High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo

Toxicological Sciences

Volumn 112, Issue 2, 2009, Pages 521-531

  Antoine, Daniel J ^a   Williams, Dominic P ^a   Jenkins, Anja Kipar ^a   Regan, Sophie L ^a   Sathish, Jean G ^a   Kitteringham, Neil R ^a   Park, B Kevin ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Bioactivation; Biomarker; Caspase; Hepatotoxicity; Inflammation; ROC

Indexed keywords

ALANINE AMINOTRANSFERASE; CASPASE 3; CYTOKERATIN 18; HIGH MOBILITY GROUP B1 PROTEIN; PARACETAMOL; CASPASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HISTOPATHOLOGY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER TOXICITY; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; RECEIVER OPERATING CHARACTERISTIC; TANDEM MASS SPECTROMETRY; ACETYLATION; AMINO ACID SEQUENCE; ANIMAL; BLOOD; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; MALE; MOLECULAR GENETICS; NECROSIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; WESTERN BLOTTING;

ACETAMINOPHEN; ACETYLATION; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CHROMATOGRAPHY, LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HMGB1 PROTEIN; KERATIN-18; MALE; MICE; MOLECULAR SEQUENCE DATA; NECROSIS; TANDEM MASS SPECTROMETRY;

EID: 74949101589     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp235     Document Type: Article

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