C-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

Toxicology and Applied Pharmacology

Volumn 246, Issue 1-2, 2010, Pages 8-17

  Saito, Chieko ^a   Lemasters, John J ^b,c   Jaeschke, Hartmut ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Acetaminophen; Bax; Hepatotoxicity; JNK; Mitochondria; Oxidant stress; SP600125

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; APOPTOSIS INDUCING FACTOR; GLUTATHIONE DISULFIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PARACETAMOL; PEROXYNITRITE; PROTEIN BAX; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; LIVER INJURY; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN TRANSPORT;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTHRACENES; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; ENZYME ACTIVATION; ENZYME INDUCTION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, LIVER; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; PEROXYNITROUS ACID; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUBCELLULAR FRACTIONS; TRANSLOCATION, GENETIC;

ANIMALIA; MUS;

EID: 77953701589     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.04.015     Document Type: Article

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