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Volumn 309, Issue 8, 2015, Pages E691-E714

Revisiting the adipocyte: A model for integration of cytokine signaling in the regulation of energy metabolism

Author keywords

Adipocyte hypertrophy and hyperplasia; Adipose tissue inflammation; Extracellular matrix remodeling; Fat browning; White and brown adipogenesis

Indexed keywords

ADIPOCYTOKINE; CALGRANULIN; CHEMERIN; CHITINASE; CHITINASE 3 LIKE; CYTOKINE; GLUCOSE; GROWTH FACTOR; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; OSTEOPONTIN; SCLEROPROTEIN; TENASCIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84945242753     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00297.2015     Document Type: Review
Times cited : (222)

References (359)
  • 5
    • 84899480761 scopus 로고    scopus 로고
    • Stable SREBP-1a knockdown decreases the cell proliferation rate in human preadipocyte cells without inducing senescence
    • lvarez MS, Fernández-Álvarez A, Cucarella C, Casado M. Stable SREBP-1a knockdown decreases the cell proliferation rate in human preadipocyte cells without inducing senescence. Biochem Biophys Res Commun 447: 51-56, 2014.
    • (2014) Biochem Biophys Res Commun , vol.447 , pp. 51-56
    • Lvarez, M.S.1    Fernández-Álvarez, A.2    Cucarella, C.3    Casado, M.4
  • 7
    • 84887334311 scopus 로고    scopus 로고
    • Weight cycling increases T-cell accumulation in adipose tissue and impairs systemic glucose tolerance
    • Anderson EK, Gutierrez DA, Kennedy A, Hasty AH. Weight cycling increases T-cell accumulation in adipose tissue and impairs systemic glucose tolerance. Diabetes 62: 3180-3188, 2013.
    • (2013) Diabetes , vol.62 , pp. 3180-3188
    • Anderson, E.K.1    Gutierrez, D.A.2    Kennedy, A.3    Hasty, A.H.4
  • 12
    • 84874647272 scopus 로고    scopus 로고
    • BMP signaling in development and diseases: A pharmacological perspective
    • Bandyopadhyay A, Yadav PS, Prashar P. BMP signaling in development and diseases: a pharmacological perspective. Biochem Pharmacol 85: 857-864, 2013.
    • (2013) Biochem Pharmacol , vol.85 , pp. 857-864
    • Bandyopadhyay, A.1    Yadav, P.S.2    Prashar, P.3
  • 16
    • 84863736446 scopus 로고    scopus 로고
    • Transcriptional analysis of brown adipose tissue in leptin-deficient mice lacking inducible nitric oxide synthase: Evidence of the role of Med1 in energy balance
    • Becerril S, Rodríguez A, Catalán V, Sáinz N, Ramírez B, Gómez-Ambrosi J, Frühbeck G. Transcriptional analysis of brown adipose tissue in leptin-deficient mice lacking inducible nitric oxide synthase: evidence of the role of Med1 in energy balance. Physiol Genomics 44: 678-688, 2012.
    • (2012) Physiol Genomics , vol.44 , pp. 678-688
    • Becerril, S.1    Rodríguez, A.2    Catalán, V.3    Sáinz, N.4    Ramírez, B.5    Gómez-Ambrosi, J.6    Frühbeck, G.7
  • 19
  • 22
    • 1442330395 scopus 로고    scopus 로고
    • Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia
    • Bing C, Bao Y, Jenkins J, Sanders P, Manieri M, Cinti S, Tisdale MJ, Trayhurn P. Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia. Proc Natl Acad Sci USA 101: 2500-2505, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2500-2505
    • Bing, C.1    Bao, Y.2    Jenkins, J.3    Sanders, P.4    Manieri, M.5    Cinti, S.6    Tisdale, M.J.7    Trayhurn, P.8
  • 24
    • 0028799896 scopus 로고
    • Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages
    • Boot RG, Renkema GH, Strijland A, van Zonneveld AJ, Aerts JM. Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages. J Biol Chem 270: 26252-26256, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 26252-26256
    • Boot, R.G.1    Renkema, G.H.2    Strijland, A.3    Van Zonneveld, A.J.4    Aerts, J.M.5
  • 26
    • 3242811249 scopus 로고    scopus 로고
    • Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin
    • Bouma G, Lam-Tse WK, Wierenga-Wolf AF, Drexhage HA, Versnel MA. Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin. Diabetes 53: 1979-1986, 2004.
    • (2004) Diabetes , vol.53 , pp. 1979-1986
    • Bouma, G.1    Lam-Tse, W.K.2    Wierenga-Wolf, A.F.3    Drexhage, H.A.4    Versnel, M.A.5
  • 29
    • 0035048514 scopus 로고    scopus 로고
    • Regulation of interleukin 8 production and gene expression in human adipose tissue in vitro
    • Bruun JM, Pedersen SB, Richelsen B. Regulation of interleukin 8 production and gene expression in human adipose tissue in vitro. J Clin Endocrinol Metab 86: 1267-1273, 2001.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1267-1273
    • Bruun, J.M.1    Pedersen, S.B.2    Richelsen, B.3
  • 30
    • 84875136149 scopus 로고    scopus 로고
    • Turning off the inflammatory, but not the metabolic, flames
    • Calay ES, Hotamisligil GS. Turning off the inflammatory, but not the metabolic, flames. Nat Med 19: 265-267, 2013.
    • (2013) Nat Med , vol.19 , pp. 265-267
    • Calay, E.S.1    Hotamisligil, G.S.2
  • 31
    • 84865144872 scopus 로고    scopus 로고
    • Cell biology: Neither brown nor white
    • Cannon B, Nedergaard J. Cell biology: Neither brown nor white. Nature 488: 286-287, 2012.
    • (2012) Nature , vol.488 , pp. 286-287
    • Cannon, B.1    Nedergaard, J.2
  • 34
    • 78650917241 scopus 로고    scopus 로고
    • Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: Impact of conventional weight loss and gastric bypass
    • Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Rotellar F, Valentí V, Silva C, Gil MJ, Salvador J, Frühbeck G. Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypass. J Clin Endocrinol Metab 96: 200-209, 2011.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 200-209
    • Catalán, V.1    Gómez-Ambrosi, J.2    Rodríguez, A.3    Ramírez, B.4    Rotellar, F.5    Valentí, V.6    Silva, C.7    Gil, M.J.8    Salvador, J.9    Frühbeck, G.10
  • 35
    • 84875519919 scopus 로고    scopus 로고
    • Increased levels of chemerin and its receptor, chemokine-like receptor-1, in obesity are related to inflammation: Tumor necrosis factor-alpha stimulates mRNA levels of chemerin in visceral adipocytes from obese patients
    • Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Rotellar F, Valentí V, Silva C, Gil MJ, Salvador J, Frühbeck G. Increased levels of chemerin and its receptor, chemokine-like receptor-1, in obesity are related to inflammation: tumor necrosis factor-alpha stimulates mRNA levels of chemerin in visceral adipocytes from obese patients. Surg Obes Relat Dis 9: 306-314, 2013.
    • (2013) Surg Obes Relat Dis , vol.9 , pp. 306-314
    • Catalán, V.1    Gómez-Ambrosi, J.2    Rodríguez, A.3    Ramírez, B.4    Rotellar, F.5    Valentí, V.6    Silva, C.7    Gil, M.J.8    Salvador, J.9    Frühbeck, G.10
  • 37
    • 84891831269 scopus 로고    scopus 로고
    • Six-transmem-brane epithelial antigen of prostate 4 and neutrophil gelatinase-associated lipocalin expression in visceral adipose tissue is related to iron status and inflammation in human obesity
    • Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Rotellar F, Valentí V, Silva C, Gil MJ, Salvador J, Frühbeck G. Six-transmem-brane epithelial antigen of prostate 4 and neutrophil gelatinase-associated lipocalin expression in visceral adipose tissue is related to iron status and inflammation in human obesity. Eur J Nutr 52: 1587-1595, 2013.
    • (2013) Eur J Nutr , vol.52 , pp. 1587-1595
    • Catalán, V.1    Gómez-Ambrosi, J.2    Rodríguez, A.3    Ramírez, B.4    Rotellar, F.5    Valentí, V.6    Silva, C.7    Gil, M.J.8    Salvador, J.9    Frühbeck, G.10
  • 40
    • 84928685233 scopus 로고    scopus 로고
    • Peripheral mononuclear blood cells contribute to the obesity-associated inflammatory state independently of glycemic status: Involvement of the novel proinflammatory adipokines chemerin, chitinase-3-like protein 1, lipocalin-2 and osteopontin
    • Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Valentí V, Moncada R, Silva C, Salvador J, Frühbeck G. Peripheral mononuclear blood cells contribute to the obesity-associated inflammatory state independently of glycemic status: involvement of the novel proinflammatory adipokines chemerin, chitinase-3-like protein 1, lipocalin-2 and osteopontin. Genes Nutr 10: 460, 2015.
    • (2015) Genes Nutr , vol.10 , pp. 460
    • Catalán, V.1    Gómez-Ambrosi, J.2    Rodríguez, A.3    Ramírez, B.4    Valentí, V.5    Moncada, R.6    Silva, C.7    Salvador, J.8    Frühbeck, G.9
  • 41
    • 84928107998 scopus 로고    scopus 로고
    • Thermogenic brown and beige/brite adipogenesis in humans
    • Cereijo R, Giralt M, Villarroya F. Thermogenic brown and beige/brite adipogenesis in humans. Ann Med 47: 169-177, 2015.
