-
1
-
-
26944500614
-
Role of CpG ODN in concanavalin a-induced hepatitis in mice
-
Abe K., Ohira H., Kobayashi H., Rai T., Saito H., Takahashi A., Sato Y. Role of CpG ODN in concanavalin a-induced hepatitis in mice. Fukushima J. Med. Sci. 2005, 51:41-49.
-
(2005)
Fukushima J. Med. Sci.
, vol.51
, pp. 41-49
-
-
Abe, K.1
Ohira, H.2
Kobayashi, H.3
Rai, T.4
Saito, H.5
Takahashi, A.6
Sato, Y.7
-
2
-
-
0036869347
-
Tumour necrosis factor-alpha and nitric oxide mediate apoptosis by D-galactosamine in a primary culture of rat hepatocytes: exacerbation of cell death by cocultured Kupffer cells
-
Abou-Elella A.M., Siendones E., Padillo J., Montero J.L., De la Mata M., Muntane Relat J. Tumour necrosis factor-alpha and nitric oxide mediate apoptosis by D-galactosamine in a primary culture of rat hepatocytes: exacerbation of cell death by cocultured Kupffer cells. Can. J. Gastroenterol. 2002, 16:791-799.
-
(2002)
Can. J. Gastroenterol.
, vol.16
, pp. 791-799
-
-
Abou-Elella, A.M.1
Siendones, E.2
Padillo, J.3
Montero, J.L.4
De la Mata, M.5
Muntane Relat, J.6
-
3
-
-
0027299361
-
Oxidative stress in cultured hepatocytes exposed to acetaminophen
-
Adamson G.M., Harman A.W. Oxidative stress in cultured hepatocytes exposed to acetaminophen. Biochem. Pharmacol. 1993, 45:2289-2294.
-
(1993)
Biochem. Pharmacol.
, vol.45
, pp. 2289-2294
-
-
Adamson, G.M.1
Harman, A.W.2
-
4
-
-
0021933598
-
Mechanisms of N-acetyl-p-benzoquinone imine cytotoxicity
-
Albano E., Rundgren M., Harvison P.J., Nelson S.D., Moldéus P. Mechanisms of N-acetyl-p-benzoquinone imine cytotoxicity. Mol. Pharmacol. 1985, 28:306-311.
-
(1985)
Mol. Pharmacol.
, vol.28
, pp. 306-311
-
-
Albano, E.1
Rundgren, M.2
Harvison, P.J.3
Nelson, S.D.4
Moldéus, P.5
-
5
-
-
29944444269
-
Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells
-
Aninat C., et al. Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab. Dispos. 2006, 34:75-83.
-
(2006)
Drug Metab. Dispos.
, vol.34
, pp. 75-83
-
-
Aninat, C.1
-
6
-
-
74949101589
-
High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo
-
Antoine D.J., et al. High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo. Toxicol. Sci. 2009, 112:521-531.
-
(2009)
Toxicol. Sci.
, vol.112
, pp. 521-531
-
-
Antoine, D.J.1
-
7
-
-
84864351457
-
Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans
-
Antoniades C.G., et al. Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans. Hepatology 2012, 56:735-746.
-
(2012)
Hepatology
, vol.56
, pp. 735-746
-
-
Antoniades, C.G.1
-
8
-
-
70349254047
-
Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury
-
Apte U., Singh S., Zeng G., Cieply B., Virji M.A., Wu T., Monga S.P. Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury. Am. J. Pathol. 2009, 175:1056-1065.
-
(2009)
Am. J. Pathol.
, vol.175
, pp. 1056-1065
-
-
Apte, U.1
Singh, S.2
Zeng, G.3
Cieply, B.4
Virji, M.A.5
Wu, T.6
Monga, S.P.7
-
9
-
-
33749617086
-
Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury
-
Bajt M.L., Cover C., Lemasters J.J., Jaeschke H. Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. Toxicol. Sci. 2006, 94:217-225.
-
(2006)
Toxicol. Sci.
, vol.94
, pp. 217-225
-
-
Bajt, M.L.1
Cover, C.2
Lemasters, J.J.3
Jaeschke, H.4
-
10
-
-
0035196691
-
Effects of CXC chemokines on neutrophil activation and sequestration in hepatic vasculature
-
Bajt M.L., Farhood A., Jaeschke H. Effects of CXC chemokines on neutrophil activation and sequestration in hepatic vasculature. Am. J. Physiol. Gastrointest. Liver Physiol. 2001, 281:G1188-G1195.
-
(2001)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.281
, pp. G1188-G1195
-
-
Bajt, M.L.1
Farhood, A.2
Jaeschke, H.3
-
11
-
-
37349022256
-
Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity
-
Bajt M.L., Farhood A., Lemasters J.J., Jaeschke H. Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity. J. Pharmacol. Exp. Ther. 2008, 324:8-14.
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.324
, pp. 8-14
-
-
Bajt, M.L.1
Farhood, A.2
Lemasters, J.J.3
Jaeschke, H.4
-
12
-
-
4344576889
-
Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine
-
Bajt M.L., Knight T.R., Lemasters J.J., Jaeschke H. Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine. Toxicol. Sci. 2004, 80:343-349.
-
(2004)
Toxicol. Sci.
, vol.80
, pp. 343-349
-
-
Bajt, M.L.1
Knight, T.R.2
Lemasters, J.J.3
Jaeschke, H.4
-
13
-
-
0033735804
-
Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8
-
Bajt M.L., Lawson J.A., Vonderfecht S.L., Gujral J.S., Jaeschke H. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. Toxicol. Sci. 2000, 58:109-117.
-
(2000)
Toxicol. Sci.
, vol.58
, pp. 109-117
-
-
Bajt, M.L.1
Lawson, J.A.2
Vonderfecht, S.L.3
Gujral, J.S.4
Jaeschke, H.5
-
14
-
-
0035884041
-
Differential protection with inhibitors of caspase-8 and caspase-3 in murine models of tumor necrosis factor and Fas receptor-mediated hepatocellular apoptosis
-
Bajt M.L., Vonderfecht S.L., Jaeschke H. Differential protection with inhibitors of caspase-8 and caspase-3 in murine models of tumor necrosis factor and Fas receptor-mediated hepatocellular apoptosis. Toxicol. Appl. Pharmacol. 2001, 175:243-252.
-
(2001)
Toxicol. Appl. Pharmacol.
, vol.175
, pp. 243-252
-
-
Bajt, M.L.1
Vonderfecht, S.L.2
Jaeschke, H.3
-
15
-
-
84926473432
-
Long-term coculture strategies for primary hepatocytes and liver sinusoidal endothelial cells tissue
-
Bale S.S., et al. Long-term coculture strategies for primary hepatocytes and liver sinusoidal endothelial cells tissue. Eng. Part C Methods 2014, 21:413-422.
-
(2014)
Eng. Part C Methods
, vol.21
, pp. 413-422
-
-
Bale, S.S.1
-
16
-
-
77951687800
-
Involvement of HSP70 in the protection of bicyclol on apoptosis of HepG2 cells intoxicated by D-galactosamine
-
Bao X.Q., Liu G.T. Involvement of HSP70 in the protection of bicyclol on apoptosis of HepG2 cells intoxicated by D-galactosamine. J. Asian Nat. Prod. Res. 2010, 12:313-323.
-
(2010)
J. Asian Nat. Prod. Res.
, vol.12
, pp. 313-323
-
-
Bao, X.Q.1
Liu, G.T.2
-
17
-
-
29744470255
-
Acute liver failure: a critical appraisal of available animal models
-
Bélanger M., Butterworth R.F. Acute liver failure: a critical appraisal of available animal models. Metab. Brain Dis. 2005, 20:409-423.
-
(2005)
Metab. Brain Dis.
, vol.20
, pp. 409-423
-
-
Bélanger, M.1
Butterworth, R.F.2
-
18
-
-
33645857685
-
Neurobiological characterization of an azoxymethane mouse model of acute liver failure
-
Bélanger M., Côté J., Butterworth R.F. Neurobiological characterization of an azoxymethane mouse model of acute liver failure. Neurochem. Int. 2006, 48:434-440.
-
(2006)
Neurochem. Int.
, vol.48
, pp. 434-440
-
-
Bélanger, M.1
Côté, J.2
Butterworth, R.F.3
-
19
-
-
0032721936
-
Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells
-
Bhatia S.N., Balis U.J., Yarmush M.L., Toner M. Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells. FASEB J. 1999, 13:1883-1900.
-
(1999)
FASEB J.
, vol.13
, pp. 1883-1900
-
-
Bhatia, S.N.1
Balis, U.J.2
Yarmush, M.L.3
Toner, M.4
-
20
-
-
84908180772
-
Pro-regenerative signaling after acetaminophen-induced acute liver injury in mice identified using a novel incremental dose model
-
Bhushan B., et al. Pro-regenerative signaling after acetaminophen-induced acute liver injury in mice identified using a novel incremental dose model. Am. J. Pathol. 2014, 184:3013-3025.
-
(2014)
Am. J. Pathol.
, vol.184
, pp. 3013-3025
-
-
Bhushan, B.1
-
21
-
-
33845951211
-
DAMPs, PAMPs and alarmins: all we need to know about danger
-
Bianchi M.E. DAMPs, PAMPs and alarmins: all we need to know about danger. J. Leukoc. Biol. 2007, 81:1-5.
-
(2007)
J. Leukoc. Biol.
, vol.81
, pp. 1-5
-
-
Bianchi, M.E.1
-
22
-
-
0347994956
-
Essential role for neutrophil recruitment to the liver in concanavalin a-induced hepatitis
-
Bonder C.S., Ajuebor M.N., Zbytnuik L.D., Kubes P., Swain M.G. Essential role for neutrophil recruitment to the liver in concanavalin a-induced hepatitis. J. Immunol. 2004, 172:45-53.
-
(2004)
J. Immunol.
, vol.172
, pp. 45-53
-
-
Bonder, C.S.1
Ajuebor, M.N.2
Zbytnuik, L.D.3
Kubes, P.4
Swain, M.G.5
-
23
-
-
0036181938
-
Acetaminophen induces a caspase-dependent and Bcl-XL sensitive apoptosis in human hepatoma cells and lymphocytes
-
Boulares A.H., Zoltoski A.J., Stoica B.A., Cuvillier O., Smulson M.E. Acetaminophen induces a caspase-dependent and Bcl-XL sensitive apoptosis in human hepatoma cells and lymphocytes. Pharmacol. Toxicol. 2002, 90:38-50.
-
(2002)
Pharmacol. Toxicol.
, vol.90
, pp. 38-50
-
-
Boulares, A.H.1
Zoltoski, A.J.2
Stoica, B.A.3
Cuvillier, O.4
Smulson, M.E.5
-
24
-
-
0025774993
-
Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes
-
Burcham P.C., Harman A.W. Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes. J. Biol. Chem. 1991, 266:5049-5054.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 5049-5054
-
-
Burcham, P.C.1
Harman, A.W.2
-
25
-
-
77955353208
-
Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes
-
Burke A.S., MacMillan-Crow L.A., Hinson J.A. Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes. Chem. Res. Toxicol. 2010, 23:1286-1292.
-
(2010)
Chem. Res. Toxicol.
, vol.23
, pp. 1286-1292
-
-
Burke, A.S.1
MacMillan-Crow, L.A.2
Hinson, J.A.3
-
26
-
-
0032437014
-
IL-6, IFN-gamma and TNF-alpha production by liver-associated T cells and acute liver injury in rats administered concanavalin A
-
Cao Q., Batey R., Pang G., Russell A., Clancy R. IL-6, IFN-gamma and TNF-alpha production by liver-associated T cells and acute liver injury in rats administered concanavalin A. Immunol. Cell Biol. 1998, 76:542-549.
-
(1998)
Immunol. Cell Biol.
, vol.76
, pp. 542-549
-
-
Cao, Q.1
Batey, R.2
Pang, G.3
Russell, A.4
Clancy, R.5
-
27
-
-
33846884274
-
Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies
-
Castell J.V., Jover R., Martinez-Jimenez C.P., Gomez-Lechon M.J. Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies. Expert Opin. Drug Metab. Toxicol. 2006, 2:183-212.
-
(2006)
Expert Opin. Drug Metab. Toxicol.
