscle to synaptogenesis. Proc. Natl. Acad. Sci. USA 86: 2898-2902, 1989.
91. JADOT, M., W. M. CANFIELD, W. GREGORY, AND S. KORNFELD. Characterization of the signal for rapid internalization of the bovine mannose 6-phosphate/insulin-like growth factor-II receptor. J. Biol. Chem. 267: 11069-11077, 1992.
92. JAMES, P. L., C. E. H. STEWART, AND P. ROTWEIN. Insulin-like growth factor binding protein-5 modulates muscle differentiation through an insulin-like growth factor-dependent mechanism. J. Cell Biol. 133: 683-694, 1996.
93. JENNISCHE, E., AND H.-A. HANSSON. Regenerating skeletal muscle cells express insulin-like growth factor I. Acta Physiol. Scand. 130: 327-332, 1987.
94. JOHNSON, K. F., AND S. KORNFELD. The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi. J. Cell Biol. 119: 249-257, 1992.
95. JONES, J. I., AND D. R. CLEMMONS. Insulin-like growth factors and their binding proteins: biological actions. Endocr. Rev. 16: 3-34, 1995.
96. KALEKO, M., W. J. RUTTER, AND A. D. MILLER. Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation. Mol. Cell. Biol. 10: 464-473, 1990.
97. KALSCHEUER, V. M., E. C. MARIMAN, M. T. SCHEPENS, H. REHDER, AND H.-H. ROPERS. The insulin-like growth factor type-2 receptor gene is imprinted in the mouse but not in humans. Nature Genet. 5: 74-78, 1993.
98. KAPELLER, R., AND L. C. CANTLEY. Phosphatidylinositol 3-kinase. Bioessays 16: 565-576, 1994.
99. KATO, H., T. N. FARIA, B. STANNARD, C. T. ROBERTS, JR., AND D. LEROITH. Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. J. Biol. Chem. 268: 2655-2661, 1993.
100. KATO, H., T. N. FARIA, B. STANNARD, C. T. ROBERTS, JR., AND D. LEROITH. Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action. Mol. Endocrinol. 8: 40-50, 1994.
101. KIESS, W., L. A. GREENSTEIN, R. M. WHITE, L. LEE, M. M. RECHLER, AND S. P. NISSLEY. Type II insulin-like growth factor receptor is present in rat serum. Proc. Natl. Acad. Sci. USA 84: 7720-7724, 1987.
102. KIESS, W., J. F. HASKELL, L. LEE, L. A. GREENSTEIN, B. E. MILLER, A. L. AARONS, M. M. RECHLER, AND S. P. NISSLEY. An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts. J. Biol. Chem. 262: 12745-12751, 1987.
103. KJELDSEN, T., A. S. ANDERSEN, F. C. WIBERG, J. S. RASMUSSEN, L. SCHAFFER, P. BALSCHMIDT, K. B. MOLLER, AND N. P. H. MOLLER. The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site. Proc. Natl. Acad. Sci. USA 88: 4404-4408, 1991.
104. KOJIMA, I., I. NISHIMOTO, T. IIRI, E. OGATA, AND R. ROSENFELD. Evidence that type II insulin-like growth factor receptor is coupled to calcium gating system. Biochem. Biophys. Res. Commun. 154: 9-19, 1988.
105. KORNER, C., B. NURNBERG, M. UHDE, AND T. BRAULKE. Mannose 6-phosphate/insulin-like growth factor II receptor fails to interact with G-proteins. J. Biol. Chem. 270: 287-295, 1995.
106. KORNFELD, S. Structure and function of the mannose 6-phosphate/ insulinlike growth factor II receptors. Annu. Rev. Biochem. 61: 307-330, 1992.
107. KOU, K., P. L. JAMES, D. R. CLEMMONS, N. G. COPELAND, D. J. GILBERT, N. A. JENKINS, AND P. ROTWEIN. Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11. Genomics 21: 653-655, 1994.
108. KOU, K, N. A. JENKINS, D. J. GILBERT, N. G. COPELAND, AND P. ROTWEIN. Organization, expression, and chromosomal location of the mouse insulin-like growth factor binding protein 5 gene. Genomics 20: 412-418, 1994.
109. LAMMERS, R, A. GRAY, J. SCHLESSINGER, AND A. ULLRICH. Differential signalling potential of insulin- and IGF-1-receptor cytoplasmic domains. EMBO J. 8: 1369-1375, 1989.
110. LAU, M. M. H., C. E. H. STEWART, Z. LIU, H. BHATT, P. ROTWEIN, AND C. L STEWABT. Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Genes Dev. 8: 2953-2963, 1994.
