Overview of adipose tissue and its role in obesity and metabolic disorders

Methods in Molecular Biology

Volumn 456, Issue , 2008, Pages 1-22

  Frühbeck, Gema ^a  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Adipocytes; Adipokines; Comorbidities; Cytokines; Energy homeostasis; Fat distribution; Glucose and lipid metabolism; Obesity

Indexed keywords

EID: 84934434968     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-59745-245-8_1     Document Type: Article

References (86)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432
2. Langin D, Lafontan, M (2000) Millennium fat-cell lipolysis reveals unsuspected novel tracks. Horm Metab Res 32:443-452
3. Trayhurn P, Beattie JH (2001) Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 60:329-339
4. Frühbeck G, Gómez-Ambrosi J, Muruzábal FJ, Burrell MA (2001) The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol 280:E827-E847
5. Frühbeck G, Gómez-Ambrosi J (2001) Rationale for the existence of additional adipostatic hormones. FASEB J 15:1996-2006
6. Frühbeck G (2001) A heliocentric view of leptin. Proc Nutr Soc 60:301-318
7. Marette A (2002) Mediators of cytokine-induced insulin resistance in obesity and other inflammatory settings. Curr Opin Clin Nutr Metab Care 5:377-383
8. Blake GJ, Ridker PM (2002) Inflammatory bio-markers and cardiovascular risk prediction. J Intern Med 252:283-294
9. Frühbeck G, Gómez-Ambrosi J (2003) Control of body weight: a physiologic and transgenic perspective. Diabetologia 46:143-172
10. Trayhurn P, Wood IS (2004) Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92:347-355
11. Frühbeck G (2004) The adipose tissue as a source of vasoactive factors. Curr Med Chem (Cardiovasc Hematol Agents) 2:197-208
12. La Cava A, Alviggi C, Matarese G (2004) Unravelling the multiple roles of leptin in inflammation and autoimmunity. J Mol Med 82:4-11
13. Granger JP (2004) Inflammatory cytokines, vascular function, and hypertension. Am J Physiol Reg Integr Comp Physiol 286:R989-R990
14. Gimeno RE, Klaman LD (2005) Adipose tissue as an active endocrine organ: recent advances. Curr Opin Pharmacol 5:122-128
15. Hutley L, Prins JB (2005) Fat as an endocrine organ: relationship to the metabolic syndrome. Am J Med Sci 330:280-289
16. Trayhurn, P (2005) Endocrine and signalling role of adipose tissue: new perspectives on fat. Acta Physiol Scand 184:285-293
17. Yu Y-H, Ginsberg HN (2005) Adipocyte signaling and lipid homeostasis. Sequelae of insulinresistant adipose tissue. Circ Res 96:1042-1052
18. Bell CG, Walley AJ, Froguel P (2005) The genetics of human obesity. Nat Rev Genet 6:221-234
19. Berg AH, Scherer PE (2005) Adipose tissue, inflamation and cardiovascular disease. Circ Res 96:939-949
20. Lau DCW, Dhillon B, Yan H, Szmitko PE, Verma, S (2005) Adipokines: molecular links between obesity and atherosclerosis. Am J Physiol Heart Circ Physiol 288:H2031-H2041
21. Nawrocki AR, Scherer PE (2005) Adipose tissue, adipokines, and inflammation. Drug Discovery Today 10:1219-1230
22. Fantuzzi G (2005) Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 115:911-919
23. Van Gaal LF, Mertens IL, De Block CE (2006) Mechanisms linking obesity with cardiovascular disease. Nature 444:875-880
24. Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistanceand type 2 diabetes. Nature 444:840-846
25. Fain JN (2006) Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm 74:443-477
26. Matsuzawa Y (2006) Therapy insight: adipocytokines in metabolic syndrome and related cardiovascular disease. Nat Clin Pract Cardiovasc Med 3:35-42
27. Trayhurn P, Bing C, Wood IS (2006) Adipose tissue and adipokines-energy regulation from the human perspective. J Nutr 136:1935S-1939S
28. Despres JP, Lemieux I (2006) Abdominal obesity and metabolic syndrome. Nature 444:881-887
29. Abizaid A, Gao Q, Horvath TL (2006) Thoughts for food: brain mechanisms and peripheral energy balance. Neuron 51:691-702
30. Pond CM (1999) Physiological specialisation of adipose tissue. Prog Lipid Res 38:225-248
31. Spiegelman BM, Hotamisligil GS, Graves RA, Tontonoz P (1993) Regulation of adipocyte gene expression and syndromes of obesity/diabetes. J Biol Chem 268:68236-6826
32. Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM (2000) Transcriptional regulation of adipogenesis. Genes Dev 14:1293-1307
33. Gregoire FM (2001) Adipocyte differentiation: from fibroblast to endocrine cell. Exp Biol Med 226:997-1002
34. Rosen ED, MacDougald OA (2006) Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 7:885-896
35. Unger RH (2003) The physiology of cellular liporegulation. Annu Rev Physiol 65:333-347
36. Shen W, Wang Z, Punyanita M, Lei J, Sinav A, Kral JG, Imielinska C, Ross R, Heymsfield SB (2003) Adipose quantification by imaging methods: a proposed classification. Obesity Res 11:5-16
37. Cannon B, Nedergaard, J (2004) Brown adipose tissue: function and physiological significance. Physiol Rev 84:277-359
38. Wajchenberg BL (2000) Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocrine Rev 21:697-738
39. Lafontan M, Berlan M (2003) Do regional differences in adipocyte biology provide new pathophysiological insights? Trends Pharmacol Sci 24:276-283
40. Fried SK, Ross RR (2004) Biology of visceral adipose tissue. In: Bray GA, Bouchard C (eds) Handbook of obesity. Etiology and pathophysiology, 2nd edn. Marcel Dekker, Inc., New York, pp 589-614
41. Gómez-Ambrosi J, Catalán V, Diez-Caballero A, Martínez-Cruz A, Gil MJ, García-Foncillas J, Cienfuegos JA, Salvador J, Mato JM, Frühbeck G (2004) Gene expression profile of omental adipose tissue in human obesity. FASEB J 18:215-217
42. Linder K, Arner P, Flores-Morales A, Tollet-Egnell P, Norstedt G (2004) Differentially expressed genes in visceral and subcutaneous adipose tissue of obese men and women. Prog Lipid Res 45:148-154
43. Schäffler A, Schölmerich J, Buechler C (2006) The role of 'adipotropins' and the clinical importance of a potential hypothalamic- pituitary-adipose axis. Nat Clin Pract Endocrinol Metab 2:374-383
44. Jump DB (2004) Fatty acid regulation of gene transcription. Crit Rev Clin Lab Sci 41:41-78
45. Cousin B, Munoz O, Andre M, Fontanilles AM, Dani C, Cousin JL, et al (1999) A role for preadipocytes as macrophage-like cells. FASEB J 13:305-312
46. Peeraully MR, Jenkins JR, Trayhurn P (2004) NGF gene expression and secretion in white adipose tissue: regulation in 3T3-L1 adipocytes by hormones and inflammatory cytokines. Am J Physiol Endocrinol Metab 287:E331-E339
47. Wang B, Jenkins JR, Trayhurn, P (2005) Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-α. Am J Physiol Endocrinol Metab 288:E731-E740
48. Lehrke M, Reilly MP, Millington SC, Iqbal N, Rader DJ, Lazar MA (2004) An inflammatory cascade leading to hyper-resistinemia in humans. PloS Med 1:161-168
49. Frühbeck G (2006) Vasoactive factors and inflammatory mediators produced in adipose tissue. In: Fantuzzi G, Mazzone T (eds) Health and nutrition. Adipose tissue and adipokines in health and disease. Humana Press Inc., Totowa, NJ, pp 61-75
50. Chaldakov GN, Tonchev AB, Tuncel N, Atanassova P, Aloe L. Adipose tissue and mast cells. Adipokines as yin-yang modulators of inflammation. In: Fantuzzi G, Mazzone T, (eds) Health and nutrition. Adipose tissue and adipokines in health and disease. Humana Press Inc., Totowa, NJ, pp 147-154
51. Murdolo G, Smith U (2006) The dysregulated adipose tissue: a connecting link between insulin resistance, type 2 diabetes mellitus and atherosclerosis. Nutr Metab Cardiovasc Dis 16:S35-S38
52. Shoelson SE, Lee J, Goldfine AB (2006) Inflammation and insulin resistance. J Clin Invest 116:1793-1801
53. Wenger RH (2002) Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxiainducible transcription factors, and O2-regulated gene expression. FASEB J 16:1151-1162
54. Fearnly GR, Vincent CT, Chakrabarti R (1959) Reduction of blood fibrinolytic activity in diabetes mellitus by insulin. Lancet 2:1067
55. Ogston D, McAndrew GM (1964) Fibrinolysis in obesity. Lancet 14:1205-1207
56. Grace CS, Goldrick RB (1968) Fibrinolysis.and body build. Interrelationships between blood fibrinolysis, body composition and parameters of lipid and carbohydrate metabolism. J Atheroscler Res 8:705-719