, vol.2
, pp. 183-212
-
-
Castell, J.V.1
Jover, R.2
Martinez-Jimenez, C.P.3
Gomez-Lechon, M.J.4
-
28
-
-
0021238748
-
Role of the microsomal FAD-containing monooxygenase in the liver toxicity of thioacetamide S-oxide
-
Chieli E., Malvaldi G. Role of the microsomal FAD-containing monooxygenase in the liver toxicity of thioacetamide S-oxide. Toxicology 1984, 31:41-52.
-
(1984)
Toxicology
, vol.31
, pp. 41-52
-
-
Chieli, E.1
Malvaldi, G.2
-
29
-
-
0031008369
-
Neutrophil margination and extravasation in sinusoids and venules of liver during endotoxin-induced injury
-
Chosay J.G., Essani N.A., Dunn C.J., Jaeschke H. Neutrophil margination and extravasation in sinusoids and venules of liver during endotoxin-induced injury. Am. J. Physiol. 1997, 272:G1195-G1200.
-
(1997)
Am. J. Physiol.
, vol.272
, pp. G1195-G1200
-
-
Chosay, J.G.1
Essani, N.A.2
Dunn, C.J.3
Jaeschke, H.4
-
30
-
-
0022541787
-
Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice
-
Corcoran G.B., Wong B.K. Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice. J. Pharmacol. Exp. Ther. 1986, 238:54-61.
-
(1986)
J. Pharmacol. Exp. Ther.
, vol.238
, pp. 54-61
-
-
Corcoran, G.B.1
Wong, B.K.2
-
31
-
-
0021955464
-
Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice
-
Corcoran G.B., Racz W.J., Smith C.V., Mitchell J.R. Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice. J. Pharmacol. Exp. Ther. 1985, 232:864-872.
-
(1985)
J. Pharmacol. Exp. Ther.
, vol.232
, pp. 864-872
-
-
Corcoran, G.B.1
Racz, W.J.2
Smith, C.V.3
Mitchell, J.R.4
-
32
-
-
0021955462
-
Effects of N-acetylcysteine on the disposition and metabolism of acetaminophen in mice
-
Corcoran G.B., Todd E.L., Racz W.J., Hughes H., Smith C.V., Mitchell J.R. Effects of N-acetylcysteine on the disposition and metabolism of acetaminophen in mice. J. Pharmacol. Exp. Ther. 1985, 232:857-863.
-
(1985)
J. Pharmacol. Exp. Ther.
, vol.232
, pp. 857-863
-
-
Corcoran, G.B.1
Todd, E.L.2
Racz, W.J.3
Hughes, H.4
Smith, C.V.5
Mitchell, J.R.6
-
33
-
-
27144508153
-
Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity
-
Cover C., Mansouri A., Knight T.R., Bajt M.L., Lemasters J.J., Pessayre D., Jaeschke H. Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J. Pharmacol. Exp. Ther. 2005, 315:879-887.
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.315
, pp. 879-887
-
-
Cover, C.1
Mansouri, A.2
Knight, T.R.3
Bajt, M.L.4
Lemasters, J.J.5
Pessayre, D.6
Jaeschke, H.7
-
34
-
-
0021345926
-
N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen
-
Dahlin D.C., Miwa G.T., Lu A.Y., Nelson S.D. N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proc. Natl. Acad. Sci. U. S. A. 1984, 81:1327-1331.
-
(1984)
Proc. Natl. Acad. Sci. U. S. A.
, vol.81
, pp. 1327-1331
-
-
Dahlin, D.C.1
Miwa, G.T.2
Lu, A.Y.3
Nelson, S.D.4
-
35
-
-
0029002112
-
Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfecte HepG2 cells
-
Dai Y., Cederbaum A.I. Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfecte HepG2 cells. J. Pharmacol. Exp. Ther. 1995, 273:1497-1505.
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.273
, pp. 1497-1505
-
-
Dai, Y.1
Cederbaum, A.I.2
-
36
-
-
0016138336
-
Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen
-
Davis D.C., Potter W.Z., Jollow D.J., Mitchell J.R. Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen. Life Sci. 1974, 14:2099-2109.
-
(1974)
Life Sci.
, vol.14
, pp. 2099-2109
-
-
Davis, D.C.1
Potter, W.Z.2
Jollow, D.J.3
Mitchell, J.R.4
-
37
-
-
0016180377
-
Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death
-
Decker K., Keppler D. Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death. Rev. Physiol. Biochem. Pharmacol. 1974, 77-106.
-
(1974)
Rev. Physiol. Biochem. Pharmacol.
, pp. 77-106
-
-
Decker, K.1
Keppler, D.2
-
38
-
-
0030793294
-
Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains
-
DeLeve L.D., Wang X., Kaplowitz N., Shulman H.M., Bart J.A., van der Hoek A. Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains. Biochem. Pharmacol. 1997, 53:1339-1345.
-
(1997)
Biochem. Pharmacol.
, vol.53
, pp. 1339-1345
-
-
DeLeve, L.D.1
Wang, X.2
Kaplowitz, N.3
Shulman, H.M.4
Bart, J.A.5
van der Hoek, A.6
-
39
-
-
84970916712
-
Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury
-
Deutsch M., et al. Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury. Cell Death Dis. 2015, 6.
-
(2015)
Cell Death Dis.
, vol.6
-
-
Deutsch, M.1
-
40
-
-
84887978689
-
Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering
-
Donato M.T., Jover R., Gómez-Lechón M.J. Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering. Curr. Drug Metab. 2013, 14:946-968.
-
(2013)
Curr. Drug Metab.
, vol.14
, pp. 946-968
-
-
Donato, M.T.1
Jover, R.2
Gómez-Lechón, M.J.3
-
41
-
-
38849184046
-
Cell lines: a tool for in vitro drug metabolism studies
-
Donato M.T., Lahoz A., Castell J.V., Gómez-Lechón M.J. Cell lines: a tool for in vitro drug metabolism studies. Curr. Drug Metab. 2008, 9:1-11.
-
(2008)
Curr. Drug Metab.
, vol.9
, pp. 1-11
-
-
Donato, M.T.1
Lahoz, A.2
Castell, J.V.3
Gómez-Lechón, M.J.4
-
42
-
-
17644390629
-
Generation and functional significance of CXC chemokines for neutrophil-induced liver injury during endotoxemia
-
Dorman R.B., Gujral J.S., Bajt M.L., Farhood A., Jaeschke H. Generation and functional significance of CXC chemokines for neutrophil-induced liver injury during endotoxemia. Am. J. Physiol. Gastrointest. Liver Physiol. 2005, 288:G880-G886.
-
(2005)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.288
, pp. G880-G886
-
-
Dorman, R.B.1
Gujral, J.S.2
Bajt, M.L.3
Farhood, A.4
Jaeschke, H.5
-
43
-
-
79956326320
-
Macrophage activation by factors released from acetaminophen-injured hepatocytes: potential role of HMGB1
-
Dragomir A.C., Laskin J.D., Laskin D.L. Macrophage activation by factors released from acetaminophen-injured hepatocytes: potential role of HMGB1. Toxicol. Appl. Pharmacol. 2011, 253:170-177.
-
(2011)
Toxicol. Appl. Pharmacol.
, vol.253
, pp. 170-177
-
-
Dragomir, A.C.1
Laskin, J.D.2
Laskin, D.L.3
-
44
-
-
84908340821
-
Lower susceptibility of female mice to acetaminophen hepatotoxicity: role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase
-
Du K., Williams C.D., McGill M.R., Jaeschke H. Lower susceptibility of female mice to acetaminophen hepatotoxicity: role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase. Toxicol. Appl. Pharmacol. 2014, 281:58-66.
-
(2014)
Toxicol. Appl. Pharmacol.
, vol.281
, pp. 58-66
-
-
Du, K.1
Williams, C.D.2
McGill, M.R.3
Jaeschke, H.4
-
45
-
-
0026158432
-
Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration
-
Dunn J.C., Tompkins R.G., Yarmush M.L. Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnol. Prog. 1991, 7:237-245.
-
(1991)
Biotechnol. Prog.
, vol.7
, pp. 237-245
-
-
Dunn, J.C.1
Tompkins, R.G.2
Yarmush, M.L.3
-
46
-
-
0029100301
-
Protective effect of nifedipine against cytotoxicity and intracellular calcium alterations induced by acetaminophen in rat hepatocyte cultures
-
Ellouk-Achard S., Mawet E., Thibault N., Dutertre-Catella H., Thevenin M., Claude J.R. Protective effect of nifedipine against cytotoxicity and intracellular calcium alterations induced by acetaminophen in rat hepatocyte cultures. Drug Chem. Toxicol. 1995, 18:105-117.
-
(1995)
Drug Chem. Toxicol.
, vol.18
, pp. 105-117
-
-
Ellouk-Achard, S.1
Mawet, E.2
Thibault, N.3
Dutertre-Catella, H.4
Thevenin, M.5
Claude, J.R.6
-
47
-
-
0031570450
-
Transcriptional activation of vascular cell adhesion molecule-1 gene in vivo and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock
-
Essani N.A., Bajt M.L., Farhood A., Vonderfecht S.L., Jaeschke H. Transcriptional activation of vascular cell adhesion molecule-1 gene in vivo and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock. J. Immunol. 1997, 158:5941-5948.
-
(1997)
J. Immunol.
, vol.158
, pp. 5941-5948
-
-
Essani, N.A.1
Bajt, M.L.2
Farhood, A.3
Vonderfecht, S.L.4
Jaeschke, H.5
-
48
-
-
0029073683
-
Cytokine-induced upregulation of hepatic intercellular adhesion molecule-1 messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure
-
Essani N.A., Fisher M.A., Farhood A., Manning A.M., Smith C.W., Jaeschke H. Cytokine-induced upregulation of hepatic intercellular adhesion molecule-1 messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure. Hepatology 1995, 21:1632-1639.
-
(1995)
Hepatology
, vol.21
, pp. 1632-1639
-
-
Essani, N.A.1
Fisher, M.A.2
Farhood, A.3
Manning, A.M.4
Smith, C.W.5
Jaeschke, H.6
-
49
-
-
0031908271
-
Increased P-selectin gene expression in the liver vasculature and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock
-
Essani N.A., Fisher M.A., Simmons C.A., Hoover J.L., Farhood A., Jaeschke H. Increased P-selectin gene expression in the liver vasculature and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock. J. Leukoc. Biol. 1998, 63:288-296.
-
(1998)
J. Leukoc. Biol.
, vol.63
, pp. 288-296
-
-
Essani, N.A.1
Fisher, M.A.2
Simmons, C.A.3
Hoover, J.L.4
Farhood, A.5
Jaeschke, H.6
-
50
-
-
0031051775
-
Anti-Fas IgG1 antibodies recognizing the same epitope of Fas/APO-1 mediate different biological effects in vitro
-
Fadeel B., Thorpe C.J., Yonehara S., Chiodi F. Anti-Fas IgG1 antibodies recognizing the same epitope of Fas/APO-1 mediate different biological effects in vitro. Int. Immunol. 1997, 9:201-209.
-
(1997)
Int. Immunol.
, vol.9
, pp. 201-209
-
-
Fadeel, B.1
Thorpe, C.J.2
Yonehara, S.3
Chiodi, F.4
-
51
-
-
0035966059
-
Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway
-
Faouzi S., Burckhardt B.E., Hanson J.C., Campe C.B., Schrum L.W., Rippe R.A., Maher J.J. Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway. J. Biol. Chem. 2001, 276:49077-49082.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 49077-49082
-
-
Faouzi, S.1
Burckhardt, B.E.2
Hanson, J.C.3
Campe, C.B.4
Schrum, L.W.5
Rippe, R.A.6
Maher, J.J.7
-
52
-
-
0034776411
-
Animal models of fulminant hepatic failure: need to test liver support devices
-
Filipponi F., Mosca F. Animal models of fulminant hepatic failure: need to test liver support devices. Dig. Liver Dis. 2001, 33:607-613.
-
(2001)
Dig. Liver Dis.
, vol.33
, pp. 607-613
-
-
Filipponi, F.1
Mosca, F.2
-
53
-
-
7644235281
-
Hypothermia inhibits Fas-mediated apoptosis of primary mouse hepatocytes in culture
-
Fu T., et al. Hypothermia inhibits Fas-mediated apoptosis of primary mouse hepatocytes in culture. Cell Transplant. 2004, 13:667-676.
