-
1
-
-
70349495203
-
Ageing populations: The challenges ahead
-
doi:10.1016/S0140- 6736(09)61460-4
-
Christensen, K., Doblhammer, G., Rau, R. & Vaupel, J. W. 2009 Ageing populations: The challenges ahead. Lancet 374, 1196-1208. (doi:10.1016/S0140- 6736(09)61460-4)
-
(2009)
Lancet
, vol.374
, pp. 1196-1208
-
-
Christensen, K.1
Doblhammer, G.2
Rau, R.3
Vaupel, J.W.4
-
2
-
-
75449088805
-
The newbiology of ageing
-
doi: 10.1098/rstb.2009.0222
-
Partridge, L. 2010 The newbiology of ageing. Phil.Trans. R. Soc. B 365, 147-154. (doi: 10.1098/rstb.2009.0222)
-
(2010)
Phil.Trans. R. Soc. B
, vol.365
, pp. 147-154
-
-
Partridge, L.1
-
3
-
-
25644439283
-
The demographic characteristics of the oldest old in the United Kingdom
-
Tomassini, C. 2005 The demographic characteristics of the oldest old in the United Kingdom. Popul. Trends 120, 15-22.
-
(2005)
Popul. Trends
, vol.120
, pp. 15-22
-
-
Tomassini, C.1
-
4
-
-
77950191531
-
Biodemography of human ageing
-
doi:10.1038/nature08984
-
Vaupel, J. W. 2010 Biodemography of human ageing. Nature 464, 536-542. (doi:10.1038/nature08984)
-
(2010)
Nature
, vol.464
, pp. 536-542
-
-
Vaupel, J.W.1
-
5
-
-
77950229880
-
Neural mechanisms of ageing and cognitive decline
-
doi:10.1038/nature08983
-
Bishop, N. A., Lu, T. & Yankner, B. A. 2010 Neural mechanisms of ageing and cognitive decline. Nature 464, 529-535. (doi:10.1038/nature08983)
-
(2010)
Nature
, vol.464
, pp. 529-535
-
-
Bishop, N.A.1
Lu, T.2
Yankner, B.A.3
-
6
-
-
33745384267
-
Molecular mechanisms of aging-associated inflammation
-
doi:10.1016/j.canlet.2005.04.009
-
Sarkar, D. & Fisher, P. B. 2006 Molecular mechanisms of aging-associated inflammation. Cancer Lett. 236, 13-23. (doi:10.1016/j.canlet. 2005.04.009)
-
(2006)
Cancer Lett.
, vol.236
, pp. 13-23
-
-
Sarkar, D.1
Fisher, P.B.2
-
7
-
-
59849091257
-
Insulin/IGF-like signalling, the central nervous system and aging
-
doi:10.1042/BJ20082102
-
Broughton, S. & Partridge, L. 2009 Insulin/IGF-like signalling, the central nervous system and aging. Biochem. J. 418, 1-12. (doi:10.1042/ BJ20082102)
-
(2009)
Biochem. J.
, vol.418
, pp. 1-12
-
-
Broughton, S.1
Partridge, L.2
-
8
-
-
77950200010
-
The genetics of ageing
-
doi:10.1038/nature08980
-
Kenyon, C. J. 2010 The genetics of ageing. Nature 464, 504-512. (doi:10.1038/nature08980)
-
(2010)
Nature
, vol.464
, pp. 504-512
-
-
Kenyon, C.J.1
-
9
-
-
38349103636
-
Separating cause from effect: How does insulin/ IGF signalling control lifespan in worms, flies and mice?
-
doi:10.1111/j. 1365-2796.2007.01906.x
-
Piper, M. D., Selman, C., McElwee, J. J. & Partridge, L. 2008 Separating cause from effect: How does insulin/ IGF signalling control lifespan in worms, flies and mice? J. Intern. Med. 263, 179-191. (doi:10.1111/j. 1365-2796.2007.01906.x)
-
(2008)
J. Intern. Med.
, vol.263
, pp. 179-191
-
-
Piper, M.D.1
Selman, C.2
McElwee, J.J.3
Partridge, L.4
-
10
-
-
22744445281
-
Overview of caloric restriction and ageing
-
doi:10. 1016/j.mad.2005.03.012
-
Masoro, E. J. 2005 Overview of caloric restriction and ageing. Mech. Ageing Dev. 126, 913-922. (doi:10. 1016/j.mad.2005.03.012)
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 913-922
-
-
Masoro, E.J.1
-
11
-
-
0002458132
-
The effect of retarded growth upon the length of life and upon the ultimate body size
-
McCay, C. M., Crowell, L. A. & Maynard, L. A. 1935 The effect of retarded growth upon the length of life and upon the ultimate body size. J. Nutr. 10, 63-79.
-
(1935)
J. Nutr.
, vol.10
, pp. 63-79
-
-
McCay, C.M.1
Crowell, L.A.2
Maynard, L.A.3
-
12
-
-
0003540187
-
The retardation of aging and disease by dietary restriction
-
IL: Charles C. Thomas
-
Weindruch, R. & Walford, R. L. 1988 The retardation of aging and disease by dietary restriction. Springfield, IL: Charles C. Thomas.
-
(1988)
Springfield
-
-
Weindruch, R.1
Walford, R.L.2
-
13
-
-
13944269223
-
The plasticity of aging: Insights from long-lived mutants
-
doi:10.1016/j. cell.2005.02.002
-
Kenyon, C. 2005 The plasticity of aging: Insights from long-lived mutants. Cell 120, 449-460. (doi:10.1016/j. cell.2005.02.002)
-
(2005)
Cell
, vol.120
, pp. 449-460
-
-
Kenyon, C.1
-
14
-
-
36048939348
-
Benchmarks for ageing studies
-
doi:10.1038/ 450165a
-
Partridge, L. & Gems, D. 2007 Benchmarks for ageing studies. Nature 450, 165-167. (doi:10.1038/ 450165a)
-
(2007)
Nature
, vol.450
, pp. 165-167
-
-
Partridge, L.1
Gems, D.2
-
15
-
-
50649101095
-
Puzzles, promises and a cure for ageing
-
doi:10.1038/ nature07216
-
Vijg, J. & Campisi, J. 2008 Puzzles, promises and a cure for ageing. Nature 454, 1065-1071. (doi:10.1038/ nature07216)
-
(2008)
Nature
, vol.454
, pp. 1065-1071
-
-
Vijg, J.1
Campisi, J.2
-
16
-
-
0037942739
-
Extended longevity in mice lacking the insulin receptor in adipose tissue
-
doi:10.1126/science.1078223
-
Bluher, M., Kahn, B. B. & Kahn, C. R. 2003 Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299, 572-574. (doi:10.1126/science. 1078223)
-
(2003)
Science
, vol.299
, pp. 572-574
-
-
Bluher, M.1
Kahn, B.B.2
Kahn, C.R.3
-
17
-
-
0035815414
-
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
-
doi:10.1126/science.1057991
-
Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J. & Partridge, L. 2001 Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104-106. (doi:10.1126/science.1057991)
-
(2001)
Science
, vol.292
, pp. 104-106
-
-
Clancy, D.J.1
Gems, D.2
Harshman, L.G.3
Oldham, S.4
Stocker, H.5
Hafen, E.6
Leevers, S.J.7
Partridge, L.8
-
18
-
-
54949143977
-
Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism
-
doi:10.1371/journal.pbio.0060254
-
Kappeler, L. et al. 2008 Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism. PLoS Biol. 6, e254. (doi:10.1371/ journal.pbio.0060254)
-
(2008)
PLoS Biol.
, vol.6
-
-
Kappeler, L.1
-
19
-
-
40449142493
-
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
-
doi:10.1096/fj.07-9261com
-
Selman, C. et al. 2008 Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J. 22, 807-818. (doi:10.1096/fj.07-9261com)
-
(2008)
FASEB J.
