Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human

Cell

Volumn 150, Issue 2, 2012, Pages 366-376

  Wu, Jun ^a   Boström, Pontus ^a   Sparks, Lauren M ^b   Ye, Li ^a   Choi, Jang Hyun ^a   Giang, An Hoa ^a   Khandekar, Melin ^a   Virtanen, Kirsi A ^e   Nuutila, Pirjo ^e   Schaart, Gert ^c   Huang, Kexin ^f   Tu, Hua ^f   Van Marken Lichtenbelt, Wouter D ^b   Hoeks, Joris ^b   Enerbäck, Sven ^d   Schrauwen, Patrick ^b   Spiegelman, Bruce M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

^e UNIVERSITY OF TURKU   (Finland)

^f LakePharma Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE HORMONE; UNCOUPLING PROTEIN 1;

ADIPOCYTE; ANIMAL CELL; ARTICLE; BEIGE ADIPOCYTE; BREATHING RATE; CELL ISOLATION; CELL TYPE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; LIPID STORAGE; MAMMAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

MAMMALIA; MURINAE;

EID: 84864287504     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2012.05.016     Document Type: Article

References (42)

1. N. Billon, and C. Dani Developmental origins of the adipocyte lineage: new insights from genetics and genomics studies Stem Cell Rev. 8 2011 55 66
2. M. Bordicchia, D. Liu, E.Z. Amri, G. Ailhaud, P. Dessì-Fulgheri, C. Zhang, N. Takahashi, R. Sarzani, and S. Collins Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes J. Clin. Invest. 122 2012 1022 1036
3. P. Boström, J. Wu, M.P. Jedrychowski, A. Korde, L. Ye, J.C. Lo, K.A. Rasbach, E.A. Boström, J.H. Choi, and J.Z. Long A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis Nature 481 2012 463 468
4. S. Cinti Adipocyte differentiation and transdifferentiation: plasticity of the adipose organ J. Endocrinol. Invest. 25 2002 823 835 (Pubitemid 35446350)
5. S. Collins, K.W. Daniel, A.E. Petro, and R.S. Surwit Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice Endocrinology 138 1997 405 413 (Pubitemid 27009450)
6. S. Collins, W. Cao, and J. Robidoux Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism Mol. Endocrinol. 18 2004 2123 2131 (Pubitemid 39215245)
7. A.A. Coulter, C.M. Bearden, X. Liu, R.A. Koza, and L.P. Kozak Dietary fat interacts with QTLs controlling induction of Pgc-1 alpha and Ucp1 during conversion of white to brown fat Physiol. Genomics 14 2003 139 147 (Pubitemid 37345222)
8. B. Cousin, S. Cinti, M. Morroni, S. Raimbault, D. Ricquier, L. Pénicaud, and L. Casteilla Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization J. Cell Sci. 103 1992 931 942 (Pubitemid 23042237)
9. A.M. Cypess, S. Lehman, G. Williams, I. Tal, D. Rodman, A.B. Goldfine, F.C. Kuo, E.L. Palmer, Y.H. Tseng, and A. Doria Identification and importance of brown adipose tissue in adult humans N. Engl. J. Med. 360 2009 1509 1517
10. F.M. Fisher, S. Kleiner, N. Douris, E.C. Fox, R.J. Mepani, F. Verdeguer, J. Wu, A. Kharitonenkov, J.S. Flier, E. Maratos-Flier, and B.M. Spiegelman FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis Genes Dev. 26 2012 271 281
11. S. Gesta, M. Blüher, Y. Yamamoto, A.W. Norris, J. Berndt, S. Kralisch, J. Boucher, C. Lewis, and C.R. Kahn Evidence for a role of developmental genes in the origin of obesity and body fat distribution Proc. Natl. Acad. Sci. USA 103 2006 6676 6681
12. C. Guerra, R.A. Koza, H. Yamashita, K. Walsh, and L.P. Kozak Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity J. Clin. Invest. 102 1998 412 420 (Pubitemid 28335201)
13. R.K. Gupta, Z. Arany, P. Seale, R.J. Mepani, L. Ye, H.M. Conroe, Y.A. Roby, H. Kulaga, R.R. Reed, and B.M. Spiegelman Transcriptional control of preadipocyte determination by Zfp423 Nature 464 2010 619 623
14. J. Himms-Hagen, J. Cui, E. Danforth Jr., D.J. Taatjes, S.S. Lang, B.L. Waters, and T.H. Claus Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats Am. J. Physiol. 266 1994 R1371 R1382
15. J. Himms-Hagen, A. Melnyk, M.C. Zingaretti, E. Ceresi, G. Barbatelli, and S. Cinti Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes Am. J. Physiol. Cell Physiol. 279 2000 C670 C681
16. J. Ishibashi, and P. Seale Medicine. Beige can be slimming Science 328 2010 1113 1114
17. A.W. Joe, L. Yi, Y. Even, A.W. Vogl, and F.M. Rossi Depot-specific differences in adipogenic progenitor abundance and proliferative response to high-fat diet Stem Cells 27 2009 2563 2570
18. A.W. Joe, L. Yi, A. Natarajan, F. Le Grand, L. So, J. Wang, M.A. Rudnicki, and F.M. Rossi Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis Nat. Cell Biol. 12 2010 153 163
