-
1
-
-
84866395319
-
Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults
-
Neeland IJ, Turer AT, Ayers CR, et al. Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults. JAMA 2012;308:1150-1159.
-
(2012)
JAMA
, vol.308
, pp. 1150-1159
-
-
Neeland, I.J.1
Turer, A.T.2
Ayers, C.R.3
-
2
-
-
61449209861
-
Adipose tissue distribution is different in type 2 diabetes
-
MRI Ancillary Study Group of the Look AHEAD Research Group
-
Gallagher D, Kelley DE, Yim JE, et al.; MRI Ancillary Study Group of the Look AHEAD Research Group. Adipose tissue distribution is different in type 2 diabetes. Am J Clin Nutr 2009;89:807-814.
-
(2009)
Am J Clin Nutr
, vol.89
, pp. 807-814
-
-
Gallagher, D.1
Kelley, D.E.2
Yim, J.E.3
-
3
-
-
70350064027
-
Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis
-
Gastaldelli A, Harrison SA, Belfort-Aguilar R, et al. Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis. Hepatology 2009;50: 1087-1093.
-
(2009)
Hepatology
, vol.50
, pp. 1087-1093
-
-
Gastaldelli, A.1
Harrison, S.A.2
Belfort-Aguilar, R.3
-
4
-
-
77449111670
-
Adipocyte turnover: Relevance to human adipose tissue morphology
-
Arner E, Westermark PO, Spalding KL, et al. Adipocyte turnover: Relevance to human adipose tissue morphology. Diabetes 2010;59:105-109.
-
(2010)
Diabetes
, vol.59
, pp. 105-109
-
-
Arner, E.1
Westermark, P.O.2
Spalding, K.L.3
-
5
-
-
79954459509
-
Genetic predisposition for type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis
-
Arner P, Arner E, Hammarstedt A, Smith U. Genetic predisposition for type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis. PLoS ONE 2011;6:e18284.
-
(2011)
PLoS ONE
, vol.6
, pp. e18284
-
-
Arner, P.1
Arner, E.2
Hammarstedt, A.3
Smith, U.4
-
6
-
-
84860591046
-
The WNT inhibitor Dickkopf 1 and bone morphogenetic protein 4 rescue adipogenesis in hypertrophic obesity in humans
-
Gustafson B, Smith U. The WNT inhibitor Dickkopf 1 and bone morphogenetic protein 4 rescue adipogenesis in hypertrophic obesity in humans. Diabetes 2012;61:1217-1224.
-
(2012)
Diabetes
, vol.61
, pp. 1217-1224
-
-
Gustafson, B.1
Smith, U.2
-
7
-
-
67650242164
-
Impaired preadipocyte differentiation in human abdominal obesity: Role of Wnt, tumor necrosis factoralpha, and inflammation
-
Isakson P, Hammarstedt A, Gustafson B, Smith U. Impaired preadipocyte differentiation in human abdominal obesity: Role of Wnt, tumor necrosis factoralpha, and inflammation. Diabetes 2009;58:1550-1557.
-
(2009)
Diabetes
, vol.58
, pp. 1550-1557
-
-
Isakson, P.1
Hammarstedt, A.2
Gustafson, B.3
Smith, U.4
-
8
-
-
0042209622
-
A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin
-
Jansson PA, Pellmé F, Hammarstedt A, et al. A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin. FASEB J 2003;17:1434-1440.
-
(2003)
FASEB J
, vol.17
, pp. 1434-1440
-
-
Jansson, P.A.1
Pellmé, F.2
Hammarstedt, A.3
-
9
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112:1796-1808.
-
(2003)
J Clin Invest
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante, A.W.6
-
10
-
-
85019244388
-
Family history of type 2 diabetes increases the risk of both obesity and its complications: Is type 2 diabetes a disease of inappropriate lipid storage?
-
12 July, [Epub ahead of print]
-
Cederberg H, Stan-cáková A, Kuusisto J, Laakso M, Smith U. Family history of type 2 diabetes increases the risk of both obesity and its complications: is type 2 diabetes a disease of inappropriate lipid storage? J Intern Med. 12 July 2014 [Epub ahead of print].