57. Schmidt MI, Duncan BB, Sharrett AR, Lindberg G, Savage PJ, Offenbacher S, et al (1999) Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet 353:1649-1652
58. Barzilay JI, Abraham L, Heckbert SR, Cushman M, Kuller LH, Resnick HE, et al (2001) The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study. Diabetes 50:2384-2389
59. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM (2001) C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286:327-334
60. Festa A, D'Agostino R Jr., Tracy RP, Haffner SM (2002) Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes 51:1131-1137
61. Freeman DJ, Norrie J, Caslake, MJ, Gaw A, Ford I, Lowe GD, et al (2002) C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes 51:1596-1600
62. Haffner S, Temprosa M, Crandall J, Fowler S, Goldberg R, Horton E, et al (2005) Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired fasting glucose tolerance. Diabetes 54:1566-1572
63. Linton MF, Fazio S (2003) Macrophages, inflammation, and atherosclerosis. Int J Obes Relat Metab Disord 27(Suppl 3):S35-S40
64. Castrillo A, Tontonoz P (2004) Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation. Annu Rev Cell Dev Biol 20:455-480
65. Clément K, Viguerie N, Poitou C, Carette C, Peñoux V, Curat CA, et al (2004) Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB J 18:1657-1669
66. Poitou C, Viguerie N, Cancello R, De Matteis R, Cinti S, Stich, V. et al (2005) Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition. Diabetologia 48:519-528
67. Charo IF, Taubman MB (2004) Chemokines in the pathogenesis of vascular disease. Circ Res 95:858-866
68. Malavazos AE, Cereda E, Morricone L, Coman C, Corsi MM, Ambrosi B (2005) Monocyte chemoattractant protein 1: a possible link between visceral adipose tissue-associated inflammation and subclinical echocardiographic abnormalities in uncomplicated obesity. Eur J Endocrinol 153:871-877
69. Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, et al (2005) Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 307:426-430
70. Berndt J, Kloting N, Kralisch S, Kovacs P, Fasshauer M, Schon MR, et al (2005) Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes 54:2911-2916
71. Yang Q, Graham TE., Mody N, Preitner F, Peroni OD., Zabolotny JM, et al (2005) Serum retinol binding protein 4 contributes to insulin resistance and type 2 diabetes. Nature 436:356-362
72. Cancello R, Clement, K (2006) Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG 113:1141-1147
73. Arner P (2006) Visfatin-a true or false trail to type 2 diabetes mellitus. J Clin Endocrinol Metab 91:28-30
74. Graham TE, Yang Q, Blüher M, Hammarstedt A, Ciaraldi TP, Henry RR, et al (2006) Retinolbinding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med 354:2552-2563
75. Cho YM, Youn BS, Lee H, Lee N, Min SS, Kwak SH, et al (2006) Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes. Diabetes Care 29:2457-2461
76. Janke J, Engeli S, Boschmann M, Adams F, Bohnke J, Luft FC, et al (2006) Retinol-binding protein 4 in human obesity. Diabetes 55:2805-2810
77. Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116:3015-3025
78. Song MJ, Kim KH., Yoon JM, Kim JB (2006) Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun 346:739-745
79. Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444:860-867
80. Tilg H, Moschen AR (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6:772-783
81. Lumeng CN, Bodzin JL, Saltiel AR (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117:175-184
82. Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR (2007) Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 56:16-23
83. Choudhury J, Sanyal AJ (2004) Clinical aspects of fatty liver disease. Semin Liver Dis 24:349-362
84. Roden M (2006) Mechanisms of disease: hepatic steatosis in type 2 diabetes-pathogenesis and clinical relevance. Nat Clin Pract Endocrinol Metab 2:335-348
85. Tilg H, Hotamisligil GS (2006) Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology 131:934-945
86. Utzschneider KM, Kahn SE (2006) The role of insulin resistance in nonalcoholic fatty liver disease. J Clin Endocrinol Metab 91:4753-4761