메뉴 건너뛰기




Volumn 54, Issue , 2014, Pages 89-100

Irisin as a muscle-derived hormone stimulating thermogenesis - A critical update

Author keywords

Brown adipose tissue; Exercise; FNDC5; Obesity

Indexed keywords

FIBRONECTIN; HORMONE; IRISIN; UNCLASSIFIED DRUG; FNDC5 PROTEIN, HUMAN; FNDC5 PROTEIN, MOUSE; GLUCOSE;

EID: 84893933424     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2014.01.016     Document Type: Review
Times cited : (123)

References (84)
  • 2
    • 84885830481 scopus 로고    scopus 로고
    • Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45 min of a Turkish bath or running
    • S. Aydin, S. Aydin, T. Kuloglu, M. Yilmaz, M. Kalayci, and I. Sahin et al. Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45 min of a Turkish bath or running Peptides 50 2013 13 18
    • (2013) Peptides , vol.50 , pp. 13-18
    • Aydin, S.1    Aydin, S.2    Kuloglu, T.3    Yilmaz, M.4    Kalayci, M.5    Sahin, I.6
  • 3
    • 84885129114 scopus 로고    scopus 로고
    • Copeptin, adropin and irisin concentrations in breast milk and plasma of healthy women and those with gestational diabetes mellitus
    • S. Aydin, T. Kuloglu, and S. Aydin Copeptin, adropin and irisin concentrations in breast milk and plasma of healthy women and those with gestational diabetes mellitus Peptides 47 2013 66 70
    • (2013) Peptides , vol.47 , pp. 66-70
    • Aydin, S.1    Kuloglu, T.2    Aydin, S.3
  • 4
    • 84891598333 scopus 로고    scopus 로고
    • Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle
    • S. Aydin, T. Kuloglu, S. Aydin, M.N. Eren, A. Celik, and M. Yilmaz et al. Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: cardiac muscle produces more irisin than skeletal muscle Peptides 52C 2013 68 73
    • (2013) Peptides , vol.52 C , pp. 68-73
    • Aydin, S.1    Kuloglu, T.2    Aydin, S.3    Eren, M.N.4    Celik, A.5    Yilmaz, M.6
  • 5
    • 79958082780 scopus 로고    scopus 로고
    • The effects of ghrelin on inflammation and the immune system
    • D. Baatar, K. Patel, and D.D. Taub The effects of ghrelin on inflammation and the immune system Mol Cell Endocrinol 340 2011 44 58
    • (2011) Mol Cell Endocrinol , vol.340 , pp. 44-58
    • Baatar, D.1    Patel, K.2    Taub, D.D.3
  • 6
    • 0035847001 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell
    • DOI 10.1074/jbc.M006246200
    • M.J. Barbera, A. Schluter, N. Pedraza, R. Iglesias, F. Villarroya, and M. Giralt Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell J Biol Chem 276 2001 1486 1493 (Pubitemid 32096582)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.2 , pp. 1486-1493
    • Barbera, M.J.1    Schluter, A.2    Pedraza, N.3    Iglesias, R.4    Villarroya, F.5    Giralt, M.6
  • 7
    • 84899992518 scopus 로고    scopus 로고
    • Effect of endurance training on skeletal muscle myokine expression in obese men: Identification of apelin as a novel myokine
    • A. Besse-Patin, E. Montastier, C. Vinel, I. Castan-Laurell, K. Louche, and C. Dray et al. Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine Int J Obes (Lond) 2013
    • (2013) Int J Obes (Lond)
    • Besse-Patin, A.1    Montastier, E.2    Vinel, C.3    Castan-Laurell, I.4    Louche, K.5    Dray, C.6
  • 8
    • 80054104413 scopus 로고    scopus 로고
    • Sex-specific differences in the dynamics of cocaine- and amphetamine-regulated transcript and nesfatin-1 expressions in the midbrain of depressed suicide victims vs. Controls
    • B. Bloem, L. Xu, E. Morava, G. Faludi, M. Palkovits, and E.W. Roubos et al. Sex-specific differences in the dynamics of cocaine- and amphetamine-regulated transcript and nesfatin-1 expressions in the midbrain of depressed suicide victims vs. controls Neuropharmacology 62 2012 297 303