    • (2015) Ann Med , vol.47 , pp. 169-177
    • Cereijo, R.1    Giralt, M.2    Villarroya, F.3
  • 43
    • 0038823617 scopus 로고    scopus 로고
    • Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation
    • Chavey C, Mari B, Monthouel MN, Bonnafous S, Anglard P, Van Obberghen E, Tartare-Deckert S. Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation. J Biol Chem 278: 11888-11896, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 11888-11896
    • Chavey, C.1    Mari, B.2    Monthouel, M.N.3    Bonnafous, S.4    Anglard, P.5    Van Obberghen, E.6    Tartare-Deckert, S.7
  • 44
    • 0030183983 scopus 로고    scopus 로고
    • Influence of thyroxine in vivo on preadipocyte development and insulin-like growth factor-I and IGF binding protein secretion in fetal stromal vascular cell cultures
    • Chen NX, Hausman GJ, Wright JT. Influence of thyroxine in vivo on preadipocyte development and insulin-like growth factor-I and IGF binding protein secretion in fetal stromal vascular cell cultures. Obes Res 4: 357-366, 1996.
    • (1996) Obes Res , vol.4 , pp. 357-366
    • Chen, N.X.1    Hausman, G.J.2    Wright, J.T.3
  • 45
    • 33646139156 scopus 로고    scopus 로고
    • A pericellular collagenase directs the 3-dimensional development of white adipose tissue
    • Chun TH, Hotary KB, Sabeh F, Saltiel AR, Allen ED, Weiss SJ. A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell 125: 577-591, 2006.
    • (2006) Cell , vol.125 , pp. 577-591
    • Chun, T.H.1    Hotary, K.B.2    Sabeh, F.3    Saltiel, A.R.4    Allen, E.D.5    Weiss, S.J.6
  • 47
    • 84865484612 scopus 로고    scopus 로고
    • The adipose organ at a glance
    • Cinti S. The adipose organ at a glance. Dis Model Mech 5: 588-594, 2012.
    • (2012) Dis Model Mech , vol.5 , pp. 588-594
    • Cinti, S.1
  • 51
    • 84928975351 scopus 로고    scopus 로고
    • IL-7-induced glycerol transport and TAG synthesis promotes memory CD8 T cell longevity
    • Cui G, Staron MM, Gray SM, Ho PC, Amezquita RA, Wu J, Kaech SM. IL-7-induced glycerol transport and TAG synthesis promotes memory CD8 T cell longevity. Cell 161: 750-761, 2015.
    • (2015) Cell , vol.161 , pp. 750-761
    • Cui, G.1    Staron, M.M.2    Gray, S.M.3    Ho, P.C.4    Amezquita, R.A.5    Wu, J.6    Kaech, S.M.7
  • 52
    • 2342537773 scopus 로고    scopus 로고
    • From blood monocytes to adipose tissue-resident macrophages: Induction of diapedesis by human mature adipocytes
    • Curat CA, Miranville A, Sengenes C, Diehl M, Tonus C, Busse R, Bouloumie A. From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes 53: 1285-1292, 2004.
    • (2004) Diabetes , vol.53 , pp. 1285-1292
    • Curat, C.A.1    Miranville, A.2    Sengenes, C.3    Diehl, M.4    Tonus, C.5    Busse, R.6    Bouloumie, A.7
  • 56
    • 0032515065 scopus 로고    scopus 로고
    • The role of C/EBP genes in adipocyte differentiation
    • Darlington GJ, Ross SE, MacDougald OA. The role of C/EBP genes in adipocyte differentiation. J Biol Chem 273: 30057-30060, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 30057-30060
    • Darlington, G.J.1    Ross, S.E.2    Macdougald, O.A.3
  • 57
    • 15044365690 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1: A common denominator in obesity, diabetes and cardiovascular disease
    • De Taeye B, Smith LH, Vaughan DE. Plasminogen activator inhibitor-1: a common denominator in obesity, diabetes and cardiovascular disease. Curr Opin Pharmacol 5: 149-154, 2005.
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 149-154
    • De Taeye, B.1    Smith, L.H.2    Vaughan, D.E.3
  • 58
    • 0035021027 scopus 로고    scopus 로고
    • Osteopontin as a means to cope with environmental insults: Regulation of inflammation, tissue remodeling, and cell survival
    • Denhardt DT, Noda M, O’Regan AW, Pavlin D, Berman JS. Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest 107: 1055-1061, 2001.
    • (2001) J Clin Invest , vol.107 , pp. 1055-1061
    • Denhardt, D.T.1    Noda, M.2    O’Regan, A.W.3    Pavlin, D.4    Berman, J.S.5
  • 59
    • 23644446750 scopus 로고    scopus 로고
    • Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: Association with cytokine expression, insulin resistance, and reduction by pioglitazone
    • Di Gregorio GB, Yao-Borengasser A, Rasouli N, Varma V, Lu T, Miles LM, Ranganathan G, Peterson CA, McGehee RE, Kern PA. Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes 54: 2305-2313, 2005.
    • (2005) Diabetes , vol.54 , pp. 2305-2313
    • Di Gregorio, G.B.1    Yao-Borengasser, A.2    Rasouli, N.3    Varma, V.4    Lu, T.5    Miles, L.M.6    Ranganathan, G.7    Peterson, C.A.8    McGehee, R.E.9    Kern, P.A.10
  • 60
    • 79955044996 scopus 로고    scopus 로고
    • Architecture and the extracellular matrix: The still unappreciated components of the adipose tissue
    • Divoux A, Clément K. Architecture and the extracellular matrix: the still unappreciated components of the adipose tissue. Obes Rev 12: e494-e503, 2011.
    • (2011) Obes Rev , vol.12
    • Divoux, A.1    Clément, K.2
  • 63
    • 53149119231 scopus 로고    scopus 로고
    • Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding
    • Elgazar-Carmon V, Rudich A, Hadad N, Levy R. Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding. J Lipid Res 49: 1894-1903, 2008.
    • (2008) J Lipid Res , vol.49 , pp. 1894-1903
    • Elgazar-Carmon, V.1    Rudich, A.2    Hadad, N.3    Levy, R.4
  • 64
    • 84962074566 scopus 로고    scopus 로고
    • Adipose tissue-derived stem cells from obese subjects contribute to inflammation and reduced insulin response in adipocytes through differential regulation of the Th1/Th17 balance and monocyte activation
    • Eljaafari A, Robert M, Chehimi M, Chanon S, Durand C, Vial G, Bendridi N, Disse E, Laville M, Rieusset J, Lefai E, Vidal H, Pirola L. Adipose tissue-derived stem cells from obese subjects contribute to inflammation and reduced insulin response in adipocytes through differential regulation of the Th1/Th17 balance and monocyte activation. Diabetes, 2015.
    • (2015) Diabetes
    • Eljaafari, A.1    Robert, M.2    Chehimi, M.3    Chanon, S.4    Durand, C.5    Vial, G.6    Bendridi, N.7    Disse, E.8    Laville, M.9    Rieusset, J.10    Lefai, E.11    Vidal, H.12    Pirola, L.13
  • 65
    • 65649111494 scopus 로고    scopus 로고
    • The origins of brown adipose tissue
    • Enerbäck S. The origins of brown adipose tissue. N Engl J Med 360: 2021-2023, 2009.
    • (2009) N Engl J Med , vol.360 , pp. 2021-2023
    • Enerbäck, S.1
  • 66
    • 84888386052 scopus 로고    scopus 로고
    • Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor?
    • Erickson HP. Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor? Adipocyte 2: 289-293, 2013.
    • (2013) Adipocyte , vol.2 , pp. 289-293
    • Erickson, H.P.1
  • 69
    • 84874515764 scopus 로고    scopus 로고
    • Elevated chemerin levels in Pakistani men: An interrelation with metabolic syndrome phenotypes
    • Fatima SS, Bozaoglu K, Rehman R, Alam F, Memon AS. Elevated chemerin levels in Pakistani men: an interrelation with metabolic syndrome phenotypes. PLoS One 8: e57113, 2013.
    • (2013) Plos One , vol.8
    • Fatima, S.S.1    Bozaoglu, K.2    Rehman, R.3    Alam, F.4    Memon, A.S.5
  • 70
    • 84890011257 scopus 로고    scopus 로고
    • Macrophages, fat, and the emergence of immunometabolism
    • Ferrante AW Jr. Macrophages, fat, and the emergence of immunometabolism. J Clin Invest 123: 4992-4993, 2013.
    • (2013) J Clin Invest , vol.123 , pp. 4992-4993
    • Ferrante, A.W.1
  • 72
    • 33644660537 scopus 로고    scopus 로고
    • PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease
    • Finck BN, Kelly DP. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest 116: 615-622, 2006.
    • (2006) J Clin Invest , vol.116 , pp. 615-622
    • Finck, B.N.1    Kelly, D.P.2
  • 74
    • 10444270993 scopus 로고    scopus 로고
    • Proinflammatory S100 proteins in arthritis and autoimmune disease
    • Foell D, Roth J. Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis Rheum 50: 3762-3771, 2004.
    • (2004) Arthritis Rheum , vol.50 , pp. 3762-3771
    • Foell, D.1    Roth, J.2
  • 75
    • 0027482040 scopus 로고
    • Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men
    • Fried SK, Russell CD, Grauso NL, Brolin RE. Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men. J Clin Invest 92: 2191-2198, 1993.