, vol.22
, pp. 807-818
-
-
Selman, C.1
-
20
-
-
67651151249
-
Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
-
doi:10. 1111/j.1474-9726.2009.00493.x
-
Pawlikowska, L. et al. 2009 Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell 8, 460-472. (doi:10. 1111/j.1474-9726.2009.00493.x)
-
(2009)
Aging Cell
, vol.8
, pp. 460-472
-
-
Pawlikowska, L.1
-
21
-
-
42149141146
-
Functionally significant insulin-like growth factor I receptor mutations in centenarians
-
doi:10.1073/pnas.0705467105
-
Suh, Y., Atzmon, G., Cho, M. O., Hwang, D., Liu, B., Leahy, D. J., Barzilai, N. & Cohen, P. 2008 Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc. Natl Acad. Sci. USA 105, 3438-3442. (doi:10.1073/pnas.0705467105)
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 3438-3442
-
-
Suh, Y.1
Atzmon, G.2
Cho, M.O.3
Hwang, D.4
Liu, B.5
Leahy, D.J.6
Barzilai, N.7
Cohen, P.8
-
22
-
-
22144477243
-
Reduced insulin/IGF-1 signalling and human longevity
-
doi:10.1111/j.1474-9728.2005.00148.x
-
van Heemst, D., Beekman, M., Mooijaart, S. P., Heijmans, B. T., Brandt, B.W., Zwaan, B. J., Slagboom, P. E. & Westendorp, R. G. 2005 Reduced insulin/IGF-1 signalling and human longevity. Aging Cell 4, 79-85. (doi:10.1111/j.1474-9728.2005.00148.x)
-
(2005)
Aging Cell
, vol.4
, pp. 79-85
-
-
Van Heemst, D.1
Beekman, M.2
Mooijaart, S.P.3
Heijmans, B.T.4
Brandt, B.W.5
Zwaan, B.J.6
Slagboom, P.E.7
Westendorp, R.G.8
-
23
-
-
65549122452
-
Insulin sensitivity as a key mediator of growth hormone actions on longevity
-
doi:10. 1093/gerona/glp024
-
Masternak, M. M., Panici, J. A., Bonkowski, M. S., Hughes, L. F. & Bartke, A. 2009 Insulin sensitivity as a key mediator of growth hormone actions on longevity. J. Gerontol. A Biol. Sci. Med. Sci. 64, 516-521. (doi:10. 1093/gerona/glp024)
-
(2009)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.64
, pp. 516-521
-
-
Masternak, M.M.1
Panici, J.A.2
Bonkowski, M.S.3
Hughes, L.F.4
Bartke, A.5
-
24
-
-
72649091698
-
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
-
doi:10.1016/j.cmet.2009.11.010
-
Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A. & Partridge, L. 2010 Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab. 11, 35-46. (doi:10.1016/j.cmet. 2009.11.010)
-
(2010)
Cell Metab.
, vol.11
, pp. 35-46
-
-
Bjedov, I.1
Toivonen, J.M.2
Kerr, F.3
Slack, C.4
Jacobson, J.5
Foley, A.6
Partridge, L.7
-
25
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
doi:10.1038/nature08221
-
Harrison, D. E. et al. 2009 Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392-395. (doi:10.1038/ nature08221)
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
-
26
-
-
76549104638
-
Resveratrol and rapamycin: Are they anti-aging drugs?
-
doi:10. 1002/bies.200900171
-
Kaeberlein, M. 2010 Resveratrol and rapamycin: Are they anti-aging drugs? Bioessays 32, 96-99. (doi:10. 1002/bies.200900171)
-
(2010)
Bioessays
, vol.32
, pp. 96-99
-
-
Kaeberlein, M.1
-
27
-
-
3042648746
-
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
-
doi:10.1016/j.cub. 2004.03.059
-
Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V. & Benzer, S. 2004 Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr. Biol. 14, 885-890. (doi:10.1016/j.cub. 2004.03.059)
-
(2004)
Curr. Biol.
, vol.14
, pp. 885-890
-
-
Kapahi, P.1
Zid, B.M.2
Harper, T.3
Koslover, D.4
Sapin, V.5
Benzer, S.6
-
28
-
-
33846418352
-
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
-
doi:10.1111/j.1474-9726.2006.00266.x
-
Pan, K. Z., Palter, J. E., Rogers, A. N., Olsen, A., Chen, D., Lithgow, G. J. & Kapahi, P. 2007 Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6, 111-119. (doi:10.1111/j.1474- 9726.2006.00266.x)
-
(2007)
Aging Cell
, vol.6
, pp. 111-119
-
-
Pan, K.Z.1
Palter, J.E.2
Rogers, A.N.3
Olsen, A.4
Chen, D.5
Lithgow, G.J.6
Kapahi, P.7
-
29
-
-
70349669095
-
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
-
doi:10.1126/science.1177221
-
Selman, C. et al. 2009 Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326, 140-144. (doi:10.1126/science.1177221)
-
(2009)
Science
, vol.326
, pp. 140-144
-
-
Selman, C.1
-
30
-
-
77950485782
-
Skeletal muscle loss: Cachexia, sarcopenia, and inactivity
-
doi:10.3945/ajcn.2010.28608A
-
Evans, W. J. 2010 Skeletal muscle loss: Cachexia, sarcopenia, and inactivity. Am. J. Clin. Nutr. 91, 1123S- 1127S. (doi:10.3945/ajcn.2010.28608A)
-
(2010)
Am. J. Clin. Nutr.
, vol.91
-
-
Evans, W.J.1
-
31
-
-
69949106011
-
Role of visceral adipose tissue in aging
-
Huffman, D. M. & Barzilai, N. 2009 Role of visceral adipose tissue in aging. Biochim. Biophys. Acta 1790, 1117-1123.
-
(2009)
Biochim. Biophys. Acta
, vol.1790
, pp. 1117-1123
-
-
Huffman, D.M.1
Barzilai, N.2
-
32
-
-
77449109099
-
Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function
-
doi:10.2337/db09-0591
-
Karakelides, H., Irving, B. A., Short, K. R., O'Brien, P. & Nair, K. S. 2010 Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function. Diabetes 59, 89-97. (doi:10.2337/db09-0591)
-
(2010)
Diabetes
, vol.59
, pp. 89-97
-
-
Karakelides, H.1
Irving, B.A.2
Short, K.R.3
O'Brien, P.4
Nair, K.S.5
-
33
-
-
77953199006
-
Insulin resistance and cancer: Epidemiological evidence
-
doi:10.1111/j.1349-7006.2010.01521.x
-
Tsugane, S. & Inoue, M. 2010 Insulin resistance and cancer: Epidemiological evidence. Cancer Sci. 101, 1073-1079. (doi:10.1111/j.1349-7006. 2010.01521.x)
-
(2010)
Cancer Sci.
, vol.101
, pp. 1073-1079
-
-
Tsugane, S.1
Inoue, M.2
-
34
-
-
77951769605
-
Metabolic syndrome, central obesity and insulin resistance are associated with adverse pathological features in postmenopausal breast cancer
-
doi:10.1016/j.clon. 2010.02.001
-
Healy, L. A., Ryan, A. M., Carroll, P., Ennis, D., Crowley, V., Boyle, T., Kennedy, M. J., Connolly, E. & Reynolds, J. V. 2010 Metabolic syndrome, central obesity and insulin resistance are associated with adverse pathological features in postmenopausal breast cancer. Clin. Oncol. UK 22, 281-288. (doi:10.1016/j.clon. 2010.02.001)
-
(2010)
Clin. Oncol. UK
, vol.22
, pp. 281-288
-
-
Healy, L.A.1
Ryan, A.M.2
Carroll, P.3
Ennis, D.4
Crowley, V.5
Boyle, T.6
Kennedy, M.J.7
Connolly, E.8
Reynolds, J.V.9
-
35
-
-
70450255115
-
Obesity and Alzheimer's disease: A link between body weight and cognitive function in old age
-
doi:10.1177/1533317509348208
-
Naderali, E. K., Ratcliffe, S. H. & Dale, M. C. 2009 Obesity and Alzheimer's disease: A link between body weight and cognitive function in old age. Am. J. Alzheimers Dis. Other. Demen. 24, 445-449. (doi:10.1177/ 1533317509348208)
-
(2009)
Am. J. Alzheimers Dis. Other. Demen.
