Differential protection with inhibitors of caspase-8 and caspase-3 in murine models of tumor necrosis factor and fas receptor-mediated hepatocellular apoptosis

Toxicology and Applied Pharmacology

Volumn 175, Issue 3, 2001, Pages 243-252

  Bajt, Mary Lynn ^a   Vonderfecht, Steven L ^b   Jaeschke, Hartmut ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b PFIZER INC   (United States)

Author keywords

Caspase cascade; Caspase 3 inhibitor DEVD CHO; Caspase 8 inhibitor IETD CHO; Endotoxin; Fas induced liver failure; Liver failure; TNF induced apoptosis

Indexed keywords

ALANINE AMINOTRANSFERASE; CASPASE 3; CASPASE 9; CASPASE INHIBITOR; FAS ANTIGEN; GALACTOSAMINE; N ACETYLASPARTYLGLUTAMYLVALYLASPARTALDEHYDE; N ACETYLISOLEUCYLGLUTAMYLTHREONYLASPARTALDEHYDE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; LIVER INJURY; MALE; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION;

MURINAE;

EID: 0035884041     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2001.9242     Document Type: Article

References (34)

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