Metabolism and disposition of acetaminophen: Recent advances in relation to hepatotoxicity and diagnosis

Pharmaceutical Research

Volumn 30, Issue 9, 2013, Pages 2174-2187

  McGill, Mitchell R ^a   Jaeschke, Hartmut ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

acetaminophen; drug metabolism; drug transporters; hepatotoxicity; nuclear receptors

Indexed keywords

CYTOCHROME P450; GLUTATHIONE; GLUTATHIONE TRANSFERASE; PARACETAMOL;

CELL CULTURE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG ABSORPTION; DRUG DISPOSITION; DRUG ELIMINATION; DRUG GLUCURONIDATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG STRUCTURE; DRUG SULFATION; HUMAN; LIVER INJURY; LIVER NECROSIS; LIVER TOXICITY; METABOLIC ACTIVATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; REVIEW; TOXIC HEPATITIS;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTIPYRETICS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG-INDUCED LIVER INJURY; GLUTATHIONE TRANSFERASE; HUMANS; LIVER; PROTEIN BINDING;

EID: 84883295568     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-013-1007-6     Document Type: Review

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