, vol.24
, pp. 445-449
-
-
Naderali, E.K.1
Ratcliffe, S.H.2
Dale, M.C.3
-
36
-
-
33646731782
-
Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction
-
doi:10.1073/pnas.0600161103
-
Bonkowski, M. S., Rocha, J. S., Masternak, M. M., Al Regaiey, K. A. & Bartke, A. 2006 Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc. Natl Acad. Sci. USA 103, 7901-7905. (doi:10.1073/pnas.0600161103)
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 7901-7905
-
-
Bonkowski, M.S.1
Rocha, J.S.2
Masternak, M.M.3
Al Regaiey, K.A.4
Bartke, A.5
-
37
-
-
0033835911
-
Compensatory alterations of insulin signal transduction in liver of growth hormone receptor knockout mice
-
doi:10.1677/joe.0.1660579
-
Dominici, F. P., Arostegui Diaz, G., Bartke, A., Kopchick, J. J. & Turyn, D. 2000 Compensatory alterations of insulin signal transduction in liver of growth hormone receptor knockout mice. J. Endocrinol. 166, 579-590. (doi:10.1677/joe.0.1660579)
-
(2000)
J. Endocrinol.
, vol.166
, pp. 579-590
-
-
Dominici, F.P.1
Arostegui Diaz, G.2
Bartke, A.3
Kopchick, J.J.4
Turyn, D.5
-
38
-
-
0036237480
-
Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice
-
doi:10.1677/joe.0.1730081
-
Dominici, F. P., Hauck, S., Argentino,D. P., Bartke, A. & Turyn, D. 2002 Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice. J. Endocrinol. 173, 81-94. (doi:10.1677/joe.0. 1730081)
-
(2002)
J. Endocrinol.
, vol.173
, pp. 81-94
-
-
Dominici, F.P.1
Hauck, S.2
Argentino, D.P.3
Bartke, A.4
Turyn, D.5
-
39
-
-
74049145768
-
The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet
-
doi:10.1111/j.1474-9726.2009.00520.x
-
Arum, O., Bonkowski, M. S., Rocha, J. S. & Bartke, A. 2009 The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet. Aging Cell 8, 756-760. (doi:10.1111/j.1474-9726. 2009.00520.x)
-
(2009)
Aging Cell
, vol.8
, pp. 756-760
-
-
Arum, O.1
Bonkowski, M.S.2
Rocha, J.S.3
Bartke, A.4
-
40
-
-
42449146120
-
THow diet interacts with longevity genes
-
Bartke, A., Bonkowski, M. & Masternak, M. 2008 THow diet interacts with longevity genes. Hormones (Athens) 7, 17-23.
-
(2008)
Hormones (Athens)
, vol.7
, pp. 17-23
-
-
Bartke, A.1
Bonkowski, M.2
Masternak, M.3
-
41
-
-
0035811073
-
Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
-
doi:10.1073/pnas.111158898
-
Flurkey, K., Papaconstantinou, J., Miller, R. A. & Harrison, D. E. 2001 Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl Acad. Sci. USA 98, 6736-6741. (doi:10.1073/pnas.111158898)
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 6736-6741
-
-
Flurkey, K.1
Papaconstantinou, J.2
Miller, R.A.3
Harrison, D.E.4
-
42
-
-
0036103401
-
Implications for the insulin signaling pathway in Snell dwarf mouse longevity: A similarity with the C. elegans longevity paradigm
-
Hsieh, C. C., DeFord, J. H., Flurkey, K., Harrison, D. E. & Papaconstantinou, J. 2002 Implications for the insulin signaling pathway in Snell dwarf mouse longevity: A similarity with the C. elegans longevity paradigm. Mech. Ageing Dev. 123, 1229-1244.
-
(2002)
Mech. Ageing Dev.
, vol.123
, pp. 1229-1244
-
-
Hsieh, C.C.1
DeFord, J.H.2
Flurkey, K.3
Harrison, D.E.4
Papaconstantinou, J.5
-
43
-
-
74049103564
-
Two-year body composition analyses of long-lived GHR null mice
-
doi:10. 1093/gerona/glp175
-
Berryman, D. E., List, E. O., Palmer, A. J., Chung, M. Y., Wright-Piekarski, J., Lubbers, E., O'Connor, P., Okada, S. & Kopchick, J. J. 2010 Two-year body composition analyses of long-lived GHR null mice. J. Gerontol. A Biol. Sci. Med. Sci. 65, 31-40. (doi:10. 1093/gerona/glp175)
-
(2010)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.65
, pp. 31-40
-
-
Berryman, D.E.1
List, E.O.2
Palmer, A.J.3
Chung, M.Y.4
Wright-Piekarski, J.5
Lubbers, E.6
O'Connor, P.7
Okada, S.8
Kopchick, J.J.9
-
44
-
-
34547097247
-
Brain IRS2 signaling coordinates life span and nutrient homeostasis
-
doi:10.1126/ science.1142179
-
Taguchi, A., Wartschow, L. M. & White, M. F. 2007 Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317, 369-372. (doi:10.1126/ science.1142179)
-
(2007)
Science
, vol.317
, pp. 369-372
-
-
Taguchi, A.1
Wartschow, L.M.2
White, M.F.3
-
45
-
-
46449091994
-
Comment on 'Brain IRS2 signaling coordinates life span and nutrient homeostasis'
-
doi:10.1126/science.1152366
-
Selman, C., Lingard, S., Gems, D., Partridge, L. & Withers, D. J. 2008 Comment on 'Brain IRS2 signaling coordinates life span and nutrient homeostasis'. Science 320, 1012. (doi:10.1126/science.1152366)
-
(2008)
Science
, vol.320
, pp. 1012
-
-
Selman, C.1
Lingard, S.2
Gems, D.3
Partridge, L.4
Withers, D.J.5
-
46
-
-
0347664057
-
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
-
doi:10.1038/nature01298
-
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Geloen, A., Even, P. C., Cervera, P. & Le Bouc, Y. 2003 IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421, 182-187. (doi:10.1038/nature01298)
-
(2003)
Nature
, vol.421
, pp. 182-187
-
-
Holzenberger, M.1
Dupont, J.2
Ducos, B.3
Leneuve, P.4
Geloen, A.5
Even, P.C.6
Cervera, P.7
Le Bouc, Y.8
-
47
-
-
0347416781
-
Genetic mouse models of extended lifespan
-
doi:10.1016/j.exger.2003.10.019
-
Liang, H., Masoro, E. J., Nelson, J. F., Strong, R., McMahan, C. A. & Richardson, A. 2003 Genetic mouse models of extended lifespan. Exp. Gerontol. 38, 1353-1364. (doi:10.1016/j.exger.2003.10.019)
-
(2003)
Exp. Gerontol.
, vol.38
, pp. 1353-1364
-
-
Liang, H.1
Masoro, E.J.2
Nelson, J.F.3
Strong, R.4
McMahan, C.A.5
Richardson, A.6
-
48
-
-
67650149336
-
Disruption of protein kinase A in mice enhances healthy aging
-
doi:10.1371/journal.pone.0005963
-
Enns, L. C., Morton, J. F., Treuting, P. R., Emond, M. J., Wolf, N. S., McKnight, G. S., Rabinovitch, P. S. & Ladiges, W. C. 2009 Disruption of protein kinase A in mice enhances healthy aging. PLoS ONE 4, e5963. (doi:10.1371/journal.pone.0005963)
-
(2009)
PLoS ONE
, vol.4
-
-
Enns, L.C.1
Morton, J.F.2
Treuting, P.R.3
Emond, M.J.4
Wolf, N.S.5
McKnight, G.S.6
Rabinovitch, P.S.7
Ladiges, W.C.8
-
49
-
-
0035355340
-
Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
-
doi:10. 1093/emboj/20.11.2619
-
Gonzalez-Suarez, E., Samper, E., Ramirez, A., Flores, J. M., Martin-Caballero, J., Jorcano, J. L. & Blasco, M. A. 2001 Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J. 20, 2619-2630. (doi:10. 1093/emboj/20.11.2619)
-
(2001)
EMBO J.
