Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells

Experimental Biology and Medicine

Volumn 240, Issue 2, 2015, Pages 261-272

  Tobwala, Shakila ^a   Khayyat, Ahdab ^a   Fan, Weili ^a   Ercal, Nuran ^a  

^a MISSOURI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (United States)

Author keywords

glutathione; Glutathione prodrug; mitochondria; N acetyl p benzoquinoneimine; oxidative stress

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; LACTATE DEHYDROGENASE; N ACETYLCYSTEINEAMIDE; PARACETAMOL; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANALGESIC AGENT; ANTIDOTE; N-ACETYLCYSTEINAMIDE; SCAVENGER;

ARTICLE; CELL CULTURE; CELL VIABILITY ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG COST; ENDOTHELIAL DYSFUNCTION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER PROTECTION; LIVER TOXICITY; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PROTEIN DETERMINATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ANALOGS AND DERIVATIVES; DRUG EFFECTS; DRUG OVERDOSE; LIVER CELL CARCINOMA; LIVER MITOCHONDRION; LIVER TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ACETAMINOPHEN; ACETYLCYSTEINE; ANALGESICS, NON-NARCOTIC; ANTIDOTES; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DRUG OVERDOSE; FREE RADICAL SCAVENGERS; HUMANS; LIPID PEROXIDATION; LIVER NEOPLASMS; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84922756226     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370214549520     Document Type: Article

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