-
1
-
-
0034808023
-
Caspase activation correlates with the degree of inflammatory liver injury in chronic hepatitis C virus infection
-
Bantel H., Lugering A., Poremba C., Lugering N., Held J., Domschke W., Schulze-Osthoff K. Caspase activation correlates with the degree of inflammatory liver injury in chronic hepatitis C virus infection. Hepatology 2001, 34:758-767.
-
(2001)
Hepatology
, vol.34
, pp. 758-767
-
-
Bantel, H.1
Lugering, A.2
Poremba, C.3
Lugering, N.4
Held, J.5
Domschke, W.6
Schulze-Osthoff, K.7
-
2
-
-
34250016249
-
Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury
-
Beraza N., Ludde T., Assmus U., Roskams T., Vander Borght S., Trautwein C. Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury. Gastroenterology 2007, 132:2504-2517.
-
(2007)
Gastroenterology
, vol.132
, pp. 2504-2517
-
-
Beraza, N.1
Ludde, T.2
Assmus, U.3
Roskams, T.4
Vander Borght, S.5
Trautwein, C.6
-
3
-
-
68149171396
-
Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage
-
Beraza N., Malato Y., Sander L.E., Al-Masaoudi M., Freimuth J., Riethmacher D., Gores G.J., Roskams T., Liedtke C., Trautwein C. Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage. J. Exp. Med. 2009, 206:1727-1737.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1727-1737
-
-
Beraza, N.1
Malato, Y.2
Sander, L.E.3
Al-Masaoudi, M.4
Freimuth, J.5
Riethmacher, D.6
Gores, G.J.7
Roskams, T.8
Liedtke, C.9
Trautwein, C.10
-
4
-
-
42549144094
-
Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis
-
Beraza N., Malato Y., Vander Borght S., Liedtke C., Wasmuth H.E., Dreano M., de Vos R., Roskams T., Trautwein C. Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis. Gut 2008, 57:655-663.
-
(2008)
Gut
, vol.57
, pp. 655-663
-
-
Beraza, N.1
Malato, Y.2
Vander Borght, S.3
Liedtke, C.4
Wasmuth, H.E.5
Dreano, M.6
de Vos, R.7
Roskams, T.8
Trautwein, C.9
-
5
-
-
0042466637
-
Interdimer processing mechanism of procaspase-8 activation
-
Chang D.W., Xing Z., Capacio V.L., Peter M.E., Yang X. Interdimer processing mechanism of procaspase-8 activation. EMBO J. 2003, 22:4132-4142.
-
(2003)
EMBO J.
, vol.22
, pp. 4132-4142
-
-
Chang, D.W.1
Xing, Z.2
Capacio, V.L.3
Peter, M.E.4
Yang, X.5
-
6
-
-
66449133280
-
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
-
Cho Y.S., Challa S., Moquin D., Genga R., Ray T.D., Guildford M., Chan F.K. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 2009, 137:1112-1123.
-
(2009)
Cell
, vol.137
, pp. 1112-1123
-
-
Cho, Y.S.1
Challa, S.2
Moquin, D.3
Genga, R.4
Ray, T.D.5
Guildford, M.6
Chan, F.K.7
-
7
-
-
0025053246
-
Heterologous protein expression by transimmortalized differentiated liver cell lines derived from transgenic mice (hepatomas/alpha 1 antitrypsin/ONC mouse)
-
Dalemans W., Perraud F., Le Meur M., Gerlinger P., Courtney M., Pavirani A. Heterologous protein expression by transimmortalized differentiated liver cell lines derived from transgenic mice (hepatomas/alpha 1 antitrypsin/ONC mouse). Biologicals 1990, 18:191-198.
-
(1990)
Biologicals
, vol.18
, pp. 191-198
-
-
Dalemans, W.1
Perraud, F.2
Le Meur, M.3
Gerlinger, P.4
Courtney, M.5
Pavirani, A.6
-
8
-
-
33845398930
-
An interferon-sensitive response element is involved in constitutive caspase-8 gene expression in neuroblastoma cells
-
De Ambrosis A., Casciano I., Croce M., Pagnan G., Radic L., Banelli B., Di Vinci A., Allemanni G., Tonini G.P., Ponzoni M., et al. An interferon-sensitive response element is involved in constitutive caspase-8 gene expression in neuroblastoma cells. Int. J. Cancer 2007, 120:39-47.