    • (1993) J Clin Invest , vol.92 , pp. 2191-2198
    • Fried, S.K.1    Russell, C.D.2    Grauso, N.L.3    Brolin, R.E.4
  • 78
    • 28544441849 scopus 로고    scopus 로고
    • Obesity: Aquaporin enters the picture
    • Frühbeck G. Obesity: aquaporin enters the picture. Nature 438: 436-437, 2005.
    • (2005) Nature , vol.438 , pp. 436-437
    • Frühbeck, G.1
  • 79
    • 84934434968 scopus 로고    scopus 로고
    • Overview of adipose tissue and its role in obesity and metabolic disorders
    • Frühbeck G. Overview of adipose tissue and its role in obesity and metabolic disorders. Methods Mol Biol 456: 1-22, 2008.
    • (2008) Methods Mol Biol , vol.456 , pp. 1-22
    • Frühbeck, G.1
  • 81
    • 0037298988 scopus 로고    scopus 로고
    • Control of body weight: A physiologic and transgenic perspective
    • Frühbeck G, Gómez-Ambrosi J. Control of body weight: a physiologic and transgenic perspective. Diabetologia 46: 143-172, 2003.
    • (2003) Diabetologia , vol.46 , pp. 143-172
    • Frühbeck, G.1    Gómez-Ambrosi, J.2
  • 82
    • 0034987715 scopus 로고    scopus 로고
    • The adipocyte: A model for integration of endocrine and metabolic signaling in energy metabolism regulation
    • Frühbeck G, Gómez-Ambrosi J, Muruzabal FJ, Burrell MA. The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab 280: E827-E847, 2001.
    • (2001) Am J Physiol Endocrinol Metab , vol.280
    • Frühbeck, G.1    Gómez-Ambrosi, J.2    Muruzabal, F.J.3    Burrell, M.A.4
  • 83
    • 0035128497 scopus 로고    scopus 로고
    • Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes
    • Frühbeck G, Gómez-Ambrosi J, Salvador J. Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes. FASEB J 15: 333-340, 2001.
    • (2001) FASEB J , vol.15 , pp. 333-340
    • Frühbeck, G.1    Gómez-Ambrosi, J.2    Salvador, J.3
  • 84
    • 34250755430 scopus 로고    scopus 로고
    • Role of caveolins in body weight and insulin resistance regulation
    • Frühbeck G, López M, Diéguez C. Role of caveolins in body weight and insulin resistance regulation. Trends Endocrinol Metab 18: 177-182, 2007.
    • (2007) Trends Endocrinol Metab , vol.18 , pp. 177-182
    • Frühbeck, G.1    López, M.2    Diéguez, C.3
  • 86
    • 63449111349 scopus 로고    scopus 로고
    • PRDM16: The interconvertible adipo-myocyte switch
    • Frühbeck G, Sesma P, Burrell MA. PRDM16: the interconvertible adipo-myocyte switch. Trends Cell Biol 19: 141-146, 2009.
    • (2009) Trends Cell Biol , vol.19 , pp. 141-146
    • Frühbeck, G.1    Sesma, P.2    Burrell, M.A.3
  • 87
    • 84918547886 scopus 로고    scopus 로고
    • Need for a paradigm shift in adult overweight and obesity management-an EASO position statement on a pressing public health, clinical and scientific challenge in Europe
    • Frühbeck G, Toplak H, Woodward E, Halford JC, Yumuk V. Need for a paradigm shift in adult overweight and obesity management-an EASO position statement on a pressing public health, clinical and scientific challenge in Europe. Obes Facts 7: 408-416, 2014.
    • (2014) Obes Facts , vol.7 , pp. 408-416
    • Frühbeck, G.1    Toplak, H.2    Woodward, E.3    Halford, J.C.4    Yumuk, V.5
  • 88
    • 84875657566 scopus 로고    scopus 로고
    • Obesity: The gateway to ill health - an EASO position statement on a rising public health, clinical and scientific challenge in Europe
    • Frühbeck G, Toplak H, Woodward E, Yumuk V, Maislos M, Oppert JM. Obesity: the gateway to ill health - an EASO position statement on a rising public health, clinical and scientific challenge in Europe. Obes Facts 6: 117-120, 2013.
    • (2013) Obes Facts , vol.6 , pp. 117-120
    • Frühbeck, G.1    Toplak, H.2    Woodward, E.3    Yumuk, V.4    Maislos, M.5    Oppert, J.M.6
  • 89
    • 33746886979 scopus 로고    scopus 로고
    • Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
    • Fulda S, Debatin KM. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 25: 4798-4811, 2006.
    • (2006) Oncogene , vol.25 , pp. 4798-4811
    • Fulda, S.1    Debatin, K.M.2
  • 90
    • 84940417333 scopus 로고    scopus 로고
    • TNF-related apoptosis-inducing ligand promotes human preadipocyte proliferation via ERK1/2 activation
    • Funcke JB, Zoller V, El Hay MA, Debatin KM, Wabitsch M, and Fischer-Posovszky P. TNF-related apoptosis-inducing ligand promotes human preadipocyte proliferation via ERK1/2 activation. FASEB J 29: 3065-3075, 2015.
    • (2015) FASEB J , vol.29 , pp. 3065-3075
    • Funcke, J.B.1    Zoller, V.2    El Hay, M.A.3    Debatin, K.M.4    Wabitsch, M.5    Fischer-Posovszky, P.6
  • 91
  • 93
    • 0031906847 scopus 로고    scopus 로고
    • Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo
    • Giachelli CM, Lombardi D, Johnson RJ, Murry CE, Almeida M. Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo. Am J Pathol 152: 353-358, 1998.
    • (1998) Am J Pathol , vol.152 , pp. 353-358
    • Giachelli, C.M.1    Lombardi, D.2    Johnson, R.J.3    Murry, C.E.4    Almeida, M.5
  • 95
  • 96
    • 84883145789 scopus 로고    scopus 로고
    • White, brown, beige/brite: Different adipose cells for different functions?
    • Giralt M, Villarroya F. White, brown, beige/brite: different adipose cells for different functions? Endocrinology 154: 2992-3000, 2013.
    • (2013) Endocrinology , vol.154 , pp. 2992-3000
    • Giralt, M.1    Villarroya, F.2
  • 104
    • 42949088997 scopus 로고    scopus 로고
    • The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance
    • Goossens GH. The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance. Physiol Behav 94: 206-218, 2008.
    • (2008) Physiol Behav , vol.94 , pp. 206-218
    • Goossens, G.H.1
  • 107
    • 34547431645 scopus 로고    scopus 로고
    • Adipose tissue expandability in the maintenance of metabolic homeostasis
    • Gray SL, Vidal-Puig AJ. Adipose tissue expandability in the maintenance of metabolic homeostasis. Nutr Rev 65: S7-S12, 2007.
    • (2007) Nutr Rev , vol.65
    • Gray, S.L.1    Vidal-Puig, A.J.2
  • 108
    • 84907618625 scopus 로고    scopus 로고
    • Lipocalin 2 is a regulator of macrophage polarization and NF-kappaB/STAT3 pathway activation
    • Guo H, Jin D, Chen X. Lipocalin 2 is a regulator of macrophage polarization and NF-kappaB/STAT3 pathway activation. Mol Endocrinol 28: 1616-1628, 2014.
    • (2014) Mol Endocrinol , vol.28 , pp. 1616-1628
    • Guo, H.1    Jin, D.2    Chen, X.3
  • 109
    • 84863115382 scopus 로고    scopus 로고
    • Lipocalin 2 deficiency alters estradiol production and estrogen receptor signaling in female mice
    • Guo H, Zhang Y, Brockman DA, Hahn W, Bernlohr DA, Chen X. Lipocalin 2 deficiency alters estradiol production and estrogen receptor signaling in female mice. Endocrinology 153: 1183-1193, 2012.
    • (2012) Endocrinology , vol.153 , pp. 1183-1193
    • Guo, H.1    Zhang, Y.2    Brockman, D.A.3    Hahn, W.4    Bernlohr, D.A.5    Chen, X.6
  • 110
    • 84920887709 scopus 로고    scopus 로고
    • Transcriptional regulation of adipocyte differentiation: A central role for CCAAT/enhancer-binding protein (C/EBP) beta
    • Guo L, Li X, Tang QQ. Transcriptional regulation of adipocyte differentiation: a central role for CCAAT/enhancer-binding protein (C/EBP) beta. J Biol Chem 290: 755-761, 2015.
    • (2015) J Biol Chem , vol.290 , pp. 755-761
    • Guo, L.1    Li, X.2    Tang, Q.Q.3
  • 114
    • 0027505001 scopus 로고
    • Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family
    • Hakala BE, White C, Recklies AD. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. J Biol Chem 268: 25803-25810, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 25803-25810
    • Hakala, B.E.1    White, C.2    Recklies, A.D.3
  • 116
    • 0025923845 scopus 로고
    • Intracellular targeting of the insulin-regulatable glucose transporter (GLUT4) is isoform specific and independent of cell type
    • Haney PM, Slot JW, Piper RC, James DE, Mueckler M. Intracellular targeting of the insulin-regulatable glucose transporter (GLUT4) is isoform specific and independent of cell type. J Cell Biol 114: 689-699, 1991.
