AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver

Archives of Toxicology

Volumn 87, Issue 1, 2013, Pages 155-165

  Hadi, Mackenzie ^a   Dragovic, Sanja ^c   Van Swelm, Rachel ^d   Herpers, Bram ^b   Van De Water, Bob ^b   Russel, Frans G M ^d   Commandeur, Jan N M ^c   Groothuis, Geny M M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Acetaminophen (APAP); Drug metabolism; N acetyl metaaminophenol (AMAP); Precision cut liver slices; Species difference; Toxicity

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINOPHENOL DERIVATIVE; DRUG METABOLITE; N ACETYL META AMINOPHENOL; PARACETAMOL; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; EX VIVO STUDY; FEMALE; HUMAN; HUMAN TISSUE; ISOMER; LIVER HISTOLOGY; LIVER SLICE; LIVER TOXICITY; MALE; MORPHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; SPECIES DIFFERENCE;

ACETAMINOPHEN; ADENOSINE TRIPHOSPHATE; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CHILD; FEMALE; HUMANS; HYDROQUINONES; ISOMERISM; LIVER; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; PROTEINS; RATS; RATS, WISTAR; SPECIES SPECIFICITY; TOXICITY TESTS;

CRICETINAE; MUS; RATTUS;

EID: 84872317734     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0924-1     Document Type: Article

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