-
(2007)
Int. J. Cancer
, vol.120
, pp. 39-47
-
-
De Ambrosis, A.1
Casciano, I.2
Croce, M.3
Pagnan, G.4
Radic, L.5
Banelli, B.6
Di Vinci, A.7
Allemanni, G.8
Tonini, G.P.9
Ponzoni, M.10
-
9
-
-
0348134733
-
Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice
-
Feldstein A.E., Canbay A., Guicciardi M.E., Higuchi H., Bronk S.F., Gores G.J. Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice. J. Hepatol. 2003, 39:978-983.
-
(2003)
J. Hepatol.
, vol.39
, pp. 978-983
-
-
Feldstein, A.E.1
Canbay, A.2
Guicciardi, M.E.3
Higuchi, H.4
Bronk, S.F.5
Gores, G.J.6
-
10
-
-
3042824524
-
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
-
Feldstein A.E., Werneburg N.W., Canbay A., Guicciardi M.E., Bronk S.F., Rydzewski R., Burgart L.J., Gores G.J. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 2004, 40:185-194.
-
(2004)
Hepatology
, vol.40
, pp. 185-194
-
-
Feldstein, A.E.1
Werneburg, N.W.2
Canbay, A.3
Guicciardi, M.E.4
Bronk, S.F.5
Rydzewski, R.6
Burgart, L.J.7
Gores, G.J.8
-
11
-
-
0344825070
-
AS602868, a pharmacological inhibitor of IKK2, reveals the apoptotic potential of TNF-alpha in Jurkat leukemic cells
-
Frelin C., Imbert V., Griessinger E., Loubat A., Dreano M., Peyron J.F. AS602868, a pharmacological inhibitor of IKK2, reveals the apoptotic potential of TNF-alpha in Jurkat leukemic cells. Oncogene 2003, 22:8187-8194.
-
(2003)
Oncogene
, vol.22
, pp. 8187-8194
-
-
Frelin, C.1
Imbert, V.2
Griessinger, E.3
Loubat, A.4
Dreano, M.5
Peyron, J.F.6
-
12
-
-
39749101215
-
A promoter polymorphism in the CASP8 gene is not associated with cancer risk
-
author reply 251-260
-
Haiman C.A., Garcia R.R., Kolonel L.N., Henderson B.E., Wu A.H., Le Marchand L. A promoter polymorphism in the CASP8 gene is not associated with cancer risk. Nat. Genet. 2008, 40:259-260. author reply 251-260.
-
(2008)
Nat. Genet.
, vol.40
, pp. 259-260
-
-
Haiman, C.A.1
Garcia, R.R.2
Kolonel, L.N.3
Henderson, B.E.4
Wu, A.H.5
Le Marchand, L.6
-
13
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
14
-
-
66749183275
-
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha
-
He S., Wang L., Miao L., Wang T., Du F., Zhao L., Wang X. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 2009, 137:1100-1111.
-
(2009)
Cell
, vol.137
, pp. 1100-1111
-
-
He, S.1
Wang, L.2
Miao, L.3
Wang, T.4
Du, F.5
Zhao, L.6
Wang, X.7
-
15
-
-
0033537767
-
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase
-
Hu Y., Baud V., Delhase M., Zhang P., Deerinck T., Ellisman M., Johnson R., Karin M. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science 1999, 284:316-320.
-
(1999)
Science
, vol.284
, pp. 316-320
-
-
Hu, Y.1
Baud, V.2
Delhase, M.3
Zhang, P.4
Deerinck, T.5
Ellisman, M.6
Johnson, R.7
Karin, M.8
-
16
-
-
79952811804
-
RIP3 mediates the embryonic lethality of caspase-8-deficient mice
-
Kaiser W.J., Upton J.W., Long A.B., Livingston-Rosanoff D., Daley-Bauer L.P., Hakem R., Caspary T., Mocarski E.S. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 2011, 471:368-372.
-
(2011)
Nature
, vol.471
, pp. 368-372
-
-
Kaiser, W.J.1
Upton, J.W.2
Long, A.B.3
Livingston-Rosanoff, D.4
Daley-Bauer, L.P.5
Hakem, R.6
Caspary, T.7
Mocarski, E.S.8
-
17
-
-
77953859606
-
NF-kappaB as a critical link between inflammation and cancer
-
Karin M. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol 2009, 1:a000141.