    • (1991) J Cell Biol , vol.114 , pp. 689-699
    • Haney, P.M.1    Slot, J.W.2    Piper, R.C.3    James, D.E.4    Mueckler, M.5
  • 117
    • 18144401213 scopus 로고    scopus 로고
    • Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation
    • Hara-Chikuma M, Sohara E, Rai T, Ikawa M, Okabe M, Sasaki S, Uchida S, Verkman AS. Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation. J Biol Chem 280: 15493-15496, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 15493-15496
    • Hara-Chikuma, M.1    Sohara, E.2    Rai, T.3    Ikawa, M.4    Okabe, M.5    Sasaki, S.6    Uchida, S.7    Verkman, A.S.8
  • 119
    • 78649844951 scopus 로고    scopus 로고
    • Chemerin contributes to inflammation by promoting macrophage adhesion to VCAM-1 and fibronectin through clustering of VLA-4 and VLA-5
    • Hart R, Greaves DR. Chemerin contributes to inflammation by promoting macrophage adhesion to VCAM-1 and fibronectin through clustering of VLA-4 and VLA-5. J Immunol 185: 3728-3739, 2010.
    • (2010) J Immunol , vol.185 , pp. 3728-3739
    • Hart, R.1    Greaves, D.R.2
  • 120
    • 0032472834 scopus 로고    scopus 로고
    • Expression of the Elm1 gene, a novel gene of the CCN (Connective tissue growth factor, Cyr61/Cef10, and neuroblastoma overexpressed gene) family, suppresses In vivo tumor growth and metastasis of K-1735 murine melanoma cells
    • Hashimoto Y, Shindo-Okada N, Tani M, Nagamachi Y, Takeuchi K, Shiroishi T, Toma H, Yokota J. Expression of the Elm1 gene, a novel gene of the CCN (connective tissue growth factor, Cyr61/Cef10, and neuroblastoma overexpressed gene) family, suppresses In vivo tumor growth and metastasis of K-1735 murine melanoma cells. J Exp Med 187: 289-296, 1998.
    • (1998) J Exp Med , vol.187 , pp. 289-296
    • Hashimoto, Y.1    Shindo-Okada, N.2    Tani, M.3    Nagamachi, Y.4    Takeuchi, K.5    Shiroishi, T.6    Toma, H.7    Yokota, J.8
  • 121
    • 68949172222 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates lipopolysaccharideinduced collagen secretion by phosphoinositide3-kinase-Akt pathway in fibroblasts during acute lung injury
    • He Z, Zhu Y, Jiang H. Toll-like receptor 4 mediates lipopolysaccharideinduced collagen secretion by phosphoinositide3-kinase-Akt pathway in fibroblasts during acute lung injury. J Recept Signal Transduct Res 29: 119-125, 2009.
    • (2009) J Recept Signal Transduct Res , vol.29 , pp. 119-125
    • He, Z.1    Zhu, Y.2    Jiang, H.3
  • 127
    • 33847258328 scopus 로고    scopus 로고
    • Constitutive and regulated expression and secretion of interferon-gamma-inducible protein 10 (IP-10/CXCL10) in human adipocytes
    • Herder C, Hauner H, Kempf K, Kolb H, Skurk T. Constitutive and regulated expression and secretion of interferon-gamma-inducible protein 10 (IP-10/CXCL10) in human adipocytes. Int J Obes 31: 403-410, 2007.
    • (2007) Int J Obes , vol.31 , pp. 403-410
    • Herder, C.1    Hauner, H.2    Kempf, K.3    Kolb, H.4    Skurk, T.5
  • 128
  • 132
    • 84893933424 scopus 로고    scopus 로고
    • Irisin as a muscle-derived hormone stimulating thermogenesis-a critical update
    • Hofmann T, Elbelt U, Stengel A. Irisin as a muscle-derived hormone stimulating thermogenesis-a critical update. Peptides 54: 89-100, 2014.
    • (2014) Peptides , vol.54 , pp. 89-100
    • Hofmann, T.1    Elbelt, U.2    Stengel, A.3
  • 133
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259: 87-91, 1993.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 134
    • 0031053823 scopus 로고    scopus 로고
    • Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance
    • Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BM. Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes 46: 451-455, 1997.
    • (1997) Diabetes , vol.46 , pp. 451-455
    • Hotamisligil, G.S.1    Arner, P.2    Atkinson, R.L.3    Spiegelman, B.M.4
  • 135
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259: 87-91, 1993.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 137
    • 69149091047 scopus 로고    scopus 로고
    • BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage
    • Huang H, Song TJ, Li X, Hu L, He Q, Liu M, Lane MD, Tang QQ. BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci USA 106: 12670-12675, 2009.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12670-12675
    • Huang, H.1    Song, T.J.2    Li, X.3    Hu, L.4    He, Q.5    Liu, M.6    Lane, M.D.7    Tang, Q.Q.8
  • 139
    • 84869497609 scopus 로고    scopus 로고
    • FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise
    • Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, Mantzoros CS. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 61: 1725-1738, 2012.
    • (2012) Metabolism , vol.61 , pp. 1725-1738
    • Huh, J.Y.1    Panagiotou, G.2    Mougios, V.3    Brinkoetter, M.4    Vamvini, M.T.5    Schneider, B.E.6    Mantzoros, C.S.7
  • 140
    • 84961289743 scopus 로고    scopus 로고
    • PRDM16 enhances nuclear receptor-dependent transcription of the brown fatspecific Ucp1 gene through interactions with Mediator subunit MED1
    • Iida S, Chen W, Nakadai T, Ohkuma Y, Roeder RG. PRDM16 enhances nuclear receptor-dependent transcription of the brown fatspecific Ucp1 gene through interactions with Mediator subunit MED1. Genes Dev 29: 308-321, 2015.
    • (2015) Genes Dev , vol.29 , pp. 308-321
    • Iida, S.1    Chen, W.2    Nakadai, T.3    Ohkuma, Y.4    Roeder, R.G.5
  • 141
    • 58249095114 scopus 로고    scopus 로고
    • WHO recognition of the global obesity epidemic
    • James WP. WHO recognition of the global obesity epidemic. Int J Obes (Lond) 32, Suppl 7: S120-S126, 2008.
    • (2008) Int J Obes (Lond) , vol.32
    • James, W.P.1
  • 142
    • 84870170324 scopus 로고    scopus 로고
    • Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression
    • Jansen HJ, van Essen P, Koenen T, Joosten LA, Netea MG, Tack CJ, Stienstra R. Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression. Endocrinology 153: 5866-5874, 2012.
    • (2012) Endocrinology , vol.153 , pp. 5866-5874
    • Jansen, H.J.1    Van Essen, P.2    Koenen, T.3    Joosten, L.A.4    Netea, M.G.5    Tack, C.J.6    Stienstra, R.7
  • 145
    • 79551616552 scopus 로고    scopus 로고
    • Lipocalin 2 is a selective modulator of peroxisome proliferator-activated receptor-gamma activation and function in lipid homeostasis and energy expenditure
    • Jin D, Guo H, Bu SY, Zhang Y, Hannaford J, Mashek DG, Chen X. Lipocalin 2 is a selective modulator of peroxisome proliferator-activated receptor-gamma activation and function in lipid homeostasis and energy expenditure. FASEB J 25: 754-764, 2011.
    • (2011) FASEB J , vol.25 , pp. 754-764
    • Jin, D.1    Guo, H.2    Bu, S.Y.3    Zhang, Y.4    Hannaford, J.5    Mashek, D.G.6    Chen, X.7
  • 149
    • 0034117025 scopus 로고    scopus 로고
    • The tenascin family of ECM glycoproteins: Structure, function, and regulation during embryonic development and tissue remodeling
    • Jones FS, Jones PL. The tenascin family of ECM glycoproteins: structure, function, and regulation during embryonic development and tissue remodeling. Dev Dyn 218: 235-259, 2000.
    • (2000) Dev Dyn , vol.218 , pp. 235-259
    • Jones, F.S.1    Jones, P.L.2
  • 150
    • 84864118287 scopus 로고    scopus 로고
    • Immunological complications of obesity
    • Kanneganti TD, Dixit VD. Immunological complications of obesity. Nat Immunol 13: 707-712, 2012.
    • (2012) Nat Immunol , vol.13 , pp. 707-712
    • Kanneganti, T.D.1    Dixit, V.D.2
  • 152
    • 0025950322 scopus 로고
    • Transforming growth factor-beta: An important mediator of immunoregulation
    • Kehrl JH. Transforming growth factor-beta: an important mediator of immunoregulation. Int J Cell Cloning 9: 438-450, 1991.
    • (1991) Int J Cell Cloning , vol.9 , pp. 438-450
    • Kehrl, J.H.1
  • 161
    • 0030007427 scopus 로고    scopus 로고
    • ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism
    • Kim JB, Spiegelman BM. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev 10: 1096-1107, 1996.
    • (1996) Genes Dev , vol.10 , pp. 1096-1107
    • Kim, J.B.1    Spiegelman, B.M.2
  • 162
    • 0032516081 scopus 로고    scopus 로고
    • ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand
    • Kim JB, Wright HM, Wright M, Spiegelman BM. ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand. Proc Natl Acad Sci USA 95: 4333-4337, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 4333-4337
    • Kim, J.B.1    Wright, H.M.2    Wright, M.3    Spiegelman, B.M.4
  • 164
    • 0027256664 scopus 로고
    • Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase
    • Kjeldsen L, Johnsen AH, Sengelov H, Borregaard N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 268: 10425-10432, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 10425-10432
    • Kjeldsen, L.1    Johnsen, A.H.2    Sengelov, H.3    Borregaard, N.4
  • 165
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman PG. Obesity as a medical problem. Nature 404: 635-643, 2000.