-
(2004)
Cell Transplant.
, vol.13
, pp. 667-676
-
-
Fu, T.1
-
55
-
-
0028203276
-
Activated neutrophils from rat injured isolated hepatocytes
-
Ganey P.E., Bailie M.B., VanCise S., Colligan M.E., Madhukar B.V., Robinson J.P., Roth R.A. Activated neutrophils from rat injured isolated hepatocytes. Lab. Investig. 1994, 70:53-60.
-
(1994)
Lab. Investig.
, vol.70
, pp. 53-60
-
-
Ganey, P.E.1
Bailie, M.B.2
VanCise, S.3
Colligan, M.E.4
Madhukar, B.V.5
Robinson, J.P.6
Roth, R.A.7
-
56
-
-
84883464564
-
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
-
Godoy P., et al. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch. Toxicol. 2013, 87:1315-1530.
-
(2013)
Arch. Toxicol.
, vol.87
, pp. 1315-1530
-
-
Godoy, P.1
-
57
-
-
0036158769
-
Sensitive markers used to identify compounds that trigger apoptosis in cultured hepatocytes
-
Gómez-Lechón M.J., O'Connor E., Castell J.V., Jover R. Sensitive markers used to identify compounds that trigger apoptosis in cultured hepatocytes. Toxicol. Sci. 2002, 65:299-308.
-
(2002)
Toxicol. Sci.
, vol.65
, pp. 299-308
-
-
Gómez-Lechón, M.J.1
O'Connor, E.2
Castell, J.V.3
Jover, R.4
-
58
-
-
0023729096
-
Cellular interactions promote tissue-specific function, biomatrix deposition and junctional communication of primary cultured hepatocytes
-
Goulet F., Normand C., Morin O. Cellular interactions promote tissue-specific function, biomatrix deposition and junctional communication of primary cultured hepatocytes. Hepatology 1988, 8:1010-1018.
-
(1988)
Hepatology
, vol.8
, pp. 1010-1018
-
-
Goulet, F.1
Normand, C.2
Morin, O.3
-
59
-
-
32844464922
-
A Fas agonist induces high levels of apoptosis in haematological malignancies
-
Greaney P., et al. A Fas agonist induces high levels of apoptosis in haematological malignancies. Leuk. Res. 2006, 30:415-426.
-
(2006)
Leuk. Res.
, vol.30
, pp. 415-426
-
-
Greaney, P.1
-
60
-
-
3442886811
-
The pathophysiology of mitochondrial cell death
-
Green D.R., Kroemer G. The pathophysiology of mitochondrial cell death. Science 2004, 305:626-629.
-
(2004)
Science
, vol.305
, pp. 626-629
-
-
Green, D.R.1
Kroemer, G.2
-
61
-
-
34247517355
-
The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics
-
Guillouzo A., Corlu A., Aninat C., Glaise D., Morel F., Guguen-Guillouzo C. The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem. Biol. Interact. 2007, 168:66-73.
-
(2007)
Chem. Biol. Interact.
, vol.168
, pp. 66-73
-
-
Guillouzo, A.1
Corlu, A.2
Aninat, C.3
Glaise, D.4
Morel, F.5
Guguen-Guillouzo, C.6
-
62
-
-
0042766884
-
Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice
-
Gujral J.S., Farhood A., Bajt M.L., Jaeschke H. Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice. Hepatology 2003, 38:355-363.
-
(2003)
Hepatology
, vol.38
, pp. 355-363
-
-
Gujral, J.S.1
Farhood, A.2
Bajt, M.L.3
Jaeschke, H.4
-
63
-
-
3042634915
-
NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia
-
Gujral J.S., Hinson J.A., Farhood A., Jaeschke H. NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia. Am. J. Physiol. Gastrointest. Liver Physiol. 2004, 287:G243-G252.
-
(2004)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.287
, pp. G243-G252
-
-
Gujral, J.S.1
Hinson, J.A.2
Farhood, A.3
Jaeschke, H.4
-
64
-
-
0036304261
-
Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic Necrosis?
-
Gujral J.S., Knight T.R., Farhood A., Bajt M.L., Jaeschke H. Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic Necrosis?. Toxicol. Sci. 2002, 67:322-328.
-
(2002)
Toxicol. Sci.
, vol.67
, pp. 322-328
-
-
Gujral, J.S.1
Knight, T.R.2
Farhood, A.3
Bajt, M.L.4
Jaeschke, H.5
-
65
-
-
84872317734
-
AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver
-
Hadi M., Dragovic R., Van Swelm B., Herpers B., Van de Water F., Russel G., Commandeur J.N., Groothuis G.M. AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver. Arch. Toxicol. 2013, 87:155-165.
-
(2013)
Arch. Toxicol.
, vol.87
, pp. 155-165
-
-
Hadi, M.1
Dragovic, R.2
Van Swelm, B.3
Herpers, B.4
Van de Water, F.5
Russel, G.6
Commandeur, J.N.7
Groothuis, G.M.8
-
66
-
-
84866417633
-
Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes
-
Hajovsky H., et al. Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes. Chem. Res. Toxicol. 2012, 25:1955-1963.
-
(2012)
Chem. Res. Toxicol.
, vol.25
, pp. 1955-1963
-
-
Hajovsky, H.1
-
68
-
-
46649084880
-
Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury
-
Hanawa N., Shinohara M., Saberi B., Gaarde W.A., Han D., Kaplowitz N. Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J. Biol. Chem 2008, 283:13565-13577.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 13565-13577
-
-
Hanawa, N.1
Shinohara, M.2
Saberi, B.3
Gaarde, W.A.4
Han, D.5
Kaplowitz, N.6
-
69
-
-
0027183742
-
Hepatocyte injury by activated neutrophils in vitro is mediated by proteases
-
Harbrecht B.G., Billiar T.R., Curran R.D., Stadler J., Simmons R.L. Hepatocyte injury by activated neutrophils in vitro is mediated by proteases. Ann. Surg. 1993, 218:120-128.
-
(1993)
Ann. Surg.
, vol.218
, pp. 120-128
-
-
Harbrecht, B.G.1
Billiar, T.R.2
Curran, R.D.3
Stadler, J.4
Simmons, R.L.5
-
70
-
-
67649202201
-
Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel
-
Harrill A.H., Ross P.K., Gatti D.M., Threadgill D.W., Rusyn I. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicol. Sci. 2009, 110:235-243.
-
(2009)
Toxicol. Sci.
, vol.110
, pp. 235-243
-
-
Harrill, A.H.1
Ross, P.K.2
Gatti, D.M.3
Threadgill, D.W.4
Rusyn, I.5
-
71
-
-
2142764409
-
Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells
-
Harris A.J., Dial S.L., Casciano D.A. Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells. Mutat. Res. 2004, 549:79-99.
-
(2004)
Mutat. Res.
, vol.549
, pp. 79-99
-
-
Harris, A.J.1
Dial, S.L.2
Casciano, D.A.3
-
72
-
-
84979850744
-
The concanavalin A model of acute hepatitis in mice
-
Heymann F., Hamesch K., Weiskirchen R., Tacke F. The concanavalin A model of acute hepatitis in mice. Lab. Anim. 2015, 49:12-20.
-
(2015)
Lab. Anim.
, vol.49
, pp. 12-20
-
-
Heymann, F.1
Hamesch, K.2
Weiskirchen, R.3
Tacke, F.4
-
73
-
-
0031802829
-
Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice
-
Hinson J.A., Pike S.L., Pumford N.R., Mayeux P.R. Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice. Chem. Res. Toxicol. 1998, 11:604-607.
-
(1998)
Chem. Res. Toxicol.
, vol.11
, pp. 604-607
-
-
Hinson, J.A.1
Pike, S.L.2
Pumford, N.R.3
Mayeux, P.R.4
-
74
-
-
0029891492
-
Identification of factors from rat neutrophils responsible for cytotoxicity to isolated hepatocytes
-
Ho J.S., Buchweitz J.P., Roth R.A., Ganey P.E. Identification of factors from rat neutrophils responsible for cytotoxicity to isolated hepatocytes. J. Leukoc. Biol. 1996, 59:716-724.
-
(1996)
J. Leukoc. Biol.
, vol.59
, pp. 716-724
-
-
Ho, J.S.1
Buchweitz, J.P.2
Roth, R.A.3
Ganey, P.E.4
-
75
-
-
0021950344
-
Identification of the major covalent adduct formed in vitro and in vivo between acetaminophen and mouse liver proteins
-
Hoffmann K.J., Streeter A.J., Axworthy D.B., Baillie T.A. Identification of the major covalent adduct formed in vitro and in vivo between acetaminophen and mouse liver proteins. Mol. Pharmacol. 1985, 27:566-573.
-
(1985)
Mol. Pharmacol.
, vol.27
, pp. 566-573
-
-
Hoffmann, K.J.1
Streeter, A.J.2
Axworthy, D.B.3
Baillie, T.A.4
-
76
-
-
0037315457
-
Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex
-
Holler N., et al. Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex. Mol. Cell. Biol. 2003, 23:1428-1440.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 1428-1440
-
-
Holler, N.1
-
77
-
-
57149108312
-
Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury
-
Holt M.P., Cheng L., Ju C. Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury. J. Leukoc. Biol. 2008, 84:1410-1421.
-
(2008)
J. Leukoc. Biol.
, vol.84
, pp. 1410-1421
-
-
Holt, M.P.1
Cheng, L.2
Ju, C.3
-
78
-
-
77956399506
-
Matrigel: a complex protein mixture required for optimal growth of cell culture
-
Hughes C.S., Postovit L.M., Lajoie G.A. Matrigel: a complex protein mixture required for optimal growth of cell culture. Proteomics 2010, 10:1886-1890.
-
(2010)
Proteomics
, vol.10
, pp. 1886-1890
-
-
Hughes, C.S.1
Postovit, L.M.2
Lajoie, G.A.3
-
80
-
-
33745777182
-
Mechanisms and pathophysiological implications of sinusoidal endothelial cell gap formation following treatment with galactosamine/endotoxin in mice
-
Ito Y., Abril E.R., Bethea N.W., McCuskey M.K., Cover C., Jaeschke H., McCuskey R.S. Mechanisms and pathophysiological implications of sinusoidal endothelial cell gap formation following treatment with galactosamine/endotoxin in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2006, 291:G211-G218.
-
(2006)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.291
, pp. G211-G218
-
-
Ito, Y.1
Abril, E.R.2
Bethea, N.W.3
McCuskey, M.K.4
Cover, C.5
Jaeschke, H.6
McCuskey, R.S.7
-
81
-
-
0025916387
-
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
-
Itoh N., et al. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 1991, 66:233-243.
-
(1991)
Cell
, vol.66
, pp. 233-243
-
-
Itoh, N.1
-
82
-
-
0025673837
-
Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol
-
Jaeschke H. Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol. J. Pharmacol. Exp. Ther. 1990, 255:935-941.
-
(1990)
J. Pharmacol. Exp. Ther.
, vol.255
, pp. 935-941
-
-
Jaeschke, H.1
-
83
-
-
33646867426
-
Mechanisms of liver injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions
-
Jaeschke H. Mechanisms of liver injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions. Am. J. Physiol. Gastrointest. Liver Physiol. 2006, 290:G1083-G1088.
-
(2006)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.290
, pp. G1083-G1088
-
-
Jaeschke, H.1
-
84
-
-
33244469737
-
Role of caspases in acetaminophen-induced liver injury
-
Jaeschke H., Cover C., Bajt M.L. Role of caspases in acetaminophen-induced liver injury. Life Sci. 2006, 78:1670-1676.
-
(2006)
Life Sci.
, vol.78
, pp. 1670-1676
-
-
Jaeschke, H.1
Cover, C.2
Bajt, M.L.3
-
85
-
-
0025687478
-
Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo
-
Jaeschke H., Farhood A., Smith C.W. Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. FASEB J. 1990, 4:3355-3359.
-
(1990)
FASEB J.