-
(2014)
J Intern Med
-
-
Cederberg, H.1
Stan-Cáková, A.2
Kuusisto, J.3
Laakso, M.4
Smith, U.5
-
11
-
-
84911949202
-
Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity
-
RISC Study Group; EPIC-InterAct Consortium
-
Scott RA, Fall T, Pasko D, et al.; RISC Study Group; EPIC-InterAct Consortium. Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity. Diabetes 2014;63: 4378-4387.
-
(2014)
Diabetes
, vol.63
, pp. 4378-4387
-
-
Scott, R.A.1
Fall, T.2
Pasko, D.3
-
12
-
-
33748374453
-
Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: Role of the BMP-4 gene
-
Bowers RR, Kim JW, Otto TC, Lane MD. Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: Role of the BMP-4 gene. Proc Natl Acad Sci U S A 2006;103:13022-13027.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 13022-13027
-
-
Bowers, R.R.1
Kim, J.W.2
Otto, T.C.3
Lane, M.D.4
-
13
-
-
33847773447
-
A role for bone morphogenetic protein-4 in adipocyte development
-
Bowers RR, Lane MD. A role for bone morphogenetic protein-4 in adipocyte development. Cell Cycle 2007;6:385-389.
-
(2007)
Cell Cycle
, vol.6
, pp. 385-389
-
-
Bowers, R.R.1
Lane, M.D.2
-
14
-
-
3042759742
-
Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage
-
Tang QQ, Otto TC, Lane MD. Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci U S A 2004;101:9607-9611.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 9607-9611
-
-
Tang, Q.Q.1
Otto, T.C.2
Lane, M.D.3
-
15
-
-
50049127055
-
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
-
Tseng YH, Kokkotou E, Schulz TJ, et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 2008;454: 1000-1004.
-
(2008)
Nature
, vol.454
, pp. 1000-1004
-
-
Tseng, Y.H.1
Kokkotou, E.2
Schulz, T.J.3
-
16
-
-
84887391597
-
Restricted adipogenesis in hypertrophic obesity: The role of WISP2, WNT, and BMP4
-
Gustafson B, Hammarstedt A, Hedjazifar S, Smith U. Restricted adipogenesis in hypertrophic obesity: The role of WISP2, WNT, and BMP4. Diabetes 2013;62:2997-3004.
-
(2013)
Diabetes
, vol.62
, pp. 2997-3004
-
-
Gustafson, B.1
Hammarstedt, A.2
Hedjazifar, S.3
Smith, U.4
-
17
-
-
84899461858
-
BMP4 and BMP7 induce the whiteto- brown transition of primary human adipose stem cells
-
Elsen M, Raschke S, Tennagels N, et al. BMP4 and BMP7 induce the whiteto- brown transition of primary human adipose stem cells. Am J Physiol Cell Physiol 2014;306:C431-C440.
-
(2014)
Am J Physiol Cell Physiol
, vol.306
, pp. C431-C440
-
-
Elsen, M.1
Raschke, S.2
Tennagels, N.3
-
18
-
-
77950081353
-
Transcriptional control of preadipocyte determination by Zfp423
-
Gupta RK, Arany Z, Seale P, et al. Transcriptional control of preadipocyte determination by Zfp423. Nature 2010;464:619-623.
-
(2010)
Nature
, vol.464
, pp. 619-623
-
-
Gupta, R.K.1
Arany, Z.2
Seale, P.3
-
19
-
-
84873712772
-
WISP2 regulates preadipocyte commitment and PPARg activation by BMP4
-
Hammarstedt A, Hedjazifar S, Jenndahl L, et al. WISP2 regulates preadipocyte commitment and PPARg activation by BMP4. Proc Natl Acad Sci U S A 2013;110:2563-2568.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 2563-2568
-
-
Hammarstedt, A.1
Hedjazifar, S.2
Jenndahl, L.3
-
20
-
-
84902298025
-
Early B cell factor 1 regulates adipocyte morphology and lipolysis in white adipose tissue
-
Gao H, Mejhert N, Fretz JA, et al. Early B cell factor 1 regulates adipocyte morphology and lipolysis in white adipose tissue. Cell Metab 2014;19:981-992.