-
(2009)
Cold Spring Harb Perspect Biol
, vol.1
-
-
Karin, M.1
-
18
-
-
0034903710
-
Prevention of fat-induced insulin resistance by salicylate
-
Kim J.K., Kim Y.J., Fillmore J.J., Chen Y., Moore I., Lee J., Yuan M., Li Z.W., Karin M., Perret P., et al. Prevention of fat-induced insulin resistance by salicylate. J. Clin. Invest. 2001, 108:437-446.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 437-446
-
-
Kim, J.K.1
Kim, Y.J.2
Fillmore, J.J.3
Chen, Y.4
Moore, I.5
Lee, J.6
Yuan, M.7
Li, Z.W.8
Karin, M.9
Perret, P.10
-
19
-
-
0033621839
-
NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis
-
Kuhnel F., Zender L., Paul Y., Tietze M.K., Trautwein C., Manns M., Kubicka S. NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis. J. Biol. Chem. 2000, 275:6421-6427.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 6421-6427
-
-
Kuhnel, F.1
Zender, L.2
Paul, Y.3
Tietze, M.K.4
Trautwein, C.5
Manns, M.6
Kubicka, S.7
-
20
-
-
33746709906
-
Intrahepatic activation of caspases in human fulminant hepatic failure
-
Leifeld L., Nattermann J., Fielenbach M., Schmitz V., Sauerbruch T., Spengler U. Intrahepatic activation of caspases in human fulminant hepatic failure. Liver Int. 2006, 26:872-879.
-
(2006)
Liver Int.
, vol.26
, pp. 872-879
-
-
Leifeld, L.1
Nattermann, J.2
Fielenbach, M.3
Schmitz, V.4
Sauerbruch, T.5
Spengler, U.6
-
21
-
-
0033532386
-
The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis
-
Li Z.W., Chu W., Hu Y., Delhase M., Deerinck T., Ellisman M., Johnson R., Karin M. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J. Exp. Med. 1999, 189:1839-1845.
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1839-1845
-
-
Li, Z.W.1
Chu, W.2
Hu, Y.3
Delhase, M.4
Deerinck, T.5
Ellisman, M.6
Johnson, R.7
Karin, M.8
-
22
-
-
0042346302
-
The human caspase-8 promoter sustains basal activity through SP1 and ETS-like transcription factors and can be up-regulated by a p53-dependent mechanism
-
Liedtke C., Groger N., Manns M.P., Trautwein C. The human caspase-8 promoter sustains basal activity through SP1 and ETS-like transcription factors and can be up-regulated by a p53-dependent mechanism. J. Biol. Chem. 2003, 278:27593-27604.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 27593-27604
-
-
Liedtke, C.1
Groger, N.2
Manns, M.P.3
Trautwein, C.4
-
23
-
-
30344462991
-
Interferon-alpha enhances TRAIL-mediated apoptosis by up-regulating caspase-8 transcription in human hepatoma cells
-
Liedtke C., Groger N., Manns M.P., Trautwein C. Interferon-alpha enhances TRAIL-mediated apoptosis by up-regulating caspase-8 transcription in human hepatoma cells. J. Hepatol. 2006, 44:342-349.
-
(2006)
J. Hepatol.
, vol.44
, pp. 342-349
-
-
Liedtke, C.1
Groger, N.2
Manns, M.P.3
Trautwein, C.4
-
24
-
-
35948952340
-
Molecular mechanism of Mitomycin C-dependent caspase-8 regulation: implications for apoptosis and synergism with interferon-alpha signalling
-
Liedtke C., Lambertz D., Schnepel N., Trautwein C. Molecular mechanism of Mitomycin C-dependent caspase-8 regulation: implications for apoptosis and synergism with interferon-alpha signalling. Apoptosis 2007, 12:2259-2270.
-
(2007)
Apoptosis
, vol.12
, pp. 2259-2270
-
-
Liedtke, C.1
Lambertz, D.2
Schnepel, N.3
Trautwein, C.4
-
25
-
-
27744513584
-
Silencing of caspase-8 in murine hepatocellular carcinomas is mediated via methylation of an essential promoter element
-
Liedtke C., Zschemisch N.H., Cohrs A., Roskams T., Borlak J., Manns M.P., Trautwein C. Silencing of caspase-8 in murine hepatocellular carcinomas is mediated via methylation of an essential promoter element. Gastroenterology 2005, 129:1602-1615.