, vol.4
, pp. 3355-3359
-
-
Jaeschke, H.1
Farhood, A.2
Smith, C.W.3
-
86
-
-
0032055225
-
Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alpha-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model
-
Jaeschke H., Fisher M.A., Lawson J.A., Simmons C.A., Farhood A., Jones D.A. Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alpha-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model. J. Immunol. 1998, 160:3480-3486.
-
(1998)
J. Immunol.
, vol.160
, pp. 3480-3486
-
-
Jaeschke, H.1
Fisher, M.A.2
Lawson, J.A.3
Simmons, C.A.4
Farhood, A.5
Jones, D.A.6
-
88
-
-
0032987412
-
Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress
-
Jaeschke H., Ho Y.S., Fisher M.A., Lawson J.A., Farhood A. Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress. Hepatology 1999, 29:443-450.
-
(1999)
Hepatology
, vol.29
, pp. 443-450
-
-
Jaeschke, H.1
Ho, Y.S.2
Fisher, M.A.3
Lawson, J.A.4
Farhood, A.5
-
89
-
-
84855892790
-
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity
-
Jaeschke H., McGill M.R., Ramachandran A. Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab. Rev. 2012, 44:88-106.
-
(2012)
Drug Metab. Rev.
, vol.44
, pp. 88-106
-
-
Jaeschke, H.1
McGill, M.R.2
Ramachandran, A.3
-
90
-
-
79954615800
-
Current issues with acetaminophen hepatotoxicity: a clinically relevant model to test the efficacy of natural products
-
Jaeschke H., McGill M.R., Williams C.D., Ramachandran A. Current issues with acetaminophen hepatotoxicity: a clinically relevant model to test the efficacy of natural products. Life Sci. 2011, 88:737-745.
-
(2011)
Life Sci.
, vol.88
, pp. 737-745
-
-
Jaeschke, H.1
McGill, M.R.2
Williams, C.D.3
Ramachandran, A.4
-
91
-
-
83255192265
-
Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity
-
Jaeschke H., Williams C.D., Ramachandran A., Bajt M.L. Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity. Liver Int. 2012, 32:8-20.
-
(2012)
Liver Int.
, vol.32
, pp. 8-20
-
-
Jaeschke, H.1
Williams, C.D.2
Ramachandran, A.3
Bajt, M.L.4
-
92
-
-
7044235774
-
IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1
-
Jaruga B., Hong F., Kim W.H., Gao B. IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1. Am. J. Physiol. Gastrointest. Liver Physiol. 2004, 287:G1044-G1052.
-
(2004)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.287
, pp. G1044-G1052
-
-
Jaruga, B.1
Hong, F.2
Kim, W.H.3
Gao, B.4
-
93
-
-
41949112162
-
Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes
-
Jemnitz K., Veres Z., Monostory K., Kobori L., Vereczkey L. Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes. Toxicol. in Vitro 2008, 22:961-967.
-
(2008)
Toxicol. in Vitro
, vol.22
, pp. 961-967
-
-
Jemnitz, K.1
Veres, Z.2
Monostory, K.3
Kobori, L.4
Vereczkey, L.5
-
94
-
-
65449164969
-
TLR-9 activation aggravates concanavalin A-induced hepatitis via promoting accumulation and activation of liver CD4+ NKT cells
-
Jiang W., Sun R., Zhou R., Wei H., Tian Z. TLR-9 activation aggravates concanavalin A-induced hepatitis via promoting accumulation and activation of liver CD4+ NKT cells. J. Immunol. 2009, 182:3768-3774.
-
(2009)
J. Immunol.
, vol.182
, pp. 3768-3774
-
-
Jiang, W.1
Sun, R.2
Zhou, R.3
Wei, H.4
Tian, Z.5
-
95
-
-
84924760307
-
Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation
-
Jiang Y., et al. Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation. Chem. Biol. Interact. 2015, 231:83-89.
-
(2015)
Chem. Biol. Interact.
, vol.231
, pp. 83-89
-
-
Jiang, Y.1
-
96
-
-
0015754446
-
Acetaminophen-induced hepatic necrosis II. Role of covalent binding in vivo
-
Jollow D.J., Mitchell J.R., Potter W.Z., Davis D.C., Gillette J.R., Brodie B.B. Acetaminophen-induced hepatic necrosis II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. 1973, 187:195-202.
-
(1973)
J. Pharmacol. Exp. Ther.
, vol.187
, pp. 195-202
-
-
Jollow, D.J.1
Mitchell, J.R.2
Potter, W.Z.3
Davis, D.C.4
Gillette, J.R.5
Brodie, B.B.6
-
97
-
-
46449089949
-
Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies
-
Kanebratt K.P., Andersson T.B. Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies. Drug Metab. Dispos. 2008, 36:1444-1452.
-
(2008)
Drug Metab. Dispos.
, vol.36
, pp. 1444-1452
-
-
Kanebratt, K.P.1
Andersson, T.B.2
-
98
-
-
37549004782
-
HepaRG cells as an in vitro model for evaluation of cytochrome p450 induction in humans
-
Kanebratt K.P., Andersson T.B. HepaRG cells as an in vitro model for evaluation of cytochrome p450 induction in humans. Drug Metab. Dispos. 2008, 36:137-145.
-
(2008)
Drug Metab. Dispos.
, vol.36
, pp. 137-145
-
-
Kanebratt, K.P.1
Andersson, T.B.2
-
99
-
-
1342326759
-
The role of apoptosis in acetaminophen-induced injury
-
Kass G.E., Macanas-Pirard P., Lee P.C., Hinton R.H. The role of apoptosis in acetaminophen-induced injury. Ann. N. Y. Acad. Sci. 2003, 1010:557-559.
-
(2003)
Ann. N. Y. Acad. Sci.
, vol.1010
, pp. 557-559
-
-
Kass, G.E.1
Macanas-Pirard, P.2
Lee, P.C.3
Hinton, R.H.4
-
100
-
-
79551518847
-
Hepatic stellate cell-mediated three-dimensional hepatocyte and endothelial cell triculture model
-
Kasuya J., Sudo R., Mitaka T., Ikeda M., Tanishita K. Hepatic stellate cell-mediated three-dimensional hepatocyte and endothelial cell triculture model. Tissue Eng. A 2011, 17:361-370.
-
(2011)
Tissue Eng. A
, vol.17
, pp. 361-370
-
-
Kasuya, J.1
Sudo, R.2
Mitaka, T.3
Ikeda, M.4
Tanishita, K.5
-
101
-
-
78649746439
-
3D hepatic cultures simultaneously maintain primary hepatocyte and liver sinusoidal endothelial cell phenotypes
-
Kim Y., Rajagopalan P. 3D hepatic cultures simultaneously maintain primary hepatocyte and liver sinusoidal endothelial cell phenotypes. PLoS One 2010, 5.
-
(2010)
PLoS One
, vol.5
-
-
Kim, Y.1
Rajagopalan, P.2
-
102
-
-
78649665276
-
A comparative study of genome-wide transcriptional profiles of primary hepatocytes in collagen sandwich and monolayer cultures
-
Kim Y., Lasher C.D., Milford L.M., Murali T.M., Rajagopalan P. A comparative study of genome-wide transcriptional profiles of primary hepatocytes in collagen sandwich and monolayer cultures. Tissue Eng. Part C Methods 2010, 16:1449-1460.
-
(2010)
Tissue Eng. Part C Methods
, vol.16
, pp. 1449-1460
-
-
Kim, Y.1
Lasher, C.D.2
Milford, L.M.3
Murali, T.M.4
Rajagopalan, P.5
-
103
-
-
77649273272
-
Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver
-
Klaassen C.D., Reisman S.A. Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver. Toxicol. Appl. Pharmacol. 2010, 244:57-65.
-
(2010)
Toxicol. Appl. Pharmacol.
, vol.244
, pp. 57-65
-
-
Klaassen, C.D.1
Reisman, S.A.2
-
104
-
-
0036828064
-
Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione
-
Knight T.R., Ho Y.S., Farhood A., Jaeschke H. Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione. J. Pharmacol. Exp. Ther. 2002, 303:468-475.
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.303
, pp. 468-475
-
-
Knight, T.R.1
Ho, Y.S.2
Farhood, A.3
Jaeschke, H.4
-
105
-
-
0029810563
-
Role of sinusoidal endothelial cells of the liver in concanavalin A-induced hepatic injury in mice
-
Knolle P.A., et al. Role of sinusoidal endothelial cells of the liver in concanavalin A-induced hepatic injury in mice. Hepatology 1996, 24:824-829.
-
(1996)
Hepatology
, vol.24
, pp. 824-829
-
-
Knolle, P.A.1
-
106
-
-
7044226521
-
Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes
-
Kon K., Kim J.S., Jaeschke H., Lemasters J.J. Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology 2004, 40:1170-1179.
-
(2004)
Hepatology
, vol.40
, pp. 1170-1179
-
-
Kon, K.1
Kim, J.S.2
Jaeschke, H.3
Lemasters, J.J.4
-
107
-
-
34249796413
-
Role of apoptosis in acetaminophen hepatotoxicity
-
Kon K., et al. Role of apoptosis in acetaminophen hepatotoxicity. J. Gastroenterol. Hepatol. 2007, 22(Suppl. 1):S49-S52.
-
(2007)
J. Gastroenterol. Hepatol.
, vol.22
, pp. S49-S52
-
-
Kon, K.1
-
108
-
-
33747145962
-
The model of D-galactosamine-induced injury of rat hepatocytes in primary culture
-
Kucera O., Lotková H., Kand'ár R., Hézová R., Muzáková V., Cervinková Z. The model of D-galactosamine-induced injury of rat hepatocytes in primary culture. Acta Med. 2006, 49:59-65.
-
(2006)
Acta Med.
, vol.49
, pp. 59-65
-
-
Kucera, O.1
Lotková, H.2
Kand'ár, R.3
Hézová, R.4
Muzáková, V.5
Cervinková, Z.6
-
109
-
-
33750243674
-
Protective effect of S-adenosylmethionine against galactosamine-induced injury of rat hepatocytes in primary culture
-
Kucera O., et al. Protective effect of S-adenosylmethionine against galactosamine-induced injury of rat hepatocytes in primary culture. Physiol. Res. 2006, 55:551-560.
-
(2006)
Physiol. Res.
, vol.55
, pp. 551-560
-
-
Kucera, O.1
-
110
-
-
0032737476
-
Concanavalin A hepatotoxicity in mice: tumor necrosis factor-mediated organ failure independent of caspase-3-like protease activation
-
Künstle G., Hentze H., Germann P.G., Tiegs G., Meergans T., Wendel A. Concanavalin A hepatotoxicity in mice: tumor necrosis factor-mediated organ failure independent of caspase-3-like protease activation. Hepatology 1999, 30:1241-1251.
-
(1999)
Hepatology
, vol.30
, pp. 1241-1251
-
-
Künstle, G.1
Hentze, H.2
Germann, P.G.3
Tiegs, G.4
Meergans, T.5
Wendel, A.6
-
111
-
-
0030964037
-
ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha
-
Künstle G., Leist M., Uhlig S., Revesz L., Feifel R., MacKenzie A., Wendel A. ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha. Immunol. Lett. 1997, 55:5-10.
-
(1997)
Immunol. Lett.
, vol.55
, pp. 5-10
-
-
Künstle, G.1
Leist, M.2
Uhlig, S.3
Revesz, L.4
Feifel, R.5
MacKenzie, A.6
Wendel, A.7
-
112
-
-
0030017301
-
Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A
-
Küsters S., Gantner F., Künstle G., Tiegs G. Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology 1996, 111:462-471.
-
(1996)
Gastroenterology
, vol.111
, pp. 462-471
-
-
Küsters, S.1
Gantner, F.2
Künstle, G.3
Tiegs, G.4
-
113
-
-
13344279418
-
Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice
-
Lacronique V., et al. Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nat. Med. 1996, 2:80-86.
-
(1996)
Nat. Med.
, vol.2
, pp. 80-86
-
-
Lacronique, V.1
-
114
-
-
0033766332
-
Pathophysiologic importance of E- and L-selectin for neutrophil-induced liver injury during endotoxemia in mice
-
Lawson J.A., Burns A.R., Farhood A., Lynn Bajt M., Collins R.G., Smith C.W., Jaeschke H. Pathophysiologic importance of E- and L-selectin for neutrophil-induced liver injury during endotoxemia in mice. Hepatology 2000, 32:990-998.