-
(2014)
Cell Metab
, vol.19
, pp. 981-992
-
-
Gao, H.1
Mejhert, N.2
Fretz, J.A.3
-
21
-
-
33846004405
-
Bone morphogenetic proteins and their antagonists
-
Gazzerro E, Canalis E. Bone morphogenetic proteins and their antagonists. Rev Endocr Metab Disord 2006;7:51-65.
-
(2006)
Rev Endocr Metab Disord
, vol.7
, pp. 51-65
-
-
Gazzerro, E.1
Canalis, E.2
-
22
-
-
77952548279
-
Extracellular BMP- Antagonist regulation in development and disease: Tied up in knots
-
Walsh DW, Godson C, Brazil DP, Martin F. Extracellular BMP- Antagonist regulation in development and disease: Tied up in knots. Trends Cell Biol 2010; 20:244-256.
-
(2010)
Trends Cell Biol
, vol.20
, pp. 244-256
-
-
Walsh, D.W.1
Godson, C.2
Brazil, D.P.3
Martin, F.4
-
23
-
-
77957589305
-
Activin a plays a critical role in proliferation and differentiation of human adipose progenitors
-
Zaragosi LE, Wdziekonski B, Villageois P, et al. Activin a plays a critical role in proliferation and differentiation of human adipose progenitors. Diabetes 2010; 59:2513-2521.
-
(2010)
Diabetes
, vol.59
, pp. 2513-2521
-
-
Zaragosi, L.E.1
Wdziekonski, B.2
Villageois, P.3
-
24
-
-
63349103940
-
ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease
-
Carlsson LM, Jacobson P, Walley A, et al. ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease. Biochem Biophys Res Commun 2009;382:309-314.
-
(2009)
Biochem Biophys Res Commun
, vol.382
, pp. 309-314
-
-
Carlsson, L.M.1
Jacobson, P.2
Walley, A.3
-
25
-
-
38949123031
-
Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice
-
Nakatani M, Takehara Y, Sugino H, et al. Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice. FASEB J 2008;22:477- 487.
-
(2008)
FASEB J
, vol.22
, pp. 477-487
-
-
Nakatani, M.1
Takehara, Y.2
Sugino, H.3
-
26
-
-
84555177944
-
Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors
-
Luo X, Hutley LJ, Webster JA, et al. Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors. Diabetes 2012; 61:124-136.
-
(2012)
Diabetes
, vol.61
, pp. 124-136
-
-
Luo, X.1
Hutley, L.J.2
Webster, J.A.3
-
28
-
-
20144389935
-
Noggin and bFGF cooperate to maintain the pluripotency of human embryonic stem cells in the absence of feeder layers
-
Wang G, Zhang H, Zhao Y, et al. Noggin and bFGF cooperate to maintain the pluripotency of human embryonic stem cells in the absence of feeder layers. Biochem Biophys Res Commun 2005;330:934-942.
-
(2005)
Biochem Biophys Res Commun
, vol.330
, pp. 934-942
-
-
Wang, G.1
Zhang, H.2
Zhao, Y.3
-
29
-
-
0036152855
-
A role for the BMP antagonist chordin in endochondral ossification
-
Zhang D, Ferguson CM, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. A role for the BMP antagonist chordin in endochondral ossification. J Bone Miner Res 2002;17:293-300.
-
(2002)
J Bone Miner Res
, vol.17
, pp. 293-300
-
-
Zhang, D.1
Ferguson, C.M.2
O'Keefe, R.J.3
Puzas, J.E.4
Rosier, R.N.5
Reynolds, P.R.6
-
30
-
-
77952951901
-
Effect of chordin-like 1 on MC3T3-E1 and human mesenchymal stem cells
-
Fernandes H, Dechering K, van Someren E, et al. Effect of chordin-like 1 on MC3T3-E1 and human mesenchymal stem cells. Cells Tissues Organs 2010;191: 443-452.
