Transcriptional Activation of Vascular Cell Adhesion Molecule-1 Gene In Vivo and Its Role in the Pathophysiology of Neutrophil-Induced Liver Injury in Murine Endotoxin Shock

Journal of Immunology

Volumn 158, Issue 12, 1997, Pages 5941-5948

  Essani, Naeem A ^a   Bajt, Mary Lynn ^a   Farhood, Anwar ^b   Vonderfecht, Steven L ^a   Jaeschke, Hartmut ^a  

^a PFIZER INC   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL; ARTICLE; C3H MOUSE; GENETICS; IMMUNOLOGY; LIVER; LIVER DISEASE; MALE; MOUSE; NECROSIS; NEUTROPHIL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SEPTIC SHOCK; TRANSACTIVATION;

ANIMALS; LIVER; LIVER DISEASES; MALE; MICE; MICE, INBRED C3H; NECROSIS; NEUTROPHILS; RNA, MESSENGER; SHOCK, SEPTIC; TRANS-ACTIVATION (GENETICS); VASCULAR CELL ADHESION MOLECULE-1;

EID: 0031570450     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Osborn, L., C. Hession, R. Tizard, C. Vassallo, S. Luhowskyi, G. Chi-Rosso, and R. Lobb. 1989. Direct cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell 59:1203.
2. Elices, M. J., Osborn, L., Y. Takada, C. Crouse, S. Luhowskyi, M. E. Hemler, and R. R. Lobb. 1990. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 60:577.
3. Chuluyan, H. E., and A. C. Issekutz. 1993. VLA-4 integrin can mediate CD11/ CD18-independent transendothelial migration of human monocytes. J. Clin. Invest. 92:2768.
4. 1) integrin receptors on T cells. Nature 345:250.
5. Bochner, B. S., F. W. Luscinskas, M. A. Gimbrone, Jr., W. Newman, S. A. Sterbinsky, C. P. Derse-Anthony, D. Klunk, and R. P. Schleimer. 1991. Adhesion of human basophils, eosinophils, and neutrophils to IL 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. J. Exp. Med. 173:1553.
6. Carlos, T. M., B. R. Schwartz, N. L. Kovach, E. Yee, M. Rosa, L. Osborn, G. Chi-Rosso, R. Lobb, and J. M. Harlan. 1990. Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells. Blood 76:965.
7. Meerschaert, J., and M. B. Furie. 1994. Monocytes use either CD11/CD18 or VLA-4 to migrate across human endothelium in vitro. J. Immunol. 152:1915.
8. Chan, P. Y., and A. Aruffo. 1993. VLA-4 integrin mediates lymphocyte migration on the inducible endothelial cell ligand VCAM-1 and the extracellular matrix ligand fibronectin. J. Biol. Chem. 268:24655.
9. 2 integrins. J. Cell Biol. 125:1417.
10. Van Dinther-Janssen, A. C. H. M., E. Horst, G. Koopman, W. Newmann, R. J. Scheper, C. J. L. M. Meijer, and S. T. Pals. 1991. The VLA-4/VCAM-1 pathway is involved in lymphocyte adhesion to endothelium in rheumatoid synovium. J. Immunol. 147:4207.
11. Oppenheimer-Marks, N., L. S. Davis, D. Tompkins-Bogue, J. Ramberg, and P. E. Lipsky. 1991. Different utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes. J. Immunol. 147:2913.
12. Winn, R. K., and J. M. Harlan. 1993. CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits. J. Clin. Invest. 92: 1168.
13. 4 integrins in vivo. J. Clin. Invest. 94:1722.
14. Issekutz, T. B. 1995. In vivo blood monocyte migration to acute inflammatory reactions, IL-1α, TNF-α, IFN-γ, and C5a utilizes LFA-1, Mac-1 and VLA-4: the relative importance of each integrin. J. Immunol. 154:6533.
15. Issekutz, A. C., and T. B. Issekutz. 1995. Monocyte migration to arthritis in the rat utilizes both CD11/CD18 and VLA-4 integrin mechanisms. J. Exp. Med. 181:1197.
16. 1-dependent adhesion pathway on neutrophils: a mechanism invoked by dihydrocytochalasin B or endothelial transmigration. FASEB J. 9:1103.
17. Issekutz, T. B., M. Miyasaka, and A. C. Issekutz. 1996. Rat blood neutrophils express very late Ag 4 and it mediates migration to arthritic joint and dermal inflammation. J. Exp. Med. 183:2175.
18. Jaeschke, H., A. Farhood, and C. W. Smith. 1990. Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. FASEB J. 4:3355.
