Peroxisome proliferator-activated receptor γ target gene encoding a novel angiopoietin-related protein associated with adipose differentiation

Molecular and Cellular Biology

Volumn 20, Issue 14, 2000, Pages 5343-5349

  Cliff Yoon, J ^a   Chickering, Troy W ^b   Rosen, Evan D ^a   Dussault, Barry ^b   Qin, Yubin ^b   Soukas, Alexander ^c   Friedman, Jeffrey M ^c   Holmes, William E ^b   Spiegelman, Bruce M ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROTEIN DERIVATIVE;

ADIPOSE TISSUE CELL; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE INDUCTION; GENE ISOLATION; GENE LOCATION; GENETIC ANALYSIS; GENETIC CODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

3T3 CELLS; ADIPOSE TISSUE; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOOD PROTEINS; CELL DIFFERENTIATION; CYCLOHEXIMIDE; FEMALE; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HUMANS; HYPOGLYCEMIC AGENTS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; MICE; MICE, INBRED C57BL; MICE, OBESE; MOLECULAR SEQUENCE DATA; MUSCLE PROTEINS; NUTRITION PHYSIOLOGY; PLACENTA; PREGNANCY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SEQUENCE HOMOLOGY, AMINO ACID; THIAZOLES; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS;

EID: 0343060983     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.14.5343-5349.2000     Document Type: Article

References (33)

