Mitochondrial Bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity

Journal of Pharmacology and Experimental Therapeutics

Volumn 324, Issue 1, 2008, Pages 8-14

  Bajt, Mary Lynn ^a,b   Farhood, Anwar ^c   Lemasters, John J ^d   Jaeschke, Hartmut ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c Brackenridge Hospital   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ALANINE AMINOTRANSFERASE; CELL NUCLEUS DNA; DNA FRAGMENT; ENDONUCLEASE; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; PARACETAMOL; PEROXYNITRITE; PROTEIN BAX; REACTIVE OXYGEN METABOLITE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CELL DEATH; CONTROLLED STUDY; CYTOSOL; DISEASE MODEL; DRUG OVERDOSE; IMMUNOHISTOCHEMISTRY; KNOCKOUT GENE; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN TRANSPORT;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; BCL-2-ASSOCIATED X PROTEIN; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; LIVER DISEASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA, LIVER; NECROSIS; PEROXYNITROUS ACID;

EID: 37349022256     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.129445     Document Type: Article

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