-
(2000)
Hepatology
, vol.32
, pp. 990-998
-
-
Lawson, J.A.1
Burns, A.R.2
Farhood, A.3
Lynn Bajt, M.4
Collins, R.G.5
Smith, C.W.6
Jaeschke, H.7
-
115
-
-
0034127036
-
The hepatic inflammatory response after acetaminophen overdose: role of neutrophils
-
Lawson J.A., Farhood A., Hopper R.D., Bajt M.L., Jaeschke H. The hepatic inflammatory response after acetaminophen overdose: role of neutrophils. Toxicol. Sci. 2000, 54:509-516.
-
(2000)
Toxicol. Sci.
, vol.54
, pp. 509-516
-
-
Lawson, J.A.1
Farhood, A.2
Hopper, R.D.3
Bajt, M.L.4
Jaeschke, H.5
-
116
-
-
0031721754
-
Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and Fas-antibody-induced liver injury
-
Lawson J.A., Fisher M.A., Simmons C.A., Farhood A., Jaeschke H. Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and Fas-antibody-induced liver injury. Hepatology 1998, 28:761-767.
-
(1998)
Hepatology
, vol.28
, pp. 761-767
-
-
Lawson, J.A.1
Fisher, M.A.2
Simmons, C.A.3
Farhood, A.4
Jaeschke, H.5
-
117
-
-
78049369209
-
Isolation and culture of primary hepatocytes from resected human liver tissue
-
LeCluyse E.L., Alexandre E. Isolation and culture of primary hepatocytes from resected human liver tissue. Methods Mol. Biol. 2010, 640:57-82.
-
(2010)
Methods Mol. Biol.
, vol.640
, pp. 57-82
-
-
LeCluyse, E.L.1
Alexandre, E.2
-
118
-
-
16644386406
-
Isolation and culture of primary human hepatocytes
-
LeCluyse E.L., Alexandre E., Hamilton G.A., Viollon-Abadie C., Coon D.J., Jolley S., Richert L. Isolation and culture of primary human hepatocytes. Methods Mol. Biol. 2005, 290:207-229.
-
(2005)
Methods Mol. Biol.
, vol.290
, pp. 207-229
-
-
LeCluyse, E.L.1
Alexandre, E.2
Hamilton, G.A.3
Viollon-Abadie, C.4
Coon, D.J.5
Jolley, S.6
Richert, L.7
-
119
-
-
43049137743
-
Etiologies of acute liver failure
-
Lee W.M. Etiologies of acute liver failure. Semin. Liver Dis. 2008, 28:142-152.
-
(2008)
Semin. Liver Dis.
, vol.28
, pp. 142-152
-
-
Lee, W.M.1
-
120
-
-
15844419997
-
Role of CYP2E1 in the hepatotoxicity of acetaminophen
-
Lee S.S., Buters J.T., Pineau T., Fernandez-Salguero P., Gonzalez F.J. Role of CYP2E1 in the hepatotoxicity of acetaminophen. J. Biol. Chem. 1996, 271:12063-12067.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 12063-12067
-
-
Lee, S.S.1
Buters, J.T.2
Pineau, T.3
Fernandez-Salguero, P.4
Gonzalez, F.J.5
-
121
-
-
0345447674
-
Cutting edge: SDS-stable Fas microaggregates: an early event of Fas activation occurring with agonistic anti-Fas antibody but not with Fas ligand
-
Legembre P., Beneteau M., Daburon S., Moreau J.F., Taupin J.L. Cutting edge: SDS-stable Fas microaggregates: an early event of Fas activation occurring with agonistic anti-Fas antibody but not with Fas ligand. J. Immunol. 2003, 171:5659-5662.
-
(2003)
J. Immunol.
, vol.171
, pp. 5659-5662
-
-
Legembre, P.1
Beneteau, M.2
Daburon, S.3
Moreau, J.F.4
Taupin, J.L.5
-
122
-
-
33947614806
-
SiRNA-mediated Bcl-2 and Bcl-xl gene silencing sensitizes human hepatoblastoma cells to chemotherapeutic drugs
-
Lei X.Y., Zhong M., Feng L.F., Zhu B.Y., Tang S.S., Liao D.F. SiRNA-mediated Bcl-2 and Bcl-xl gene silencing sensitizes human hepatoblastoma cells to chemotherapeutic drugs. Clin. Exp. Pharmacol. Physiol. 2007, 34:450-456.
-
(2007)
Clin. Exp. Pharmacol. Physiol.
, vol.34
, pp. 450-456
-
-
Lei, X.Y.1
Zhong, M.2
Feng, L.F.3
Zhu, B.Y.4
Tang, S.S.5
Liao, D.F.6
-
123
-
-
0028895940
-
Activation of the 55kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release
-
Leist M., Gantner F., Jilg S., Wendel A. Activation of the 55kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release. J. Immunol. 1995, 154:1307-1316.
-
(1995)
J. Immunol.
, vol.154
, pp. 1307-1316
-
-
Leist, M.1
Gantner, F.2
Jilg, S.3
Wendel, A.4
-
124
-
-
0032555697
-
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
-
Li H., Zhu H., Xu C.J., Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998, 94:491-501.
-
(1998)
Cell
, vol.94
, pp. 491-501
-
-
Li, H.1
Zhu, H.2
Xu, C.J.3
Yuan, J.4
-
125
-
-
84860260420
-
The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer
-
Liedtke C., Trautwein C. The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer. Eur. J. Cell Biol. 2012, 91:582-589.
-
(2012)
Eur. J. Cell Biol.
, vol.91
, pp. 582-589
-
-
Liedtke, C.1
Trautwein, C.2
-
126
-
-
84856974159
-
Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism
-
Lin J., et al. Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism. Arch. Toxicol. 2012, 86:87-95.
-
(2012)
Arch. Toxicol.
, vol.86
, pp. 87-95
-
-
Lin, J.1
-
127
-
-
33747834655
-
Role of innate immunity in acetaminophen-induced hepatotoxicity
-
Liu Z.X., Kaplowitz N. Role of innate immunity in acetaminophen-induced hepatotoxicity. Expert Opin. Drug Metab. Toxicol. 2006, 2:493-503.
-
(2006)
Expert Opin. Drug Metab. Toxicol.
, vol.2
, pp. 493-503
-
-
Liu, Z.X.1
Kaplowitz, N.2
-
128
-
-
9644289366
-
Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity
-
Liu Z.X., Govindarajan S., Kaplowitz N. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology 2004, 127:1760-1774.
-
(2004)
Gastroenterology
, vol.127
, pp. 1760-1774
-
-
Liu, Z.X.1
Govindarajan, S.2
Kaplowitz, N.3
-
129
-
-
58249144385
-
Protective effects of Asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway
-
Ma K., Zhang Y., Zhu D., Lou Y. Protective effects of Asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway. Eur. J. Pharmacol. 2009, 603:98-107.
-
(2009)
Eur. J. Pharmacol.
, vol.603
, pp. 98-107
-
-
Ma, K.1
Zhang, Y.2
Zhu, D.3
Lou, Y.4
-
130
-
-
2442680168
-
N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis
-
Manov I., Hirsh M., Iancu T.C. N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis. Basic Clin Pharmacol. Toxicol. 2004, 94:213-225.
-
(2004)
Basic Clin Pharmacol. Toxicol.
, vol.94
, pp. 213-225
-
-
Manov, I.1
Hirsh, M.2
Iancu, T.C.3
-
131
-
-
75349095405
-
The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice
-
Martin-Murphy B.V., Holt M.P., Ju C. The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice. Toxicol. Lett. 2010, 192:387-394.
-
(2010)
Toxicol. Lett.
, vol.192
, pp. 387-394
-
-
Martin-Murphy, B.V.1
Holt, M.P.2
Ju, C.3
-
132
-
-
11144310166
-
Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice
-
Masubuchi Y., Suda C., Horie T. Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice. J. Hepatol. 2005, 42:110-116.
-
(2005)
J. Hepatol.
, vol.42
, pp. 110-116
-
-
Masubuchi, Y.1
Suda, C.2
Horie, T.3
-
133
-
-
0032850665
-
Azoxymethane-induced fulminant hepatic failure in C57BL/6J mice: characterization of a new animal model
-
Matkowskyj K.A., Marrero J.A., Carroll R.E., Danilkovich A.V., Green R.M., Benya R.V. Azoxymethane-induced fulminant hepatic failure in C57BL/6J mice: characterization of a new animal model. Am. J. Physiol. 1999, 277:G455-G462.
-
(1999)
Am. J. Physiol.
, vol.277
, pp. G455-G462
-
-
Matkowskyj, K.A.1
Marrero, J.A.2
Carroll, R.E.3
Danilkovich, A.V.4
Green, R.M.5
Benya, R.V.6
-
134
-
-
0023882573
-
In vitro toxicity of polymorphonuclear neutrophils to rat hepatocytes: evidence for a proteinase-mediated mechanism
-
Mavier P., Preaux A.M., Guigui B., Lescs M.C., Zafrani E.S., Dhumeaux D. In vitro toxicity of polymorphonuclear neutrophils to rat hepatocytes: evidence for a proteinase-mediated mechanism. Hepatology 1988, 8:254-258.
-
(1988)
Hepatology
, vol.8
, pp. 254-258
-
-
Mavier, P.1
Preaux, A.M.2
Guigui, B.3
Lescs, M.C.4
Zafrani, E.S.5
Dhumeaux, D.6
-
135
-
-
0018857260
-
Potentiation of acetaminophen hepatotoxicity by alcohol
-
McClain C.J., Kromhout J.P., Peterson F.J., Holtzman J.L. Potentiation of acetaminophen hepatotoxicity by alcohol. JAMA 1980, 244:251-253.
-
(1980)
JAMA
, vol.244
, pp. 251-253
-
-
McClain, C.J.1
Kromhout, J.P.2
Peterson, F.J.3
Holtzman, J.L.4
-
136
-
-
84883295568
-
Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis
-
McGill M.R., Jaeschke H. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm. Res. 2013, 30:2174-2187.
-
(2013)
Pharm. Res.
, vol.30
, pp. 2174-2187
-
-
McGill, M.R.1
Jaeschke, H.2
-
137
-
-
84902484331
-
Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients
-
McGill M.R., Jaeschke H. Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients. Expert Opin. Drug Metab. Toxicol. 2014, 10:1005-1017.
-
(2014)
Expert Opin. Drug Metab. Toxicol.
, vol.10
, pp. 1005-1017
-
-
McGill, M.R.1
Jaeschke, H.2
-
138
-
-
84859708101
-
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
-
McGill M.R., Sharpe M.R., Williams C.D., Taha M., Curry S.C., Jaeschke H. The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J. Clin. Invest. 2012, 122:1574-1583.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 1574-1583
-
-
McGill, M.R.1
Sharpe, M.R.2
Williams, C.D.3
Taha, M.4
Curry, S.C.5
Jaeschke, H.6
-
139
-
-
84867847425
-
Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity
-
McGill M.R., Williams C.D., Xie Y., Ramachandran A., Jaeschke H. Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. Toxicol. Appl. Pharmacol. 2012, 264:387-394.
-
(2012)
Toxicol. Appl. Pharmacol.
, vol.264
, pp. 387-394
-
-
McGill, M.R.1
Williams, C.D.2
Xie, Y.3
Ramachandran, A.4
Jaeschke, H.5
-
140
-
-
79952207647
-
HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity
-
McGill M.R., Yan H.M., Ramachandran A., Murray G.J., Rollins D.E., Jaeschke H. HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity. Hepatology 2011, 53:974-982.
-
(2011)
Hepatology
, vol.53
, pp. 974-982
-
-
McGill, M.R.1
Yan, H.M.2
Ramachandran, A.3
Murray, G.J.4
Rollins, D.E.5
Jaeschke, H.6
-
141
-
-
84877002894
-
Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications
-
McGill M.R., et al. Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications. Toxicol. Appl. Pharmacol. 2013, 269:240-249.
-
(2013)
Toxicol. Appl. Pharmacol.
, vol.269
, pp. 240-249
-
-
McGill, M.R.1
-
142
-
-
13444269608
-
Tissue repair: an important determinant of final outcome of toxicant-induced injury
-
Mehendale H.M. Tissue repair: an important determinant of final outcome of toxicant-induced injury. Toxicol. Pathol. 2005, 33:41-51.