1. Ausubel, F., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1991. Current protocols in molecular biology. John Wiley & Sons. Inc., New York, N.Y.
2. Barak, Y., M. C. Nelson, E. S. Ong, Y. Z. Jones, P. Ruiz-Lozano, K. R. Chien, A. Koder, and R. M. Evans. 1999. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol. Cell 4:585-595.
3. Barroso, I., M. Gurnell, V. E. F. Crowley, M. Agnosti, J. W. Schwabe, M. A. Soos, G. L. Maslen, T. D. M. Williams, H. Lewis, A. J. Schafer, V. K. K. Chatterjee, and S. O'Rahilly. 1999. Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus, and hypertension. Nature 402:880-883.
4. Bishop-Bailey, D., and T. Hla. 1999. Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-delta 12, 14-prostaglandin J2. J. Biol. Chem. 274:17042-17048.
5. Busfleld, S. J., D. A. Michnick, T. W. Chickering, T. L. Revett, J. Ma, E. A. Woolf, C. A. Comrack, B. J. Dussault, J. Woolf, A. D. J. Goodearl, and D. P. Gearing. 1997. Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus. Mol. Cell. Biol. 17:4007-4014.
6. Christy, R. J., V. W. Yang, J. M. Ntambi, D. E. Geiman, W. M. Landschulz, A. D. Friedman, U. Nakbeppu, T. J. Kelly, and M. D. Lane. 1989. Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes Dev. 3:1323-1335.
7. Cochran, B. H., A. C. Reffel, and C. D. Stiles. 1983. Molecular cloning of genes regulated by platelet-derived growth factor. Cell 33:939-947.
8. Davis, S., T. H. Aldrich, P. F. Jones, A. Acheson, D. L. Compton, V. Jain, T. E. Ryan, J. Bruno, C. Radziejewski, P. C. Maisonpierre, and G. D. Yancopoulos. 1996. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion trap expression cloning. Cell 87:1161-1169.
9. Forman, B. M., P. Tontonoz, J. Chen, R. P. Brun, B. M. Spiegelman, and R. M. Evans. 1995. 15-Deoxy-Δ2,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR-γ. Cell 83:803-812.
10. Hotamisligil, G. S., N. S. Shargill, and B. M. Spiegelman. 1993. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87-91.
11. Hu, E., P. Tontonoz, and B. M. Spiegelman. 1995. Transdifferentiation of myoblasts by the adipogenic transcription factors PPARγ and C/EBPα. Proc. Natl. Acad. Sci. USA 92:9856-9860.
12. Jiang, C., A. T. Ting, and B. Seed. 1998. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature 391:82-86.
13. Kliewer, S. A., S. S. Sunddseth, S. A. Jones, P. J. Brown, G. B. Wisely, C. S. Koble, P. Devchand, W. Wahli, T. M. Willson, J. M. Lenhard, and J. M. Lehmann. 1997. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ. Proc. Natl. Acad. Sci. USA 94:4318-4323.
14. Kubota, N., Y. Terauchi, H. Miki, H. Tamamoto, T. Yamauchi, K. Komeda, S. Satoh, R. Nakano, C. Ishii, T. Sugiyama, K. Eto, Y. Tsubamoto, A. Okuno, K. Murakami, H. Sekihara, G. Hasegawa, M. Naito, Y. Toyoshima, S. Tanaka, K. Shiota, T. Kitamura, T. Fujita, O. Ezaki, S. Aizawa, R. Nagai, K. Tobe, S. Kimura, and T. Kadowaki. 1999. PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol. Cell 4:597-609.
15. Lehmann, J. M., L. B. Moore, T. A. Smith-Olivier, W. O. Wilkison, T. M. Willson, and S. A. Kliewer. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ. J. Biol. Chem. 270:12953-12956.
16. Lowell, B. B. 1999. PPARγ: an essential regulator of adipogenesis and modulator of fat cell function. Cell 99:239-242.
17. Maisonpierre, P. C., C. Suri, P. F. Jones, S. Bartunkova, S. J. Wiegand, C. Radziejewski, D. Compton, J. McCain, T. H. Aldrich, N. Padopoulos, T. J. Daly, S. Davis, T. N. Sato, and G. D. Yancopoulos. 1997. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277: 55-60.
18. Mueller, E., P. Sarraf, P. Tontonoz, R. M. Evans, K. J. Martin, M. Zhang, C. Fletcher, S. Singer, and B. M. Spiegelman. 1998. Terminal differentiation of human breast cancer through PPARγ. Mol. Cell 1:465-470.
19. Procopio, W. N., P. I. Pelavin, W. M. F. Lee, and N. M. Yeilding. 1999. Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, hut fibrinogen-like domains mediate ligand activity. J. Biol. Chem. 274:30196-30201.
20. Ricote, M., A. C. Li, A. M. Willson, C. J. Kelly, and C. K. Glass. 1998. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391:79-82.
21. Rosen, E. D., P. Sarraf, A. E. Troy, G. Bradwin, K. Moore, D. S. Milstone, B. M. Spiegelman, and R. M. Mortensen. PPARγ is required for the differentiation of adipose tissue in vivo and in vitro. Mol. Cell 4:611-617.
22. Sarraf, P., E. Mueller, D. Jones, F. King, D. DeAngelo, S. Partridge, S. Holden, L. Chen, S. Singer, C. Fletcher, and B. Spiegelman. 1998. Differentiation and reversal of malignant changes in colon cancer through PPARγ. Nat. Med. 4:1046-1052.
23. Schoonjans, K., J. Peinado-Onsurbe, A. M. Lefebvre, R. A. Heyman, M. Briggs, S. Deeb, B. Staels, and J. Auwerx. 1996. PPARα and PPARγ activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J. 15:5336-5348.
24. Slieker, L. J., K. W. Sloop, P. L. Surface, A. Kriauciunas, F. LaQuier, J. Manetta, J. Bue-Valleskey, and T. W. Stevens. 1996 Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J. Biol. Chem. 271:5301-5304.
25. Spiegelman, B. M. 1998. PPARγ: adipogenic regulator and thiazolidinedione receptor. Diabetes 47:507-514.
26. Suri, C., P. F. Jones, S. Patan, S. Bartunkova, P. C. Maisonpierre, S. Davis, T. N. Sato, and G. D. Yancopoulos. 1996. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87:1171-1180.
27. Tartaglia, L. A., M. Dembski, X. Weng, N. Deng, J. Culpepper, R. Devos, G. J. Richards, L. A. Campfield, F. T. Clark, and J. Deeds. 1995. Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271.
28. Tontonoz, P., E. Hu, and B. M. Spiegelman. 1994. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79:1147-1156.
29. Tontonoz, P., E. Hu, J. Devine, E. G. Beale, and B. M. Spiegelman. 1994. PPARγ2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 15:351-357.
30. Wasserman, F. 1965. The development of adipose tissue, p. 87-100. In A. E. Renold and G. F. Cahill (ed.). Handbook of physiology, vol. 5. American Physiology Society, Washington, D.C.
31. Wilson, T. M., J. E. Cobb, D. J. Cowan, R. W. Wiethe, I. D. Correa, S. R. Prakash, K. D. Beck, L. B. Moore, S. A. Kliewer, and J. M. Lehmann. 1996. The structure-activity relationship between peroxisome-proliferator-activated receptor gamma agonism and the antihyperglycemic activity of the thiazolidinediones. J. Med. Chem. 39:665-668.
32. Xin, X., S. Yang, J. Kowalski, M. E. Gerritsen. 1999. Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo. J. Biol. Chem. 274:9116-9121.
33. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. Friedman. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432.