    • (2000) Nature , vol.404 , pp. 635-643
    • Kopelman, P.G.1
  • 168
    • 84918563183 scopus 로고    scopus 로고
    • Macrophage polarization in obesity and type 2 diabetes: Weighing down our understanding of macrophage function?
    • Kraakman MJ, Murphy AJ, Jandeleit-Dahm K, Kammoun HL. Macrophage polarization in obesity and type 2 diabetes: weighing down our understanding of macrophage function? Front Immunol 5: 470, 2014.
    • (2014) Front Immunol , vol.5 , pp. 470
    • Kraakman, M.J.1    Murphy, A.J.2    Jandeleit-Dahm, K.3    Kammoun, H.L.4
  • 174
    • 84901983235 scopus 로고    scopus 로고
    • Antiinflammatory effects of hepatocyte growth factor on the vicious cycle of macrophages and adipocytes
    • Kusunoki H, Taniyama Y, Otsu R, Rakugi H, Morishita R. Antiinflammatory effects of hepatocyte growth factor on the vicious cycle of macrophages and adipocytes. Hypertens Res 37: 500-506, 2014.
    • (2014) Hypertens Res , vol.37 , pp. 500-506
    • Kusunoki, H.1    Taniyama, Y.2    Otsu, R.3    Rakugi, H.4    Morishita, R.5
  • 175
    • 84873840901 scopus 로고    scopus 로고
    • Aquaporin-10 represents an alternative pathway for glycerol efflux from human adipocytes
    • Laforenza U, Scaffino MF, Gastaldi G. Aquaporin-10 represents an alternative pathway for glycerol efflux from human adipocytes. PLoS One 8: e54474, 2013.
    • (2013) Plos One , vol.8
    • Laforenza, U.1    Scaffino, M.F.2    Gastaldi, G.3
  • 177
    • 84901630148 scopus 로고    scopus 로고
    • Osteopontin deletion prevents the development of obesity and hepatic steatosis via impaired adipose tissue matrix remodeling and reduced inflammation and fibrosis in adipose tissue and liver in mice
    • Lancha A, Rodríguez A, Catalán V, Becerril S, Sáinz N, Ramírez B, Burrell MA, Salvador J, Frühbeck G, Gómez-Ambrosi J. Osteopontin deletion prevents the development of obesity and hepatic steatosis via impaired adipose tissue matrix remodeling and reduced inflammation and fibrosis in adipose tissue and liver in mice. PLoS One 9: e98398, 2014.
    • (2014) Plos One , vol.9
    • Lancha, A.1    Rodríguez, A.2    Catalán, V.3    Becerril, S.4    Sáinz, N.5    Ramírez, B.6    Burrell, M.A.7    Salvador, J.8    Frühbeck, G.9    Gómez-Ambrosi, J.10
  • 178
    • 33646778517 scopus 로고    scopus 로고
    • Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome
    • Langin D. Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Pharmacol Res 53: 482-491, 2006.
    • (2006) Pharmacol Res , vol.53 , pp. 482-491
    • Langin, D.1
  • 180
    • 35148869758 scopus 로고    scopus 로고
    • Serum and mucosal S100 proteins, calprotectin (S100A8/S100A9) and S100A12, are elevated at diagnosis in children with inflammatory bowel disease
    • Leach ST, Yang Z, Messina I, Song C, Geczy CL, Cunningham AM, Day AS. Serum and mucosal S100 proteins, calprotectin (S100A8/S100A9) and S100A12, are elevated at diagnosis in children with inflammatory bowel disease. Scand J Gastroenterol 42: 1321-1331, 2007.
    • (2007) Scand J Gastroenterol , vol.42 , pp. 1321-1331
    • Leach, S.T.1    Yang, Z.2    Messina, I.3    Song, C.4    Geczy, C.L.5    Cunningham, A.M.6    Day, A.S.7
  • 181
    • 84945221434 scopus 로고    scopus 로고
    • Non-pharmacological and pharmacological strategies of brown adipose tissue recruitment in humans
    • Lee P, Greenfield JR. Non-pharmacological and pharmacological strategies of brown adipose tissue recruitment in humans. Mol Cell Endocrinol: doi: 10.1016/j.mce.2015.1005.1025, 2015.
    • (2015) Mol Cell Endocrinol
    • Lee, P.1    Greenfield, J.R.2
  • 182
    • 84896710569 scopus 로고    scopus 로고
    • Functional thermogenic beige adipogenesis is inducible in human neck fat
    • Lee P, Werner CD, Kebebew E, Celi FS. Functional thermogenic beige adipogenesis is inducible in human neck fat. Int J Obes 38: 170-176, 2014.
    • (2014) Int J Obes , vol.38 , pp. 170-176
    • Lee, P.1    Werner, C.D.2    Kebebew, E.3    Celi, F.S.4
  • 183
    • 84908112058 scopus 로고    scopus 로고
    • Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes
    • Li Y, Fromme T, Schweizer S, Schottl T, Klingenspor M. Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes. EMBO Rep 15: 1069-1076, 2014.
    • (2014) EMBO Rep , vol.15 , pp. 1069-1076
    • Li, Y.1    Fromme, T.2    Schweizer, S.3    Schottl, T.4    Klingenspor, M.5
  • 185
    • 0036092411 scopus 로고    scopus 로고
    • Metalloproteases and adipogenesis: A weighty subject
    • Lilla J, Stickens D, Werb Z. Metalloproteases and adipogenesis: a weighty subject. Am J Pathol 160: 1551-1554, 2002.
    • (2002) Am J Pathol , vol.160 , pp. 1551-1554
    • Lilla, J.1    Stickens, D.2    Werb, Z.3
  • 188
    • 43049179999 scopus 로고    scopus 로고
    • LPS/TLR4 signal transduction pathway
    • Lu YC, Yeh WC, Ohashi PS. LPS/TLR4 signal transduction pathway. Cytokine 42: 145-151, 2008.
    • (2008) Cytokine , vol.42 , pp. 145-151
    • Lu, Y.C.1    Yeh, W.C.2    Ohashi, P.S.3
  • 189
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117: 175-184, 2007.
    • (2007) J Clin Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 190
    • 33847073149 scopus 로고    scopus 로고
    • Increased inflammatory properties of adipose tissue macrophages recruited during dietinduced obesity
    • Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR. Increased inflammatory properties of adipose tissue macrophages recruited during dietinduced obesity. Diabetes 56: 16-23, 2007.
    • (2007) Diabetes , vol.56 , pp. 16-23
    • Lumeng, C.N.1    Deyoung, S.M.2    Bodzin, J.L.3    Saltiel, A.R.4
  • 193
    • 84925656183 scopus 로고    scopus 로고
    • Aquaporin-5 is expressed in adipocytes with implications in adipose differentiation
    • Madeira A, Mosca AF, Moura TF, Soveral G. Aquaporin-5 is expressed in adipocytes with implications in adipose differentiation. IUBMB Life 67: 54-60, 2015.
    • (2015) IUBMB Life , vol.67 , pp. 54-60
    • Madeira, A.1    Mosca, A.F.2    Moura, T.F.3    Soveral, G.4
  • 194
    • 77953521260 scopus 로고    scopus 로고
    • Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis
    • Mader I, Wabitsch M, Debatin KM, Fischer-Posovszky P, Fulda S. Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis. FASEB J 24: 1997-2009, 2010.
    • (2010) FASEB J , vol.24 , pp. 1997-2009
    • Mader, I.1    Wabitsch, M.2    Debatin, K.M.3    Fischer-Posovszky, P.4    Fulda, S.5
  • 198
    • 80052531958 scopus 로고    scopus 로고
    • Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans
    • Meissburger B, Stachorski L, Roder E, Rudofsky G, Wolfrum C. Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans. Diabetologia 54: 1468-1479, 2011.
    • (2011) Diabetologia , vol.54 , pp. 1468-1479
    • Meissburger, B.1    Stachorski, L.2    Roder, E.3    Rudofsky, G.4    Wolfrum, C.5
  • 202
    • 0023057194 scopus 로고
    • Adipsin, the adipocyte serine protease: Gene structure and control of expression by tumor necrosis factor
    • Min HY, Spiegelman BM. Adipsin, the adipocyte serine protease: gene structure and control of expression by tumor necrosis factor. Nucleic Acids Res 14: 8879-8892, 1986.
    • (1986) Nucleic Acids Res , vol.14 , pp. 8879-8892
    • Min, H.Y.1    Spiegelman, B.M.2
  • 207
    • 84906775801 scopus 로고    scopus 로고
    • Characteristic expression of extracellular matrix in subcutaneous adipose tissue development and adipogenesis; comparison with visceral adipose tissue
    • Mori S, Kiuchi S, Ouchi A, Hase T, Murase T. Characteristic expression of extracellular matrix in subcutaneous adipose tissue development and adipogenesis; comparison with visceral adipose tissue. Int J Biol Sci 10: 825-833, 2014.
    • (2014) Int J Biol Sci , vol.10 , pp. 825-833
    • Mori, S.1    Kiuchi, S.2    Ouchi, A.3    Hase, T.4    Murase, T.5
  • 209
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136: 2348-2357, 1986.
