The inhibitory effect of leptin on angiotensin II-induced vasoconstriction in vascular smooth muscle cells is mediated via a nitric oxide-dependent mechanism

Endocrinology

Volumn 148, Issue 1, 2007, Pages 324-331

  Rodríguez, Amaia ^a   Fortuño, Ana ^b   Gómez Ambrosi, Javier ^a   Zalba, Guillermo ^b   Díez, Javier ^a,b   Frühbeck, Gema ^a  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; ARGININE; CITRULLINE; JANUS KINASE; LEPTIN; N 6 (1 IMINOETHYL)LYSINE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYGENASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STAT3 PROTEIN; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANGIOTENSIN II; ANIMALS; AORTA, THORACIC; CALCIUM; CELLS, CULTURED; DRUG INTERACTIONS; ENZYME ACTIVATION; ENZYME INHIBITORS; JANUS KINASE 2; LEPTIN; MALE; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OMEGA-N-METHYLARGININE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; STAT3 TRANSCRIPTION FACTOR; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS;

EID: 33845914627     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2006-0940     Document Type: Article

References (47)

1. Eckel RH, Krauss RM 1998 American Heart Association call to action: obesity as a major risk factor for coronary heart disease. AHA Nutrition Committee. Circulation 97:2099-2100
2. Wilson PW, D'Agostino RB, Sullivan L, Parise H, Kannel WB 2002 Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med 162:1867-1872
3. Sahu A 2004 A hypothalamic role in energy balance with special emphasis on leptin. Endocrinology 145:2613-2620
4. Rahmouni K, Correia ML, Haynes WG, Mark AL 2005 Obesity-associated hypertension: new insights into mechanisms. Hypertension 45:9-14
5. Frühbeck G 2004 The adipose tissue as a source of vasoactive factors. Curr Med Chem Cardiovasc Hematol Agents 2:197-208
6. Beltowski J, Wojcicka G, Jamroz-Wisniewska A 2006 Role of nitric oxide and endothelium-derived hyperpolarizing factor (EDHF) in the regulation of blood pressure by leptin in lean and obese rats. Life Sci 79:63-71
7. Frühbeck G 1999 Pivotal role of nitric oxide in the control of blood pressure after leptin administration. Diabetes 48:903-908
8. Lembo G, Vecchione C, Fratta L, Marino G, Trimarco V, d'Amati G, Trimarco B 2000 Leptin induces direct vasodilation through distinct endothelial mechanisms. Diabetes 49:293-297
9. Kimura K, Tsuda K, Baba A, Kawabe T, Boh-oka S, Ibata M, Moriwaki C, Hano T, Nishio I 2000 Involvement of nitric oxide in endothelium-dependent arterial relaxation by leptin. Biochem Biophys Res Commun 273:745-749
10. Winters B, Mo Z, Brooks-Asplund E, Kim S, Shoukas A, Li D, Nyhan D, Berkowitz DE 2000 Reduction of obesity, as induced by leptin, reverses endothelial dysfunction in obese (Lepob) mice. J Appl Physiol 89:2382-2390
11. Beltowski J, Wójcicka G, Borkowska E 2002 Human leptin stimulates systemic nitric oxide production in the rat. Obes Res 10:939-946
12. Vecchione C, Maffei A, Colella S, Aretini A, Poulet R, Frati G, Gentile MT, Fratta L, Trimarco V, Trimarco B, Lembo G 2002 Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway. Diabetes 51:168-173
13. Fortuño A, Rodríguez A, Gómez-Ambrosi J, Muñiz P, Salvador J, Díez J, Frühbeck G 2002 Leptin inhibits angiotensin II-induced intracellular calcium increase and vasoconstriction in the rat aorta. Endocrinology 143:3555-3560
14. Rodríguez A, Frühbeck G, Gómez-Ambrosi J, Catalán V, Sainz N, Díez J, Zalba G, Fortuño A 2006 The inhibitory effect of leptin on angiotensin II-induced vasoconstriction is blunted in spontaneously hypertensive rats. J Hypertens 24:1589-1597
15. Kleinert H, Pautz A, Linker K, Schwarz PM 2004 Regulation of the expression of inducible nitric oxide synthase. Eur J Pharmacol 500:255-266
16. Isenovic ER, Meng Y, Divald A, Milivojevic N, Sowers JR 2002 Role of phosphatidylinositol 3-kinase/Akt pathway in angiotensin II and insulin-like growth factor-1 modulation of nitric oxide synthase in vascular smooth muscle cells. Endocrine 19:287-292
17. Bolli R, Dawn B, Xuan YT 2003 Role of the JAK-STAT pathway in protection against myocardial ischemia/reperfusion injury. Trends Cardiovasc Med 13:72-79
18. Frühbeck G 2006 Intracellular signalling pathways activated by leptin. Biochem J 393:7-20
19. Yu WH, Walczewska A, Karanth S, McCann SM 1997 Nitric oxide mediates leptin-induced luteinizing hormone-releasing hormone (LHRH) and LHRH and leptin-induced LH release from the pituitary gland. Endocrinology 138:5055-5058
20. Shiuchi T, Nakagami H, Iwai M, Takeda Y, Cui T, Chen R, Minokoshi Y, Horiuchi M 2001 Involvement of bradykinin and nitric oxide in leptin-mediated glucose uptake in skeletal muscle. Endocrinology 142:608-612
21. Dixit VD, Mielenz M, Taub DD, Parvizi N 2003 Leptin induces growth hormone secretion from peripheral blood mononuclear cells via a protein kinase C- and nitric oxide-dependent mechanism. Endocrinology 144:5595-5603