111. LAUREYS, G., D. E. BARTON, A. ULLRICH, AND U. FRANCKE. Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse. Genomics 3: 224-229, 1988.
112. LEE, S.-J., AND D. NATHANS. Proliferin secreted by cultured cells binds to mannose 6-phosphate receptors. J. Biol. Chem. 263: 3521-3527, 1988.
113. LEIGHTON, P. A., R. S. INGRAM, J. EGGENSCHWILER, A. EFSTRATIADIS, AND S. M. TILGHMAN. Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature Lond. 375: 34-39, 1995.
114. LEONG, S. R., R. C. BAXTER, T. CAMERATO, J. DAI, AND W. I. WOOD. Structure and functional expression of the acid-labile subunit of the insulin-like growth factor-binding protein complex. Mol. Endocrinol. 6: 870-876, 1992.
115. LEROITH, D., H. WERNER, D. BEITNER-JOHNSON, AND C. T. ROBERTS, JR. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr. Rev. 16: 143-163, 1995.
116. LI, S., A. FERBER, M. MIURA, AND R. BASERGA. Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain. J. Biol. Chem. 269: 32558-32564, 1994.
117. LIU, J.-P., J. BAKER, A. S. PERKINS, E. J. ROBERTSON, AND A. EFSTRATIADIS. Mice carrying null mutations of the genes encoding insulin-like growth factor I (IGF-1) and type 1 IGF receptor (Igf1r). Cell 75: 59-72, 1993.
118. LOBEL, P., N. M. DAHMS, AND S. KORNFELD. Cloning and sequence analysis of the cation-independent mannose 6-phosphate receptor. J. Biol. Chem. 263: 2563-2570, 1988.
119. LOBEL, P., K. FUJIMOTO, R. D. YE, G. GRIFFITHS, AND S. KORNFELD. Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis. Cell 57: 787-796, 1989.
120. LONG, L., R. RUBIN, R. BASERGA, AND P. BRODT. Loss of the metastatic phenotype in murine carcinoma cells expressing and antisense RNA to the insulin-like growth factor receptor. Cancer Res. 55: 1006-1009, 1995.
121. LONROTH, P., K. C. APPELL, C. WESSLAU, S. W. CUSHMAN, I. A. SIMPSON, AND U. SMITH. Insulin-induced subcellular redistribution of insulin-like growth factor II receptors in the rat adipose cell. Counterregulatory effects of isoproterenol, adenosine, and cAMP analogues. J. Biol. Chem. 263: 15386-15391, 1988.
122. LUDWIG, T., H. MUNIER-LEHMANN, U. BAUER, M. HOLLINSHEAD, C. OVITT, P. LOBEL, AND B. HOFLACK. Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts. EMBO J. 13: 3430-3437, 1994.
123. LUTTRELL, L. M., T. VAN BIESEN, B. E. HAWES, W. J. KOCH, K. TOUHARA, AND R. J. LEFKOWITZ. Gbg subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. J. Biol. Chem. 270: 16495-16498, 1995.
124. MACDONALD, R. G., S. R. PFEFFER, L. COUSSENS, M. A. TEPPER, C. M. BROCKLEBANK, J. E. MOLE, J. K. ANDERSON, E. CHEN, M. P. CZECH, AND A. ULLRICH. A single receptor binds both insulin-like growth factor II and mannose-6-phosphate. Science Wash. DC 239: 1134-1137, 1988.
125. MACDONALD, R. G., M. A. TEPPER, K. B. CLAIRMONT, S. B. PERREGAUX, AND M. P. CZECH. Serum form of the rat insulin-like growth factor II/mannose 6-phosphate receptor is truncated in the carboxyl-terminal domain. J. Biol. Chem. 264: 3256-3261, 1989.
126. MARSHALL, R. N., L. E. UNDERWOOD, S. J. VOINA, D. B. FOUSHEE, AND J. J. VAN WYK. Characterization of the insulin and somatomedin-C receptors in human placental cell membranes. J. Clin. Endocrinol. Metab. 39: 283-292, 1974.
127. MATHEWS, L. S., B. ENBERG, AND G. NORSTEDT. Regulation of rat growth hormone receptor gene expression. J. Biol. Chem. 264: 9905-9910, 1989.
128. MATHEWS, L. S., R. E. HAMMER, R. R. BEHRINGER, A. J. D'ERCOLE, G. I. BELL, R. L. BRINSTER, AND R. D. PALMITER. Growth enchancement of transgenic mice expressing human insulin-like growth factor I. Endocrinology 123: 2827-2833, 1988.
