Acetaminophen induces a caspase-dependent and Bcl-xL sensitive apoptosis in human hepatoma cells and lymphocytes

Pharmacology and Toxicology

Volumn 90, Issue 1, 2002, Pages 38-50

  Hamid Boulares, A ^a   Zoltoski, Anna J ^a   Stoica, Bogdan A ^a   Cuvillier, Olivier ^a   Smulson, Mark E ^a,b  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPYRETIC ANALGESIC AGENT; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; CYTOCHROME P450; DNA; DRUG METABOLITE; FAS ANTIGEN; LAMIN B; LIPOCORTIN 5; MEMBRANE PHOSPHOLIPID; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARACETAMOL; PROTEIN BCL XL;

APOPTOSIS; ARTICLE; CELL LABELING; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CLEAVAGE; DNA DEGRADATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; HEPATOMA CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LIVER TOXICITY; LYMPHOCYTE; MEMBRANE DAMAGE; MITOCHONDRION; NEPHROTOXICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN MODIFICATION;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; APOPTOSIS; CASPASES; CELL SURVIVAL; DNA FRAGMENTATION; ENZYME ACTIVATION; HUMANS; LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 0036181938     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0773.2002.900108.x     Document Type: Article

References (64)

1. Human ICE/CED-3 protease nomenclature
2. Acetaminophen inhibits NF-κB activation by interfering with the oxidant signal in murine Hepa 1-6 cells
3. Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase in an amplification phase of TNF-induced apoptosis
4. Role of poly(ADP-ribose) polymerase cleavage in apoptosis: Caspase 3 resistant poly(ADP-ribose) polymerase mutant increases rates of apoptosis in transfected cells
5. Modulation of serum growth factor signal transduction in Hepa 1-6 cells by acetaminophen: An inhibition of c-myc expression, NF-κB activation, and Raf-1 kinase activity
6. Testicular atrophy from analgesic drugs
7. Inhibition of protein phosphatase activity and changes in protein phosphorylation following acetaminophen exposure in cultured mouse hepatocytes
8. Role of specific apoptotic pathways in the restoration of paclitaxel- induced apoptosis by valspodar in doxorubicin-resistant MCF-7 breast cancer cells
9. BCL-2 family: Regulators of cell death
10. Caspases: The executioners of apoptosis
11. Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes
12. Selective protein covalent binding and target organ toxicity
13. Proteases to die for
14. Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells
15. N-acetyl-p-benzoquinone imine: A cytochrome P-450-mediated oxidation product of acetaminophen
16. Cytotoxicity of acetaminophen in human cytochrome P450E1-transfected Hep2G cells
17. Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptosis
18. More than one way to die: Apoptosis, necrosis and reactive oxygen damage
19. Molecular determinants of apoptosis induced by cytotoxic drugs
20. Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells
21. NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-alpha and Fas ligation: The role of reactive oxygen species
22. Mitochondria and apoptosis
23. Cell membrane permeabilization and cellular collapse, followed by loss of dehydrogenase activity: Early events in tumour necrosis factor-induced cytotoxicity
24. BCL-2 family members and the mitochondria in apoptosis
25. Activation and localization of transcription factor, nuclear factor-κB, in asthma
26. Toxic effects of paracetamol and related structures in V79 Chinese hamster cells
27. Acetaminophen metabolism and cytotoxicity in PC12 cells transfected with cytochrome P4502E1
28. Paracetamol inhibits replicative DNA synthesis and induces sister chromatid exchange and chromosomal aberrations by inhibition of ribonucleotide reductase
29. Inhibition of replicative DNA synthesis by paracetamol in V79 Chinese hamster cells
30. Genotoxic effects of paracetamol in V79 Chinese hamster cells
31. Genotoxicity of paracetamol in mice and rats
32. Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4
33. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
34. Apoptosis in human hepatoma cell lines by chemotherapeutic drugs via Fas-dependent and Fas-independent pathways
35. Apoptosis. Molecules and mechanisms
36. Large-scale fragmentation of mammalian DNA in the course of apoptosis proceeds via excision of chromosomal DNA loops and their oligomers
37. Inhibition of Fas receptor (CD95)-induced hepatic caspase activation and apoptosis by acetaminophen in mice
38. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
39. The regulation and biological activity of interleukin 12
40. Mechanisms of liver damage
41. Apoptosis induced by a chimeric Fas/FLICE receptor: Lack of requirement for Fas- or FADD-binding proteins
42. Degradation of lamin. B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei
43. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
44. Interferon-gamma modulates a p53-independent apoptotic pathway and apoptosis-related gene expression
45. Ultrastructural changes during acute acetaminophen-induced hepatotoxicity in the mouse: A time and dose study
46. Lamin. Proteolysis facilitates nuclear events during apoptosis
47. A hepatotoxic dose of acetaminophen modulates expression of BCL-2, BCL- X(L), and BCL-X(S) during apoptotic and necrotic death of mouse liver cells in vivo
48. A novel proanthocyanidin IH636 grape seed extract increases in vivo Bcl- XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver
49. 2+ in the nucleus during acetaminophen-induced liver injury
50. 2+ in vivo early after hepatotoxic acetaminophen overdose in mice
51. Acetaminophen inhibits iNOS gene expression in RAW 264.7 macrophages: Differential regulation of NF-κB by acetaminophen and salicylates
52. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
53. Two CD95 (APO-1/Fas) signaling pathways
54. Different cleavage pattern for poly(ADP-ribose) polymerase during necrosis and apoptosis in HL-60 cells
55. 2+ accumulation and early DNA fragmentation with cell death
56. 2+-endonuclease, DNA repair, and glutathione depletion inhibitors on DNA fragmentation and cell death
57. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
58. Irreversible binding of poly(ADP)ribose polymerase cleavage product to DNA ends revealed by atomic force microscopy: Possible role in apoptosis
59. Glutathione synthetase-deficient lymphocytes and acetaminophen toxicity
60. Cleavage of lamin. A by Mch2 alpha but not CPP32: Multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis
61. New aspects of the mechanism of DNA fragmentation in apoptosis
62. Paracetamol inhibits cell cycling and induces apoptosis in HL-60 cells
63. Effects of acetaminophen and hydroxyurea on spermatogenesis and sperm chromatin structure in laboratory mice
64. Acetaminophen cytotoxicity in mouse eye: Mitochondria in anterior tissues are the primary target