3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-γ-dependent and mediated by the caspase-3-dependent apoptotic pathway

FEBS Journal

Volumn 277, Issue 3, 2010, Pages 687-696

  Xiao, Yuanyuan ^a   Yuan, Taichang ^a   Yao, Wenqi ^a   Liao, Kan ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

3T3 L1 adipocyte; Adipocyte apoptosis; Akt 1; PPAR ; Thiazolidinediones

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; CASPASE 3; CASPASE 3 INHIBITOR; CYTOCHROME C; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PIOGLITAZONE; PROSTAGLANDIN J2; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; TROGLITAZONE;

ADIPOCYTE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MATURATION; CELL STRAIN 3T3; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENZYME INHIBITION; ENZYME RELEASE; GENE OVEREXPRESSION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN CONTENT; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CASPASE 3; CHROMANS; MALE; MICE; PPAR GAMMA; PROSTAGLANDIN D2; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, ZUCKER; THIAZOLIDINEDIONES;

RATTUS;

EID: 75149191885     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.07514.x     Document Type: Article

References (43)

1. Wood RJ (2008) Vitamin D and adipogenesis: new molecular insights. Nutr Rev 66, 40 46.
2. Prestwich TC Macdougald OA (2007) Wnt/beta-catenin signaling in adipogenesis and metabolism. Curr Opin Cell Biol 19, 612 617.
3. Cousin W, Fontaine C, Dani C Peraldi P (2007) Hedgehog and adipogenesis: fat and fiction. Biochimie 89, 1447 1453.
4. Rosen ED MacDougald OA (2006) Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 7, 885 896.
5. Prins JB, Walker NI, Winterford CM Cameron DP (1994) Human adipocyte apoptosis occurs in malignancy. Biochem Biophys Res Commun 205, 625 630.
6. Prins JB, Walker NI, Winterford CM Cameron DP (1994) Apoptosis of human adipocytes in vitro. Biochem Biophys Res Commun 201, 500 507.
7. Loftus TM, Kuhajda FP Lane MD (1998) Insulin depletion leads to adipose-specific cell death in obese but not lean mice. Proc Natl Acad Sci USA 95, 14168 14172.
8. Papineau D, Gagnon A Sorisky A (2003) Apoptosis of human abdominal preadipocytes before and after differentiation into adipocytes in culture. Metabolism 52, 987 992.
9. Pajvani UB, Trujillo ME, Combs TP, Iyengar P, Jelicks L, Roth KA, Kitsis RN Scherer PE (2005) Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nat Med 11, 797 803.
10. Della-Fera MA, Qian H Baile CA (2001) Adipocyte apoptosis in the regulation of body fat mass by leptin. Diabetes Obes Metab 3, 299 310.
11. Prins JB, Niesler CU, Winterford CM, Bright NA, Siddle K, O'Rahilly S, Walker NI Cameron DP (1997) Tumor necrosis factor-alpha induces apoptosis of human adipose cells. Diabetes 46, 1939 1944.
12. Qian H, Azain MJ, Compton MM, Hartzell DL, Hausman GJ Baile CA (1998) Brain administration of leptin causes deletion of adipocytes by apoptosis. Endocrinology 139, 791 794.
13. Yang JY, Della-Fera MA, Hausman DB Baile CA (2007) Enhancement of ajoene-induced apoptosis by conjugated linoleic acid in 3T3-L1 adipocytes. Apoptosis 12, 1117 1128.
14. Yang JY, Della-Fera MA, Rayalam S Baile CA (2007) Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis. Apoptosis 12, 1953 1963.
15. Yang JY, Della-Fera MA Baile CA (2008) Guggulsterone inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 cells. Obesity 16, 16 22, doi:.
16. Elte JW Blickle JF (2007) Thiazolidinediones for the treatment of type 2 diabetes. Eur J Intern Med 18, 18 25.
17. Okuno A, Tamemoto H, Tobe K, Ueki K, Mori Y, Iwamoto K, Umesono K, Akanuma Y, Fujiwara T, Horikoshi H et al. (1998) Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest 101, 1354 1361.