129. MATHEWS, L. S., R. E. HAMMER, R. L. BRINSTER, AND R. D. PALMITER. Expression of insulin-like growth factor I in transgenic mice with elevated levels of growth hormone is correlated with growth. Endocrinology 123: 433-437, 1988.
130. 2, growth hormone, and the insulin-like growth factors. J. Cell. Physiol. 160: 163-175, 1994.
131. MCMORRIS, F. A., T. M. SMITH, S. DESALVO, AND R. W. FURLANETTO. Insulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte development. Proc. Natl. Acad. Sci. USA 83: 822-826, 1986.
132. MEGYESI, K., C. R. KAHN, J. ROTH, AND P. GORDEN. Hypoglycemia in association with extrapancreatic tumors: demonstration of elevated plasma NSILA-s by a new radioreceptor assay. J. Clin. Endocrinol. Metab. 38: 931-934, 1974.
133. MEGYESI, K., C. R. KAHN, J. ROTH, D. M. NEVILLE, JR., S. P. NISSLEY, R. E. HUMBEL, AND E. R. FROESCH. The NSILA-s receptor in liver plasma membranes. J. Biol. Chem. 250: 8990-8996, 1975.
134. MERESSE, S., T. LUDWIG, R. FRANK, AND B. HOFLACK. Phosphorylation of the cytoplasmic domain of the bovine cation-independent mannose 6-phosphate receptor. J. Biol. Chem. 265: 18833-18842, 1980.
135. MINNITI, C. P., D. LUAN, C. O'GRADY, R. G. ROSENFELD, AND L. J. HELMAN. Insulin-like growth factor II overexpression in myoblasts induces phenotypic changes typical of the malignant phenotype. Cell Growth Differ. 6: 263-269, 1995.
136. MIURA, M., S. LI, AND R. BASERGA. Effect of a mutation at tyrosine 950 of the insulin-like growth factor I receptor on the growth and transformation of cells. Cancer Res. 55: 663-667, 1995.
137. MIURA, M., E. SURMACZ, J.-L. BURGAUD, AND R. BASERGA. Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor. J. Biol. Chem. 270: 22639-22644, 1995.
138. MORGAN, D. O., J. C. EDMAN, D. N. STANDRING, V. A. FRIED, M. C. SMITH, R. A. ROTH, AND W. J. RUTTER. Insulin-like growth factor II receptor as a multifunctional binding protein. Nature Lond. 329: 301-307, 1987,
139. MOSES, A. C., S. P. NISSLEY, P. A. SHORT, M. M. RECHLER, R. M. WHITE, A. B. KNIGHT, AND O. Z. HIGA. Increased levels of multiplication-stimulating activity, an insulin-like growth factor, in fetal rat serum. Proc. Natl Acad. Sci. USA 77: 3649-3653, 1980.
140. MOXHAM, C. P., V. DURONIO, AND S. JACOBS. Insulin-like growth factor I receptor β-subunit heterogeneity. J. Biol. Chem. 264: 13238-13244, 1989.
141. MURPHY, L. J., P. MOLNAR, X. LU, AND H. HUANG. Expression of human insulin-like growth factor-binding protein-3 in transgenic mice. J. Mol. Endocrinol. 15: 293-303, 1995.
142. MYERS, M. G., JR., X. J. SUN, AND M. F. WHITE. The IRS-1 signaling system. Trends Biochem Sci. 19: 289-294, 1994.
143. MYERS, M. G., JR., AND M. F. WHITE. New frontiers in insulin receptor substrate signaling. Trends Endocrinol. Metab. 6: 209-215, 1995.
144. NISHIMOTO, I., Y. MURAYAMA, T. KATADA, M. UI, AND E. OGATA. Possible direct linkage of insulin-like growth factor-II receptor with guanine nucleotide-binding proteins. J. Biol. Chem. 264: 14029-14038, 1989.
145. OGAWA, O., M. R. ECCELS, J. SZETO, L. A. MCNOE, K. YUN, M. A. MAW, P. J. SMITH, AND A. E. REEVE. Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour. Nature Lond. 362: 749-751, 1993.
146. OH, Y., H. L. MULLER, L. NG, AND R. G. ROSENFELD. Transforming growth factor-β-induced cell growth inhibition in human breast cancer cells is mediated through insulin-like growth factor-binding protein-3 action. J. Biol. Chem. 270: 13589-13592, 1995.
