Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: A valuable model for in vitro toxicity and drug-drug interaction studies

Chemico-Biological Interactions

Volumn 181, Issue 1, 2009, Pages 124-137

  Tuschl, Gregor ^a   Hrach, Jens ^a   Walter, Yvonne ^a   Hewitt, Philip G ^a   Mueller, Stefan O ^a,b  

^a Merck Serono GmbH   (Germany)

^b UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

Bile canaliculi; Cytochrome P450 induction; In vitro model; Primary hepatocytes; Real time PCR; Sandwich culture

Indexed keywords

ADENOSINE TRIPHOSPHATE; COLLAGEN; CYTOCHROME P450 1A; CYTOCHROME P450 2B; CYTOCHROME P450 2C; CYTOCHROME P450 3A; GLUTATHIONE; LACTATE DEHYDROGENASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SHAPE; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME RELEASE; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; LIVER CELL CULTURE; MALE; MONOLAYER CULTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT;

ANIMALS; BASE SEQUENCE; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; DNA PROBES; DRUG INTERACTIONS; GENE EXPRESSION PROFILING; HEPATOCYTES; MALE; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

RATTUS;

EID: 67650982782     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.05.015     Document Type: Article

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