Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice

Hepatology

Volumn 38, Issue 2, 2003, Pages 355-363

  Gujral, Jaspreet S ^a,b   Farhood, Anwar ^c   Bajt, Mary Lynn ^a,b   Jaeschke, Hartmut ^a,b,d  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; BETA2 INTEGRIN; CD11B ANTIGEN; CD18 ANTIGEN; L SELECTIN; REACTIVE OXYGEN METABOLITE;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; CHOLESTASIS; CONTROLLED STUDY; HEPATITIS; IMMUNOHISTOCHEMISTRY; LIVER INJURY; MOUSE; NECROSIS; NEUTROPHIL; NONHUMAN; OBSTRUCTIVE BILE DUCT DISEASE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

EID: 0042766884     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2003.50341     Document Type: Article

References (50)

1. Hofmann AF. Cholestatic liver disease: pathophysiology and therapeutic options. Liver 2002;22(Suppl 2):14-19.
2. Scobie BA, Summerskill WHJ. Hepatic cirrhosis secondary to obstruction of the biliary system. Am J Dig Dis 1965;10:135-146.
3. Kountouras J, Billing BH, Scheuer PJ. Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. Br J Exp Pathol 1984;65:305-311.
4. Snover DC. Biopsy diagnosis of liver disease. Baltimore: Williams & Wilkins, 1992:92-111.
5. Parola M, Leonarduzzi G, Robino G, Albano E, Poli G, Dianzani MU. On the role of lipid peroxidation in the pathogenesis of liver damage induced by long-scanding cholescasis. Free Radic Biol Med 1996;20:351-359.
6. Koeppel TA, Trauner M, Bass JC, Thies JC, Schlosser SF, Post S, Gebhard MM, et al. Extrahepatic biliary obstruction impairs microvascular perfusion and increases leukocyte adhesion in rat liver. HEPATOLOGY 1997;26:1085-1091.
7. Saito JM, Maher JJ. Bile duct ligation in rats induces biliary expression of cytokine-induced neutrophil chemoattractant. Gastroenterology 2000;118:1157-1168.
8. Ito Y, Bethea NW, Baker GL, McCuskey MK, Urbaschek R, McCuskey RS. Hepatic microcirculatory dysfunction during cholestatic liver injury in rats. Microcirculation 2003 (in press).
9. Bemelmans MHA, Gouma DJ, Greve JW, Buurman WA. Cytokines tumor necrosis factor and interleukin-6 in experimental biliary obstruction in mice. HEPATOLOGY 1992;15:1132-1136.
10. Zhou W, Chao W, Levine BA, Olson MS. Role of platelet-activating factor in hepatic responses after bile duct ligation in rats. Am J Physiol 1992;263: G587-G592.
11. Levy R, Schlaeffer F, Keynan A, Nagauker O, Yaari A, Sikuler E. Increased neutrophil function induced by bile duct ligation in a rat model. HEPATOLOGY 1993;17:908-914.
12. Gulubova MV. Intercellular adhesion molecule-1 (ICAM-1) expressionin the liver of patients with extrahepatic cholestasis. Acta Histochem 1998;100:59-74.
13. Jaeschke H. Cellular adhesion molecules: regulation and functional significance in the pathogenesis of liver diseases. Am J Physiol 1997;273:G602-G611.
14. Lawson JA, Farhood A, Hopper RD, Bajt ML, Jaeschke H. The hepatic inflammatory response after acetaminophen overdose: role of neutrophils. Toxicol Sci 2000;54:509-516.
15. Maher JJ. Interactions between hepatic stellate cells and the immune system. Sem Liver Dis 2001;21:417-426.
16. Jaeschke H, Farhood A, Smith CW. Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. FASEB J 1990;4:3355-3359.
17. Jaeschke H, Farhood A, Smith CW: Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18 - dependent mechanism. Am J Physiol 1991;261:G1051-G1056.
18. Molnar RG, Wang P, Ayala A, Ganey PE, Roth RA, Chaudry IH. The role of neutrophils in producing hepatocellular dysfunction during the hyperdynamic stage of sepsis in rats. J Surg Res 1997;73:117-122.
19. Bautista AP. Chronic alcohol intoxication induces hepatic injury through enhanced macrophage inflammatory protein-2 production and intercellular adhesion molecule-1 expression in the liver. HEPATOLOGY 1997;25:335-342.
20. Hill J, Lindsay T, Rusche J, Valeri D, Shepro D, Hechtman HB. A Mac-1 antibody reduces liver and lung injury but not neutrophil sequestration after intestinal ischemia-reperfusion. Surgery 1992;112:166-172.
21. Vollmar B, Menger MD, Glasz J, Leiderer R, Messmer K. Impact of leukocyte-endothelial cell interaction in hepatic ischemia-reperfusion injury. Am J Physiol 1994;267:G786-G793.
22. Chosay JG, Essani NA, Dunn CJ, Jaeschke H. Neutrophil margination and extravasation in sinusoids and venules of the liver during endotoxin-induced injury. Am J Physiol 1997;272:G1195-G1200.
23. Jaeschke H, Smith CW. Mechanisms of neutrophil-induced parenchymal cell injury. J Leukoc Biol 1997;61:647-653.
24. Essani NA, Fisher MA, Farhood A, Manning AM, Smith CW, Jaeschke H. Cytokine-induced hepatic intercellular adhesion molecule-1 (ICAM-1) mRNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure. HEPATOLOGY 1995;21:1632-1639.