    • (1986) J Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 211
    • 0028152707 scopus 로고
    • Macrophages express osteopontin during repair of myocardial necrosis
    • Murry CE, Giachelli CM, Schwartz SM, Vracko R. Macrophages express osteopontin during repair of myocardial necrosis. Am J Pathol 145: 1450-1462, 1994.
    • (1994) Am J Pathol , vol.145 , pp. 1450-1462
    • Murry, C.E.1    Giachelli, C.M.2    Schwartz, S.M.3    Vracko, R.4
  • 217
    • 79952160358 scopus 로고    scopus 로고
    • New powers of brown fat: Fighting the metabolic syndrome
    • Nedergaard J, Bengtsson T, Cannon B. New powers of brown fat: fighting the metabolic syndrome. Cell Metab 13: 238-240, 2011.
    • (2011) Cell Metab , vol.13 , pp. 238-240
    • Nedergaard, J.1    Bengtsson, T.2    Cannon, B.3
  • 218
    • 84877329765 scopus 로고    scopus 로고
    • How brown is brown fat? It depends where you look
    • Nedergaard J, Cannon B. How brown is brown fat? It depends where you look. Nat Med 19: 540-541, 2013.
    • (2013) Nat Med , vol.19 , pp. 540-541
    • Nedergaard, J.1    Cannon, B.2
  • 221
    • 0033789865 scopus 로고    scopus 로고
    • IGF-I inhibits apoptosis induced by serum withdrawal, but potentiates TNF-alpha-induced apoptosis, in 3T3-L1 preadipocytes
    • Niesler CU, Urso B, Prins JB, Siddle K. IGF-I inhibits apoptosis induced by serum withdrawal, but potentiates TNF-alpha-induced apoptosis, in 3T3-L1 preadipocytes. J Endocrinol 167: 165-174, 2000.
    • (2000) J Endocrinol , vol.167 , pp. 165-174
    • Niesler, C.U.1    Urso, B.2    Prins, J.B.3    Siddle, K.4
  • 226
    • 33947249865 scopus 로고    scopus 로고
    • A constitutive endogenous osteopontin production is important for macrophage function and differentiation
    • Nystrom T, Duner P, Hultgardh-Nilsson A. A constitutive endogenous osteopontin production is important for macrophage function and differentiation. Exp Cell Res 313: 1149-1160, 2007.
    • (2007) Exp Cell Res , vol.313 , pp. 1149-1160
    • Nystrom, T.1    Duner, P.2    Hultgardh-Nilsson, A.3
  • 229
    • 84889604511 scopus 로고    scopus 로고
    • EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex
    • Ohno H, Shinoda K, Ohyama K, Sharp LZ, Kajimura S. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature 504: 163-167, 2013.
    • (2013) Nature , vol.504 , pp. 163-167
    • Ohno, H.1    Shinoda, K.2    Ohyama, K.3    Sharp, L.Z.4    Kajimura, S.5
  • 230
    • 84858039282 scopus 로고    scopus 로고
    • PPARgamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
    • Ohno H, Shinoda K, Spiegelman BM, Kajimura S. PPARgamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab 15: 395-404, 2012.
    • (2012) Cell Metab , vol.15 , pp. 395-404
    • Ohno, H.1    Shinoda, K.2    Spiegelman, B.M.3    Kajimura, S.4
  • 237
    • 78650098848 scopus 로고    scopus 로고
    • Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans
    • Ouellet V, Routhier-Labadie A, Bellemare W, Lakhal-Chaieb L, Turcotte E, Carpentier AC, Richard D. Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans. J Clin Endocrinol Metab 96: 192-199, 2011.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 192-199
    • Ouellet, V.1    Routhier-Labadie, A.2    Bellemare, W.3    Lakhal-Chaieb, L.4    Turcotte, E.5    Carpentier, A.C.6    Richard, D.7
  • 238
    • 84896290419 scopus 로고    scopus 로고
    • The physiological roles of apolipoprotein J/clusterin in metabolic and cardiovascular diseases
    • Park S, Mathis KW, Lee IK. The physiological roles of apolipoprotein J/clusterin in metabolic and cardiovascular diseases. Rev Endocr Metab Disord 15: 45-53, 2013.
    • (2013) Rev Endocr Metab Disord , vol.15 , pp. 45-53
    • Park, S.1    Mathis, K.W.2    Lee, I.K.3
  • 239
    • 52749092267 scopus 로고    scopus 로고
    • Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals
    • Patsouris D, Li PP, Thapar D, Chapman J, Olefsky JM, Neels JG. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 8: 301-309, 2008.
    • (2008) Cell Metab , vol.8 , pp. 301-309
    • Patsouris, D.1    Li, P.P.2    Thapar, D.3    Chapman, J.4    Olefsky, J.M.5    Neels, J.G.6
  • 240
    • 84965094994 scopus 로고    scopus 로고
    • Plasma calprotectin and its association with cardiovascular disease manifestations, obesity and the metabolic syndrome in type 2 diabetes mellitus patients
    • Pedersen L, Nybo M, Poulsen MK, Henriksen JE, Dahl J, Rasmussen LM. Plasma calprotectin and its association with cardiovascular disease manifestations, obesity and the metabolic syndrome in type 2 diabetes mellitus patients. BMC Cardiovasc Disord 14: 196, 2014.
    • (2014) BMC Cardiovasc Disord , vol.14 , pp. 196
    • Pedersen, L.1    Nybo, M.2    Poulsen, M.K.3    Henriksen, J.E.4    Dahl, J.5    Rasmussen, L.M.6
  • 242
    • 0034917476 scopus 로고    scopus 로고
    • Increased level of YKL-40 in sera from patients with early rheumatoid arthritis: A new marker for disease activity
    • Peltomaa R, Paimela L, Harvey S, Helve T, Leirisalo-Repo M. Increased level of YKL-40 in sera from patients with early rheumatoid arthritis: a new marker for disease activity. Rheumatol Int 20: 192-196, 2001.
    • (2001) Rheumatol Int , vol.20 , pp. 192-196
    • Peltomaa, R.1    Paimela, L.2    Harvey, S.3    Helve, T.4    Leirisalo-Repo, M.5
  • 243
    • 40749112792 scopus 로고    scopus 로고
    • Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10
    • Pereira C, Schaer DJ, Bachli EB, Kurrer MO, Schoedon G. Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arterioscler Thromb Vasc Biol 28: 504-510, 2008.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 504-510
    • Pereira, C.1    Schaer, D.J.2    Bachli, E.B.3    Kurrer, M.O.4    Schoedon, G.5
  • 245
    • 0034719136 scopus 로고    scopus 로고
    • Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state
    • Poon S, Easterbrook-Smith SB, Rybchyn MS, Carver JA, Wilson MR. Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state. Biochemistry 39: 15953-15960, 2000.
    • (2000) Biochemistry , vol.39 , pp. 15953-15960
    • Poon, S.1    Easterbrook-Smith, S.B.2    Rybchyn, M.S.3    Carver, J.A.4    Wilson, M.R.5
  • 247
    • 0035428060 scopus 로고    scopus 로고
    • Beyond body mass index
    • Prentice AM, Jebb SA. Beyond body mass index. Obes Rev 2: 141-147, 2001.
    • (2001) Obes Rev , vol.2 , pp. 141-147
    • Prentice, A.M.1    Jebb, S.A.2
  • 251
    • 0030898101 scopus 로고    scopus 로고
    • Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway
    • Rammes A, Roth J, Goebeler M, Klempt M, Hartmann M, Sorg C. Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J Biol Chem 272: 9496-9502, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 9496-9502
    • Rammes, A.1    Roth, J.2    Goebeler, M.3    Klempt, M.4    Hartmann, M.5    Sorg, C.6
  • 253
    • 61849086267 scopus 로고    scopus 로고
    • YKL-40, a marker of inflammation and endothelial dysfunction, is elevated in patients with type 1 diabetes and increases with levels of albuminuria
    • Rathcke CN, Persson F, Tarnow L, Rossing P, Vestergaard H. YKL-40, a marker of inflammation and endothelial dysfunction, is elevated in patients with type 1 diabetes and increases with levels of albuminuria. Diabetes Care 32: 323-328, 2009.
    • (2009) Diabetes Care , vol.32 , pp. 323-328
    • Rathcke, C.N.1    Persson, F.2    Tarnow, L.3    Rossing, P.4    Vestergaard, H.5
  • 254
    • 33748485114 scopus 로고    scopus 로고
    • YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis
    • Rathcke CN, Vestergaard H. YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis. Inflamm Res 55: 221-227, 2006.
    • (2006) Inflamm Res , vol.55 , pp. 221-227
    • Rathcke, C.N.1    Vestergaard, H.2
  • 256
    • 0031571093 scopus 로고    scopus 로고
    • Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation
    • Rehli M, Krause SW, Andreesen R. Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation. Genomics 43: 221-225, 1997.
    • (1997) Genomics , vol.43 , pp. 221-225
    • Rehli, M.1    Krause, S.W.2    Reesen, R.3
  • 260
    • 84924732269 scopus 로고    scopus 로고
    • Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice
    • Rodríguez A, Becerril S, Méndez-Giménez L, Ramírez B, Sáinz N, Catalán V, Gómez-Ambrosi J, Frühbeck G. Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice. Int J Obes 39: 397-407, 2015.