-
(2010)
Cells Tissues Organs
, vol.191
, pp. 443-452
-
-
Fernandes, H.1
Dechering, K.2
Van Someren, E.3
-
31
-
-
17644378679
-
Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease
-
Lin J, Patel SR, Cheng X, et al. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Nat Med 2005;11:387-393.
-
(2005)
Nat Med
, vol.11
, pp. 387-393
-
-
Lin, J.1
Patel, S.R.2
Cheng, X.3
-
32
-
-
0034708483
-
Biosynthesis, post- Translation modification, and functional characterization of Drm/Gremlin
-
Topol LZ, Bardot B, Zhang Q, et al. Biosynthesis, post- Translation modification, and functional characterization of Drm/Gremlin. J Biol Chem 2000;275: 8785-8793.
-
(2000)
J Biol Chem
, vol.275
, pp. 8785-8793
-
-
Topol, L.Z.1
Bardot, B.2
Zhang, Q.3
-
33
-
-
77951645428
-
Role of gremlin in the lung: Development and disease
-
Costello CM, Cahill E, Martin F, Gaine S, McLoughlin P. Role of gremlin in the lung: development and disease. Am J Respir Cell Mol Biol 2010;42:517- 523.
-
(2010)
Am J Respir Cell Mol Biol
, vol.42
, pp. 517-523
-
-
Costello, C.M.1
Cahill, E.2
Martin, F.3
Gaine, S.4
McLoughlin, P.5
-
34
-
-
84911896533
-
Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans
-
Chondronikola M, Volpi E, Børsheim E, et al. Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans. Diabetes 2014;63:4089-4099.
-
(2014)
Diabetes
, vol.63
, pp. 4089-4099
-
-
Chondronikola, M.1
Volpi, E.2
Børsheim, E.3
-
35
-
-
84877263632
-
A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans
-
Jespersen NZ, Larsen TJ, Peijs L, et al. A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab 2013;17:798-805.
-
(2013)
Cell Metab
, vol.17
, pp. 798-805
-
-
Jespersen, N.Z.1
Larsen, T.J.2
Peijs, L.3
-
36
-
-
83455198397
-
Recruited vs. Nonrecruited molecular signatures of brown, "brite, " and white adipose tissues
-
Waldén TB, Hansen IR, Timmons JA, Cannon B, Nedergaard J. Recruited vs. nonrecruited molecular signatures of brown, "brite, " and white adipose tissues. Am J Physiol Endocrinol Metab 2012;302:E19-E31.
-
(2012)
Am J Physiol Endocrinol Metab
, vol.302
, pp. E19-E31
-
-
Waldén, T.B.1
Hansen, I.R.2
Timmons, J.A.3
Cannon, B.4
Nedergaard, J.5
-
37
-
-
78650945931
-
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
-
Seale P, Conroe HM, Estall J, et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest 2011;121: 96-105.
-
(2011)
J Clin Invest
, vol.121
, pp. 96-105
-
-
Seale, P.1
Conroe, H.M.2
Estall, J.3
-
38
-
-
33646934768
-
Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes
-
Gustafson B, Smith U. Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J Biol Chem 2006;281:9507-9516.
-
(2006)
J Biol Chem
, vol.281
, pp. 9507-9516
-
-
Gustafson, B.1
Smith, U.2
-
39
-
-
84873296127
-
The transcription factor paired-related homeobox 1 (Prrx1) inhibits adipogenesis by activating transforming growth factor-b (TGFb) signaling
-
Du B, Cawthorn WP, Su A, et al. The transcription factor paired-related homeobox 1 (Prrx1) inhibits adipogenesis by activating transforming growth factor-b (TGFb) signaling. J Biol Chem 2013;288:3036-3047.
