Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes

Toxicology in Vitro

Volumn 22, Issue 4, 2008, Pages 961-967

  Jemnitz, Katalin ^a   Veres, Zsuzsa ^a   Monostory, Katalin ^a   Kóbori, László ^b   Vereczkey, László ^a  

^a CHEMICAL RESEARCH CENTER   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Acetaminophen toxicity; Hepatocyte; Species difference

Indexed keywords

CYTOCHROME P450 2E1; DRUG METABOLITE; N ACETYLBENZOQUINONEIMINE; PARACETAMOL; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL VIABILITY; CYTOTOXICITY TEST; DRUG SENSITIVITY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; MALE; MOUSE; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; RAT; SPECIES DIFFERENCE;

ACETAMINOPHEN; ADULT; ANALGESICS, NON-NARCOTIC; ANIMALS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEPATOCYTES; HUMANS; MALE; MICE; MICROSOMES, LIVER; RATS; SPECIES SPECIFICITY; TIME FACTORS;

ANIMALIA; MUS; RATTUS;

EID: 41949112162     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.02.001     Document Type: Article

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