18. Yamauchi T, Kamon J, Waki H, Murakami K, Motojima K, Komeda K, Ide T, Kubota N, Terauchi Y, Tobe K et al. (2001) The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. J Biol Chem 276, 41245 41254.
19. Berger J Moller DE (2002) The mechanisms of action of PPARs. Annu Rev Med 53, 409 435.
20. Bishop-Bailey D Hla T (1999) Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-delta12,14- prostaglandin J2. J Biol Chem 274, 17042 17048.
21. Satoh T, Toyoda M, Hoshino H, Monden T, Yamada M, Shimizu H, Miyamoto K Mori M (2002) Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells. Oncogene 21, 2171 2180.
22. Betz MJ, Shapiro I, Fassnacht M, Hahner S, Reincke M Beuschlein F (2005) Peroxisome proliferator-activated receptor-gamma agonists suppress adrenocortical tumor cell proliferation and induce differentiation. J Clin Endocrinol Metab 90, 3886 3896.
23. Chang TH Szabo E (2000) Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor gamma in non-small cell lung cancer. Cancer Res 60, 1129 1138.
24. Krishnan A, Nair SA Pillai MR (2007) Biology of PPAR gamma in cancer: a critical review on existing lacunae. Curr Mol Med 7, 532 540.
25. Harris SG Phipps RP (2001) The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis. Eur J Immunol 31, 1098 1105.
26. Green H Meuth M (1974) An established pre-adipose cell line and its differentiation in culture. Cell 3, 127 133.
27. Green H Kehinde O (1975) An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 5, 19 27.
28. Han S Roman J (2006) Rosiglitazone suppresses human lung carcinoma cell growth through PPARgamma-dependent and PPARgamma-independent signal pathways. Mol Cancer Ther 5, 430 437.
29. Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC Lehmann JM (1995) A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 83, 813 819.
30. Xu J Liao K (2004) Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation. J Biol Chem 279, 35914 35922.
31. Song G, Ouyang G Bao S (2005) The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 9, 59 71.
32. Reed JC (1998) Bcl-2 family proteins. Oncogene 17, 3225 3236.
33. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y Greenberg ME (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231 241.
34. Murphy KM, Ranganathan V, Farnsworth ML, Kavallaris M Lock RB (2000) Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells. Cell Death Differ 7, 102 111.
35. Adams JM Cory S (1998) The Bcl-2 protein family: arbiters of cell survival. Science 281, 1322 1326.
36. Datta SR, Brunet A Greenberg ME (1999) Cellular survival: a play in three Akts. Genes Dev 13, 2905 2927.
37. Goetze S, Eilers F, Bungenstock A, Kintscher U, Stawowy P, Blaschke F, Graf K, Law RE, Fleck E Grafe M (2002) PPAR activators inhibit endothelial cell migration by targeting Akt. Biochem Biophys Res Commun 293, 1431 1437.
38. Patel L, Pass I, Coxon P, Downes CP, Smith SA Macphee CH (2001) Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN. Curr Biol 11, 764 768.
39. Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, Funahashi T Walsh K (2004) Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem 279, 1304 1309. (Pubitemid 38082655)
40. Shiau CW, Yang CC, Kulp SK, Chen KF, Chen CS, Huang JW Chen CS (2005) Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 functions independently of PPARgamma. Cancer Res 65, 1561 1569.
41. Jin S, Zhai B, Qiu Z, Wu J, Lane MD Liao K (2000) c-Crk, a substrate of the insulin-like growth factor-1 receptor tyrosine kinase, functions as an early signal mediator in the adipocyte differentiation process. J Biol Chem 275, 34344 34352.
42. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F Riccardi C (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139, 271 279.
43. Piper RC, Hess LJ James DE (1991) Differential sorting of two glucose transporters expressed in insulin-sensitive cells. Am J Physiol 260, C570 C580.