Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis

Science

Volumn 332, Issue 6026, 2011, Pages 243-247

  Wu, Davina ^a   Molofsky, Ari B ^b   Liang, Hong Erh ^a   Ricardo Gonzalez, Roberto R ^c   Jouihan, Hani A ^c   Bando, Jennifer K ^a   Chawla, Ajay ^a   Locksley, Richard M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; INTERLEUKIN 13; INTERLEUKIN 4;

ALLERGY; CELL ORGANELLE; GLUCOSE; HOMEOSTASIS; IMMUNITY; INVERTEBRATE; METABOLISM; RODENT; TOLERANCE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BASOPHIL; BODY FAT; CD4+ T LYMPHOCYTE; CELL MIGRATION; CONTROLLED STUDY; EOSINOPHIL; EOSINOPHILIA; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HELMINTH; HELPER CELL; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; LIPID DIET; LUNG LOBE; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; ADIPOSE TISSUE, WHITE; ANIMALS; BLOOD GLUCOSE; CELL MOVEMENT; DIETARY FATS; EOSINOPHILIA; EOSINOPHILS; GLUCOSE INTOLERANCE; HOMEOSTASIS; INSULIN; INSULIN RESISTANCE; INTERLEUKIN-13; INTERLEUKIN-4; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; NIPPOSTRONGYLUS; STRONGYLIDA INFECTIONS;

MUS; VERMES;

EID: 79953815551     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1201475     Document Type: Article

References (27)

1. G. S. Hotamisligil, Nature 444, 860 (2006).
2. C. N. Lumeng, J. L. Bodzin, A. R. Saltiel, ;.J Clin. Invest. 117, 175 (2007).
3. J. I. Odegaard et al, Nature 447, 1116 (2007).
4. M. A. Bouhlel et al, Cell Metab. 6, 137 (2007).
5. E. H. Jeninga, M. Gurnell, E. Kalkhoven, Trends Endocrinol. Metab. 20, 380 (2009).
6. F. O. Martinez, L. Helming, S. Gordon, Annu. Rev. Immunol. 27, 451 (2009).
7. K. Kang et al, Cell Metab. 7, 485 (2008).
8. Materials and methods are available as supporting material on Science Online.
9. M. Mohrs, K. Shinkai, K. Mohrs, R. M. Locksley, Immunity 15, 303 (2001).
10. K. Mohrs, A. E. Wakil, N. Killeen, R. M. Locksley, M. Mohrs, Immunity 23, 419 (2005).
11. C. Yu et al, J. Exp. Med. 195, 1387 (2002).
12. D. Voehringer, N. van Rooijen, R. M. Locksley, ;J. Leukoc. Biol. 81, 1434 (2007).
13. N. A. Lee et al, J. Immunol. 158, 1332 (1997).
14. M. E. Rothenberg, S. P. Hogan, Annu. Rev. Immunol. 24, 147 (2006).
15. M. M. Fort et al, Immunity 15, 985 (2001).
16. T. A. Reese et al, Nature 447, 92 (2007).
17. G. J. McKenzie, P. G. Fallon, C. L. Emson, R. K. Grencis, A. N. McKenzie, J. Exp. Med. 189, 1565 (1999).
18. K. Mora et al, Nature 463, 540 (2010).
19. S. Nishimura et al, Nat. Med. 15, 914 (2009).
20. S. Winer et al, Nat. Med. 15, 921 (2009).
21. M. Feuerer et al, Nat. Med. 15, 930 (2009).
22. E. Karita et al, PLoS ONE 4, e4401 (2009).
23. G. S. Hotamisligil, E. Erbay, Nat. Rev. Immunol. 8, 923 (2008).
24. L. Zu et al, J. Biol. Chem. 284, 5915 (2009).
25. V. Emilsson et al, Nature 452, 423 (2008).
26. Y. Chen et al, Nature 452, 429 (2008).
27. We thank J. Cyster, D. Erle, C. Gerard, J. Lee, and A. McKenzie for reagents and mice; N. Flores for animal husbandry; Z. Wang for technical assistance; and M. Anderson and C. Lowell for constructive review of the manuscript. This work was supported by the Howard Hughes Medical Institute and grants from the NIH (AI026918), Juvenile Diabetes Research Foundation Innovative Grant, Larry L. Hillblom Foundation Network Grant and the Sandler Asthma Basic Research Center. Support was provided by the Diabetes Endocrinology Research Center grant DK063720, UCSF Medical Scientist Training Program (D.W.), UCSF Department of Laboratory Medicine (A.B.M.), and 5F30DK083194-02 from the National Institutes of Health (D.W.). Animal care was in accordance with UCSF Laboratory Animal Resource Center committee guidelines. Mouse strains described are available upon completion of standard institutional Material Transfer Agreements.