147. OKA, Y., AND M. P. CZECH. The type II insulin-like growth factor receptor is internalized and recycles in the absence of ligand. J. Biol. Chem. 261: 9090-9093, 1986.
148. OKAMOTO, T., T. KATADA, Y. MURAYAMA, M. UI, E. OGATA, AND I. NISHIMOTO. A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor. Cell 62: 709-717, 1990.
149. OKAMOTO, T., AND I. NISHIMOTO. Analysis of stimulation-G protein subunit coupling by using active insulin-like growth factor II receptor peptide. Proc. Natl. Acad. Sci. USA 88: 8020-8023, 1991.
150. OSHIMA, A., C. M. NOLAN, J. W. KYLE, J. H. GRUBB, AND W. S. SLY. The human cation-independent mannose 6-phosphate receptor. J. Biol. Chem. 263: 2553-2562, 1988.
151. PAHLMAN, S., G. MEYERSON, E. LINDGREN, M. SCHALLING, AND I. JOHANSSON. Insulin-like growth factor I shifts from promoting cell division to potentiating maturation during neuronal differentiation. Proc. Natl. Acad. Sci. USA 88: 9994-9998, 1991.
152. PALMITER, R. D., G. NORSTEDT, R. E. GELINAS, R. E. HAMMER, AND R. L. BRINSTER. Metallothionein-human GH fusion genes stimulate growth of mice. Science Wash. DC 222: 809-814, 1983.
153. 1 events and regulation of cell proliferation. Science Wash. DC 246: 603-608, 1989.
154. PELICCI, G., L. LANFRANCONE, F. R. GRIGNANI, J. MCGLADE, F. CAVALLO, G. FORNI, I. NICOLETTI, F. A. GRIGNANI, T. PAWSON, AND P. G. PELICCI. A novel transforming protein (shc) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70: 93-104, 1992.
155. PETERSON, J. E., T. JELINEK, M. KALEKO, K. SIDDLE, AND M. J. WEBER. C phosphorylation and activitation of the IGF-I receptor in src-transformed cells. J. Biol. Chem. 269: 27315-27321, 1994.
156. PIERSON, R. W., JR., AND H. M. TEMIN. The partial purification from calf serum of a fraction with multiplication-stimulating activity for chicken fibroblasts in cell culture and with non-suppressible insulin-like activity. J. Cell. Physiol. 79: 319-330, 1972.
157. POHLMANN, R., M. W. C. BOEKER, AND K. VON FIGURA. The two mannose 6-phosphate receptors transport distinct complements of lysosomal proteins. J. Biol. Chem. 270: 27311-27318, 1995.
158. POWELL-BRAXTON, L., P. HOLLINGSHEAD, C. WARBURTON, M. DOWD, S. PITTS-MEEK, D. DALTON, N. GILLETT, AND T. A. STEWART. IGF-I is required for normal embryonic growth in mice. Genes Dev. 7: 2609-2617, 1993.
159. PRAGER, D., H.-L. LI, S. ASA, AND S. MELMED. Dominant negative inhibiton of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant. Proc. Natl. Acad. Sci. USA 91: 2181-2185, 1994.
160. QUINN, L. S., B. STEINMETZ, A. MAAS, L. ONG, AND M. KALEKO. Type-1 insulin-like growth factor receptor overexpression produces dual effects on myoblast proliferation and differentiation. J. Cell. Physiol. 159: 387-398, 1994.
161. RAFF, M. C., B. A. BARRES, J. F. BURNE, H. S. COLES, Y. ISHIZAKI, AND M. D. JACOBSON. Programmed cell death and the control of cell survival: lessons from the nervous system. Science Wash. DC 262: 695-700, 1993.
162. RAINIER, S., L. A. JOHNSON, C. J. DOBRY, A. J. PING, P. E. GRUNDY, AND A. P. FEINBERG. Relaxation of imprinted genes in human cancer. Nature Lond. 362: 747-749, 1993.
163. RAJKUMAR, K., D. BARRON, M. S. LEWITT, AND L. J. MURPHY. Growth retardation and hyperglycemia in insulin-like growth factor binding protein-1 transgenic mice. Endocrinology 136: 4029-4034, 1995.
164. RAO, G. N., P. DELAFONTAINE, AND M. S. RUNGE. Thrombin stimulates phosphorylation of insulin-like growth factor-1 receptor, insulin receptor substrate-1, and phospholipase C-γ1 in rat aortic smooth muscle cells. J. Biol. Chem. 270: 27871-27875, 1995.