    • (2012) Neuropharmacology , vol.62 , pp. 297-303
    • Bloem, B.1    Xu, L.2    Morava, E.3    Faludi, G.4    Palkovits, M.5    Roubos, E.W.6
  • 9
    • 84863229962 scopus 로고    scopus 로고
    • Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
    • M. Bordicchia, D. Liu, E.Z. Amri, G. Ailhaud, P. Dessi-Fulgheri, and C. Zhang et al. Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes J Clin Invest 122 2012 1022 1036
    • (2012) J Clin Invest , vol.122 , pp. 1022-1036
    • Bordicchia, M.1    Liu, D.2    Amri, E.Z.3    Ailhaud, G.4    Dessi-Fulgheri, P.5    Zhang, C.6
  • 10
    • 84862776702 scopus 로고    scopus 로고
    • A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
    • P. Boström, J. Wu, M.P. Jedrychowski, A. Korde, L. Ye, and J.C. Lo et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis Nature 481 2012 463 468
    • (2012) Nature , vol.481 , pp. 463-468
    • Boström, P.1    Wu, J.2    Jedrychowski, M.P.3    Korde, A.4    Ye, L.5    Lo, J.C.6
  • 11
    • 84860726725 scopus 로고    scopus 로고
    • Total daily physical activity and the risk of AD and cognitive decline in older adults
    • A.S. Buchman, P.A. Boyle, L. Yu, R.C. Shah, R.S. Wilson, and D.A. Bennett Total daily physical activity and the risk of AD and cognitive decline in older adults Neurology 78 2012 1323 1329
    • (2012) Neurology , vol.78 , pp. 1323-1329
    • Buchman, A.S.1    Boyle, P.A.2    Yu, L.3    Shah, R.C.4    Wilson, R.S.5    Bennett, D.A.6
  • 13
    • 0035787319 scopus 로고    scopus 로고
    • The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis
    • S. Collins, and R.S. Surwit The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis Recent Prog Horm Res 56 2001 309 328
    • (2001) Recent Prog Horm Res , vol.56 , pp. 309-328
    • Collins, S.1    Surwit, R.S.2
  • 16
    • 84894272878 scopus 로고    scopus 로고
    • Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women
    • A.B. Crujeiras, M. Pardo, R.R. Arturo, N.C. Santiago, M.A. Zulet, and J.A. Martinez et al. Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women Am J Hum Biol 2013
    • (2013) Am J Hum Biol
    • Crujeiras, A.B.1    Pardo, M.2    Arturo, R.R.3    Santiago, N.C.4    Zulet, M.A.5    Martinez, J.A.6
  • 17
    • 84875859444 scopus 로고    scopus 로고
    • Irisin-immunoreactivity in neural and non-neural cells of the rodent
    • S.L. Dun, R.M. Lyu, Y.H. Chen, J.K. Chang, J.J. Luo, and N.J. Dun Irisin-immunoreactivity in neural and non-neural cells of the rodent Neuroscience 240 2013 155 162
    • (2013) Neuroscience , vol.240 , pp. 155-162
    • Dun, S.L.1    Lyu, R.M.2    Chen, Y.H.3    Chang, J.K.4    Luo, J.J.5    Dun, N.J.6
  • 18
    • 84892480227 scopus 로고    scopus 로고
    • Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery
    • T. Ebert, H. Stepan, S. Schrey, S. Kralisch, J. Hindricks, and L. Hopf et al. Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery Cytokine 65 2 2013 Feb 153 158
    • (2013) Cytokine , vol.65 , Issue.2 , pp. 153-158
    • Ebert, T.1    Stepan, H.2    Schrey, S.3    Kralisch, S.4    Hindricks, J.5    Hopf, L.6
  • 19
    • 84888386052 scopus 로고    scopus 로고
    • Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor
    • H.P. Erickson Irisin and FNDC5 in retrospect: an exercise hormone or a transmembrane receptor Adipocyte 2 2013 289 293
    • (2013) Adipocyte , vol.2 , pp. 289-293
    • Erickson, H.P.1
  • 20
    • 84884533614 scopus 로고    scopus 로고
    • Exercise training does not increase muscle FNDC5 protein or mRNA expression in pigs