, vol.20
, pp. 2619-2630
-
-
Gonzalez-Suarez, E.1
Samper, E.2
Ramirez, A.3
Flores, J.M.4
Martin-Caballero, J.5
Jorcano, J.L.6
Blasco, M.A.7
-
50
-
-
55449122193
-
Telomerase reverse transcriptase delays aging in cancer-resistant mice
-
doi:10.1016/j.cell.2008.09.034
-
Tomas-Loba, A. et al. 2008 Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell 135, 609-622. (doi:10.1016/j.cell.2008.09.034)
-
(2008)
Cell
, vol.135
, pp. 609-622
-
-
Tomas-Loba, A.1
-
51
-
-
24944481544
-
Suppression of aging in mice by the hormone Klotho
-
doi:10. 1126/science.1112766
-
Kurosu, H. et al. 2005 Suppression of aging in mice by the hormone Klotho. Science 309, 1829-1833. (doi:10. 1126/science.1112766)
-
(2005)
Science
, vol.309
, pp. 1829-1833
-
-
Kurosu, H.1
-
52
-
-
0035209308
-
Annual incidence of Alzheimer disease in the United States projected to the years 2000 through 2050
-
doi:10.1097/00002093-200110000-00002
-
Hebert, L. E., Beckett, L. A., Scherr, P. A. & Evans, D. A. 2001 Annual incidence of Alzheimer disease in the United States projected to the years 2000 through 2050. Alzheimer Dis. Assoc. Disord. 15, 169-173. (doi:10.1097/00002093-200110000-00002)
-
(2001)
Alzheimer Dis. Assoc. Disord.
, vol.15
, pp. 169-173
-
-
Hebert, L.E.1
Beckett, L.A.2
Scherr, P.A.3
Evans, D.A.4
-
53
-
-
1242292288
-
Could a deficiency in growth hormone signaling be beneficial to the aging brain?
-
doi:10.1016/j.physbeh.2003.10.018
-
Kinney-Forshee, B. A., Kinney, N. E., Steger, R. W. & Bartke, A. 2004 Could a deficiency in growth hormone signaling be beneficial to the aging brain? Physiol. Behav. 80, 589-594. (doi:10.1016/j.physbeh.2003. 10.018)
-
(2004)
Physiol. Behav.
, vol.80
, pp. 589-594
-
-
Kinney-Forshee, B.A.1
Kinney, N.E.2
Steger, R.W.3
Bartke, A.4
-
54
-
-
0035051811
-
Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice
-
doi:10.1016/S0031-9384(01)00423-1
-
Kinney, B. A., Coschigano, K. T., Kopchick, J. J., Steger, R. W. & Bartke, A. 2001 Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice. Physiol. Behav. 72, 653-660. (doi:10.1016/S0031-9384(01)00423-1)
-
(2001)
Physiol. Behav.
, vol.72
, pp. 653-660
-
-
Kinney, B.A.1
Coschigano, K.T.2
Kopchick, J.J.3
Steger, R.W.4
Bartke, A.5
-
55
-
-
0034966342
-
Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters
-
doi:10.1006/hbeh.2001.1654
-
Kinney, B. A., Meliska, C. J., Steger, R.W. & Bartke, A. 2001 Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters. Horm. Behav. 39, 277-284. (doi:10.1006/hbeh.2001.1654)
-
(2001)
Horm. Behav.
, vol.39
, pp. 277-284
-
-
Kinney, B.A.1
Meliska, C.J.2
Steger, R.W.3
Bartke, A.4
-
56
-
-
34249684293
-
Adult neurogenesis in the hippocampus of long-lived mice during aging
-
Sun, L. Y. & Bartke, A. 2007 Adult neurogenesis in the hippocampus of long-lived mice during aging. J. Gerontol. A Biol. Sci. Med. Sci. 62, 117-125.
-
(2007)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.62
, pp. 117-125
-
-
Sun, L.Y.1
Bartke, A.2
-
57
-
-
14244266395
-
Increased neurogenesis in dentate gyrus of longlived Ames dwarf mice
-
doi:10.1210/en.2004-1115
-
Sun, L. Y., Evans, M. S., Hsieh, J., Panici, J. & Bartke, A. 2005 Increased neurogenesis in dentate gyrus of longlived Ames dwarf mice. Endocrinology 146, 1138-1144. (doi:10.1210/en.2004-1115)
-
(2005)
Endocrinology
, vol.146
, pp. 1138-1144
-
-
Sun, L.Y.1
Evans, M.S.2
Hsieh, J.3
Panici, J.4
Bartke, A.5
-
58
-
-
40849102760
-
Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels
-
doi:10.1002/hipo.20387
-
Schrag, M., Sharma, S., Brown-Borg, H. & Ghribi, O. 2008 Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels. Hippocampus 18, 239-244. (doi:10.1002/hipo.20387)
-
(2008)
Hippocampus
, vol.18
, pp. 239-244
-
-
Schrag, M.1
Sharma, S.2
Brown-Borg, H.3
Ghribi, O.4
-
59
-
-
70349672704
-
Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease
-
doi:10.1096/fj.09-132043
-
Freude, S. et al. 2009 Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease. FASEB J. 23, 3315-3324. (doi:10.1096/fj.09-132043)
-
(2009)
FASEB J.
, vol.23
, pp. 3315-3324
-
-
Freude, S.1
-
60
-
-
67649224051
-
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
-
doi:10.1016/j.bbrc.2009.06.032
-
Killick, R. et al. 2009 Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice. Biochem. Biophys. Res. Commun. 386, 257-262. (doi:10.1016/j.bbrc.2009.06.032)
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.386
, pp. 257-262
-
-
Killick, R.1
-
61
-
-
71449108913
-
Reduced IGF-1 signaling delays age-associated proteotoxicity in mice
-
doi:10.1016/j.cell.2009.11.014
-
Cohen, E. et al. 2009 Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell 139, 1157-1169. (doi:10.1016/j.cell.2009.11.014)
-
(2009)
Cell
, vol.139
, pp. 1157-1169
-
-
Cohen, E.1
-
62
-
-
77951227122
-
Molecular interplay between mTOR, amyloid-b, and Tau: Effects on cognitive impairments
-
doi:10.1074/jbc.M110.100420
-
Caccamo, A., Majumder, S., Richardson, A., Strong, R. & Oddo, S. 2010 Molecular interplay between mTOR, amyloid-b, and Tau: Effects on cognitive impairments. J. Biol. Chem. 285, 13 107-13 120. (doi:10.1074/jbc.M110.100420)
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 13107-13120
-
-
Caccamo, A.1
Majumder, S.2
Richardson, A.3
Strong, R.4
Oddo, S.5
-
63
-
-
77956305343
-
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-b levels in a mouse model of Alzheimer's disease
-
doi:10.1371/journal.pone.0009979
-
Spilman, P., Podlutskaya, N., Hart, M. J., Debnath, J., Gorostiza, O., Bredesen, D., Richardson, A., Strong, R. & Galvan, V. 2010 Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-b levels in a mouse model of Alzheimer's disease. PLoS ONE 5, e9979. (doi:10.1371/journal. pone.0009979)
-
(2010)
PLoS ONE
, vol.5
-
-
Spilman, P.1
Podlutskaya, N.2
Hart, M.J.3
Debnath, J.4
Gorostiza, O.5
Bredesen, D.6
Richardson, A.7
Strong, R.8
Galvan, V.9
-
64
-
-
75149193373
-
Update in male osteoporosis
-
doi:10.1210/jc.2009-1740
-
Khosla, S. 2010 Update in male osteoporosis. J. Clin. Endocrinol. Metab. 95, 3-10. (doi:10.1210/jc.2009-1740)
-
(2010)
J. Clin. Endocrinol. Metab.
, vol.95
, pp. 3-10
-
-
Khosla, S.1
-
65
-
-
77649218774
-
Epidemiologic link between osteoporosis and cardiovascular disease
-
Crepaldi, G. & Maggi, S. 2009 Epidemiologic link between osteoporosis and cardiovascular disease. J. Endocrinol. Invest. 32, 2-5.