-
(2005)
Gastroenterology
, vol.129
, pp. 1602-1615
-
-
Liedtke, C.1
Zschemisch, N.H.2
Cohrs, A.3
Roskams, T.4
Borlak, J.5
Manns, M.P.6
Trautwein, C.7
-
26
-
-
20144388823
-
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury
-
Luedde T., Assmus U., Wustefeld T., Meyer zu Vilsendorf A., Roskams T., Schmidt-Supprian M., Rajewsky K., Brenner D.A., Manns M.P., Pasparakis M., et al. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J. Clin. Invest. 2005, 115:849-859.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 849-859
-
-
Luedde, T.1
Assmus, U.2
Wustefeld, T.3
Meyer zu Vilsendorf, A.4
Roskams, T.5
Schmidt-Supprian, M.6
Rajewsky, K.7
Brenner, D.A.8
Manns, M.P.9
Pasparakis, M.10
-
27
-
-
33846839443
-
Deletion of NEMO/IKK gamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma
-
Luedde T., Beraza N., Kotsikoris V., van Loo G., Nenci A., De Vos R., Roskams T., Trautwein C., Pasparakis M. Deletion of NEMO/IKK gamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell 2007, 11:119-132.
-
(2007)
Cancer Cell
, vol.11
, pp. 119-132
-
-
Luedde, T.1
Beraza, N.2
Kotsikoris, V.3
van Loo, G.4
Nenci, A.5
De Vos, R.6
Roskams, T.7
Trautwein, C.8
Pasparakis, M.9
-
28
-
-
34547193134
-
Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity
-
Malhi H., Barreyro F.J., Isomoto H., Bronk S.F., Gores G.J. Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity. Gut 2007, 56:1124-1131.
-
(2007)
Gut
, vol.56
, pp. 1124-1131
-
-
Malhi, H.1
Barreyro, F.J.2
Isomoto, H.3
Bronk, S.F.4
Gores, G.J.5
-
29
-
-
0030925774
-
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
-
Medema J.P., Scaffidi C., Kischkel F.C., Shevchenko A., Mann M., Krammer P.H., Peter M.E. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J. 1997, 16:2794-2804.
-
(1997)
EMBO J.
, vol.16
, pp. 2794-2804
-
-
Medema, J.P.1
Scaffidi, C.2
Kischkel, F.C.3
Shevchenko, A.4
Mann, M.5
Krammer, P.H.6
Peter, M.E.7
-
30
-
-
0031018914
-
FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens
-
Muzio M., Salvesen G.S., Dixit V.M. FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. J. Biol. Chem. 1997, 272:2952-2956.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 2952-2956
-
-
Muzio, M.1
Salvesen, G.S.2
Dixit, V.M.3
-
31
-
-
79952810024
-
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis
-
Oberst A., Dillon C.P., Weinlich R., McCormick L.L., Fitzgerald P., Pop C., Hakem R., Salvesen G.S., Green D.R. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 2011, 471:363-367.
-
(2011)
Nature
, vol.471
, pp. 363-367
-
-
Oberst, A.1
Dillon, C.P.2
Weinlich, R.3
McCormick, L.L.4
Fitzgerald, P.5
Pop, C.6
Hakem, R.7
Salvesen, G.S.8
Green, D.R.9
-
32
-
-
4644324186
-
NF-kappaB functions as a tumour promoter in inflammation-associated cancer
-
Pikarsky E., Porat R.M., Stein I., Abramovitch R., Amit S., Kasem S., Gutkovich-Pyest E., Urieli-Shoval S., Galun E., Ben-Neriah Y. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 2004, 431:461-466.
-
(2004)
Nature
, vol.431
, pp. 461-466
-
-
Pikarsky, E.1
Porat, R.M.2
Stein, I.3
Abramovitch, R.4
Amit, S.5
Kasem, S.6
Gutkovich-Pyest, E.7
Urieli-Shoval, S.8
Galun, E.9
Ben-Neriah, Y.10
-
33
-
-
42149097703
-
CASP8 variants D302H and -652 6N ins/del do not influence the risk of colorectal cancer in the United Kingdom population
-
Pittman A.M., Broderick P., Sullivan K., Fielding S., Webb E., Penegar S., Tomlinson I., Houlston R.S. CASP8 variants D302H and -652 6N ins/del do not influence the risk of colorectal cancer in the United Kingdom population. Br. J. Cancer 2008, 98:1434-1436.