165. RECHLER, M. M., J. ZAPF, S. P. NISSLEY, E. R. FROESCH, A. C. MOSES, J. M. PODSKALNY, E. E. SCHILLING, AND R. E. HUMBEL. Interactions of insulin-like growth factors I and II and multiplication-stimulating activity with receptors and serum carrier proteins. Endocrinology 107: 1451-1459, 1980.
166. REEVE, A. E., M. R. ECCLES, R. J. WILKINS, G. I. BELL, AND L. J. MILLOW. Expression of insulin-like growth factor-II transcripts in Wilms' tumour. Nature Lond. 317: 258-260, 1985.
167. RESNICOFF, M., D. ABRAHAM, W. YUTANAWIBOONCHAI, H. L. ROTMAN, J. KAJSTURA, R. RUBIN, P. ZOLTICK, AND R. BASERGA. The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo. Cancer Res. 55: 2463-2469, 1995.
168. RESNICOFF, M., J.-L. BURGAUD, H. L. ROTMAN, D. ABRAHAM, AND R. BASERGA. Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor I receptors. Cancer Res. 55: 3739-3741, 1995.
169. RESNICOFF, M., C. SELL, M. RUBINI, D. COPPOLA, D. AMBROSE, R. BASERGA, AND R. RUBIN. Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (1GF-1) receptor are nontumorigenic and induce regression of wild-type tumors. Cancer Res. 54: 2218-2222, 1994.
170. RINDERKNECHT, E., AND R. E. HUMBEL. Amino-terminal sequences of two polypeptides from human serum with nonsuppressible insulin-like and cell-growth-promoting activities: evidence for structural homology with insulin B chain. Proc. Natl. Acad. Sci. USA 73: 4379-4381, 1976.
171. RINDERKNECHT, E., AND R. E. HUMBEL. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J. Biol. Chem. 253: 2769-2776, 1978.
172. RINDERKNECHT, E., AND R. E. HUMBEL. Primary structure of human insulin-like growth factor II. FEBS Lett. 89: 283-286, 1978.
173. RODRIGUEZ-TARDUCHY, G., M. K. L. COLLINS, I. GARCIA, AND A. LOPEZ-RIVAS. Insulin-like growth factor-I inhibits apoptosis in IL-3-dependent hemopoietic cells. J. Immunol. 149: 535-540, 1992.
174. ROGLER, C. E., D. YANG, L. ROSSETTI, J. DONOHOE, E. ALT, C. J. CHANG, R. ROSENFELD, K. NEELY, AND R. HINTZ. Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice. J. Biol. Chem. 269: 13779-13784, 1994.
175. ROSORIUS, O., G. MIESKES, O.-G. ISSINGER, C. KORNER, B. SCHMIDT, K. VON FIGURA, AND T. BRAULKE. Characterization of phosphorylation sites in the cytoplasmic domain of the 300 kDa mannose-6-phosphate receptor. Biochem. J. 292: 833-838, 1993.
176. ROTWEIN, P. Structure, evolution, expression and regulation of insulin-like growth factors I and II. Growth Factors 5: 3-18, 1991.
177. SAKANO, K.-I., T. ENJOH, F. NUMATA, H. FUJIWARA, Y. MARUMOTO, N. HIGASHIHASHI, Y. SATO, J. F. PERDUE, AND Y. FUJITA-YAMAGUCHI. The design, expression, and characterization of human insulin-like growth factor II (IGF-II) mutants specific for either the IGF-II/cation-independent mannose 6-phosphate receptor or IGF-I receptor. J. Biol. Chem. 266: 20626-20635, 1991.
178. SALMON, W. D., JR., AND W. H. DAUGHADAY. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J. Lab. Clin. Med. 49: 825-836, 1957.
179. SCHIRMACHER, P., W. A. HELD, D. YANG, F. V. CHISARI, Y. RUSTUM, AND C. E. ROGLER. Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth. Cancer Res. 5: 2549-2556, 1992.
180. SCHMIDT, B., C. KIECKE-SIEMSEN, A. WAHEED, T. BRAULKE, AND K. VON FIGURA. Localization of the insulin-like growth factor II binding site to amino acids 1508-1566 in repeat 11 of the mannose 6-phosphate/insulin-like growth factor II receptor. J. Biol. Chem. 270: 14975-14982, 1995.
181. SCHOENLE, E., J. ZAPF, R. E. HUMBEL, AND E. R. FROESCH. Insulin-like growth factor I stimulates growth in hypophysectomized rats. Nature Lond. 296: 252-253, 1982.
182. SCHUMACHER, R., L. MOSTHAF, J. SCHLESSINGER, D. BRANDENBURG, AND A. ULLRICH. Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors. J. Biol. Chem. 266: 19288-19295, 1991.
