Identification of factors from rat neutrophils responsible for cytotoxicity to isolated hepatocytes

Journal of Leukocyte Biology

Volumn 59, Issue 5, 1996, Pages 716-724

  Ho, John S ^a   Buchweitz, John P ^b   Roth, Robert A ^a,c   Ganey, Patricia E ^b,c  

^a Michigan State University   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

cathepsin G; elastase; hepatotoxicity; injury; liver; proteases

Indexed keywords

ALPHA 1 ANTITRYPSIN; CATHEPSIN G; ELASTASE; MYELOPEROXIDASE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL ISOLATION; CYTOTOXICITY; ENZYME ACTIVITY; KILLER CELL; LEUKOCYTE ACTIVATION; LIVER CELL; LIVER INJURY; LIVER PARENCHYMA; LIVER TOXICITY; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE INJURY;

ANIMALIA; GLYCINE MAX;

EID: 0029891492     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.59.5.716     Document Type: Article

References (50)

1. Hewett, J. A., Schultze, A. E., VanCise, S., Roth, R. A. (1992) Neutrophil depletion protects against liver injury from bacterial endotoxin. Lab. Invest. 66, 347-361.
2. Arthur, M. J. P., Kowolski-Saunders, P., Wright, R. (1986) Corynebacterium parvum elicited hepatic macrophages demonstrate enhanced respiratory burst activity compared with resident Kupffer cells in the rat. Gastroenterology 91, 174-181.
3. Dahm, L. J., Schultze, A. E., Roth, R. A. (1991) An antibody to neutrophils attenuates α-naphthylisothiocyanate-induced liver injury. J. Pharmacol. Exp. Ther. 256, 412-420.
4. Ganey, P. E., Bailie, M. B., VanCise, S., Colligan, M. E., Madhukar, B. V., Robinson, J. P., Roth, R. A. (1994) Activated neutrophils from rat injured isolated hepatocytes. Lab. Invest. 70, 53-60.
5. Wagner, J. G., Ganey, P. E., Roth, R. A. (1996) Nitric oxide is not involved in hepatocyte killing by neutrophils activated by fMLP or PMA in vitro. Hepatology 23, 803-810.
6. Jaeschke, H., Bautista, A. P., Spolarics, Z., Spitzer, J. J. (1992) Superoxide generation by neutrophils and Kupffer cells during in vivo reperfusion after hepatic ischemia in rats. J. Leukoc. Biol. 52, 377-382.
7. Weiss, S. J. (1989) Tissue destruction by neutrophils. N. Engl. J. Med. 320, 365-376.
8. Brass, C. A., Nunes, F., Nagpal, R. (1994) Increased oxyradical production during reoxygenation of perfused rat liver: Signal versus injury. Transplantation 12, 1329-1335.
9. Elsbach, P., Weiss, J. (1992) Oxygen-independent antimicrobial systems. In Inflammation: Basic Principles and Clinical Correlates (J.I. Gallin, I.M. Goldstein, and R. Snyderman, eds.), New York, Raven, 603-636.
10. Borregaard, N., Lollike, K., Kjeldsen, L., Sengeløov, H., Bastholm, L., Nielsen, M. H., Bainton, D. F. (1993) Human neutrophil granules and secretory vesicles. Eur. J. Haematol. 51, 187-193.
11. Tanner, A., Keyhani, A., Reiner, R., Holdstock, G., Wright, R. (1981) Proteolytic enzymes released by liver macrophages may promote hepatic injury in a rat model of hepatic damage. Gastroenterology 80, 647-654.
12. Mavier, P., Preaux A-M., Guigui, B., Leses, M., Zafrani, E., Dhumeaux, D. (1988) In vitro toxicity of polymorphonuclear neutrophils to rat hepatocytes: evidence for a proteinase-mediated mechanism. Hepatology 8, 254-258.
13. Harbrecht, B. G., Billiar, T., Curran, R. D., Stadler, J., Simmons, R. L. (1993) Hepatocyte injury by activated neutrophils in vitro is mediated by proteases. Ann. Surg. 218, 120-128.
