Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway

European Journal of Pharmacology

Volumn 603, Issue 1-3, 2009, Pages 98-107

  Ma, Kuifen ^a,b   Zhang, Yuyu ^a   Zhu, Danyan ^a   Lou, Yijia ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b First Affiliated Hospital   (China)

Author keywords

Asiatic acid; D galactosamine lipopolysaccharide; Hepatotoxicity; Leukotriene C4 synthase; Redox

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ASIATIC ACID; ASPARTATE AMINOTRANSFERASE; GALACTOSAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTATE DEHYDROGENASE; LEUKOTRIENE C4 SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL PROTECTION; CELL VIABILITY; COCULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; KUPFFER CELL; LIVER CELL; LIVER TOXICITY; MALE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BUTADIENES; COCULTURE TECHNIQUES; ENZYME ACTIVATION; GALACTOSAMINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE TRANSFERASE; HEPATOCYTES; KUPFFER CELLS; LEUKOTRIENE C4; LIPOPOLYSACCHARIDES; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; NITRILES; OXIDATION-REDUCTION; PROLINE; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THIOCARBAMATES; TIME FACTORS; TRITERPENES;

EID: 58249144385     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.11.054     Document Type: Article

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