Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase

Toxicology and Applied Pharmacology

Volumn 281, Issue 1, 2014, Pages 58-66

  Du, Kuo ^a   Williams, C David ^a   McGill, Mitchell R ^a   Jaeschke, Hartmut ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Acetaminophen hepatotoxicity; C jun N terminal kinase; Gender difference; Glutathione; Oxidant stress; Protein adducts

Indexed keywords

3 NITROTYROSINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ESTRADIOL; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; PARACETAMOL; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; ANALGESIC AGENT; ANTHRACENE DERIVATIVE; PYRAZOLANTHRONE;

ACETAMINOPHEN OVERDOSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DRUG DETOXIFICATION; DRUG INTOXICATION; DRUG METABOLISM; ENZYME ACTIVATION; ESTROGEN THERAPY; FEMALE; INFANT; LIVER INJURY; LIVER MITOCHONDRION; LIVER PROTECTION; LIVER TOXICITY; MALE; METABOLIC ACTIVATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN FUNCTION; SEX DIFFERENCE; STAINING; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICAL AND DRUG INDUCED LIVER INJURY; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; SEXUAL DEVELOPMENT;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTHRACENES; CHEMICAL AND DRUG INDUCED LIVER INJURY; DISEASE SUSCEPTIBILITY; FEMALE; GLUTATHIONE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; SEX CHARACTERISTICS;

EID: 84908340821     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.09.002     Document Type: Article

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