14. Harlam, J. M., Killen, P. D., Harker, L. A., Striker, G. E., Wright, D. G. (1981) Neutrophil-mediated endothelial injury in vitro. Mechanisms of cell detachment. J. Clin. Invest. 68, 1394-1403.
15. Smedley, L. A., Tonnesen, M. G., Sandhans, R. A., Haslett, C., Guthrie, L. A., Johnslon, R. B., Henson, P. M., Worthen, G. S. (1986) Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase. J. Clin. Invest. 77, 1233-1243.
16. Mavier, P., Preaux, A-M., Rosenbaum, J., Zafrani, E. S., Dhumeaux, D. (1989) Toxicity of polymorphonuclear neutrophils against hepatocytes: protective effect of heparin. Biochem. Pharmacol. 38, 1865-1867.
17. Seglen, P. O. (1973) Preparation of rat liver cells. III. Enzymatic requirements for dispersion. Exp. Cell Res. 82, 391-398.
18. Klaunig, J. E., Goldblatt, P. J., Hinton, D. E., Lipsky, M. M., Chacko, J., Trump, B. F. (1981) Mouse liver cell culture. I. Hepatocyte isolation. In Vitro 17, 913-925.
19. Björk, P., Ohlsson, K. (1990) Purification and N-terminal amino-acid sequence analysis of rat polymorphonuclear leukocyte cathepsin G. Biol. Chem. Hoppe-Seylers. Arch. 371, 595-601.
20. Ferrer-Lopez, P., Renesto, P., Schattner, M., Bassot, S., Laurent, P., Chignard, M. (1990) Activation of human platelets by C5a-stimulated neutrophils: a role for cathepsin G. Am. J. Physiol. 258, C1100-C1107.
21. Blum, H., Beier, H., Cross, H. (1987) Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels. Electrophoresis 8, 93-99.
22. Laemmli, U. K. (1970) Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature 227, 680-685.
23. Henson, P. M., Zanolati, B., Schwartzman, N. A., Hong, S. K. (1978) C5a-induced stimulus-specific desensitization and the effects of cytochalasin B. J. Immunol. 121, 851-855.
24. Smolen, J. E., Korchak, H. M., Weissmann, G. (1981) The roles of extracellular and intracellular calcium in lysosomal enzyme release and superoxide anion generation by human neutrophils. Biochim. Biophys. Acta 677, 512-520.
25. 2+-requiring proteinase. J. Biol. Chem. 261, 8309-8313.
26. Redini, F., Tixier, J. M., Petitou, M., Choay, J., Robert, L., Hornebeck, W. (1988) Inhibition of leukocyte elastase by heparin and its derivatives. Biochem. J. 252, 515-519.
27. Wilde, C. G., Snable, J. L., Griffin, J. E., Scott, R. W. (1990) Characterization of two azurophil granule proteases with active-site homology to neutrophil elastase. J. Biol. Chem. 265, 2038-2041.
28. Kao, R. C., Wehner, N. G., Skubitz, K. M., Gray, B. H., Hoidal, J. R. (1988) Protease 3. A disinct human polymophonuclear leukocyte proteinase that produces emphysema in hamsters. J. Clin. Invest. 82, 1963-1973.
29. Baugh, R. J., Travis, J. (1976) Human leukocyte granule elastase: rapid isolation and characterization. Biochemistry 15, 836-841.
30. Matrisian, L. M. (1992) The matrix-degrading metalloproteinases. BioEssays 14, 455-463.
31. Weiss, S. J., Peppin, G. J. (1986) Collagenolytic metalloenzymes of the human neutrophil. Characteristics, regulation and potential function in vivo. Biochem. Pharmacol. 35, 3189-3197.
32. Murphy, G., Crockett, M. I., Ward, R. V., Docherty, A. J. P. (1991) Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan: a quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stomelysins-1 and -2 and punctuated metalloproteinase (PUMP). Biochem. J. 277, 277-279.
33. Odeberg, H., Ohlsson, I. (1975) Antibacterial activity of cationic proteins from human granulocytes. J. Clin. Invest. 56, 1118-1124.