183. SCOTT, J., J. COWELL, M. E. ROBERTSON, L. M. PRIESTLEY, R. WADEY, B. HOPKINS, J. PRITCHARD, G. I. BELL, L. B. RALL, C. F. GRAHAM, AND T. J. KNOTT. Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues. Nature Lond. 317: 260-262, 1985.
184. SEELY, B. L., D. R. REICHART, P. A. STAUBS, B. H. JHUN, D. HSU, H. MAEGAWA, K. L. MILARSKI, A. R. SALTIEL, AND J. M. OLEFSKY. Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein. J. Biol. Chem. 270: 19151-19157, 1995.
185. SELL, C., R. BASERGA, AND R. RUBIN. Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis. Cancer Res. 55: 303-306, 1995.
186. SELL, C., G. DUMENIL, C. DEVEAUD, M. MIURA, D. COPPOLA, T. DEANGLEIS, R. RUBIN, A. EFSTRATIADIS, AND R. BASERGA. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol. Cell. Biol. 14: 3604-3612, 1994.
187. SELL, C, M. RUBINI, R. RUBIN, J.-P. LIU, A. EFSTRATIADIS, AND R. BASERGA. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc. Natl. Acad. Sci. USA 90:11217-11221, 1993.
188. SILVERMAN, L. A., Z. Q. CHENG, D. HSIAO, AND S. M. ROSENTHAL. Skeletal muscle cell-derived insulin-like growth factor (IGF) binding proteins inhibit IGF-I-induced myogenesis in rat L6E9 cells. Endocrinology 136: 720-726, 1995.
189. SKOTTNER, A., R. G. CLARK, L. FRYKLUND, AND I. C. A. F. ROBINSON. Growth responses in a mutant dwarf rat to human growth hormone and recombinant human insulin-like growth factor I. Endocrinology 124: 2519-2526, 1989.
190. SMITH, J., G. FOWKES, AND P. N. SCHOFFIELD. Programmed cell death in dystrophic (mdx) muscle is inhibited by IGF-II. Death Differ. 2: 243-251, 1995.
191. SOOS, M. A., C. E. FIELD, AND K. SIDDLE. Purified hybrid insulin/ insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Biochem. J. 290: 419-426, 1993.
192. STANNARD, B., V. BLAKESLEY, H. KATO, C. T. ROBERTS, JR., AND D. LEROITH. Single tyrosine substitution in the insulin-like growth factor I receptor inhibits ligand-induced receptor autophosphorylation and internalization, but not mitogenesis. Endocrinology 136: 4918-4924, 1995.
193. STEWART, C. E. H., P. L. JAMES, M. E. FANT, AND P. ROTWEIN. Overexpression of insulin-like growth factor-II induces accelerated myoblast differentiation. J. Cell. Physiol. In press.
194. STEWART, C. E. H., AND P. ROTWEIN. Insulin-like growth factor-II is an automne survival factor for differentiating myoblasts. J. Biol. Chem. 271: 11330-11338, 1996.
195. SUN, X. J., L.-M. WANG, Y. ZHANG, L. YENUSH, M. G. MYERS, JR., E. GLASHEEN, W. S. LANE, J. H. PIERCE, AND M. F. WHITE. Role of IRS-2 in insulin and cytokine signalling. Nature Lond. 377: 173-177, 1995.
196. SURMACZ, E., C. SELL, J. SWANTEK, H. KATO, C. T. ROBERTS, JR., D. LEROITH, AND R. BASERGA. Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor. Exp. Cell Res. 218: 370-380, 1995.
197. SZEBENYI, G., AND P. ROTWEIN. The mouse insulin-like growth factor II/cation-independent mannose 6-phosphate (IGF-II/MPR) receptor gene: molecular cloning and genomic organization. Genomics 19: 120-129, 1994.
198. TAKADA, K., H. TADA, T. TAKANO, S. NISHIYAMA, AND N. AMINO. Functional regulation of the GTP-binding protein coupled to insulin-like growth factor-I receptor by lithium during G, phase of the rat thyroid cell cycle. FEBS Lett. 318: 245-248, 1993.
199. TAMEMOTO, H., T. KADOWAKI, K. TOBE, T. YAGI, H. SAKURA, T. HAYAKAWA, Y. TERAUCHI, K. UEKI, Y. KABURAGI, S. SATOH, H. SEHHARA, S. YOSHIOKA, H. HORIKOSHI, Y. FURUTA, Y. IKAWA, M. KASUGA, Y. YAZAH, AND S. AIZAWA. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature Lond. 372: 182-186, 1994.