    • (2015) Int J Obes , vol.39 , pp. 397-407
    • Rodríguez, A.1    Becerril, S.2    Méndez-Giménez, L.3    Ramírez, B.4    Sáinz, N.5    Catalán, V.6    Gómez-Ambrosi, J.7    Frühbeck, G.8
  • 262
    • 34447560040 scopus 로고    scopus 로고
    • Visceral and subcutaneous adiposity: Are both potential therapeutic targets for tackling the metabolic syndrome?
    • Rodríguez A, Catalán V, Gomez-Ambrosi J, Frühbeck G. Visceral and subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome? Curr Pharm Des 13: 2169-2175, 2007.
    • (2007) Curr Pharm Des , vol.13 , pp. 2169-2175
    • Rodríguez, A.1    Catalán, V.2    Gomez-Ambrosi, J.3    Frühbeck, G.4
  • 263
    • 79956028093 scopus 로고    scopus 로고
    • Aquaglyceroporins serve as metabolic gateways in adiposity and insulin resistance control
    • Rodríguez A, Catalán V, Gómez-Ambrosi J, Frühbeck G. Aquaglyceroporins serve as metabolic gateways in adiposity and insulin resistance control. Cell Cycle 10: 1548-1556, 2011.
    • (2011) Cell Cycle , vol.10 , pp. 1548-1556
    • Rodríguez, A.1    Catalán, V.2    Gómez-Ambrosi, J.3    Frühbeck, G.4
  • 265
    • 33845914627 scopus 로고    scopus 로고
    • The inhibitory effect of leptin on angiotensin II-induced vasoconstriction in vascular smooth muscle cells is mediated via a nitric oxide-dependent mechanism
    • Rodríguez A, Fortuño A, Gómez-Ambrosi J, Zalba G, Díez J, Frühbeck G. The inhibitory effect of leptin on angiotensin II-induced vasoconstriction in vascular smooth muscle cells is mediated via a nitric oxide-dependent mechanism. Endocrinology 148: 324-331, 2007.
    • (2007) Endocrinology , vol.148 , pp. 324-331
    • Rodríguez, A.1    Fortuño, A.2    Gómez-Ambrosi, J.3    Zalba, G.4    Díez, J.5    Frühbeck, G.6
  • 270
    • 0032510987 scopus 로고    scopus 로고
    • Characterization of CCAAT/enhancer-binding protein alpha as a cyclic AMP-responsive nuclear regulator
    • Roesler WJ, Park EA, McFie PJ. Characterization of CCAAT/enhancer-binding protein alpha as a cyclic AMP-responsive nuclear regulator. J Biol Chem 273: 14950-14957, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 14950-14957
    • Roesler, W.J.1    Park, E.A.2    McFie, P.J.3
  • 271
    • 84920391043 scopus 로고    scopus 로고
    • Heat shock proteins: In vivo heat treatments reveal adipose tissue depotspecific effects
    • Rogers RS, Beaudoin MS, Wheatley JL, Wright DC, Geiger PC. Heat shock proteins: in vivo heat treatments reveal adipose tissue depotspecific effects. J Appl Physiol 118: 98-106, 2015.
    • (2015) J Appl Physiol , vol.118 , pp. 98-106
    • Rogers, R.S.1    Beaudoin, M.S.2    Wheatley, J.L.3    Wright, D.C.4    Geiger, P.C.5
  • 273
    • 33845325476 scopus 로고    scopus 로고
    • Adipocyte differentiation from the inside out
    • Rosen ED, MacDougald OA. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 7: 885-896, 2006.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 885-896
    • Rosen, E.D.1    Macdougald, O.A.2
  • 278
    • 0032806620 scopus 로고    scopus 로고
    • Regulation of macrophage migration inhibitory factor (MIF) expression by glucose and insulin in adipocytes in vitro
    • Sakaue S, Nishihira J, Hirokawa J, Yoshimura H, Honda T, Aoki K, Tagami S, Kawakami Y. Regulation of macrophage migration inhibitory factor (MIF) expression by glucose and insulin in adipocytes in vitro. Mol Med 5: 361-371, 1999.
    • (1999) Mol Med , vol.5 , pp. 361-371
    • Sakaue, S.1    Nishihira, J.2    Hirokawa, J.3    Yoshimura, H.4    Honda, T.5    Aoki, K.6    Tagami, S.7    Kawakami, Y.8
  • 279
    • 0032560479 scopus 로고    scopus 로고
    • Tissue factor gene expression in the adipose tissues of obese mice
    • Samad F, Pandey M, Loskutoff DJ. Tissue factor gene expression in the adipose tissues of obese mice. Proc Natl Acad Sci USA 95: 7591-7596, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7591-7596
    • Samad, F.1    Pandey, M.2    Loskutoff, D.J.3
  • 280
    • 0038809142 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 1 in obesity and insulin resistance
    • Sartipy P, Loskutoff DJ. Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci USA 100: 7265-7270, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7265-7270
    • Sartipy, P.1    Loskutoff, D.J.2
  • 282
    • 36048959129 scopus 로고    scopus 로고
    • Osteopontin: A multifunctional molecule regulating chronic inflammation and vascular disease
    • Scatena M, Liaw L, Giachelli CM. Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease. Arterioscler Thromb Vasc Biol 27: 2302-2309, 2007.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2302-2309
    • Scatena, M.1    Liaw, L.2    Giachelli, C.M.3
  • 283
    • 84907542588 scopus 로고    scopus 로고
    • Cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses
    • Schenkel JM, Fraser KA, Beura LK, Pauken KE, Vezys V, Masopust D. T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses. Science 346: 98-101, 2014.
    • (2014) Science , vol.346 , pp. 98-101
    • Schenkel, J.M.1    Fraser, K.A.2    Beura, L.K.3    Pauken, K.E.4    Vezys, V.5    Masopust, D.T.6
  • 284
    • 0028787490 scopus 로고
    • A novel serum protein similar to C1q, produced exclusively in adipocytes
    • Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270: 26746-26749, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4    Lodish, H.F.5
  • 285
    • 0025160568 scopus 로고
    • Adipose conversion of 3T3-L1 cells in a serum-free culture system depends on epidermal growth factor, insulin-like growth factor I, corticosterone, and cyclic AMP
    • Schmidt W, Poll-Jordan G, Loffler G. Adipose conversion of 3T3-L1 cells in a serum-free culture system depends on epidermal growth factor, insulin-like growth factor I, corticosterone, and cyclic AMP. J Biol Chem 265: 15489-15495, 1990.
    • (1990) J Biol Chem , vol.265 , pp. 15489-15495
    • Schmidt, W.1    Poll-Jordan, G.2    Loffler, G.3
  • 287
    • 84870058819 scopus 로고    scopus 로고
    • Adaptive immunity in obesity and insulin resistance
    • Sell H, Habich C, Eckel J. Adaptive immunity in obesity and insulin resistance. Nat Rev Endocrinol 8: 709-716, 2012.
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 709-716
    • Sell, H.1    Habich, C.2    Eckel, J.3
  • 288
    • 73249122917 scopus 로고    scopus 로고
    • Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells
    • Sell H, Laurencikiene J, Taube A, Eckardt K, Cramer A, Horrighs A, Arner P, Eckel J. Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells. Diabetes 58: 2731-2740, 2009.
    • (2009) Diabetes , vol.58 , pp. 2731-2740
    • Sell, H.1    Laurencikiene, J.2    Taube, A.3    Eckardt, K.4    Cramer, A.5    Horrighs, A.6    Arner, P.7    Eckel, J.8
  • 291
    • 84877147751 scopus 로고    scopus 로고
    • Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1alpha-Fndc5 pathway in muscle
    • Shan T, Liang X, Bi P, Kuang S. Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1alpha-Fndc5 pathway in muscle. FASEB J 27: 1981-1989, 2013.
    • (2013) FASEB J , vol.27 , pp. 1981-1989
    • Shan, T.1    Liang, X.2    Bi, P.3    Kuang, S.4
  • 294
    • 44449131554 scopus 로고    scopus 로고
    • Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells
    • Shinohara ML, Kim HJ, Kim JH, Garcia VA, Cantor H. Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells. Proc Natl Acad Sci USA 105: 7235-7239, 2008.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7235-7239
    • Shinohara, M.L.1    Kim, H.J.2    Kim, J.H.3    Garcia, V.A.4    Cantor, H.5
  • 295
    • 44449146212 scopus 로고    scopus 로고
    • Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: Role of intracellular osteopontin
    • Shinohara ML, Kim JH, Garcia VA, Cantor H. Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity 29: 68-78, 2008.
    • (2008) Immunity , vol.29 , pp. 68-78
    • Shinohara, M.L.1    Kim, J.H.2    Garcia, V.A.3    Cantor, H.4
  • 296
    • 84893413950 scopus 로고    scopus 로고
    • Autophagy in the control of food intake
    • Singh R. Autophagy in the control of food intake. Adipocyte 1: 75-79, 2012.
    • (2012) Adipocyte , vol.1 , pp. 75-79
    • Singh, R.1
  • 297
    • 79955631150 scopus 로고    scopus 로고
    • Autophagy in the cellular energetic balance
    • Singh R, Cuervo AM. Autophagy in the cellular energetic balance. Cell Metab 13: 495-504, 2011.
