Comparative analysis of phase i and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism

Archives of Toxicology

Volumn 86, Issue 1, 2012, Pages 87-95

  Lin, Jie ^a,b   Schyschka, Lilianna ^a   Mühl Benninghaus, Ruben ^a   Neumann, Jan ^a   Hao, Liping ^c   Nussler, Natascha ^d   Dooley, Steven ^e   Liu, Liegang ^c   Stöckle, Ulrich ^a,f   Nussler, Andreas K ^a,f   Ehnert, Sabrina ^a,f  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b Shantou Centre for Disease Control and Prevention   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d Department of Surgery   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

^f UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Drug development; Drug induced liver damage; Hepatic cell lines; Hepatocytes

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; DICLOFENAC; DRUG METABOLIZING ENZYME; GLUTATHIONE; PARACETAMOL; VERAPAMIL;

ARTICLE; CELL DIFFERENTIATION; CELL LINE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG METABOLISM; ENZYME ACTIVITY; HEPATOMA CELL; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ACETAMINOPHEN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DICLOFENAC; HEPATOCYTES; HUMANS; ISOENZYMES; LIVER NEOPLASMS; OXIDATIVE STRESS; PHARMACEUTICAL PREPARATIONS; VERAPAMIL;

EID: 84856974159     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0733-y     Document Type: Article

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