-
(2008)
Br. J. Cancer
, vol.98
, pp. 1434-1436
-
-
Pittman, A.M.1
Broderick, P.2
Sullivan, K.3
Fielding, S.4
Webb, E.5
Penegar, S.6
Tomlinson, I.7
Houlston, R.S.8
-
34
-
-
34548336791
-
Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C
-
Pockros P.J., Schiff E.R., Shiffman M.L., McHutchison J.G., Gish R.G., Afdhal N.H., Makhviladze M., Huyghe M., Hecht D., Oltersdorf T., et al. Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C. Hepatology 2007, 46:324-329.
-
(2007)
Hepatology
, vol.46
, pp. 324-329
-
-
Pockros, P.J.1
Schiff, E.R.2
Shiffman, M.L.3
McHutchison, J.G.4
Gish, R.G.5
Afdhal, N.H.6
Makhviladze, M.7
Huyghe, M.8
Hecht, D.9
Oltersdorf, T.10
-
35
-
-
0029959207
-
Conditional gene targeting
-
Rajewsky K., Gu H., Kuhn R., Betz U.A., Muller W., Roes J., Schwenk F. Conditional gene targeting. J. Clin. Invest. 1996, 98:600-603.
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 600-603
-
-
Rajewsky, K.1
Gu, H.2
Kuhn, R.3
Betz, U.A.4
Muller, W.5
Roes, J.6
Schwenk, F.7
-
36
-
-
0034175632
-
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKK gamma-deficient mice
-
Rudolph D., Yeh W.C., Wakeham A., Rudolph B., Nallainathan D., Potter J., Elia A.J., Mak T.W. Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKK gamma-deficient mice. Genes Dev. 2000, 14:854-862.
-
(2000)
Genes Dev.
, vol.14
, pp. 854-862
-
-
Rudolph, D.1
Yeh, W.C.2
Wakeham, A.3
Rudolph, B.4
Nallainathan, D.5
Potter, J.6
Elia, A.J.7
Mak, T.W.8
-
37
-
-
2442538123
-
The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1
-
Ruiz-Ruiz C., Ruiz de Almodovar C., Rodriguez A., Ortiz-Ferron G., Redondo J.M., Lopez-Rivas A. The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1. J. Biol. Chem. 2004, 279:19712-19720.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 19712-19720
-
-
Ruiz-Ruiz, C.1
Ruiz de Almodovar, C.2
Rodriguez, A.3
Ortiz-Ferron, G.4
Redondo, J.M.5
Lopez-Rivas, A.6
-
38
-
-
0027454943
-
Transforming growth factor alpha dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver
-
Sandgren E.P., Luetteke N.C., Qiu T.H., Palmiter R.D., Brinster R.L., Lee D.C. Transforming growth factor alpha dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver. Mol. Cell. Biol. 1993, 13:320-330.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 320-330
-
-
Sandgren, E.P.1
Luetteke, N.C.2
Qiu, T.H.3
Palmiter, R.D.4
Brinster, R.L.5
Lee, D.C.6
-
39
-
-
85047687948
-
Differential inactivation of caspase-8 in lung cancers
-
Shivapurkar N., Toyooka S., Eby M.T., Huang C.X., Sathyanarayana U.G., Cunningham H.T., Reddy J.L., Brambilla E., Takahashi T., Minna J.D., et al. Differential inactivation of caspase-8 in lung cancers. Cancer Biol. Ther. 2002, 1:65-69.
-
(2002)
Cancer Biol. Ther.
, vol.1
, pp. 65-69
-
-
Shivapurkar, N.1
Toyooka, S.2
Eby, M.T.3
Huang, C.X.4
Sathyanarayana, U.G.5
Cunningham, H.T.6
Reddy, J.L.7
Brambilla, E.8
Takahashi, T.9
Minna, J.D.10
-
40
-
-
12444281807
-
Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas
-
Soung Y.H., Lee J.W., Kim S.Y., Sung Y.J., Park W.S., Nam S.W., Kim S.H., Lee J.Y., Yoo N.J., Lee S.H. Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas. Oncogene 2005, 24:141-147.