25. Essani NA, Bajt ML, Vonderfecht SL, Farhood A, Jaeschke H. Transcriptional activation of vascular cell adhesion molecule-1 (VCAM-1) gene in vivo and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock. J Immunol 1997;158:5941-5948.
26. Nagendra AR, Mickelson JK, Smith CW. CD18 integrin and intercellular adhesion molecule-1 (CD54)-dependent neutrophil adhesion to cytokine-stimulated human hepatocytes. Am J Physiol 1997;272: G408-G416.
27. Jaeschke H, Ho Y-S, Fisher MA, Lawson JA, Farhood A. Glutathione peroxidase deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress. HEPATOLOGY 1999;29:443-450.
28. Kushimoto S, Okajima K, Uchiba M, Murakami K, Harada N, Okabe H, Takatsuki K. Role of granulocyte elastase in ischemia/reperfusion injury of rat liver. Crit Care Med 1996;24:1908-1912.
29. Jaeschke H, Farhood A, Bautista AP, Spolarics Z, Spitzer JJ, Smith CW. Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver. HEPATOLOGY 1993;17:915-923.
30. Liu P, McGuire GM, Fisher MA, Farhood A, Smith CW, Jaeschke H. Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin-enhanced liver injury after hepatic ischemia. Shock 1995;3:56-62.
31. Kobayashi A, Imamura H, Isobe M, Matsuyama Y, Soeda J, Matsunaga K, Kawasaki S. Mac-1 (CD11b/CD18) and intercellular adhesion molecule-1 in ischemia-reperfusion injury of rat liver. Am J Physiol 2001;281:G577-G585.
32. Jaeschke H.Mechanisms of oxidant stress-induced acute tissue injury. Proc Soc Exp Biol Med 1995;209:104-111.
33. Domigan NM, Charlton TS, Duncan MW, Winterbourn CC, Kettle AJ. Chlorination of tyrosyl residues in peptides by myeloperoxidase and human neutrophils. J Biol Chem 1995;270:16542-16548.
34. Kettle AJ. Neutrophils convert ryrosyl residues in albumin to chlorotyrosine. FEBS Lett 1996;379:103-106.
35. Hazell LJ, Arnold L, Flowers D, Waeg G, Malle E, Stocker R. Presence of hypochlorite-modified proteins in human atherosclerotic lesions. J Clin Invest 1996;97:1535-1544.
36. Gujral JS, Hinson JA, Jaeschke H. Chlorotyrosine protein adducts are reliable biomarkers of neutrophil-induced cytotoxicity in vivo. Comp Hepatol 2003 (in press).
37. Wilson RW, Ballantyne CM, Smith CW, Montgomery C, Bradley A, O'Brien WE, Beaudet AL. Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol 1993;151:1571-1578.
38. Bajt ML, Farhood A, Jaeschke H. Effects of CXC chemokines on neutrophil activation and sequestration in the hepatic vasculature. Am J Physiol 2001;281:G1188-G1195.
39. Gujral JS, Bucci TJ, Farhood A, Jaeschke H. Mechanism of cell death during warm hepatic ischemia-reperfusion in rats: apoptosis or necrosis? HEPATOLOGY 2001;33:397-405.
40. Bajt ML, Lawson JA, Vonderfecht SL, Gujral JS, Jaeschke H. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for postmitochondrial processing of caspase-8. Toxicol Sci 2000;58:109-117.
41. Rensing H, Jaeschke H, Bauer I, Patau C, Datene V, Pannen BHJ, Bauer M. Differential activation pattern of redox-sensitive transcription factors and stress-inducible dilator systems HO-1 and iNOS in hemorrhagic and endotoxin shock. Crit Care Med 2001;29:1962-1971.
42. Lin M, Rippe RA, Niemela O, Brittenham G, Tsukamoto H. Role of iron in NF-κB activation and cytokine gene expression by rat hepatic macrophages. Am J Physiol 1997;272:G1355-G1364.
43. Witthaut R, Farhood A, Smith CW, Jaeschke H. Complement and tumor necrosis factor-α contribute to Mac-1 (CD11b/CD 18) up-regulation and systemic neutrophil activation during endotoxemia in vivo. J Leukoc Biol 1994;55:105-111.
44. Bautista AP, Spitzer JJ. Platelet activating factor stimulates and primes the liver, Kupffer cells and neutrophils to release superoxide anion. Free Radic Res Commun 1992;17:195-209.
45. Bautista AP, Meszaros K, Bojta J, Spitzer JJ. Superoxide anion generation in the liver during the early stage of endotoxemia in rats. J Leukoc Biol 1990;48:123-128.
46. Jaeschke H, Farhood A, Fisher MA, Smith CW. Sequestration of neutrophils in the hepatic vasculature during endotoxemia is independent of beta 2 integrins and intercellular adhesion molecule-1. Shock 1996;6:351-356.
47. Fox-Robichaud A, Kubes P. Molecular mechanisms of tumor necrosis factor α-stimulated leukocyte recruitment into the murine hepatic circulation. HEPATOLOGY 2000;31:1123-1127.
48. Smith CW, Marlin SD, Rothlein R, Toman C, Anderson DC. Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J Clin Invest 1989;83:2008-2017.
49. Lawson JA, Fisher MA, Simmons CA, Farhood A, Jaeschke H. Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models endotoxin- and Fas-antibody-mediated liver injury. HEPATOLOGY 1998;28:761-767.
50. Casini A, Ceni E, Salzano R, Biondi P, Parola M, Galli A, Foschi M, et al. Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells: role of nitric oxide. HEPATOLOGY 1997;25:361-377.