-
(2005)
Toxicol. Pathol.
, vol.33
, pp. 41-51
-
-
Mehendale, H.M.1
-
143
-
-
0015748302
-
Acetaminophen-induced hepatic necrosis I. Role of drug metabolism
-
Mitchell J.R., Jollow D.J., Potter W.Z., Davis D.C., Gillette J.R., Brodie B.B. Acetaminophen-induced hepatic necrosis I. Role of drug metabolism. J. Pharmacol. Exp. Ther. 1973, 187:185-194.
-
(1973)
J. Pharmacol. Exp. Ther.
, vol.187
, pp. 185-194
-
-
Mitchell, J.R.1
Jollow, D.J.2
Potter, W.Z.3
Davis, D.C.4
Gillette, J.R.5
Brodie, B.B.6
-
144
-
-
0015733053
-
Acetaminophen-induced hepatic necrosis IV. Protective role of glutathione
-
Mitchell J.R., Jollow D.J., Potter W.Z., Gillette J.R., Brodie B.B. Acetaminophen-induced hepatic necrosis IV. Protective role of glutathione. J. Pharmacol. Exp. Ther. 1973, 187:211-217.
-
(1973)
J. Pharmacol. Exp. Ther.
, vol.187
, pp. 211-217
-
-
Mitchell, J.R.1
Jollow, D.J.2
Potter, W.Z.3
Gillette, J.R.4
Brodie, B.B.5
-
145
-
-
34548706468
-
Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome
-
Mookerjee R.P., Stadlbauer V., Lidder S., Wright G.A., Hodges S.J., Davies N.A., Jalan R. Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome. Hepatology 2007, 46:831-840.
-
(2007)
Hepatology
, vol.46
, pp. 831-840
-
-
Mookerjee, R.P.1
Stadlbauer, V.2
Lidder, S.3
Wright, G.A.4
Hodges, S.J.5
Davies, N.A.6
Jalan, R.7
-
146
-
-
0022982255
-
Long-term maintenance of hepatocyte functional activity in co-culture: requirements for sinusoidal endothelial cells and dexamethasone
-
Morin O., Normand C. Long-term maintenance of hepatocyte functional activity in co-culture: requirements for sinusoidal endothelial cells and dexamethasone. J. Cell. Physiol. 1986, 129:103-110.
-
(1986)
J. Cell. Physiol.
, vol.129
, pp. 103-110
-
-
Morin, O.1
Normand, C.2
-
147
-
-
0033396491
-
Fas ligand-induced apoptosis
-
Nagata S. Fas ligand-induced apoptosis. Annu. Rev. Genet. 1999, 33:29-55.
-
(1999)
Annu. Rev. Genet.
, vol.33
, pp. 29-55
-
-
Nagata, S.1
-
148
-
-
0034089243
-
Animal models of fulminant hepatic failure: a critical evaluation
-
Newsome P.N., Plevris J.N., Nelson L.J., Hayes P.C. Animal models of fulminant hepatic failure: a critical evaluation. Liver Transpl. 2000, 6:21-31.
-
(2000)
Liver Transpl.
, vol.6
, pp. 21-31
-
-
Newsome, P.N.1
Plevris, J.N.2
Nelson, L.J.3
Hayes, P.C.4
-
149
-
-
0033585143
-
Modulation of paracetamol metabolism by Kupffer cells: a study on rat liver slices
-
Neyrinck A., Eeckhoudt S.L., Meunier C.J., Pamfer S., Taper H.S., Verbeeck R.K., Delzenne N. Modulation of paracetamol metabolism by Kupffer cells: a study on rat liver slices. Life Sci. 1999, 65:2851-2859.
-
(1999)
Life Sci.
, vol.65
, pp. 2851-2859
-
-
Neyrinck, A.1
Eeckhoudt, S.L.2
Meunier, C.J.3
Pamfer, S.4
Taper, H.S.5
Verbeeck, R.K.6
Delzenne, N.7
-
150
-
-
84155194923
-
Activation of autophagy protects against acetaminophen-induced hepatotoxicity
-
Ni H.M., Bockus A., Boggess N., Jaeschke H., Ding W.X. Activation of autophagy protects against acetaminophen-induced hepatotoxicity. Hepatology 2012, 55:222-232.
-
(2012)
Hepatology
, vol.55
, pp. 222-232
-
-
Ni, H.M.1
Bockus, A.2
Boggess, N.3
Jaeschke, H.4
Ding, W.X.5
-
151
-
-
53149111140
-
Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice
-
Ni H.M., Chen X., Ding W.X., Schuchmann M., Yin X.M. Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice. Am. J. Pathol. 2008, 173:962-972.
-
(2008)
Am. J. Pathol.
, vol.173
, pp. 962-972
-
-
Ni, H.M.1
Chen, X.2
Ding, W.X.3
Schuchmann, M.4
Yin, X.M.5
-
152
-
-
0028135715
-
Fas-mediated apoptosis in primary cultured mouse hepatocytes
-
Ni R., Tomita Y., Matsuda K., Ichihara A., Ishimura K., Ogasawara J., Nagata S. Fas-mediated apoptosis in primary cultured mouse hepatocytes. Exp. Cell Res. 1994, 215:332-337.
-
(1994)
Exp. Cell Res.
, vol.215
, pp. 332-337
-
-
Ni, R.1
Tomita, Y.2
Matsuda, K.3
Ichihara, A.4
Ishimura, K.5
Ogasawara, J.6
Nagata, S.7
-
153
-
-
84883763522
-
Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver
-
Ni H.M., Williams J.A., Jaeschke H., Ding W.X. Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver. Redox Biol. 2013, 1:427-432.
-
(2013)
Redox Biol.
, vol.1
, pp. 427-432
-
-
Ni, H.M.1
Williams, J.A.2
Jaeschke, H.3
Ding, W.X.4
-
154
-
-
2342447293
-
Liver NK cells expressing TRAIL are toxic against self hepatocytes in mice
-
Ochi M., et al. Liver NK cells expressing TRAIL are toxic against self hepatocytes in mice. Hepatology 2004, 39:1321-1331.
-
(2004)
Hepatology
, vol.39
, pp. 1321-1331
-
-
Ochi, M.1
-
155
-
-
0027291205
-
Lethal effect of the anti-Fas antibody in mice
-
Ogasawara J., et al. Lethal effect of the anti-Fas antibody in mice. Nature 1993, 364:806-809.
-
(1993)
Nature
, vol.364
, pp. 806-809
-
-
Ogasawara, J.1
-
157
-
-
0037126649
-
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States
-
Ostapowicz G., et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann. Intern. Med. 2002, 137:947-954.
-
(2002)
Ann. Intern. Med.
, vol.137
, pp. 947-954
-
-
Ostapowicz, G.1
-
158
-
-
0023716281
-
Prevention of acetaminophen-induced hepatotoxicity by dimethyl sulfoxide
-
Park Y., Smith R.D., Combs A.B., Kehrer J.P. Prevention of acetaminophen-induced hepatotoxicity by dimethyl sulfoxide. Toxicology 1988, 52:165-175.
-
(1988)
Toxicology
, vol.52
, pp. 165-175
-
-
Park, Y.1
Smith, R.D.2
Combs, A.B.3
Kehrer, J.P.4
-
159
-
-
0027441986
-
Cerebral metabolic and histological effects of thioacetamide-induced liver failure
-
Peeling J., Shoemaker L., Gauthier T., Benarroch A., Sutherland G.R., Minuk G.Y. Cerebral metabolic and histological effects of thioacetamide-induced liver failure. Am. J. Physiol. 1993, 265:G572-G578.
-
(1993)
Am. J. Physiol.
, vol.265
, pp. G572-G578
-
-
Peeling, J.1
Shoemaker, L.2
Gauthier, T.3
Benarroch, A.4
Sutherland, G.R.5
Minuk, G.Y.6
-
160
-
-
4043175385
-
Management of carbon tetrachloride-induced acute liver injury in rats by syngeneic hepatocyte transplantation in spleen and peritoneal cavity
-
Pilichos C., Perrea D., Demonakou M., Preza A., Donta I. Management of carbon tetrachloride-induced acute liver injury in rats by syngeneic hepatocyte transplantation in spleen and peritoneal cavity. World J. Gastroenterol. 2004, 10:2099-2102.
-
(2004)
World J. Gastroenterol.
, vol.10
, pp. 2099-2102
-
-
Pilichos, C.1
Perrea, D.2
Demonakou, M.3
Preza, A.4
Donta, I.5
-
161
-
-
17844365270
-
AASLD positioning paper: the management of acute liver failure
-
Polson J., Lee W.M. AASLD positioning paper: the management of acute liver failure. Hepatology 2005, 41:1179-1197.
-
(2005)
Hepatology
, vol.41
, pp. 1179-1197
-
-
Polson, J.1
Lee, W.M.2
-
162
-
-
0035697715
-
Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry
-
Qiu Y., Benet L.Z., Burlingame A.L. Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry. Adv. Exp. Med. Biol. 2001, 500:663-673.
-
(2001)
Adv. Exp. Med. Biol.
, vol.500
, pp. 663-673
-
-
Qiu, Y.1
Benet, L.Z.2
Burlingame, A.L.3
-
163
-
-
0031443822
-
Apoptosis and necrosis in toxicology: a continuum or distinct modes of cell death?
-
Raffray M., Cohen G.M. Apoptosis and necrosis in toxicology: a continuum or distinct modes of cell death?. Pharmacol. Ther. 1997, 75:153-177.
-
(1997)
Pharmacol. Ther.
, vol.75
, pp. 153-177
-
-
Raffray, M.1
Cohen, G.M.2
-
164
-
-
13244292321
-
Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes
-
Reid A.B., Kurten R.C., McCullough S.S., Brock R.W., Hinson J.A. Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J. Pharmacol. Exp. Ther. 2005, 312:509-516.
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.312
, pp. 509-516
-
-
Reid, A.B.1
Kurten, R.C.2
McCullough, S.S.3
Brock, R.W.4
Hinson, J.A.5
-
165
-
-
0036727296
-
Hyperosmolarity triggers CD95 membrane trafficking and sensitizes rat hepatocytes toward CD95L-induced apoptosis
-
Reinehr R., Graf D., Fischer R., Schliess F., Haussinger D. Hyperosmolarity triggers CD95 membrane trafficking and sensitizes rat hepatocytes toward CD95L-induced apoptosis. Hepatology 2002, 36:602-614.
-
(2002)
Hepatology
, vol.36
, pp. 602-614
-
-
Reinehr, R.1
Graf, D.2
Fischer, R.3
Schliess, F.4
Haussinger, D.5
-
166
-
-
43049121406
-
Perspectives on liver failure: past and future
-
Riordan S.M., Williams R. Perspectives on liver failure: past and future. Semin. Liver Dis. 2008, 28:137-141.
-
(2008)
Semin. Liver Dis.
, vol.28
, pp. 137-141
-
-
Riordan, S.M.1
Williams, R.2
-
167
-
-
0036301269
-
Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells
-
Rodríguez-Antona C., Donato M.T., Boobis A., Edwards R.J., Watts P.S., Castell J.V., Gómez-Lechón M.J. Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells. Xenobiotica 2002, 32:505-520.
-
(2002)
Xenobiotica
, vol.32
, pp. 505-520
-
-
Rodríguez-Antona, C.1
Donato, M.T.2
Boobis, A.3
Edwards, R.J.4
Watts, P.S.5
Castell, J.V.6
Gómez-Lechón, M.J.7
-
168
-
-
0021360176
-
Reduction and glutathione conjugation reactions of N-acetyl-p-benzoquinone imine and two dimethylated analogues
-
Rosen G.M., Rauckman E.J., Ellington S.P., Dahlin D.C., Christie J.L., Nelson S.D. Reduction and glutathione conjugation reactions of N-acetyl-p-benzoquinone imine and two dimethylated analogues. Mol. Pharmacol. 1984, 25:151-157.
-
(1984)
Mol. Pharmacol.