-
(2009)
J. Endocrinol. Invest.
, vol.32
, pp. 2-5
-
-
Crepaldi, G.1
Maggi, S.2
-
66
-
-
0035999437
-
Changes in bone structure and mass with advancing age in the male C57BL/6J mouse
-
doi:10.1359/jbmr.2002.17.6.1044
-
Halloran, B. P., Ferguson, V. L., Simske, S. J., Burghardt, A., Venton, L. L. & Majumdar, S. 2002 Changes in bone structure and mass with advancing age in the male C57BL/6J mouse. J. Bone Miner. Res. 17, 1044-1050. (doi:10.1359/jbmr.2002.17.6.1044)
-
(2002)
J. Bone Miner. Res.
, vol.17
, pp. 1044-1050
-
-
Halloran, B.P.1
Ferguson, V.L.2
Simske, S.J.3
Burghardt, A.4
Venton, L.L.5
Majumdar, S.6
-
67
-
-
17144438059
-
Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover
-
doi:10.1172/ JCI9017
-
Ogata, N. et al. 2000 Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. J. Clin. Invest. 105, 935-943. (doi:10.1172/ JCI9017)
-
(2000)
J. Clin. Invest.
, vol.105
, pp. 935-943
-
-
Ogata, N.1
-
68
-
-
34447528668
-
Type 5 adenylyl cyclase disruption increases longevity and protects against stress
-
doi:10.1016/j.cell.2007.05.038
-
Yan, L. et al. 2007 Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell 130, 247-258. (doi:10.1016/j.cell. 2007.05.038)
-
(2007)
Cell
, vol.130
, pp. 247-258
-
-
Yan, L.1
-
69
-
-
0015466216
-
Articular aging and osteoarthrosis in dwarf mice
-
Silberberg, R. 1972 Articular aging and osteoarthrosis in dwarf mice. Pathol. Microbiol. (Basel) 38, 417-430.
-
(1972)
Pathol. Microbiol. (Basel)
, vol.38
, pp. 417-430
-
-
Silberberg, R.1
-
70
-
-
67649297938
-
Vision loss in older persons
-
Pelletier, A. L., Thomas, J. & Shaw, F. R. 2009 Vision loss in older persons. Am. Fam. Physician 79, 963-970.
-
(2009)
Am. Fam. Physician
, vol.79
, pp. 963-970
-
-
Pelletier, A.L.1
Thomas, J.2
Shaw, F.R.3
-
71
-
-
77950270029
-
The role of environmental light in sleep and health: Effects of ocular aging and cataract surgery
-
doi:10.1016/j.smrv.2009.11.002
-
Turner, P. L., Van Someren, E. J. & Mainster, M. A. 2010 The role of environmental light in sleep and health: Effects of ocular aging and cataract surgery. Sleep Med Rev. 14, 269-280. (doi:10.1016/j.smrv. 2009.11.002)
-
(2010)
Sleep Med Rev.
, vol.14
, pp. 269-280
-
-
Turner, P.L.1
Van Someren, E.J.2
Mainster, M.A.3
-
72
-
-
23944433155
-
Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence
-
Wolf, N., Penn, P., Pendergrass, W., Van Remmen, H., Bartke, A., Rabinovitch, P. & Martin, G. M. 2005 Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence. Exp. Eye Res. 81, 276-285.
-
(2005)
Exp. Eye Res.
, vol.81
, pp. 276-285
-
-
Wolf, N.1
Penn, P.2
Pendergrass, W.3
Van Remmen, H.4
Bartke, A.5
Rabinovitch, P.6
Martin, G.M.7
-
73
-
-
13444249466
-
Hormone-treated Snell dwarf mice regain fertility but remain long lived and disease resistant
-
Vergara, M., Smith-Wheelock, M., Harper, J. M., Sigler, R. & Miller, R. A. 2004 Hormone-treated Snell dwarf mice regain fertility but remain long lived and disease resistant. J. Gerontol. A Biol. Sci. Med. Sci. 59, 1244-1250.
-
(2004)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.59
, pp. 1244-1250
-
-
Vergara, M.1
Smith-Wheelock, M.2
Harper, J.M.3
Sigler, R.4
Miller, R.A.5
-
74
-
-
34948853679
-
Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis
-
Ran, Q., Liang, H., Ikeno,Y., Qi,W., Prolla,T. A.,Roberts II, L. J., Wolf, N., Van Remmen, H. & Richardson, A. 2007 Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis. J. Gerontol. A Biol. Sci. Med. Sci. 62, 932-942.
-
(2007)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.62
, pp. 932-942
-
-
Ran, Q.1
Liang, H.2
Ikeno, Y.3
Qi, W.4
Prolla, T.A.5
Roberts II, L.J.6
Wolf, N.7
Van Remmen, H.8
Richardson, A.9
-
75
-
-
0030983708
-
Mortality by cause for eight regions of the world: Global Burden of Disease Study
-
doi:10.1016/S0140- 6736(96)07493-4
-
Murray, C. J. & Lopez, A. D. 1997 Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet 349, 1269-1276. (doi:10.1016/S0140- 6736(96)07493-4)
-
(1997)
Lancet
, vol.349
, pp. 1269-1276
-
-
Murray, C.J.1
Lopez, A.D.2
-
76
-
-
67649204729
-
Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging
-
doi:10.1161/CIRCULATIONAHA.108.822403
-
Dai, D. F. et al. 2009 Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation 119, 2789-2797. (doi:10.1161/CIRCULATIONAHA. 108.822403)
-
(2009)
Circulation
, vol.119
, pp. 2789-2797
-
-
Dai, D.F.1
-
77
-
-
21144434217
-
Extension of murine life span by overexpression of catalase targeted to mitochondria
-
doi:10.1126/science.1106653
-
Schriner, S. E. et al. 2005 Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308, 1909-1911. (doi:10.1126/science.1106653)
-
(2005)
Science
, vol.308
, pp. 1909-1911
-
-
Schriner, S.E.1
-
78
-
-
78049434938
-
Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria
-
doi:10.1111/j.1474-9726.2010. 00581.x
-
Dai, D. F., Chen, T., Wanagat, J., Laflamme, M., Marcinek, D. J., Emond, M. J., Ngo, C. P., Prolla, T. A. & Rabinovitch, P. S. 2010 Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria. Aging Cell 9, 536-544. (doi:10.1111/j.1474- 9726.2010. 00581.x)
-
(2010)
Aging Cell
, vol.9
, pp. 536-544
-
-
Dai, D.F.1
Chen, T.2
Wanagat, J.3
Laflamme, M.4
Marcinek, D.J.5
Emond, M.J.6
Ngo, C.P.7
Prolla, T.A.8
Rabinovitch, P.S.9
-
79
-
-
33744456501
-
Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: Role of oxidative stress
-
doi:10.1096/fj.05-5288fje
-
Yang, X., Doser, T. A., Fang, C. X., Nunn, J. M., Janardhanan, R., Zhu, M., Sreejayan, N., Quinn, M. T. & Ren, J. 2006 Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: Role of oxidative stress. FASEB J. 20, 1024-1026. (doi:10.1096/fj.05-5288fje)
-
(2006)
FASEB J.
