Sensitive markers used to identify compounds that trigger apoptosis in cultured hepatocytes

Toxicological Sciences

Volumn 65, Issue 2, 2002, Pages 299-308

  Gómez Lechón, María José ^a   O'Connor, Enrique ^b   Castel, Josě Vicente ^a   Jover, Ramiro ^a  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Apoptosis sensitive markers; bclXL; Caspase 3; Cytochrome C; DNA analysis; DNA fragmentation; Flow cytometry; Hepatocytes; Toxicity

Indexed keywords

CAMPTOTHECIN; CASPASE 3; CURCUMIN; CYTOCHROME C; DNA; ETOPOSIDE; GALACTOSAMINE; HYDROPEROXIDE; LACTATE DEHYDROGENASE; PROTEIN BCL XL;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL DEATH; CELL MEMBRANE; CELL NUCLEUS; CELL VIABILITY; CHEMICAL INJURY; CHROMATIN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA DETERMINATION; DOWN REGULATION; DRUG SCREENING; ENZYME ACTIVATION; ENZYME RELEASE; FLOW CYTOMETRY; IN VITRO STUDY; LIVER CELL CULTURE; MALE; MITOCHONDRION; NONHUMAN; PARAMETER; RAT; RELIABILITY; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY;

ANIMALS; APOPTOSIS; BCL-X PROTEIN; BIOLOGICAL MARKERS; CAMPTOTHECIN; CASPASE 3; CASPASES; CELLS, CULTURED; CURCUMIN; CYTOCHROME C GROUP; DNA; DNA FRAGMENTATION; DOWN-REGULATION; ETOPOSIDE; FLOW CYTOMETRY; GALACTOSAMINE; HEPATOCYTES; MALE; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; TERT-BUTYLHYDROPEROXIDE; XENOBIOTICS;

ANIMALIA;

EID: 0036158769     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/65.2.299     Document Type: Article

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