-
(2013)
J Biol Chem
, vol.288
, pp. 3036-3047
-
-
Du, B.1
Cawthorn, W.P.2
Su, A.3
-
40
-
-
84886797652
-
Bleomycin inhibits adipogenesis and accelerates fibrosis in the subcutaneous adipose layer through TGF-b1
-
Ohgo S, Hasegawa S, Hasebe Y, Mizutani H, Nakata S, Akamatsu H. Bleomycin inhibits adipogenesis and accelerates fibrosis in the subcutaneous adipose layer through TGF-b1. Exp Dermatol 2013;22:769-771.
-
(2013)
Exp Dermatol
, vol.22
, pp. 769-771
-
-
Ohgo, S.1
Hasegawa, S.2
Hasebe, Y.3
Mizutani, H.4
Nakata, S.5
Akamatsu, H.6
-
41
-
-
78349281192
-
PPARg downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: A novel mechanism for progressive fibrogenesis
-
Wei J, Ghosh AK, Sargent JL, et al. PPARg downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: A novel mechanism for progressive fibrogenesis. PLoS ONE 2010;5:e13778.
-
(2010)
PLoS ONE
, vol.5
, pp. e13778
-
-
Wei, J.1
Ghosh, A.K.2
Sargent, J.L.3
-
42
-
-
84856970831
-
Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells
-
Gupta RK, Mepani RJ, Kleiner S, et al. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab 2012;15:230-239.
-
(2012)
Cell Metab
, vol.15
, pp. 230-239
-
-
Gupta, R.K.1
Mepani, R.J.2
Kleiner, S.3
-
43
-
-
84860850964
-
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions
-
Whittle AJ, Carobbio S, Martins L, et al. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell 2012;149: 871-885.
-
(2012)
Cell
, vol.149
, pp. 871-885
-
-
Whittle, A.J.1
Carobbio, S.2
Martins, L.3
-
44
-
-
75149169318
-
Adipocyte size predicts incidence of type 2 diabetes in women
-
Lönn M, Mehlig K, Bengtsson C, Lissner L. Adipocyte size predicts incidence of type 2 diabetes in women. FASEB J 2010;24:326-331.
-
(2010)
FASEB J
, vol.24
, pp. 326-331
-
-
Lönn, M.1
Mehlig, K.2
Bengtsson, C.3
Lissner, L.4
-
45
-
-
84892702771
-
Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch
-
Cohen P, Levy JD, Zhang Y, et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell 2014;156:304-316.
-
(2014)
Cell
, vol.156
, pp. 304-316
-
-
Cohen, P.1
Levy, J.D.2
Zhang, Y.3
-
46
-
-
84874450879
-
BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis
-
Qian SW, Tang Y, Li X, et al. BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc Natl Acad Sci U S A 2013;110:E798-E807.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. E798-E807
-
-
Qian, S.W.1
Tang, Y.2
Li, X.3
-
47
-
-
84862514392
-
Functional annotation of the human fat cell secretome
-
Dahlman I, Elsen M, Tennagels N, et al. Functional annotation of the human fat cell secretome. Arch Physiol Biochem 2012;118:84-91.
-
(2012)
Arch Physiol Biochem
, vol.118
, pp. 84-91
-
-
Dahlman, I.1
Elsen, M.2
Tennagels, N.3
-
48
-
-
84859465056
-
In vivo identification of bipotential adipocyte progenitors recruited by b3- Adrenoceptor activation and high-fat feeding
-
Lee YH, Petkova AP, Mottillo EP, Granneman JG. In vivo identification of bipotential adipocyte progenitors recruited by b3- Adrenoceptor activation and high-fat feeding. Cell Metab 2012;15:480-491.
-
(2012)
Cell Metab
, vol.15
, pp. 480-491
-
-
Lee, Y.H.1
Petkova, A.P.2
Mottillo, E.P.3
Granneman, J.G.4
-
49
-
-
84887502374
-
Tracking adipogenesis during white adipose tissue development, expansion and regeneration
-
Wang QA, Tao C, Gupta RK, Scherer PE. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat Med 2013;19: 1338-1344.
-
(2013)
Nat Med
, vol.19
, pp. 1338-1344
-
-
Wang, Q.A.1
Tao, C.2
Gupta, R.K.3
Scherer, P.E.4
|