, vol.20
, pp. 1024-1026
-
-
Yang, X.1
Doser, T.A.2
Fang, C.X.3
Nunn, J.M.4
Janardhanan, R.5
Zhu, M.6
Sreejayan, N.7
Quinn, M.T.8
Ren, J.9
-
80
-
-
0033581704
-
The p66shc adaptor protein controls oxidative stress response and life span in mammals
-
doi:10.1038/46311
-
Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L. & Pelicci, P. G. 1999 The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402, 309-313. (doi:10.1038/46311)
-
(1999)
Nature
, vol.402
, pp. 309-313
-
-
Migliaccio, E.1
Giorgio, M.2
Mele, S.3
Pelicci, G.4
Reboldi, P.5
Pandolfi, P.P.6
Lanfrancone, L.7
Pelicci, P.G.8
-
81
-
-
8144229685
-
Deletion of p66shc gene protects against age-related endothelial dysfunction
-
doi:10.1161/01.CIR.0000147731. 24444.4D
-
Francia, P. et al. 2004 Deletion of p66shc gene protects against age-related endothelial dysfunction. Circulation 110, 2889-2895. (doi:10.1161/01.CIR.0000147731. 24444.4D)
-
(2004)
Circulation
, vol.110
, pp. 2889-2895
-
-
Francia, P.1
-
82
-
-
23244434000
-
Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage
-
doi:10.1161/01.HYP.0000174986.73346.ba
-
Graiani, G. et al. 2005 Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage. Hypertension 46, 433-440. (doi:10.1161/01.HYP.0000174986.73346.ba)
-
(2005)
Hypertension
, vol.46
, pp. 433-440
-
-
Graiani, G.1
-
83
-
-
34250795031
-
Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet
-
doi:10.1161/CIRCRESAHA.106.146183
-
Harrington, S. C., Simari, R. D. & Conover, C. A. 2007 Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet. Circ. Res. 100, 1696-1702. (doi:10.1161/ CIRCRESAHA.106.146183)
-
(2007)
Circ. Res.
, vol.100
, pp. 1696-1702
-
-
Harrington, S.C.1
Simari, R.D.2
Conover, C.A.3
-
84
-
-
0037452461
-
Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet
-
doi:10.1073/pnas.0336359100
-
Napoli, C. et al. 2003 Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet. Proc. Natl Acad. Sci. USA 100, 2112-2116. (doi:10.1073/pnas.0336359100)
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 2112-2116
-
-
Napoli, C.1
-
85
-
-
77649228537
-
Aging and inflammation: Etiological culprits of cancer
-
doi:10.2174/1874609810902030174
-
Ahmad, A., Banerjee, S., Wang,Z., Kong,D., Majumdar, A. P. & Sarkar, F. H. 2009 Aging and inflammation: Etiological culprits of cancer. Curr. Aging Sci. 2, 174-186. (doi:10.2174/1874609810902030174)
-
(2009)
Curr. Aging Sci.
, vol.2
, pp. 174-186
-
-
Ahmad, A.1
Banerjee, S.2
Wang, Z.3
Kong, D.4
Majumdar, A.P.5
Sarkar, F.H.6
-
86
-
-
58149337527
-
Inflammation, ageing and cancer
-
doi:10.1016/j.mad.2008.06.003
-
Vasto, S., Carruba, G., Lio, D., Colonna-Romano, G., Di Bona, D., Candore, G. & Caruso, C. 2009 Inflammation, ageing and cancer. Mech. Ageing Dev. 130, 40-45. (doi:10.1016/j.mad.2008.06.003)
-
(2009)
Mech. Ageing Dev.
, vol.130
, pp. 40-45
-
-
Vasto, S.1
Carruba, G.2
Lio, D.3
Colonna-Romano, G.4
Di Bona, D.5
Candore, G.6
Caruso, C.7
-
87
-
-
0034962026
-
Mutant and genetically modified mice as models for studying the relationship between aging and carcinogenesis
-
doi:10.1016/S0047-6374(01)00262-7
-
Anisimov, V. N. 2001 Mutant and genetically modified mice as models for studying the relationship between aging and carcinogenesis. Mech. Ageing Dev. 122, 1221-1255. (doi:10.1016/S0047-6374(01)00262-7)
-
(2001)
Mech. Ageing Dev.
, vol.122
, pp. 1221-1255
-
-
Anisimov, V.N.1
-
88
-
-
53349153165
-
Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria
-
Treuting, P. M., Linford, N. J., Knoblaugh, S. E., Emond, M. J., Morton, J. F., Martin, G. M., Rabinovitch, P. S. & Ladiges, W. C. 2008 Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria. J. Gerontol. A Biol. Sci. Med. Sci. 63, 813-822.
-
(2008)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.63
, pp. 813-822
-
-
Treuting, P.M.1
Linford, N.J.2
Knoblaugh, S.E.3
Emond, M.J.4
Morton, J.F.5
Martin, G.M.6
Rabinovitch, P.S.7
Ladiges, W.C.8
-
89
-
-
57349170381
-
Neuroendocrine inhibition of glucose production and resistance to cancer in dwarf mice
-
doi:10.1016/j.exger. 2008.05.014
-
Alderman, J. M. et al. 2009 Neuroendocrine inhibition of glucose production and resistance to cancer in dwarf mice. Exp. Gerontol. 44, 26-33. (doi:10.1016/j.exger. 2008.05.014)
-
(2009)
Exp. Gerontol.
, vol.44
, pp. 26-33
-
-
Alderman, J.M.1
-
90
-
-
33746875150
-
Do long-lived mutant and calorie-restricted mice share common anti-aging mechanisms? - A pathological point of view
-
doi:10.1007/s11357-006-9007-7
-
Ikeno, Y., Lew, C. M., Cortez, L. A., Webb, C. R., Lee, S. & Hubbard, G. B. 2006 Do long-lived mutant and calorie-restricted mice share common anti-aging mechanisms?- a pathological point of view. Age (Dordr.) 28, 163-171. (doi:10.1007/s11357-006-9007-7)
-
(2006)
Age (Dordr.)
, vol.28
, pp. 163-171
-
-
Ikeno, Y.1
Lew, C.M.2
Cortez, L.A.3
Webb, C.R.4
Lee, S.5
Hubbard, G.B.6
-
91
-
-
0345237923
-
Delayed occurrence of fatal neoplastic diseases in Ames dwarf mice: Correlation to extended longevity
-
doi:10.1093/gerona/glp017
-
Ikeno, Y., Bronson, R. T., Hubbard, G. B., Lee, S. & Bartke, A. 2003 Delayed occurrence of fatal neoplastic diseases in Ames dwarf mice: Correlation to extended longevity. J. Gerontol. A Biol. Sci. Med. Sci. 58, 291-296. (doi:10.1093/gerona/glp017)
-
(2003)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.58
, pp. 291-296
-
-
Ikeno, Y.1
Bronson, R.T.2
Hubbard, G.B.3
Lee, S.4
Bartke, A.5
-
92
-
-
65549149453
-
Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice
-
Ikeno, Y. et al. 2009 Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J. Gerontol. A Biol. Sci. Med. Sci. 64, 522-529.
-
(2009)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.64
, pp. 522-529
-
-
Ikeno, Y.1
-
93
-
-
34548614737
-
Loss of pregnancyassociated plasma protein A extends lifespan in mice
-
doi:10.1111/j.1474-9726.2007.00328.x
-
Conover, C. A. & Bale, L. K. 2007 Loss of pregnancyassociated plasma protein A extends lifespan in mice. Aging Cell 6, 727-729. (doi:10.1111/j.1474- 9726. 2007.00328.x)
-
(2007)
Aging Cell
, vol.6
, pp. 727-729
-
-
Conover, C.A.1
Bale, L.K.2
-
94
-
-
77954444618
-
Macrophage migration inhibitory factor-knockout mice are long lived and respond to caloric restriction
-
doi:10.1096/fj.09-152223
-
Harper, J. M., Wilkinson, J. E. & Miller, R. A. 2010 Macrophage migration inhibitory factor-knockout mice are long lived and respond to caloric restriction. FASEB J. 24, 2436-2442. (doi:10.1096/fj.09-152223)
-
(2010)
FASEB J.
