Activation of caspase 3 (CPP32)-like proteases is essential for TNF-α- induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model

Journal of Immunology

Volumn 160, Issue 7, 1998, Pages 3480-3486

  Jaeschke, Hartmut ^a   Fisher, Michael A ^a   Lawson, Judy A ^a   Simmons, Carol A ^a   Farhood, Anwar ^b   Jones, David A ^a,c  

^a PFIZER INC   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ENZYME ACTIVATION; LIVER NECROSIS; LIVER PARENCHYMA; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK;

ANIMALS; APOPTOSIS; BACTERIAL TOXINS; CASPASE 3; CASPASES; CYSTEINE ENDOPEPTIDASES; DISEASE MODELS, ANIMAL; ENDOTOXINS; ENZYME ACTIVATION; GALACTOSAMINE; LIVER; MALE; MICE; MICE, INBRED C3H; NECROSIS; NEUTROPHILS; SALMONELLA; SHOCK, SEPTIC; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032055225     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Parrillo, J. E. 1993. Pathogenetic mechanisms of septic shock. N. Engl. J. Med. 328:1471.
2. Schlayer, H. J., H. Laaff, T. Peters, M. Woort-Menker, H. C. Estler, U. Karck, H. E. Schaefer, and K. Decker. 1988. Involvement of tumor necrosis factor in endotoxin-triggered neutrophil adherence to sinusoidal endothelial cells of mouse liver and its modulation in acute phase. J. Hepatol. 7:239.
3. Wang, P., and I. H. Chaudry. 1996. Mechanism of hepatocellular dysfunction during hyperdynamic sepsis. Am. J. Physiol. 270:R927.
4. Wang, P., Z. F. Ba, and I. H. Chaudry. 1997. Mechanism of hepatocellular dysfunction during early sepsis-key role of increased gene expression and release of proinflammatory cytokines tumor necrosis factor and interleukin-6. Arch. Surg. 132:364.
5. Casey, L. C. 1993. Role of cytokines in the pathogenesis of cardiopulmonary-induced multisystem organ failure. Ann. Thorac. Surg. 56:S92.
6. Witthaut, R., A. Farhood, C. W. Smith, and H. Jaeschke. 1994. Complement and tumor necrosis factor-α contribute to Mac-1 (CD11b/CD18) up-regulation and systemic neutrophil activation during endotoxemia in vivo. J. Leukocyte Biol. 55:105.
7. Bautista, A. P., A. Schuler, Z. Spolarics, and J. J. Spitzer. 1991. Tumor necrosis factor-α stimulates superoxide anion generation by perfused rat liver and Kupffer cells. Am. J. Physiol. 261:G891.
8. Nathan, C. F., S. Srimal, C. Farber, E. Sanchez, L. Kabbash, A. Asch, J. Gailit, and S. D. Wright. 1989. Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins. J. Cell Biol. 109:1341.
9. Essani, N. A., G. M. McGuire, A. M. Manning, and H. Jaeschke. 1996. Endotoxin-induced activation of the nuclear transcription factor κB and expression of E-selectin messenger RNA in hepatocytes, Kupffer cells, and endothelial cells in vivo. J. Immunol. 156:2956.
10. Thornton, A. J., R. M. Strieter, I. Lindley, M. Baggiolini, and S. L. Kunkel. 1990. Cytokine-induced gene expression of a neutrophil chemotactic factor/IL-8 in human hepatocytes. J. Immunol. 144:2609.
11. Colletti, L. M., S. L. Kunkel, A. Walz, M. D. Burdick, R. G. Kunkel, C. A. Wilke, and R. M. Stricter. 1996. The role of cytokine networks in the local liver injury following hepatic ischemia/reperfusion in the rat. Hepatology 23:506.
12. Geller, D. A., M. E. de Vera, D. A. Russell, R. A. Shapiro, A. K. Nussler, R. L. Simmons, and T. R. Billiar. 1995. A central role for the IL-1β in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase. J. Immunol. 155:4890.
13. Duval, D. L., D. R. Miller, J. Collier, and R. E. Billings. 1996. Characterization of hepatic nitric oxide synthase: identification as the cytokine-inducible form primarily regulated by oxidants. Mol. Pharmacol. 50:277.
14. Essani, N. A., M. A. Fisher, A. Farhood, A. M. Manning, C. W. Smith, and H. Jaeschke. 1995. Cytokine-induced hepatic intercellular adhesion molecule-1 (ICAM-1) mRNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure. Hepatology 21:1632.
15. Essani, N. A., G. M. McGuire, A. M. Manning, and H. Jaeschke. 1995. Differential induction of mRNA for ICAM-1 and selectins in hepatocytes, Kupffer cells and endothelial cells during endotoxemia. Biochem. Biophys. Res. Commun. 211: 74.
16. Essani, N. A., M. L. Bajt, S. L. Vonderfecht, A. Farhood, and H. Jaeschke. 1997. Transcriptional activation of vascular cell adhesion molecule-1 (VCAM-1) gene in vivo and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock. J. Immunol. 158:5941.
17. 2 integrins and intercellular adhesion molecule-1. Shock 6:345.
18. Chosay, J. G., N. A. Essani, C. J. Dunn, and H. Jaeschke. 1997. Neutrophil margination and extravasation in sinusoids and venules of the liver during endotoxin-induced injury. Am. J. Physiol. 272:G1195.