200. TARTARE, S., I. MOTHE, A. KOWALSKI-CHAUVEL, J.-P. BREITTMAYER, R. BALLOTTI, AND E. VAN OBBERGHEN. Signal transduction by a chimeric insulin-like growth factor-1 (IGF-1) receptor having the carboxyl-terminal domain of the insulin receptor. J. Biol. Chem. 269: 11449-11455, 1994.
201. TAYLOR, S. I., A. CAMA, D. ACCILI, F. BARBETTI, M. J. QUON, M. DE LA LUZ SIERRA, Y. SUZUKI, E. KOLLER, R. LEVY-TOLEDANO, E. WERTHEIMER, V. Y. MONCADA, H. KADOWAKI, AND T. KODOWAKI. Mutations in the insulin receptor gene. Endocr. Rev. 13: 566-595, 1992.
202. TIONG, T. S., AND A. C. HERINGTON. Ontogeny of messenger RNA for the rat growth hormone receptor and serum binding protein. Mol. Cell. Endocrinol. 83: 133-141, 1992.
203. TONG, P. Y., S. E. TOLLEFSEN, AND S. KORNFELD. The cation-independent mannose 6-phosphate receptor binds insulin-like growth factor II. J. Biol. Chem. 263: 2585-2588, 1988.
204. TONIN, P., E. EHRENBORG, G. LENOIR, J. FEUNTEUN, H. LYNCH, K. MORGAN, H. ZAZZI, A. VIWER, M. POLLAK, H. HUYNH, H. LUTHMAN, C. LARSSON, AND S. NAROD. The human insulin-like growth factor-binding protein 4 gene maps to chromosome region 17q12-q21.1 and is close to the gene for hereditary breast-ovarian cancer. Genomics 18: 414-417, 1993.
205. TREADWAY, J. L., A. L. FRATTALI, AND J. E. PESSIN. Intramolecular subunit interactions between insulin and insulin-like growth factor l ab half-receptors induced by ligand and Mn/MgATP binding. Biochemistry 31: 11801-11805, 1992.
206. TROJAN, J., B. K. BLOSSEY, T. R. JOHNSON, S. D. RUDIN, M. TYKOCINSKI, J. U. ILAN, AND J. O. ILAN. Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I. Proc. Natl. Acad. Sci. USA 89: 4874-4878, 1992.
207. TROJAN, J., T. R. JOHNSON, S. D. RUDIN, B. K. BLOSSEY, K. M. KELLEY, A. SHEVELEV, F. W. ABDUL-KARIM, D. D. ANTHONY, M. L. TYKOCINSKI, J. U. ILAN, AND J. O. ILAN. Gene therapy of murine teratocarcinoma: separate functions for insulin-like growth factors I and II in immunogenicity and differentiation. Proc. Natl. Acad. Sci. USA 91: 6088-6092, 1994.
208. TROJAN, J., T. R. JOHNSON, S. D. RUDIN, J. U. ILAN, M. L. TYKOCINSKI, AND J. O. ILAN. Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA. Science Wash. DC 259: 94-96, 1993.
209. ULLRICH, A., A. GRAY, A. W. TAM, T. YANG-FENG, M. TSUBOKAWA, C. COLLINS, W. HENZEL, T. LE BON, S. KATHURIA, E. CHEN, S. JACOBS, U. FRANCKE, J. RAMACHANDRAN, AND Y. FUJITA-YAMAGUCHI. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J. 5: 2503-2512, 1986.
210. VALENTINIS, B., A. BHALA, T. DEANGELIS, R. BASERGA, AND P. COHEN. The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene. Mol. Endocrinol. 9: 361-367, 1995.
211. VALENTINIS, B., P. L. PURCU, K. QUINN, AND R. BASERGA. The role of the insulin-like growth factor I receptor in the transformation by simian virus 40 T antigen. Oncogene 9: 825-831, 1994.
212. VALENZANO, K. J., J. REMMLER, AND P. LOBEL. Soluble insulin-like growth factor II/mannose 6-phosphate receptor carries multiple high molecular weight forms of insulin-like growth factor II in fetal bovine serum. J. Biol. Chem. 270: 16441-16448, 1995.
213. VAN BUUL-OFFERS, S. C., K. DE HAAN, M. G. REIJNEN-GRESNIGT, D. MEINSMA, M. JANSEN, S. L. OEI, E. J. BONTE, J. S. SUSSENBACH, AND J. L. VAN DEN BRANDE. Overexpression of human insulin-like growth factor-II in transgenic mice causes increased growth of the thymus. J. Endocrinol. 144: 491-502, 1995.