, vol.25
, pp. 151-157
-
-
Rosen, G.M.1
Rauckman, E.J.2
Ellington, S.P.3
Dahlin, D.C.4
Christie, J.L.5
Nelson, S.D.6
-
169
-
-
0030569508
-
Multiple pathways of Fas-induced apoptosis in primary culture of hepatocytes
-
Rouquet N., Carlier K., Briand P., Wiels J., Joulin V. Multiple pathways of Fas-induced apoptosis in primary culture of hepatocytes. Biochem. Biophys. Res. Commun. 1996, 229:27-35.
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.229
, pp. 27-35
-
-
Rouquet, N.1
Carlier, K.2
Briand, P.3
Wiels, J.4
Joulin, V.5
-
170
-
-
66349138228
-
Evaluation of oxidative status in acetaminophen-treated rat hepatocytes in culture
-
Rousar T., Kucera O., Krivakova P., Lotkova H., Kandar R., Muzakova V., Cervinkova Z. Evaluation of oxidative status in acetaminophen-treated rat hepatocytes in culture. Physiol. Res. 2009, 58:239-246.
-
(2009)
Physiol. Res.
, vol.58
, pp. 239-246
-
-
Rousar, T.1
Kucera, O.2
Krivakova, P.3
Lotkova, H.4
Kandar, R.5
Muzakova, V.6
Cervinkova, Z.7
-
171
-
-
0032512296
-
Paracetamol (acetaminophen) poisoning No need to change current guidelines to accident departments
-
Routledge P., et al. Paracetamol (acetaminophen) poisoning No need to change current guidelines to accident departments. BMJ 1998, 317:1609-1610.
-
(1998)
BMJ
, vol.317
, pp. 1609-1610
-
-
Routledge, P.1
-
172
-
-
77952074061
-
Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach
-
Rowe C., et al. Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach. J. Proteome Res. 2010, 9:2658-2668.
-
(2010)
J. Proteome Res.
, vol.9
, pp. 2658-2668
-
-
Rowe, C.1
-
173
-
-
77953701589
-
C-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity
-
Saito C., Lemasters J.J., Jaeschke H. c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. Toxicol. Appl. Pharmacol. 2010, 246:8-17.
-
(2010)
Toxicol. Appl. Pharmacol.
, vol.246
, pp. 8-17
-
-
Saito, C.1
Lemasters, J.J.2
Jaeschke, H.3
-
174
-
-
73449143152
-
Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine
-
Saito C., Zwingmann C., Jaeschke H. Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine. Hepatology 2010, 51:246-254.
-
(2010)
Hepatology
, vol.51
, pp. 246-254
-
-
Saito, C.1
Zwingmann, C.2
Jaeschke, H.3
-
175
-
-
0019389575
-
Mechanism of the preventive effect of ethanol on acetaminophen-induced hepatoxicity
-
Sato C., Lieber C.S. Mechanism of the preventive effect of ethanol on acetaminophen-induced hepatoxicity. J. Pharmacol. Exp. Ther. 1981, 218:811-815.
-
(1981)
J. Pharmacol. Exp. Ther.
, vol.218
, pp. 811-815
-
-
Sato, C.1
Lieber, C.S.2
-
176
-
-
0019364761
-
Increased hepatotoxicity of acetaminophen after chronic ethanol consumption in the rat
-
Sato C., Matsuda Y., Lieber C.S. Increased hepatotoxicity of acetaminophen after chronic ethanol consumption in the rat. Gastroenterology 1981, 80:140-148.
-
(1981)
Gastroenterology
, vol.80
, pp. 140-148
-
-
Sato, C.1
Matsuda, Y.2
Lieber, C.S.3
-
177
-
-
0033036748
-
Apoptosis signaling in lymphocytes
-
Scaffidi C., Kirchhoff S., Krammer P.H., Peter M.E. Apoptosis signaling in lymphocytes. Curr. Opin. Immunol. 1999, 11:277-285.
-
(1999)
Curr. Opin. Immunol.
, vol.11
, pp. 277-285
-
-
Scaffidi, C.1
Kirchhoff, S.2
Krammer, P.H.3
Peter, M.E.4
-
178
-
-
0037062934
-
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
-
Scaffidi P., Misteli T., Bianchi M.E. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002, 418:191-195.
-
(2002)
Nature
, vol.418
, pp. 191-195
-
-
Scaffidi, P.1
Misteli, T.2
Bianchi, M.E.3
-
179
-
-
0032536771
-
Two CD95 (APO-1/Fas) signaling pathways
-
Scaffidi C., et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 1998, 17:1675-1687.
-
(1998)
EMBO J.
, vol.17
, pp. 1675-1687
-
-
Scaffidi, C.1
-
180
-
-
0023680625
-
Involvement of tumor necrosis factor in endotoxin-triggered neutrophil adherence to sinusoidal endothelial cells of mouse liver and its modulation in acute phase
-
Schlayer H.J., et al. Involvement of tumor necrosis factor in endotoxin-triggered neutrophil adherence to sinusoidal endothelial cells of mouse liver and its modulation in acute phase. J. Hepatol. 1988, 7:239-249.
-
(1988)
J. Hepatol.
, vol.7
, pp. 239-249
-
-
Schlayer, H.J.1
-
181
-
-
0033807015
-
Induction of murine hepatocyte death by membrane-bound CD95 (Fas/APO-1)-ligand: characterization of an in vitro system
-
Schlosser S.F., Azzaroli F., Dao T., Hingorani R., Nicholas Crispe I., Boyer J.L. Induction of murine hepatocyte death by membrane-bound CD95 (Fas/APO-1)-ligand: characterization of an in vitro system. Hepatology 2000, 32:779-785.
-
(2000)
Hepatology
, vol.32
, pp. 779-785
-
-
Schlosser, S.F.1
Azzaroli, F.2
Dao, T.3
Hingorani, R.4
Nicholas Crispe, I.5
Boyer, J.L.6
-
182
-
-
84856396808
-
Hepatocyte polarization is essential for the productive entry of the hepatitis B virus
-
Schulze A., Mills K., Weiss T.S., Urban S. Hepatocyte polarization is essential for the productive entry of the hepatitis B virus. Hepatology 2012, 55:373-383.
-
(2012)
Hepatology
, vol.55
, pp. 373-383
-
-
Schulze, A.1
Mills, K.2
Weiss, T.S.3
Urban, S.4
-
183
-
-
0037564287
-
Primary human hepatocytes: a valuable tool for investigation of apoptosis and hepatitis B virus infection
-
Schulze-Bergkamen H., et al. Primary human hepatocytes: a valuable tool for investigation of apoptosis and hepatitis B virus infection. J. Hepatol. 2003, 38:736-744.
-
(2003)
J. Hepatol.
, vol.38
, pp. 736-744
-
-
Schulze-Bergkamen, H.1
-
184
-
-
0033694155
-
Importance of Kupffer cells for T-cell-dependent liver injury in mice
-
Schümann J., Wolf D., Pahl A., Brune K., Papadopoulos T., van Rooijen N., Tiegs G. Importance of Kupffer cells for T-cell-dependent liver injury in mice. Am. J. Pathol. 2000, 157:1671-1683.
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 1671-1683
-
-
Schümann, J.1
Wolf, D.2
Pahl, A.3
Brune, K.4
Papadopoulos, T.5
van Rooijen, N.6
Tiegs, G.7
-
185
-
-
72949085332
-
The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers
-
Schüngel S., et al. The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers. Hepatology 2009, 50:1558-1566.
-
(2009)
Hepatology
, vol.50
, pp. 1558-1566
-
-
Schüngel, S.1
-
186
-
-
0026599593
-
Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: effects of Ca(2+)-endonuclease, DNA repair, and glutathione depletion inhibitors on DNA fragmentation and cell death
-
Shen W., Kamendulis L.M., Ray S.D., Corcoran G.B. Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: effects of Ca(2+)-endonuclease, DNA repair, and glutathione depletion inhibitors on DNA fragmentation and cell death. Toxicol. Appl. Pharmacol. 1992, 112:32-40.
-
(1992)
Toxicol. Appl. Pharmacol.
, vol.112
, pp. 32-40
-
-
Shen, W.1
Kamendulis, L.M.2
Ray, S.D.3
Corcoran, G.B.4
-
187
-
-
0025772460
-
Species differences in metabolism and pharmacokinetics: are we close to an understanding?
-
Smith D.A. Species differences in metabolism and pharmacokinetics: are we close to an understanding?. Drug Metab. Rev. 1991, 23:355-373.
-
(1991)
Drug Metab. Rev.
, vol.23
, pp. 355-373
-
-
Smith, D.A.1
-
188
-
-
0033055874
-
Glycine and uridine prevent D-galactosamine hepatotoxicity in the rat: role of Kupffer cells
-
Stachlewitz R.F., Seabra V., Bradford B., Bradham C.A., Rusyn I., Germolec D., Thurman R.G. Glycine and uridine prevent D-galactosamine hepatotoxicity in the rat: role of Kupffer cells. Hepatology 1999, 29:737-745.
-
(1999)
Hepatology
, vol.29
, pp. 737-745
-
-
Stachlewitz, R.F.1
Seabra, V.2
Bradford, B.3
Bradham, C.A.4
Rusyn, I.5
Germolec, D.6
Thurman, R.G.7
-
189
-
-
78449306226
-
The toxic effect of thioacetamide on rat liver in vitro
-
Staňková P., Kučera O., Lotková H., Roušar T., Endlicher R., Cervinková Z. The toxic effect of thioacetamide on rat liver in vitro. Toxicol. in Vitro 2010, 24:2097-2103.
-
(2010)
Toxicol. in Vitro
, vol.24
, pp. 2097-2103
-
-
Staňková, P.1
Kučera, O.2
Lotková, H.3
Roušar, T.4
Endlicher, R.5
Cervinková, Z.6
-
190
-
-
15144345497
-
Pro-caspase-3 is a major physiologic target of caspase-8
-
Stennicke H.R., et al. Pro-caspase-3 is a major physiologic target of caspase-8. J. Biol. Chem. 1998, 273:27084-27090.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 27084-27090
-
-
Stennicke, H.R.1
-
191
-
-
60149085396
-
The many roles of FAS receptor signaling in the immune system
-
Strasser A., Jost P.J., Nagata S. The many roles of FAS receptor signaling in the immune system. Immunity 2009, 30:180-192.
-
(2009)
Immunity
, vol.30
, pp. 180-192
-
-
Strasser, A.1
Jost, P.J.2
Nagata, S.3
-
192
-
-
0021333072
-
The covalent binding of acetaminophen to protein Evidence for cysteine residues as major sites of arylation in vitro
-
Streeter A.J., Dahlin D.C., Nelson S.D., Baillie T.A. The covalent binding of acetaminophen to protein Evidence for cysteine residues as major sites of arylation in vitro. Chem. Biol. Interact. 1984, 48:349-366.
-
(1984)
Chem. Biol. Interact.
, vol.48
, pp. 349-366
-
-
Streeter, A.J.1
Dahlin, D.C.2
Nelson, S.D.3
Baillie, T.A.4
-
193
-
-
0027145632
-
Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family
-
Suda T., Takahashi T., Golstein P., Nagata S. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 1993, 75:1169-1178.
-
(1993)
Cell
, vol.75
, pp. 1169-1178
-
-
Suda, T.1
Takahashi, T.2
Golstein, P.3
Nagata, S.4
-
194
-
-
1342344700
-
Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes
-
Sunman J.A., Hawke R.L., LeCluyse E.L., Kashuba A.D. Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. Drug Metab. Dispos. 2004, 32:359-363.
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 359-363
-
-
Sunman, J.A.1
Hawke, R.L.2
LeCluyse, E.L.3
Kashuba, A.D.4
-
196
-
-
0034948382
-
Increased intracranial pressure in a porcine model of fulminant hepatic failure using amatoxin and endotoxin
-
Takada Y., et al. Increased intracranial pressure in a porcine model of fulminant hepatic failure using amatoxin and endotoxin. J. Hepatol. 2001, 34:825-831.
-
(2001)
J. Hepatol.
, vol.34
, pp. 825-831
-
-
Takada, Y.1
-
197
-
-
3142657270
-
Molecular process in acute liver injury and regeneration induced by carbon tetrachloride
-
Taniguchi M., Takeuchi T., Nakatsuka R., Watanabe T., Sato K. Molecular process in acute liver injury and regeneration induced by carbon tetrachloride. Life Sci. 2004, 75:1539-1549.