19. Jaeschke, H., A. Farhood, and C. W. Smith. 1991. Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18-dependent mechanism. Am. J. Physiol 261:G1051.
20. Jaeschke, H., A. Farhood, A. P. Bautista, Z. Spolarics, J. J. Spitzer, and C.W. Smith. 1993. Functional inactivation of neutrophils with a Mac-1 (CD11b/ CD18) mAb protects against ischemia-reperfusion injury in rat liver. Hepatology 17:915.
21. Essani, N. A., M. A. Fisher, A. Farhood, A. M. Manning, C. W. Smith, and H. Jaeschke. 1995. Cytokine-induced hepatic intercellular adhesion molecule-1 (ICAM-1) mRNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure. Hepatology 21:1632.
22. Witthaut, R., A. Farhood, C. W. Smith, and H. Jaeschke. 1994. Complement and TNF-α contribute to Mac-1 (CD11b/CD18) up-regulation and systemic neutrophil activation during endotoxemia in vivo. J. Leukocyte Biol. 55:105.
23. Farhood, A., G. M. McGuire, A. M. Manning, M. Miyasaka, C. W. Smith, and H. Jaeschke. 1995. Intercellular adhesion molecule-1 (ICAM-1) expression and its role in neutrophil-induced ischemia-reperfusion injury in rat liver. J. Leukocyte Biol. 57:368.
24. Essani, N. A., G. M. McGuire, A. M. Manning, and H. Jaeschke. 1995. Differential induction of mRNA for ICAM-1 and selectins in hepatocytes, Kupffer cells and endothelial cells during endotoxemia. Biochem. Biophys. Res. Commun. 211: 74.
25. Nanji, A. A., B. Griniuviene, L. K. Yacoub, F. Fogt, and S. R. Tahan. 1995. Intercellular adhesion molecule-1 expression in experimental alcoholic liver disease: relationship to endotoxemia and TNF-α messenger RNA. Exp. Mol. Pathol. 62:42.
26. Jaeschke, H., N. A. Essani, M. A. Fisher, S. L. Vonderfecht, A. Farhood, and C. W. Smith. 1996. Release of soluble intercellular adhesion molecule 1 into bile and serum in murine endotoxin shock. Hepatology 23:530.
27. Liu, P., G. M. McGuire, M. A. Fisher, A. Farhood, C. W. Smith, and H. Jaeschke. 1995. Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible tor endotoxin-enhanced liver injury after hepatic ischemia. Shock 3:56.
28. 2 integrins and intercellular adhesion molecule-1. Shock 6:345.
29. Jaeschke, H., C. W. Smith, M. G. Clemens, P. E. Ganey, and R. A. Roth. 1996. Mechanisms of inflammatory liver injury: adhesion molecules and cytotoxicity of neutrophils. Toxicol. Appl. Pharmacol. 139:213.
30. Maroushek-Boury, N., and C. J. Czuprynski. 1995. Listeria monocytogenes infection increases neutrophil adhesion and damage to a murine hepatocyte cell line in vitro. Immunol. Lett. 46:111.
31. Chomczynski, P., and N. Sacchi. 1987. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156.
32. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual, 2nd Ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
33. Hession, C. P. Moy, R. Tizard, P. Chisholm, C. Williams, M. Wysk, L. Burkly, K. Miyake, P. Kincade, and R. Lobb. 1992. Cloning of murine and rat vascular cell adhesion molecule-1. Biochem. Biophys. Res. Commun. 183:163.
34. Griffin, R. L., R. F. Krzesicki, S. F. Fidler, C. L. Rosenbloom, J. A. Auchampach, A. M. Manning, J. V. Haas, S. K. Cammarata, J. E. Chin, and I. M. Richards. 1994. Attenuation of oxidant-induced lung injury by 21-aminosteroids (lazaroids): correlation with the mRNA expression for E-selectin, P-selectin, ICAM-1 and VCAM-1. Env. Health Persp. 102:193.
35. Ruco, L. P., and M. S. Meltzer. 1978. Defective tumoricidal capacity of macrophages from C3H/HeJ mice. J. Immunol. 120:329.
36. Beutler, B., N. Krochin, I. W. Milsark, C. Luedke, and A. Cerami. 1986. Control of cachectin (TNF) synthesis: mechanism of endotoxin resistance. Science 232: 977.
37. Essani, N. A., G. M. McGuire, A. M. Manning, and H. Jaeschke. 1996. Endotoxin-induced activation of the nuclear transcription factor κB and expression of E-selectin messenger RNA in hepatocytes, Kupffer cells, and endothelial cells in vivo. J. Immunol. 156:2956.