, vol.24
, pp. 2436-2442
-
-
Harper, J.M.1
Wilkinson, J.E.2
Miller, R.A.3
-
95
-
-
0036681649
-
T cell subset patterns that predict resistance to spontaneous lymphoma, mammary adenocarcinoma, and fibrosarcoma in mice
-
Miller, R. A. & Chrisp, C. 2002 T cell subset patterns that predict resistance to spontaneous lymphoma, mammary adenocarcinoma, and fibrosarcoma in mice. J. Immunol. 169, 1619-1625.
-
(2002)
J. Immunol.
, vol.169
, pp. 1619-1625
-
-
Miller, R.A.1
Chrisp, C.2
-
96
-
-
0035074534
-
Biomarkers of aging: Prediction of longevity by using age-sensitive T-cell subset determinations in a middle-aged, genetically heterogeneous mouse population
-
Miller, R. A. 2001 Biomarkers of aging: Prediction of longevity by using age-sensitive T-cell subset determinations in a middle-aged, genetically heterogeneous mouse population. J. Gerontol. A Biol. Sci. Med. Sci. 56, B180-B186.
-
(2001)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.56
-
-
Miller, R.A.1
-
97
-
-
0030851573
-
CD4 memory T cell levels predict life span in genetically heterogeneous mice
-
Miller, R. A., Chrisp, C. & Galecki, A. 1997 CD4 memory T cell levels predict life span in genetically heterogeneous mice. FASEB J. 11, 775-783.
-
(1997)
FASEB J.
, vol.11
, pp. 775-783
-
-
Miller, R.A.1
Chrisp, C.2
Galecki, A.3
-
98
-
-
55949137713
-
Energy restriction impairs natural killer cell function and increases the severity of influenza infection in young adult male C57BL/6 mice
-
doi:10.3945/jn.108.093633
-
Ritz, B. W., Aktan, I., Nogusa, S. & Gardner, E. M. 2008 Energy restriction impairs natural killer cell function and increases the severity of influenza infection in young adult male C57BL/6 mice. J. Nutr. 138, 2269-2275. (doi:10.3945/jn.108.093633)
-
(2008)
J. Nutr.
, vol.138
, pp. 2269-2275
-
-
Ritz, B.W.1
Aktan, I.2
Nogusa, S.3
Gardner, E.M.4
-
99
-
-
75549090275
-
MTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
-
doi:10.1126/scisignal.2000559
-
Chen, C., Liu, Y. & Zheng, P. 2009 mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci. Signal. 2, ra75. (doi:10.1126/scisignal. 2000559)
-
(2009)
Sci. Signal.
, vol.2
-
-
Chen, C.1
Liu, Y.2
Zheng, P.3
-
100
-
-
67650500644
-
Resistance to agedependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A
-
doi:10.1073/pnas.0807025106
-
Vallejo, A. N., Michel, J. J., Bale, L. K., Lemster, B. H., Borghesi, L. & Conover, C. A. 2009 Resistance to agedependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A. Proc. Natl Acad. Sci. USA 106, 11 252-11 257. (doi:10.1073/pnas.0807025106)
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 11252-11257
-
-
Vallejo, A.N.1
Michel, J.J.2
Bale, L.K.3
Lemster, B.H.4
Borghesi, L.5
Conover, C.A.6
-
101
-
-
0015348919
-
Immunodeficiency of the thymus-dependent system of the Ames dwarf mouse
-
Duquesnoy, R. J. 1972 Immunodeficiency of the thymus-dependent system of the Ames dwarf mouse. J. Immunol. 108, 1578-1590.
-
(1972)
J. Immunol.
, vol.108
, pp. 1578-1590
-
-
Duquesnoy, R.J.1
-
102
-
-
0042734428
-
Oxidative stress and aging: Beyond correlation
-
doi:10.1046/j.1474-9728.2002.00015.x
-
Golden, T. R., Hinerfeld, D. A. & Melov, S. 2002 Oxidative stress and aging: Beyond correlation. Aging Cell 1, 117-123. (doi:10.1046/j.1474-9728. 2002.00015.x)
-
(2002)
Aging Cell
, vol.1
, pp. 117-123
-
-
Golden, T.R.1
Hinerfeld, D.A.2
Melov, S.3
-
103
-
-
0142213548
-
Oxidative stress, redox imbalance, and the aging process
-
doi:10.1089/152308603770310149
-
Hagen, T. M. 2003 Oxidative stress, redox imbalance, and the aging process. Antioxid. Redox Signal. 5, 503-506. (doi:10.1089/152308603770310149)
-
(2003)
Antioxid. Redox Signal.
, vol.5
, pp. 503-506
-
-
Hagen, T.M.1
-
104
-
-
66749126389
-
Antioxidant defense and aging in C. elegans: Is the oxidative damage theory of aging wrong?
-
Gems, D. & Doonan, R. 2009 Antioxidant defense and aging in C. elegans: Is the oxidative damage theory of aging wrong? Cell Cycle 8, 1681-1687.
-
(2009)
Cell Cycle
, vol.8
, pp. 1681-1687
-
-
Gems, D.1
Doonan, R.2
-
105
-
-
69949091182
-
Is the oxidative stress theory of aging dead?
-
Perez, V. I., Bokov, A., Van Remmen, H., Mele, J., Ran, Q., Ikeno, Y. & Richardson, A. 2009 Is the oxidative stress theory of aging dead? Biochim. Biophys. Acta 1790, 1005-1014.
-
(2009)
Biochim. Biophys. Acta
, vol.1790
, pp. 1005-1014
-
-
Perez, V.I.1
Bokov, A.2
Van Remmen, H.3
Mele, J.4
Ran, Q.5
Ikeno, Y.6
Richardson, A.7
-
106
-
-
12344309431
-
Broad spectrum detoxification: The major longevity assurance process regulated by insulin/IGF-1 signaling?
-
doi:10.1016/j.mad.2004.09.001
-
Gems, D. & McElwee, J. J. 2005 Broad spectrum detoxification: The major longevity assurance process regulated by insulin/IGF-1 signaling? Mech. Ageing Dev. 126, 381-387. (doi:10.1016/j.mad.2004.09.001)
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 381-387
-
-
Gems, D.1
McElwee, J.J.2
-
107
-
-
36448969497
-
Evolutionarily conservation of regulated longevity assurance mechanisms
-
doi:10.1186/gb-2007-8-7-r132
-
McElwee, J. J. et al. 2007 Evolutionarily conservation of regulated longevity assurance mechanisms. Genome Biol. 8, R132. (doi:10.1186/gb-2007-8-7- r132)
-
(2007)
Genome Biol.
, vol.8
-
-
McElwee, J.J.1
-
108
-
-
13944278132
-
Mitochondria, oxidants, and aging
-
doi:10.1016/j.cell.2005.02.001
-
Balaban, R. S., Nemoto, S. & Finkel, T. 2005 Mitochondria, oxidants, and aging. Cell 120, 483-495. (doi:10.1016/j.cell.2005.02.001)
-
(2005)
Cell
, vol.120
, pp. 483-495
-
-
Balaban, R.S.1
Nemoto, S.2
Finkel, T.3
-
109
-
-
64949111531
-
Current thoughts on the role of mitochondria and free radicals in the biology of aging
-
Van Remmen, H. & Jones, D. P. 2009 Current thoughts on the role of mitochondria and free radicals in the biology of aging. J. Gerontol. A Biol. Sci. Med. Sci 64, 171-174.