-
(2005)
Oncogene
, vol.24
, pp. 141-147
-
-
Soung, Y.H.1
Lee, J.W.2
Kim, S.Y.3
Sung, Y.J.4
Park, W.S.5
Nam, S.W.6
Kim, S.H.7
Lee, J.Y.8
Yoo, N.J.9
Lee, S.H.10
-
41
-
-
34247624135
-
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
-
Sun T., Gao Y., Tan W., Ma S., Shi Y., Yao J., Guo Y., Yang M., Zhang X., Zhang Q., et al. A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers. Nat. Genet. 2007, 39:605-613.
-
(2007)
Nat. Genet.
, vol.39
, pp. 605-613
-
-
Sun, T.1
Gao, Y.2
Tan, W.3
Ma, S.4
Shi, Y.5
Yao, J.6
Guo, Y.7
Yang, M.8
Zhang, X.9
Zhang, Q.10
-
42
-
-
0033119952
-
Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice
-
Tanaka M., Fuentes M.E., Yamaguchi K., Durnin M.H., Dalrymple S.A., Hardy K.L., Goeddel D.V. Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice. Immunity 1999, 10:421-429.
-
(1999)
Immunity
, vol.10
, pp. 421-429
-
-
Tanaka, M.1
Fuentes, M.E.2
Yamaguchi, K.3
Durnin, M.H.4
Dalrymple, S.A.5
Hardy, K.L.6
Goeddel, D.V.7
-
43
-
-
0034066405
-
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN
-
Teitz T., Wei T., Valentine M.B., Vanin E.F., Grenet J., Valentine V.A., Behm F.G., Look A.T., Lahti J.M., Kidd V.J. Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat. Med. 2000, 6:529-535.
-
(2000)
Nat. Med.
, vol.6
, pp. 529-535
-
-
Teitz, T.1
Wei, T.2
Valentine, M.B.3
Vanin, E.F.4
Grenet, J.5
Valentine, V.A.6
Behm, F.G.7
Look, A.T.8
Lahti, J.M.9
Kidd, V.J.10
-
44
-
-
0028941076
-
Autocrine mitogen IgEGF cooperates with c-myc or with the Hcs locus during hepatocarcinogenesis in transgenic mice
-
Tonjes R.R., Lohler J., O'Sullivan J.F., Kay G.F., Schmidt G.H., Dalemans W., Pavirani A., Paul D. Autocrine mitogen IgEGF cooperates with c-myc or with the Hcs locus during hepatocarcinogenesis in transgenic mice. Oncogene 1995, 10:765-768.
-
(1995)
Oncogene
, vol.10
, pp. 765-768
-
-
Tonjes, R.R.1
Lohler, J.2
O'Sullivan, J.F.3
Kay, G.F.4
Schmidt, G.H.5
Dalemans, W.6
Pavirani, A.7
Paul, D.8
-
45
-
-
77957105977
-
Molecular mechanisms of necroptosis: an ordered cellular explosion
-
Vandenabeele P., Galluzzi L., Vanden Berghe T., Kroemer G. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat. Rev. 2011, 11:700-714.
-
(2011)
Nat. Rev.
, vol.11
, pp. 700-714
-
-
Vandenabeele, P.1
Galluzzi, L.2
Vanden Berghe, T.3
Kroemer, G.4
-
46
-
-
0032143986
-
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors Fas/Apo1, and DR3 and is lethal prenatally
-
Varfolomeev E.E., Schuchmann M., Luria V., Chiannilkulchai N., Beckmann J.S., Mett I.L., Rebrikov D., Brodianski V.M., Kemper O.C., Kollet O., et al. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors Fas/Apo1, and DR3 and is lethal prenatally. Immunity 1998, 9:267-276.
-
(1998)
Immunity
, vol.9
, pp. 267-276
-
-
Varfolomeev, E.E.1
Schuchmann, M.2
Luria, V.3
Chiannilkulchai, N.4
Beckmann, J.S.5
Mett, I.L.6
Rebrikov, D.7
Brodianski, V.M.8
Kemper, O.C.9
Kollet, O.10
-
47
-
-
0032494143
-
Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways
-
Vercammen D., Brouckaert G., Denecker G., Van de Craen M., Declercq W., Fiers W., Vandenabeele P. Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways. J. Exp. Med. 1998, 188:919-930.