38. Essani, N. A., M. A. Fisher, and H. Jaeschke. 1997. Inhibition of NF-κB activation by dimethyl sulfoxide correlates with suppression of TNF-α formation, reduced ICAM-1 gene transcription and protection against endotoxin-induced liver injury. Shock 7:90.
39. Bacchi, C. E., C. L. Marsh, J. D. Perkins, R. L. Carithers, Jr., J. P. McVicar, K. L. Hudkins, C. D. Benjamin, J. M. Harlan, R. Lobb, and C. E. Alpers. 1993. Expression of vascular cell adhesion molecule (VCAM-1) in liver and pancreas allograft rejection. Am. J. Pathol. 142:579.
40. Volpes, R., J. J. Van den Oord, and V. J. Desmet. 1992. Vascular adhesion molecules in acute and chronic liver inflammation. Hepatology 15:269.
41. Adams, D. H., P. Burra, S. G. Hubscher, E. Elias, and W. Newman. 1994. Endothelial activation and circulating vascular adhesion molecules in alcoholic liver disease. Hepatology 19:588.
42. Watanabe, Y., M. Morito, N. Ikematsu, and T. Akaike. 1995. Tumor necrosis factor-α and IL-1β but not IFNγ induce vascular cell adhesion molecule-1 expression on primary cultured murine hepatocytes. Biochem. Biophys. Res. Commun. 209:335.
43. Haraldsen, G., D. Kvale, B. Lien, I. N. Farstad, and P. Brandtzaeg. 1996. Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells. J. Immunol. 156:2558.
44. Iademarco, M. F., J. J. McQuilla, G. D. Rosen, and D. C. Dean. 1992. Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1). J. Biol. Chem. 267:16323.
45. Neish, A. S., A. J. Williams, H. J. Palmer, M. Z. Whitley, and T. Collins. 1992. Functional analysis of the human vascular cell adhesion molecule-1 promoter. J. Exp. Med. 176:1583.
46. 1-integrin (CD29) mechanisms. Immunology 85:485.
47. 1 (CD29) integrins VLA-5 and VLA-6. Cell. Immunol. 163:178.
48. Issekutz, A. C., H. E. Chuluyan, and N. Lopes. 1995. CD11/CD18-independent transendothelial migration of human polymorphonuclear leukocytes and monocytes: involvement of distinct and unique mechanisms. J. Leukocyte Biol. 57:553.
49. Chosay, J. G., N. A. Essani, C. J. Dunn, and H. Jaeschke. 1997. Neutrophil margination and extravasation in sinusoids and venules of the liver during endotoxin-induced injury. Am. J. Physiol. In press.
50. Pilaro, A. M., and D. L. Laskin. 1986. Accumulation of activated mononuclear phagocytes in the liver following LPS treatment in rats. J. Leukocyte Biol. 40:29.
51. Tanaka, Y., K. Kobayashi, A. Takahashi, I. Arai, S. Higuchi, S. Otomo, S. Habu, and T. Nishimura. 1993. Inhibition of inflammatory liver injury by a mAb against lymphocyte function-associated antigen-1. J. Leukocyte Biol. 151:5088.
52. Mochida, S., A. Ohno, M. Arai, T. Tamatani, M. Miyasaka, and K. Fujiwara. 1996. Role of adhesion molecules in the development of massive hepatic necrosis in rats. Hepatology 23:320.
53. Thornton, A. J., J. Ham, and S. L. Kunkel. 1992. Kupffer cell-derived cytokines induce the synthesis of a leukocyte chemotactic peptide, IL-8, in human hepatoma and primary hepatocyte culture. Hepatology 15:1112.
54. Colletti, L. M., S. L. Kunkel, A. Walz, M. D. Burdick, R. G. Kunkel, C. A. Wilke, and R. M. Strieter. 1996. The role of cytokine networks in the local liver injury following hepatic ischemia/reperfusion in the rat. Hepatology 23:506.
55. Zhang, P., M. Xie, J. Zagorski, and J. A. Spitzer. 1995. Attenuation of hepatic neutrophil sequestration by anti-CINC Ab in endotoxic rats. Shock 4:262.
56. Essani, N. A., D. A. Remick, M. A. Fisher, and H. Jaeschke. 1996. Galactosamine primes the liver for enhanced production of the chemokine KC/gro during endotoxin shock. Shock 5(Suppl.):23 (Abstr.).
57. Leist, M., F. Gantner, I. Bohlinger, G. Tiegs, P. G. Germann, and A. Wendel. 1995. Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am. J. Pathol. 146:1220.