22. Vecchione C, Aretini A, Maffei A, Marino G, Selvetella G, Poulet R, Trimarco V, Frati G, Lembo G 2003 Cooperation between insulin and leptin in the modulation of vascular tone. Hypertension 42:166-170
23. Niswender KD, Gallis B, Blevins JE, Corson MA, Schwartz MW, Baskin DG 2003 Immunocytochemical detection of phosphatidylinositol 3-kinase activation by insulin and leptin. J Histochem Cytochem 51:275-283
24. Nickola MW, Wold LE, Colligan PB, Wang GJ, Samson WK, Ren J 2000 Leptin attenuates cardiac contraction in rat ventricular myocytes. Role of NO. Hypertension 36:501-505
25. Wold LE, Relling DP, Duan J, Norby FL, Ren J 2002 Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of JAK/STAT pathway. Hypertension 39:69-74
26. Yan C, Kim D, Aizawa T, Berk BC 2003 Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator. Arterioscler Thromb Vasc Biol 23:26-36
27. Fortuño A, Muñiz P, Ravassa S, Rodríguez JA, Fortuño MA, Zalba G, Díez J 1999 Torasemide inhibits angiotensin II-induced vasoconstriction and calcium increase in spontaneously hypertensive rats. Hypertension 34:138-143
28. Villeneuve N, Fortuño A, Sauvage M, Fournier N, Breugnot C, Jacquemin C, Petit C, Gosgnach W, Carpentier N, Vanhoutte P, Vilaine JP 2003 Persistence of the nitric oxide pathway in the aorta of hypercholesterolemic apolipoprotein-E-deficient mice. J Vasc Res 40:87-96
29. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
30. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450
31. Knudson JD, Dincer UD, Dick GM, Shibata H, Akahane R, Saito M, Tune JD 2005 Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction. Am J Physiol Heart Circ Physiol 289:H1038-H1046
32. Gálvez B, de Castro J, Herold D, Dubrovska G, Arribas S, González MC, Aránguez I, Luft FC, Ramos MP, Gollasch M, Fernández Alfonso MS 2006 Perivascular adipose tissue and mesenteric vascular function in spontaneously hypertensive rats. Arterioscler Thromb Vasc Biol 26:1297-1302
33. Otero M, Lago R, Lago F, Reino JJ, Gualillo O 2005 Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. Arthritis Res Ther 7:R581-R591
34. Raso GM, Esposito E, Iacono A, Pacilio M, Coppola A, Bianco G, Diano S, Carlo RD, Meli R 2006 Leptin induces nitric oxide synthase type II in C6 glioma cells. Role for nuclear factor-κB in hormone effect. Neurosci Lett 396:121-126
35. Raso GM, Pacilio M, Esposito E, Coppola A, Di Carlo R, Meli R 2002 Leptin potentiates IFN-γ-induced expression of nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A. 1. Br J Pharmacol 137:799-804
36. Konturek PC, Brzozowski T, Sulekova Z, Brzozowska I, Duda A, Meixner H, Hahn EG, Konturek SJ 2001 Role of leptin in ulcer healing. Eur J Pharmacol 414:87-97
37. Hattori Y, Hattori S, Kasai K 2003 Lipopolysaccharide activates Akt in vascular smooth muscle cells resulting in induction of inducible nitric oxide synthase through nuclear factor-κB activation. Eur J Pharmacol 481:153-158
38. Shin HJ, Oh J, Kang SM, Lee JH, Shin MJ, Hwang KC, Jang Y, Chung JH 2005 Leptin induces hypertrophy via p38 mitogen-activated protein kinase in rat vascular smooth muscle cells. Biochem Biophys Res Commun 329:18-24
39. Kanaide H, Ichiki T, Nishimura J, Hirano K 2003 Cellular mechanism of vasoconstriction induced by angiotensin II: it remains to be determined. Circ Res 93:1015-1017
40. Rodríguez A, Gómez-Ambrosi J, Salvador J, Frühbeck G, Díez J, Fortuño 2003A Leptin specifically inhibits angiotensin II-induced vascular actions through a NO-mediated pathway in Wistar rat vascular smooth muscle cells. J Hypertens 21:S297 (Abstract)
41. Mastronardi CA, Yu WH, McCann SM 2002 Resting and circadian release of nitric oxide is controlled by leptin in male rats. Proc Natl Acad Sci USA 99:5721-5726
42. Villarreal D, Reams G, Samar H, Spear R, Freeman RH 2004 Effects of chronic nitric oxide inhibition on the renal excretory response to leptin. Obes Res 12:1006-1010
43. Knudson JD, Dincer UD, Zhang C, Swafford Jr AN, Koshida R, Picchi A, Focardi M, Dick GM, Tune JD 2005 Leptin receptors are expressed in coronary arteries, and hyperleptinemia causes significant coronary endothelial dysfunction. Am J Physiol Heart Circ Physiol 289:H48-H56
44. Püntmann VO, Hussain MB, Mayr M, Xu Q, Singer DR 2005 Role of oxidative stress in angiotensin-II mediated contraction of human conduit arteries in patients with cardiovascular disease. Vasc Pharmacol 43:277-282
45. Caro JF, Sinha MK, Kolaczynski JW, Zhang YPL, Considine RV 1996 Leptin: the tale of an obesity gene. Diabetes 45:1455-1462
46. Rahmouni K, Morgan DA, Morgan GM, Mark AL, Haynes WG 2005 Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes 54:2012-2018
47. Barton M, Carmona R, Ortmann J, Krieger JE, Traupe T 2003 Obesity-associated activation of angiotensin and endothelin in the cardiovascular system. Int J Biochem Cell Biol 35:826-837