-
(1998)
J. Exp. Med.
, vol.188
, pp. 919-930
-
-
Vercammen, D.1
Brouckaert, G.2
Denecker, G.3
Van de Craen, M.4
Declercq, W.5
Fiers, W.6
Vandenabeele, P.7
-
48
-
-
44749090905
-
Sp1: emerging roles - beyond constitutive activation of TATA-less housekeeping genes
-
Wierstra I. Sp1: emerging roles - beyond constitutive activation of TATA-less housekeeping genes. Biochem. Biophys. Res. Commun. 2008, 372:1-13.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.372
, pp. 1-13
-
-
Wierstra, I.1
-
49
-
-
67650932090
-
Systemic therapies in hepatocellular carcinoma
-
Worns M.A., Weinmann A., Schuchmann M., Galle P.R. Systemic therapies in hepatocellular carcinoma. Dig. Dis. 2009, 27:175-188.
-
(2009)
Dig. Dis.
, vol.27
, pp. 175-188
-
-
Worns, M.A.1
Weinmann, A.2
Schuchmann, M.3
Galle, P.R.4
-
50
-
-
77349089525
-
Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation
-
Wu Y., Alvarez M., Slamon D.J., Koeffler P., Vadgama J.V. Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation. BMC Cancer 2010, 10:32.
-
(2010)
BMC Cancer
, vol.10
, pp. 32
-
-
Wu, Y.1
Alvarez, M.2
Slamon, D.J.3
Koeffler, P.4
Vadgama, J.V.5
-
51
-
-
49649106258
-
Functional variants in cell death pathway genes and risk of pancreatic cancer
-
Yang M., Sun T., Wang L., Yu D., Zhang X., Miao X., Liu J., Zhao D., Li H., Tan W., et al. Functional variants in cell death pathway genes and risk of pancreatic cancer. Clin. Cancer Res. 2008, 14:3230-3236.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 3230-3236
-
-
Yang, M.1
Sun, T.2
Wang, L.3
Yu, D.4
Zhang, X.5
Miao, X.6
Liu, J.7
Zhao, D.8
Li, H.9
Tan, W.10
-
52
-
-
33847186990
-
Death effector domain DEDa, a self-cleaved product of caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase-8 expression via a p53-dependent mechanism
-
Yao Z., Duan S., Hou D., Heese K., Wu M. Death effector domain DEDa, a self-cleaved product of caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase-8 expression via a p53-dependent mechanism. EMBO J. 2007, 26:1068-1080.
-
(2007)
EMBO J.
, vol.26
, pp. 1068-1080
-
-
Yao, Z.1
Duan, S.2
Hou, D.3
Heese, K.4
Wu, M.5
-
53
-
-
0035979775
-
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikk beta
-
Yuan M., Konstantopoulos N., Lee J., Hansen L., Li Z.W., Karin M., Shoelson S.E. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikk beta. Science 2001, 293:1673-1677.
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
Hansen, L.4
Li, Z.W.5
Karin, M.6
Shoelson, S.E.7
-
54
-
-
0038610713
-
Caspase 8 small interfering RNA prevents acute liver failure in mice
-
Zender L., Hutker S., Liedtke C., Tillmann H.L., Zender S., Mundt B., Waltemathe M., Gosling T., Flemming P., Malek N.P., et al. Caspase 8 small interfering RNA prevents acute liver failure in mice. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:7797-7802.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 7797-7802
-
-
Zender, L.1
Hutker, S.2
Liedtke, C.3
Tillmann, H.L.4
Zender, S.5
Mundt, B.6
Waltemathe, M.7
Gosling, T.8
Flemming, P.9
Malek, N.P.10
-
55
-
-
79952780505
-
Functional complementation between FADD and RIP1 in embryos and lymphocytes
-
Zhang H., Zhou X., McQuade T., Li J., Chan F.K., Zhang J. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 2011, 471:373-376.
-
(2011)
Nature
, vol.471
, pp. 373-376
-
-
Zhang, H.1
Zhou, X.2
McQuade, T.3
Li, J.4
Chan, F.K.5
Zhang, J.6
|