-
(2009)
J. Gerontol. A Biol. Sci. Med. Sci
, vol.64
, pp. 171-174
-
-
Van Remmen, H.1
Jones, D.P.2
-
110
-
-
33745026738
-
Autophagy and aging: The importance of maintaining 'clean' cells
-
doi:10.4161/auto.1.3.2017
-
Cuervo, A. M., Bergamini, E., Brunk, U. T., Droge,W., Ffrench, M. & Terman, A. 2005 Autophagy and aging: The importance of maintaining 'clean' cells. Autophagy 1, 131-140. (doi:10.4161/auto.1.3.2017)
-
(2005)
Autophagy
, vol.1
, pp. 131-140
-
-
Cuervo, A.M.1
Bergamini, E.2
Brunk, U.T.3
Droge, W.4
Ffrench, M.5
Terman, A.6
-
111
-
-
33846702991
-
Autophagy, organelles and ageing
-
doi:10.1002/path.2094
-
Terman, A., Gustafsson, B. & Brunk, U. T. 2007 Autophagy, organelles and ageing. J. Pathol. 211, 134-143. (doi:10.1002/path.2094)
-
(2007)
J. Pathol.
, vol.211
, pp. 134-143
-
-
Terman, A.1
Gustafsson, B.2
Brunk, U.T.3
-
112
-
-
67650649527
-
Long-lived Ames dwarf mice are resistant to chemical stressors
-
doi:10.1093/gerona/glp052
-
Bokov, A. F., Lindsey, M. L., Khodr, C., Sabia, M. R. & Richardson, A. 2009 Long-lived Ames dwarf mice are resistant to chemical stressors. J. Gerontol. A Biol. Sci. Med. Sci. 64, 819-827. (doi:10.1093/gerona/glp052)
-
(2009)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.64
, pp. 819-827
-
-
Bokov, A.F.1
Lindsey, M.L.2
Khodr, C.3
Sabia, M.R.4
Richardson, A.5
-
113
-
-
0042203536
-
Multiplex stress resistance in cells from long-lived dwarf mice
-
Murakami, S., Salmon, A. & Miller, R. A. 2003 Multiplex stress resistance in cells from long-lived dwarf mice. FASEB J. 17, 1565-1566.
-
(2003)
FASEB J.
, vol.17
, pp. 1565-1566
-
-
Murakami, S.1
Salmon, A.2
Miller, R.A.3
-
114
-
-
21044450084
-
Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress
-
doi:10.1152/ ajpendo.00575.2004
-
Salmon, A. B., Murakami, S., Bartke, A., Kopchick, J., Yasumura, K. & Miller, R. A. 2005 Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. Am. J. Physiol. Endocrinol. Metab. 289, E23-E29. (doi:10.1152/ ajpendo.00575.2004)
-
(2005)
Am. J. Physiol. Endocrinol. Metab.
, vol.289
-
-
Salmon, A.B.1
Murakami, S.2
Bartke, A.3
Kopchick, J.4
Yasumura, K.5
Miller, R.A.6
-
115
-
-
63049126250
-
Mechanisms of stress resistance in Snell dwarf mouse fibroblasts: Enhanced antioxidant and DNA base excision repair capacity, but no differences in mitochondrial metabolism
-
doi:10.1016/j.freeradbiomed.2009.01.014
-
Page, M. M., Salmon, A. B., Leiser, S. F., Robb, E. L., Brown, M. F., Miller, R. A. & Stuart, J. A. 2009 Mechanisms of stress resistance in Snell dwarf mouse fibroblasts: Enhanced antioxidant and DNA base excision repair capacity, but no differences in mitochondrial metabolism. Free Radic. Biol. Med. 46, 1109-1118. (doi:10.1016/j.freeradbiomed.2009.01.014)
-
(2009)
Free Radic. Biol. Med.
, vol.46
, pp. 1109-1118
-
-
Page, M.M.1
Salmon, A.B.2
Leiser, S.F.3
Robb, E.L.4
Brown, M.F.5
Miller, R.A.6
Stuart, J.A.7
-
116
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
-
doi:10.1016/j.cell.2005.02.003
-
Campisi, J. 2005 Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors. Cell 120, 513-522. (doi:10.1016/j.cell. 2005.02.003)
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
117
-
-
13944262937
-
Understanding the odd science of aging
-
doi:10.1016/j.cell.2005.01.027
-
Kirkwood, T. B. 2005 Understanding the odd science of aging. Cell 120, 437-447. (doi:10.1016/j.cell.2005. 01.027)
-
(2005)
Cell
, vol.120
, pp. 437-447
-
-
Kirkwood, T.B.1
-
118
-
-
13944249618
-
DNA repair, genome stability, and aging
-
doi:10.1016/j.cell.2005.01.028
-
Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M. & Alt, F. W. 2005 DNA repair, genome stability, and aging. Cell 120, 497-512. (doi:10.1016/j.cell.2005.01.028)
-
(2005)
Cell
, vol.120
, pp. 497-512
-
-
Lombard, D.B.1
Chua, K.F.2
Mostoslavsky, R.3
Franco, S.4
Gostissa, M.5
Alt, F.W.6
-
119
-
-
13944282128
-
Sex and death: What is the connection?
-
doi:10.1016/j.cell.2005.01.026
-
Partridge, L., Gems, D. & Withers, D. J. 2005 Sex and death: What is the connection? Cell 120, 461-472. (doi:10.1016/j.cell.2005.01.026)
-
(2005)
Cell
, vol.120
, pp. 461-472
-
-
Partridge, L.1
Gems, D.2
Withers, D.J.3
-
120
-
-
67651163661
-
Lifespan extension in genetically modified mice
-
doi:10.1111/j.1474-9726.2009. 00491.x
-
Ladiges, W., Van Remmen, H., Strong, R., Ikeno, Y., Treuting, P., Rabinovitch, P. & Richardson, A. 2009 Lifespan extension in genetically modified mice. Aging Cell 8, 346-352. (doi:10.1111/j.1474-9726.2009. 00491.x)
-
(2009)
Aging Cell
, vol.8
, pp. 346-352
-
-
Ladiges, W.1
Van Remmen, H.2
Strong, R.3
Ikeno, Y.4
Treuting, P.5
Rabinovitch, P.6
Richardson, A.7
-
121
-
-
0034987024
-
Strategy for identifying biomarkers of aging in long-lived species
-
doi:10.1016/S0531-5565(01)00110-3
-
Ingram,D. K., Nakamura, E.,Smucny,D., Roth,G. S.& Lane, M. A. 2001 Strategy for identifying biomarkers of aging in long-lived species. Exp. Gerontol. 36, 1025-1034. (doi:10.1016/S0531-5565(01)00110-3)
-
(2001)
Exp. Gerontol.
, vol.36
, pp. 1025-1034
-
-
Ingram, D.K.1
Nakamura E.Smucny, D.2
Roth, G.S.3
Lane, M.A.4
-
122
-
-
0029952098
-
Dwarf mice and the ageing process
-
doi:10.1038/384033a0
-
Brown-Borg, H. M., Borg, K. E., Meliska, C. J. & Bartke, A. 1996 Dwarf mice and the ageing process. Nature 384, 33. (doi:10.1038/384033a0)
-
(1996)
Nature
, vol.384
, pp. 33
-
-
Brown-Borg, H.M.1
Borg, K.E.2
Meliska, C.J.3
Bartke, A.4
-
123
-
-
0034455827
-
Assessment of growth parameters and life span of GHR/BP gene-disrupted mice
-
doi:10.1210/en.141.7.2608
-
Coschigano, K. T., Clemmons, D., Bellush, L. L. & Kopchick, J. J. 2000 Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology 141, 2608-2613. (doi:10.1210/en.141. 7.2608)
-
(2000)
Endocrinology
, vol.141
, pp. 2608-2613
-
-
Coschigano, K.T.1
Clemmons, D.2
Bellush, L.L.3
Kopchick, J.J.4
|