-
(2004)
Life Sci.
, vol.75
, pp. 1539-1549
-
-
Taniguchi, M.1
Takeuchi, T.2
Nakatsuka, R.3
Watanabe, T.4
Sato, K.5
-
198
-
-
0025907763
-
Animal models of fulminant hepatic failure
-
Terblanche J., Hickman R. Animal models of fulminant hepatic failure. Dig. Dis. Sci. 1991, 36:770-774.
-
(1991)
Dig. Dis. Sci.
, vol.36
, pp. 770-774
-
-
Terblanche, J.1
Hickman, R.2
-
199
-
-
0030909416
-
Agonist antibody and Fas ligand mediate different sensitivity to death in the signaling pathways of Fas and cytoplasmic mutants
-
Thilenius A.R., Braun K., Russell J.H. Agonist antibody and Fas ligand mediate different sensitivity to death in the signaling pathways of Fas and cytoplasmic mutants. Eur. J. Immunol. 1997, 27:1108-1114.
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 1108-1114
-
-
Thilenius, A.R.1
Braun, K.2
Russell, J.H.3
-
200
-
-
0026643743
-
A T cell-dependent experimental liver injury in mice inducible by concanavalin A
-
Tiegs G., Hentschel J., Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest. 1992, 90:196-203.
-
(1992)
J. Clin. Invest.
, vol.90
, pp. 196-203
-
-
Tiegs, G.1
Hentschel, J.2
Wendel, A.3
-
201
-
-
0024589094
-
Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice
-
Tiegs G., Wolter M., Wendel A. Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice. Biochem. Pharmacol. 1989, 38:627-631.
-
(1989)
Biochem. Pharmacol.
, vol.38
, pp. 627-631
-
-
Tiegs, G.1
Wolter, M.2
Wendel, A.3
-
202
-
-
0024345539
-
Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide, in mouse liver
-
Tirmenstein M.A., Nelson S.D. Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide, in mouse liver. J. Biol. Chem. 1989, 264:9814-9819.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 9814-9819
-
-
Tirmenstein, M.A.1
Nelson, S.D.2
-
203
-
-
84922756226
-
Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells
-
Tobwala S., Khayyat A., Fan W., Ercal N. Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells. Exp. Biol. Med. 2014, 240:261-272.
-
(2014)
Exp. Biol. Med.
, vol.240
, pp. 261-272
-
-
Tobwala, S.1
Khayyat, A.2
Fan, W.3
Ercal, N.4
-
204
-
-
0024347970
-
Monoclonal antibody-mediated tumor regression by induction of apoptosis
-
Trauth B.C., et al. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 1989, 245:301-305.
-
(1989)
Science
, vol.245
, pp. 301-305
-
-
Trauth, B.C.1
-
205
-
-
84899789355
-
Importance of Kupffer cells in the development of acute liver injuries in mice
-
Tsutsui H., Nishiguchi S. Importance of Kupffer cells in the development of acute liver injuries in mice. Int. J. Mol. Sci. 2014, 15:7711-7730.
-
(2014)
Int. J. Mol. Sci.
, vol.15
, pp. 7711-7730
-
-
Tsutsui, H.1
Nishiguchi, S.2
-
206
-
-
33749566060
-
Modeling inflammation-drug interactions in vitro: a rat Kupffer cell-hepatocyte coculture system
-
Tukov F.F., Maddox J.F., Amacher D.E., Bobrowski W.F., Roth R.A., Ganey P.E. Modeling inflammation-drug interactions in vitro: a rat Kupffer cell-hepatocyte coculture system. Toxicol. in Vitro 2006, 20:1488-1499.
-
(2006)
Toxicol. in Vitro
, vol.20
, pp. 1488-1499
-
-
Tukov, F.F.1
Maddox, J.F.2
Amacher, D.E.3
Bobrowski, W.F.4
Roth, R.A.5
Ganey, P.E.6
-
207
-
-
67651250551
-
An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure
-
Tuñón M.J., Alvarez M., Culebras J.M., González-Gallego J. An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure. World J. Gastroenterol. 2009, 15:3086-3098.
-
(2009)
World J. Gastroenterol.
, vol.15
, pp. 3086-3098
-
-
Tuñón, M.J.1
Alvarez, M.2
Culebras, J.M.3
González-Gallego, J.4
-
208
-
-
67650982782
-
Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: a valuable model for in vitro toxicity and drug-drug interaction studies
-
Tuschl G., Hrach J., Walter Y., Hewitt P.G., Mueller S.O. Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: a valuable model for in vitro toxicity and drug-drug interaction studies. Chem. Biol. Interact. 2009, 181:124-137.
-
(2009)
Chem. Biol. Interact.
, vol.181
, pp. 124-137
-
-
Tuschl, G.1
Hrach, J.2
Walter, Y.3
Hewitt, P.G.4
Mueller, S.O.5
-
209
-
-
0016390653
-
Massive liver cell necrosis induced in the pig with carbon tetrachloride
-
van Leenhoff J.A., Hickman R., Saunders S.J., Terblanche J. Massive liver cell necrosis induced in the pig with carbon tetrachloride. S. Afr. Med. J. 1974, 48:1201-1204.
-
(1974)
S. Afr. Med. J.
, vol.48
, pp. 1201-1204
-
-
van Leenhoff, J.A.1
Hickman, R.2
Saunders, S.J.3
Terblanche, J.4
-
210
-
-
67649531356
-
Biochemical characterisation of an in vitro model of hepatocellular apoptotic cell death
-
Vinken M., Decrock E., De Vuyst E., Leybaert L., Vanhaecke T., Rogiers V. Biochemical characterisation of an in vitro model of hepatocellular apoptotic cell death. Altern. Lab. Anim. 2009, 37:209-218.
-
(2009)
Altern. Lab. Anim.
, vol.37
, pp. 209-218
-
-
Vinken, M.1
Decrock, E.2
De Vuyst, E.3
Leybaert, L.4
Vanhaecke, T.5
Rogiers, V.6
-
211
-
-
58149390232
-
Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes
-
Walter D., et al. Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes. Hepatology 2008, 48:1942-1953.1.
-
(2008)
Hepatology
, vol.48
, pp. 1942-1953.1
-
-
Walter, D.1
-
212
-
-
84862943893
-
Immune mechanisms of concanavalin a model of autoimmune hepatitis
-
Wang H.X., et al. Immune mechanisms of concanavalin a model of autoimmune hepatitis. World J. Gastroenterol. 2012, 18:119-125.
-
(2012)
World J. Gastroenterol.
, vol.18
, pp. 119-125
-
-
Wang, H.X.1
-
213
-
-
0042904900
-
Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties
-
Wilkening S., Stahl F., Bader A. Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties. Drug Metab. Dispos. 2003, 31:1035-1042.
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 1035-1042
-
-
Wilkening, S.1
Stahl, F.2
Bader, A.3
-
214
-
-
84894079847
-
Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans
-
Williams C.D., Bajt M.L., Sharpe M.R., McGill M.R., Farhood A., Jaeschke H. Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans. Toxicol. Appl. Pharmacol. 2014, 275:122-133.
-
(2014)
Toxicol. Appl. Pharmacol.
, vol.275
, pp. 122-133
-
-
Williams, C.D.1
Bajt, M.L.2
Sharpe, M.R.3
McGill, M.R.4
Farhood, A.5
Jaeschke, H.6
-
215
-
-
84855750294
-
Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation
-
Williams C.D., Koerner M.R., Lampe J.N., Farhood A., Jaeschke H. Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation. Toxicol. Appl. Pharmacol. 2011, 257:449-458.
-
(2011)
Toxicol. Appl. Pharmacol.
, vol.257
, pp. 449-458
-
-
Williams, C.D.1
Koerner, M.R.2
Lampe, J.N.3
Farhood, A.4
Jaeschke, H.5
-
216
-
-
84907166516
-
Mechanisms of acetaminophen-induced cell death in primary human hepatocytes
-
Xie Y., McGill M.R., Dorko K., Kumer S.C., Schmitt T.M., Forster J., Jaeschke H. Mechanisms of acetaminophen-induced cell death in primary human hepatocytes. Toxicol. Appl. Pharmacol. 2014, 279:266-274.
-
(2014)
Toxicol. Appl. Pharmacol.
, vol.279
, pp. 266-274
-
-
Xie, Y.1
McGill, M.R.2
Dorko, K.3
Kumer, S.C.4
Schmitt, T.M.5
Forster, J.6
Jaeschke, H.7
-
217
-
-
79955701682
-
Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells
-
Yang X., Salminen W.F. Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells. Phytomedicine 2011, 18:592-600.
-
(2011)
Phytomedicine
, vol.18
, pp. 592-600
-
-
Yang, X.1
Salminen, W.F.2
-
218
-
-
77950620215
-
Lactoferrin protects against acetaminophen-induced liver injury in mice
-
Yin H., Cheng L., Holt M., Hail N., Maclaren R., Ju C. Lactoferrin protects against acetaminophen-induced liver injury in mice. Hepatology 2010, 51:1007-1016.
-
(2010)
Hepatology
, vol.51
, pp. 1007-1016
-
-
Yin, H.1
Cheng, L.2
Holt, M.3
Hail, N.4
Maclaren, R.5
Ju, C.6
-
219
-
-
0033607006
-
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
-
Yin X.M., et al. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 1999, 400:886-891.
-
(1999)
Nature
, vol.400
, pp. 886-891
-
-
Yin, X.M.1
-
220
-
-
0024596722
-
A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor
-
Yonehara S., Ishii A., Yonehara M. A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J. Exp. Med. 1989, 169:1747-1756.
-
(1989)
J. Exp. Med.
, vol.169
, pp. 1747-1756
-
-
Yonehara, S.1
Ishii, A.2
Yonehara, M.3
-
221
-
-
33746695454
-
Effects of dimethylsulfoxide on metabolism and toxicity of acetaminophen in mice
-
Yoon M.Y., Kim S.J., Lee B.H., Chung J.H., Kim Y.C. Effects of dimethylsulfoxide on metabolism and toxicity of acetaminophen in mice. Biol. Pharm. Bull. 2006, 29:1618-1624.
-
(2006)
Biol. Pharm. Bull.
, vol.29
, pp. 1618-1624
-
-
Yoon, M.Y.1
Kim, S.J.2
Lee, B.H.3
Chung, J.H.4
Kim, Y.C.5
-
222
-
-
37549048249
-
The BCL-2 protein family: opposing activities that mediate cell death
-
Youle R.J., Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 2008, 9:47-59.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 47-59
-
-
Youle, R.J.1
Strasser, A.2
-
223
-
-
33645765320
-
De-differentiation of primary human hepatocytes depends on the composition of specialized liver basement membrane
-
Zeisberg M., Kramer K., Sindhi N., Sarkar P., Upton M., Kalluri R. De-differentiation of primary human hepatocytes depends on the composition of specialized liver basement membrane. Mol. Cell. Biochem. 2006, 283:181-189.
-
(2006)
Mol. Cell. Biochem.
, vol.283
, pp. 181-189
-
-
Zeisberg, M.1
Kramer, K.2
Sindhi, N.3
Sarkar, P.4
Upton, M.5
Kalluri, R.6
-
224
-
-
73149094279
-
CpG ODN pretreatment attenuates concanavalin a-induced hepatitis in mice
-
Zhang H., et al. CpG ODN pretreatment attenuates concanavalin a-induced hepatitis in mice. Int. Immunopharmacol. 2010, 10:79-85.
-
(2010)
Int. Immunopharmacol.
, vol.10
, pp. 79-85
-
-
Zhang, H.1
-
225
-
-
84886563312
-
Protective effects of necrostatin-1 against concanavalin a-induced acute hepatic injury in mice
-
Zhou Y., et al. Protective effects of necrostatin-1 against concanavalin a-induced acute hepatic injury in mice. Mediat. Inflamm. 2013, 2013:706156.
-
(2013)
Mediat. Inflamm.
, vol.2013
, pp. 706156
-
-
Zhou, Y.1
-
226
-
-
0033596980
-
An APAF-1.Cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
-
Zou H., Li Y., Liu X., Wang X. An APAF-1.Cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 1999, 274:11549-11556.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 11549-11556
-
-
Zou, H.1
Li, Y.2
Liu, X.3
Wang, X.4
|