214. VANDENBURGH, H. H., P. KARLISCH, J. SHANSKY, AND R. FELDSTEIN. Insulin and IGF-I induce pronounced hypertrophy of skeletal myofibers in tissue culture. Am. J. Physiol. 260 (Cell Physiol. 29): C475-C484, 1991.
215. VON FIGURA, K. Molecular recognition and targeting of lysosomal proteins. Curr. Opin. Cell Biol. 3: 642-646, 1991.
216. VU, T. H., AND A. R. HOFFMAN. Promoter-specific imprinting of the human insulin-like growth factor-II gene. Nature Lond. 371: 714-717, 1994.
217. WANG, Z.-Q., M, R. FUNG, D. P. BARLOW, AND E. F. WAGNER. Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene. Nature Lond. 372: 464-467, 1994.
218. WARD, A., P. BATES, R. FISHER, L. RICHARDSON, AND C. F. GRAHAM. Disproportionate growth in mice with Igf-2 transgenes. Proc. Natl. Acad. Sci. USA 91: 10365-10369, 1994.
219. WERNER, H., AND D. LEROITH. Insulin-like growth factor I receptor: structure, signal transduction, and function. Diabetes Rev. 3: 28-37, 1995
220. WESTLUND, B., N. M. DAHMS, AND S. KORNFELD. The bovine mannose 6-phosphate/insulin-like growth factor II receptor. Localization of mannose 6-phosphate binding sites to domains 1-3 and 7-11 of the extracytoplasmic region. J. Biol. Chem. 266: 23233-23239, 1991.
221. WHITE, M. F., AND C. R. KAHN. The insulin signaling system. J. Biol. Chem. 269: 1-4, 1994.
222. WOLF, E., R. KRAMER, W. F. BLUM, J. FOLL, AND G. BREM. Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth. Endocrinology 135: 1877-1886, 1994.
223. WOOD, T. L., L. ROGLER, R. D. STRECK, J. CERRO, B. GREEN, A. GREWAL, AND J. E. PINTAR. Targeted disruption of IGFBP-2 gene. Growth Regul. 3: 5-8, 1993.
224. YAMAMOTO, K., D. ALTSCHULER, E. WOOD, K. HORLICK, S. JACOBS, AND E. G. LAPETINA. Association of phosphorylated insulin-like growth factor-I receptor with the SH2 domains of phosphatidylinositol 3-kinase p85. J. Biol. Chem. 267: 11337-11343, 1992.
225. 950tyrosine is required for somatotroph growth factor signal transduction. J. Biol. Chem. 267: 20953-20958, 1992.
226. YANG, D., E. ALT, AND C. E. ROGLER. Coordinate expression of N-myc 2 and insulin-like growth factor II in precancerous altered hepatic foci in woodchuck hepatitis virus carriers. Cancer Res. 53: 2020-2027, 1993.
227. YEE, D., G. S. LEVOVIC, R. R. MARCUS, AND N. ROSEN. Identification of an alternate type I insulin-like growth factor β receptor subunit mRNA transcript. J. Biol. Chem. 264: 21439-21441, 1989.
228. ZAPF, J., E. FUTO, M. PETER, AND E. R. FROESCH. Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia J. Clin. Invest. 90: 2574-2584, 1992.
229. ZAPF, J., E. SCHOENLE, G. JAGARS, I. SAND, J. GRUNWALD, AND E. R. FROESCH. Inhibition of the action of nonsuppressible insulin-like activity on isolated rat fat cells by binding to its carrier protein. J. Clin. Invest. 63: 1077-1084, 1979.
230. ZAPF, J., M. WALDVOGEL, AND E. R. FROESCH. Binding of nonsuppressible insulinlike activity to human serum. Evidence for a carrier protein. Arch. Biochem. Biophys. 168: 638-645, 1975.
231. ZHAN, S. I., D. SHAPIRO, S. G. ZHAN, L. ZHANG, S. HIRSCHFELD, J. ELASSAL, AND L. J. HELMAN. Concordant loss of imprinting of the human insulin-like growth factor II gene promoters in cancer. J. Biol. Chem. 270: 27983-27986, 1995.
232. ZHOU, M., Z. MA, AND W. S. SLY. Cloning and expression of the cDNA of chicken cation-independent mannose-6-phosphate receptor. Proc. Natl. Acad. Sci. USA 92: 9762-9766, 1995.