34. Bangalore, N., Travis, J., Onunka, V. C., Pohl, J., Shafer, W. M. (1990) Identification of the primary antimicrobial domains in human neutrophil cathepsin G. J. Biol. Chem. 265, 13584-13588.
35. 4 and the role of polymorphonuclear leukocytes. Inflammation 6, 189-200.
36. Padrines, M., Wolf, M., Walz, A., Baggiolini, M. (1994) Interleukin-8 processing by neutrophil elastase, cathepsin G and proteinase-3. FEBS Lett. 352, 231-235.
37. Renesto, P., Chignard, M. (1991) Tumor necrosis factor-α enhances platelet activation via cathepsin G released from neutrophils. J. Immunol. 146, 2305-2309.
38. Selak, M. A., Chignard, M., Smith, J. B. (1988) Cathepsin G is a strong platelet agonist released by neutrophils. Biochem. J. 251, 293-299.
39. Guigui, B., Rosenbaum, J., Préaux, A.-M., Martin, N., Zafrani, E. S., Dhumeaux, D., Mavier, P. (1988) Toxicity of phorbol myristate acetate-stimulated polymorphonuclear neutrophils against rat hepalocytes: Demonstration and mechanism. Lab. Invest. 59, 831-837.
40. Travis, J., Salvesen, G. S. (1983) Human plasma proteinase inhibitors. Ann. Rev. Biochem. 52, 655-709.
41. Björk, P., Axelsson, L., Ohlsson, K. (1991) Release of dog polymorphonuclear leukocyte cathepsin G, normally and in endotoxin and pancreatitic shock. Isolation and partial characterization of dog polymorphonuclear leukocyte cathepsin G. Biol. Chem. Hoppe-Seyler 372, 419-426.
42. Campbell, E. J., Campell, M. A. (1988) Pericellular proteolysis by neutrophils in the presence of proteinase inhibitors: effects of substrate opsonization. J. Cell Biol. 106, 667-676.
43. Weitz, J. I., Huang, A. J., Landman, S. L., Nicholson, S. C., Silverstein, S. C. (1987) Elastase-mediated fibrinogenolysis by chemoattractant-stimulated neutrophils occurs in the presence of physiologic concentrations of antiproteinases. J. Exp. Med. 166, 1836-1850.
44. Weiss, S. J., Regiani, S. (1984) Neutrophils degrade subendothelial matrices in the presence of α1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites. J. Clin. Invest. 73, 1297-1303.
45. Wewers, M. D., Herzyk, D. J., Gadek, J. E. (1988) Alveolar fluid neutrophil elastase activity in the adult respiratory distress syndrome is complexed to α2-macrogiobulin. J. Clin. Invest. 82, 1260-1267.
46. Suter, S., Schaad, U. B., Tegner, H., Ohlsson, K., Desgrandchamps, D., Wardvogel, F. A. (1986) Levels of free granulocyte elastase in bronchial secretions from patients with cystic fibrosis: effect of antimicrobial treatment against Pseudomonas aeruginosa. J. Infect. Dis. 153, 902-909.
47. Velvart, M., Fehr, K. (1987) Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic arthritis by cat heps in C and elastase from polymorphonuclear leukocytes. Rheumatol. Int. 7, 195-202.
48. Tanaka, H., Shimazu, T., Sugimoto, H., Yoshioka, T., Sugimoto, T. (1990) A sensitive and specific assay for granulocyte elastase in inflammatory tissue fluid using L-pyro-glutamyl-L-propyl-L-valine-p-nitroanuide. Clin. Chim. Acta 187, 173-180.
49. Törnebohm, E., Egberg, N., Sablica, H., Wallin, R., Lockner, D., Paul, C. (1992) Elastase activity in leukaemic cells and plasma in patients with acute leukaemia. Eur. J. Haematol. 49, 98-104.
50. Egbring, R., Schmidt, W., Fuchs, G., Havemann, K. (1977) Demonstration of granulocyte proteases in plasma of patients with acute leukemia and septicemia with coagulation defects. Blood 49, 219-231.