    • (2011) Cell Metab , vol.13 , pp. 495-504
    • Singh, R.1    Cuervo, A.M.2
  • 299
    • 77649254852 scopus 로고    scopus 로고
    • Adipose tissue-derived nerve growth factor and brain-derived neurotrophic factor: Results from experimental stress and diabetes
    • Sornelli F, Fiore M, Chaldakov GN, Aloe L. Adipose tissue-derived nerve growth factor and brain-derived neurotrophic factor: results from experimental stress and diabetes. Gen Physiol Biophys 28 Spec No: 179-183, 2009.
    • (2009) Gen Physiol Biophys 28 Spec No , pp. 179-183
    • Sornelli, F.1    Fiore, M.2    Chaldakov, G.N.3    Aloe, L.4
  • 304
    • 77957108166 scopus 로고    scopus 로고
    • T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice
    • Strissel KJ, DeFuria J, Shaul ME, Bennett G, Greenberg AS, Obin MS. T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice. Obesity 18: 1918-1925, 2010.
    • (2010) Obesity , vol.18 , pp. 1918-1925
    • Strissel, K.J.1    Defuria, J.2    Shaul, M.E.3    Bennett, G.4    Greenberg, A.S.5    Obin, M.S.6
  • 307
    • 33748753263 scopus 로고    scopus 로고
    • Cathepsin s promotes human preadipocyte differentiation: Possible involvement of fibronectin degradation
    • Taleb S, Cancello R, Clement K, Lacasa D. Cathepsin s promotes human preadipocyte differentiation: possible involvement of fibronectin degradation. Endocrinology 147: 4950-4959, 2006.
    • (2006) Endocrinology , vol.147 , pp. 4950-4959
    • Taleb, S.1    Cancello, R.2    Clement, K.3    Lacasa, D.4
  • 309
    • 3042759742 scopus 로고    scopus 로고
    • Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage
    • Tang QQ, Otto TC, Lane MD. Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci USA 101: 9607-9611, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 9607-9611
    • Tang, Q.Q.1    Otto, T.C.2    Lane, M.D.3
  • 317
    • 84926672363 scopus 로고    scopus 로고
    • Oxygen deprivation and the cellular response to hypoxia in adipocytes-perspectives on white and brown adipose tissues in obesity
    • Trayhurn P, Alomar SY. Oxygen deprivation and the cellular response to hypoxia in adipocytes-perspectives on white and brown adipose tissues in obesity. Front Endocrinol (Lausanne) 6: 19, 2015.
    • (2015) Front Endocrinol (Lausanne) , vol.6 , pp. 19
    • Trayhurn, P.1    Alomar, S.Y.2
  • 320
    • 59649115646 scopus 로고    scopus 로고
    • Mouse models of mitochondrial DNA defects and their relevance for human disease
    • Tyynismaa H, Suomalainen A. Mouse models of mitochondrial DNA defects and their relevance for human disease. EMBO Rep 10: 137-143, 2009.
    • (2009) EMBO Rep , vol.10 , pp. 137-143
    • Tyynismaa, H.1    Suomalainen, A.2
  • 325
  • 326
    • 68849107400 scopus 로고    scopus 로고
    • C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists
    • Vernochet C, Peres SB, Davis KE, McDonald ME, Qiang L, Wang H, Scherer PE, Farmer SR. C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists. Mol Cell Biol 29: 4714-4728, 2009.
    • (2009) Mol Cell Biol , vol.29 , pp. 4714-4728
    • Vernochet, C.1    Peres, S.B.2    Davis, K.E.3    McDonald, M.E.4    Qiang, L.5    Wang, H.6    Scherer, P.E.7    Farmer, S.R.8
  • 328
    • 76049099665 scopus 로고    scopus 로고
    • Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome-an allostatic perspective
    • Virtue S, Vidal-Puig A. Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome-an allostatic perspective. Biochim Biophys Acta 1801: 338-349, 2010.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 338-349
    • Virtue, S.1    Vidal-Puig, A.2
  • 331
    • 73349091842 scopus 로고    scopus 로고
    • The role of mitochondria in apoptosis
    • Wang C, Youle RJ. The role of mitochondria in apoptosis. Annu Rev Genet 43: 95-118, 2009.
    • (2009) Annu Rev Genet , vol.43 , pp. 95-118
    • Wang, C.1    Youle, R.J.2
  • 341
    • 75149191885 scopus 로고    scopus 로고
    • 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-gamma-dependent and mediated by the caspase-3-dependent apoptotic pathway
    • Xiao Y, Yuan T, Yao W, Liao K. 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-gamma-dependent and mediated by the caspase-3-dependent apoptotic pathway. FEBS J 277: 687-696, 2010.
    • (2010) FEBS J , vol.277 , pp. 687-696
    • Xiao, Y.1    Yuan, T.2    Yao, W.3    Liao, K.4
  • 342
    • 0034194261 scopus 로고    scopus 로고
    • IFN-gamma and TNF regulate macrophage expression of the chemotactic S100 protein S100A8
    • Xu K, Geczy CL. IFN-gamma and TNF regulate macrophage expression of the chemotactic S100 protein S100A8. J Immunol 164: 4916-4923, 2000.
    • (2000) J Immunol , vol.164 , pp. 4916-4923
    • Xu, K.1    Geczy, C.L.2
  • 346
    • 3042747074 scopus 로고    scopus 로고
    • Reduced expression of FOXC2 and brown adipogenic genes in human subjects with insulin resistance
    • Yang X, Enerback S, Smith U. Reduced expression of FOXC2 and brown adipogenic genes in human subjects with insulin resistance. Obes Res 11: 1182-1191, 2003.
    • (2003) Obes Res , vol.11 , pp. 1182-1191
    • Yang, X.1    Enerback, S.2    Smith, U.3
  • 347
    • 84947648618 scopus 로고    scopus 로고
    • Rapamycin improves palmitate-induced ER stress/NF kappa B pathways associated with stimulating autophagy in adipocytes
    • Yin J, Gu L, Wang Y, Fan N, Ma Y, Peng Y. Rapamycin improves palmitate-induced ER stress/NF kappa B pathways associated with stimulating autophagy in adipocytes. Mediators Inflamm 2015: 272313, 2015.
    • (2015) Mediators Inflamm , vol.2015
    • Yin, J.1    Gu, L.2    Wang, Y.3    Fan, N.4    Ma, Y.5    Peng, Y.6
  • 348
    • 0343060983 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation
    • Yoon JC, Chickering TW, Rosen ED, Dussault B, Qin Y, Soukas A, Friedman JM, Holmes WE, Spiegelman BM. Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Mol Cell Biol 20: 5343-5349, 2000.
    • (2000) Mol Cell Biol , vol.20 , pp. 5343-5349
    • Yoon, J.C.1    Chickering, T.W.2    Rosen, E.D.3    Dussault, B.4    Qin, Y.5    Soukas, A.6    Friedman, J.M.7    Holmes, W.E.8    Spiegelman, B.M.9
  • 352
    • 84940469864 scopus 로고    scopus 로고
    • Nutritional immunity: S100 proteins at the host-pathogen interface
    • Zackular JP, Chazin WJ, Skaar EP. Nutritional immunity: s100 proteins at the host-pathogen interface. J Biol Chem 290: 18991-18998, 2015.
    • (2015) J Biol Chem , vol.290 , pp. 18991-18998
    • Zackular, J.P.1    Chazin, W.J.2    Skaar, E.P.3
  • 354
    • 44649173850 scopus 로고    scopus 로고
    • The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages
    • Zhang J, Wu Y, Zhang Y, Leroith D, Bernlohr DA, Chen X. The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Mol Endocrinol 22: 1416-1426, 2008.
    • (2008) Mol Endocrinol , vol.22 , pp. 1416-1426
    • Zhang, J.1    Wu, Y.2    Zhang, Y.3    Leroith, D.4    Bernlohr, D.A.5    Chen, X.6
  • 355
    • 84919356787 scopus 로고    scopus 로고
    • Association between serum free fatty acid levels and nonalcoholic fatty liver disease: A cross-sectional study
    • Zhang J, Zhao Y, Xu C, Hong Y, Lu H, Wu J, Chen Y. Association between serum free fatty acid levels and nonalcoholic fatty liver disease: a cross-sectional study. Sci Rep 4: 5832, 2014.
    • (2014) Sci Rep , vol.4 , pp. 5832
    • Zhang, J.1    Zhao, Y.2    Xu, C.3    Hong, Y.4    Lu, H.5    Wu, J.6    Chen, Y.7
  • 356
    • 84901380117 scopus 로고    scopus 로고
    • Lipocalin 2 expression and secretion is highly regulated by metabolic stress, cytokines, and nutrients in adipocytes
    • Zhang Y, Foncea R, Deis JA, Guo H, Bernlohr DA, Chen X. Lipocalin 2 expression and secretion is highly regulated by metabolic stress, cytokines, and nutrients in adipocytes. PLoS One 9: e96997, 2014.
    • (2014) Plos One , vol.9
    • Zhang, Y.1    Foncea, R.2    Deis, J.A.3    Guo, H.4    Bernlohr, D.A.5    Chen, X.6
  • 357
    • 73949124173 scopus 로고    scopus 로고
    • Adipose-specific deletion of autophagy-related gene 7 (Atg7) in mice reveals a role in adipogenesis
    • Zhang Y, Goldman S, Baerga R, Zhao Y, Komatsu M, Jin S. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci USA 106: 19860-19865, 2009.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 19860-19865
    • Zhang, Y.1    Goldman, S.2    Baerga, R.3    Zhao, Y.4    Komatsu, M.5    Jin, S.6


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