19. Tartaglia, L. A., and D. V. Goeddel. 1992. Two TNF receptors. Immunol. Today 13:151.
20. Vandenabeele, P., W. Declercq, R. Beyaert, and W. Fiers. 1995. Two tumor necrosis factor receptors: structure and function. Trends Cell Biol. 5:392.
21. Tartaglia, L. A., T. M. Ayres, G. H. W. Wong, and D. V. Goeddel. 1993. A novel domain within the 55 kd TNF receptor signals cell death. Cell 74:845.
22. Leist, M., F. Gantner, I. Bohlinger, G. Tiegs, P. G. Germann, and A. Wendel. 1995. Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am. J. Pathol. 146:1220.
23. Haendeler, J., U. K. Messmer, B. Brune, E. Neugebauer, and S. Dimmeler. 1996. Endotoxic shock leads to apoptosis in vivo and reduces Bcl-2. Shock 6:405.
24. Morikawa, A., T. Sugiyama, Y. Kato, N. Koide, G.-Z. Jiang, K. Takahashi, Y. Tamada, and T. Yokochi. 1996. Apoptotic cell death in the response of D-galactosamine-sensitized mice to lipopolysaccharide as an experimental endotoxic shock model. Infect. Immun. 64:734.
25. Tsuji, H., A. Harada, N. Mukaida, Y. Nakanuma, H. Bluethmann, S. Kaneko, K. Yamakawa, S.-I. Nakamura, K.-I. Kobayashi, and K. Matsushima. 1997. Tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis. Infect. Immun. 65:1892.
26. Leist, M., F. Gantner, S. Jilg, and A. Wendel. 1995. Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis and nitric oxide release. J. Immunol. 154:1307.
27. Martin, S. J., and D. R. Green. 1995. Protease activation during apoptosis: death by a thousand cuts? Cell 82:349.
28. Fraser, A., and G. Evan. 1996. A license to kill. Cell 85:781.
29. Nagata, S. 1997. Apoptosis by death factor. Cell 88:355.
30. Alnemri, E. S., D. J. Livingston, D. W. Nicholson, G. Salvesen, N. A. Thornberry, W. W. Wong, and J. Yuan. 1996. Human ICE/CED-3 protease nomenclature. Cell 87:171.
31. Van de Craen, M., P. Vandenabeele, W. Declercq, I. Van den Brande, G. Van Loo, F. Molemans, P. Schotte, W. Van Criekinge, R. Beyaert, and W. Fiers. 1997. Characterization of seven murine caspase family members. FEBS Lett. 403:61.
32. Rodriguez, I., K. Matsuura, C. Ody, S. Nagata, and P. Vassalli. 1996. Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death. J. Exp. Med. 184:2067.
33. 1-induced apoptosis in rat hepatocytes. Hepatology 25:1516.
34. Shimizu, S., Y. Eguchi, W. Kamiike, Y. Akao, H. Kosaka, J.-I. Hasegawa, H. Matsuda, and Y. Tsujimoto. 1996. Involvement of ICE family proteases in apoptosis induced by reoxygenation of hypoxic hepatocytes. Am. J. Physiol. 271: G949.
35. Jaeschke, H., A. Farhood, and C. W. Smith. 1991. Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18-dependent mechanism. Am. J. Physiol. 261:G1051.
36. Gantner, F., S. Uhlig, and A. Wendel. 1995. Quinine inhibits release of tumor necrosis factor, apoptosis, necrosis and mortality in a murine model of septic liver failure. Eur. J. Pharmacol. 294:353.
37. Essani, N. A., M. A. Fisher, and H. Jaeschke. 1997. Inhibition of NF-κB activation by dimethyl sulfoxide correlates with suppression of TNF-α formation, reduced ICAM-1 gene transcription and protection against endotoxin-induced liver injury. Shock 7:90.
38. Dunn, C. J., M. M. Hardee, S. F. Fidler, S. K. Shields, and J. G. Chosay. 1996. The inflammatory potential of IL-2: local induction of a specific chronic granulomatous lesion in mice. J. Leukocyte Biol. 60:27.
39. Rouquet, N., J. C. Pages, T. Molina, P. Briand, and V. Joulin. 1996. ICE inhibitor YVAD-cmk is a potent therapeutic agent against in vivo liver apoptosis. Curr. Biol. 6:1192.
40. Rouquet, N., K. Carlier, P. Briand, J. Wiels, and V. Joulin. 1996. Multiple pathways of Fas-induced apoptosis in primary culture of hepatocytes. Biochem. Biophys. Res. Commun. 229:27.
41. Cain, K., S. H. Inayat-Hussain, C. Couet, and G. M. Cohen. 1996. A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary culture of rat hepatocytes. Biochem. J. 314:27.
42. Jaeschke, H., N. A. Essani, M. A. Fisher, S. L. Vonderfecht, A. Farhood, and C. W. Smith. 1996. Release of soluble intercellular adhesion molecule 1 into bile and serum in murine endotoxin shock. Hepatology 23:530.
43. Abastado, J. P. 1996. Apoptosis: function and regulation of cell death. Res. Immunol. 147:443.
44. Patel, T., and G. J. Gores. 1995. Apoptosis and hepatobiliary disease. Hepatology 21:1725.
45. Rogers, H. W., M. P. Callery, B. Deck, and E. R. Unanue. 1996. Listeria monocytogenes induces apoptosis of infected hepatocytes. J. Immunol. 156:679.