19. R.A. Koza, S.M. Hohmann, C. Guerra, M. Rossmeisl, and L.P. Kozak Synergistic gene interactions control the induction of the mitochondrial uncoupling protein (Ucp1) gene in white fat tissue J. Biol. Chem. 275 2000 34486 34492
20. Y.H. Lee, A.P. Petkova, E.P. Mottillo, and J.G. Granneman In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding Cell Metab. 15 2012 480 491
21. M.R. Mirbolooki, C.C. Constantinescu, M.L. Pan, and J. Mukherjee Quantitative assessment of brown adipose tissue metabolic activity and volume using 18F-FDG PET/CT and β3-adrenergic receptor activation EJNMMI Res 1 2011 30
22. J. Orava, P. Nuutila, M.E. Lidell, V. Oikonen, T. Noponen, T. Viljanen, M. Scheinin, M. Taittonen, T. Niemi, S. Enerbäck, and K.A. Virtanen Different metabolic responses of human brown adipose tissue to activation by cold and insulin Cell Metab. 14 2011 272 279
23. V. Ouellet, S.M. Labbé, D.P. Blondin, S. Phoenix, B. Guérin, F. Haman, E.E. Turcotte, D. Richard, and A.C. Carpentier Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans J. Clin. Invest. 122 2012 545 552
24. N. Petrovic, T.B. Walden, I.G. Shabalina, J.A. Timmons, B. Cannon, and J. Nedergaard Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes J. Biol. Chem. 285 2010 7153 7164
25. M.S. Rodeheffer, K. Birsoy, and J.M. Friedman Identification of white adipocyte progenitor cells in vivo Cell 135 2008 240 249
26. T.J. Schulz, T.L. Huang, T.T. Tran, H. Zhang, K.L. Townsend, J.L. Shadrach, M. Cerletti, L.E. McDougall, N. Giorgadze, and T. Tchkonia Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat Proc. Natl. Acad. Sci. USA 108 2011 143 148
27. P. Seale, S. Kajimura, W. Yang, S. Chin, L.M. Rohas, M. Uldry, G. Tavernier, D. Langin, and B.M. Spiegelman Transcriptional control of brown fat determination by PRDM16 Cell Metab. 6 2007 38 54 (Pubitemid 47008902)
28. P. Seale, B. Bjork, W. Yang, S. Kajimura, S. Chin, S. Kuang, A. Scimè, S. Devarakonda, H.M. Conroe, and H. Erdjument-Bromage PRDM16 controls a brown fat/skeletal muscle switch Nature 454 2008 961 967
29. P. Seale, H.M. Conroe, J. Estall, S. Kajimura, A. Frontini, J. Ishibashi, P. Cohen, S. Cinti, and B.M. Spiegelman Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice J. Clin. Invest. 121 2011 96 105
30. G.J. Todaro, and H. Green Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines J. Cell Biol. 17 1963 299 313
31. A. Uezumi, S. Fukada, N. Yamamoto, S. Takeda, and K. Tsuchida Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle Nat. Cell Biol. 12 2010 143 152
32. W.D. van Marken Lichtenbelt, J.W. Vanhommerig, N.M. Smulders, J.M. Drossaerts, G.J. Kemerink, N.D. Bouvy, P. Schrauwen, and G.J. Teule Cold-activated brown adipose tissue in healthy men N. Engl. J. Med. 360 2009 1500 1508
33. A. Vegiopoulos, K. Müller-Decker, D. Strzoda, I. Schmitt, E. Chichelnitskiy, A. Ostertag, M. Berriel Diaz, J. Rozman, M. Hrabe de Angelis, and R.M. Nüsing Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes Science 328 2010 1158 1161
34. K.A. Virtanen, M.E. Lidell, J. Orava, M. Heglind, R. Westergren, T. Niemi, M. Taittonen, J. Laine, N.J. Savisto, S. Enerbäck, and P. Nuutila Functional brown adipose tissue in healthy adults N. Engl. J. Med. 360 2009 1518 1525
35. A. von Heydebreck, W. Huber, A. Poustka, and M. Vingron Identifying splits with clear separation: a new class discovery method for gene expression data Bioinformatics 17 Suppl 1 2001 S107 S114
36. A.J. Whittle, M. López, and A. Vidal-Puig Using brown adipose tissue to treat obesity - the central issue Trends Mol. Med. 17 2011 405 411
37. B. Xue, A. Coulter, J.S. Rim, R.A. Koza, and L.P. Kozak Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots Mol. Cell. Biol. 25 2005 8311 8322 (Pubitemid 41263019)
38. B. Xue, J.S. Rim, J.C. Hogan, A.A. Coulter, R.A. Koza, and L.P. Kozak Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat J. Lipid Res. 48 2007 41 51 (Pubitemid 46052896)
39. P. Young, J.R. Arch, and M. Ashwell Brown adipose tissue in the parametrial fat pad of the mouse FEBS Lett. 167 1984 10 14 (Pubitemid 14198825)
40. Gentleman, R.C., Carey, V.J., Bates, D.M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004). Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5, R80.
41. Irizarry, R.A., Hobbs, B., Collin, F., Beazer-Barclay, Y.D., Antonellis, K.J., Scherf, U., and Speed, T.P. (2003). Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4, 249-264.
42. Li, C., and Wong, W.H. (2001). Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc. Natl. Acad. Sci. USA 98, 31-36. (Pubitemid 32095858)