    • J.N. Fain, J.M. Company, F.W. Booth, M.H. Laughlin, J. Padilla, and N.T. Jenkins et al. Exercise training does not increase muscle FNDC5 protein or mRNA expression in pigs Metabolism 62 2013 1503 1511
    • (2013) Metabolism , vol.62 , pp. 1503-1511
    • Fain, J.N.1    Company, J.M.2    Booth, F.W.3    Laughlin, M.H.4    Padilla, J.5    Jenkins, N.T.6
  • 21
    • 84890089673 scopus 로고    scopus 로고
    • The effect of exercise interventions on cognitive outcome in Alzheimer's disease: A systematic review
    • N. Farina, J. Rusted, and N. Tabet The effect of exercise interventions on cognitive outcome in Alzheimer's disease: a systematic review Int Psychogeriatr 26 2014 9 18
    • (2014) Int Psychogeriatr , vol.26 , pp. 9-18
    • Farina, N.1    Rusted, J.2    Tabet, N.3
  • 22
    • 0035988932 scopus 로고    scopus 로고
    • Mouse PeP: A novel peroxisomal protein linked to myoblast differentiation and development
    • DOI 10.1002/dvdy.10099
    • A. Ferrer-Martinez, P. Ruiz-Lozano, and K.R. Chien Mouse PeP: a novel peroxisomal protein linked to myoblast differentiation and development Dev Dyn 224 2002 154 167 (Pubitemid 34569057)
    • (2002) Developmental Dynamics , vol.224 , Issue.2 , pp. 154-167
    • Ferrer-Martinez, A.1    Ruiz-Lozano, P.2    Chien, K.R.3
  • 23
    • 84863012022 scopus 로고    scopus 로고
    • FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis
    • F.M. Fisher, S. Kleiner, N. Douris, E.C. Fox, R.J. Mepani, and F. Verdeguer et al. FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis Genes Dev 26 2012 271 281
    • (2012) Genes Dev , vol.26 , pp. 271-281
    • Fisher, F.M.1    Kleiner, S.2    Douris, N.3    Fox, E.C.4    Mepani, R.J.5    Verdeguer, F.6
  • 24
    • 77958195688 scopus 로고    scopus 로고
    • Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes
    • I.J. Gallagher, C. Scheele, P. Keller, A.R. Nielsen, J. Remenyi, and C.P. Fischer et al. Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes Genome Med 2 2010 9
    • (2010) Genome Med , vol.2 , pp. 9
    • Gallagher, I.J.1    Scheele, C.2    Keller, P.3    Nielsen, A.R.4    Remenyi, J.5    Fischer, C.P.6
  • 25
    • 84890182035 scopus 로고    scopus 로고
    • Ghrelin and its interactions with growth hormone, leptin and orexins: Implications for the sleep-wake cycle and metabolism
    • F. Garcia-Garcia, E. Juarez-Aguilar, J. Santiago-Garcia, and D.P. Cardinali Ghrelin and its interactions with growth hormone, leptin and orexins: implications for the sleep-wake cycle and metabolism Sleep Med Rev 18 2014 89 97
    • (2014) Sleep Med Rev , vol.18 , pp. 89-97
    • Garcia-Garcia, F.1    Juarez-Aguilar, E.2    Santiago-Garcia, J.3    Cardinali, D.P.4
  • 26
    • 72949090691 scopus 로고    scopus 로고
    • Restraint stress activates nesfatin-1-immunoreactive brain nuclei in rats
    • M. Goebel, A. Stengel, L. Wang, and Y. Taché Restraint stress activates nesfatin-1-immunoreactive brain nuclei in rats Brain Res 1300 2009 114 124
    • (2009) Brain Res , vol.1300 , pp. 114-124
    • Goebel, M.1    Stengel, A.2    Wang, L.3    Taché, Y.4
  • 27
    • 47949104798 scopus 로고    scopus 로고
    • The role of exercise and PGC1alpha in inflammation and chronic disease
    • C. Handschin, and B.M. Spiegelman The role of exercise and PGC1alpha in inflammation and chronic disease Nature 454 2008 463 469
    • (2008) Nature , vol.454 , pp. 463-469
    • Handschin, C.1    Spiegelman, B.M.2
  • 28
    • 84872288553 scopus 로고    scopus 로고
    • Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells
    • M.S. Hashemi, K. Ghaedi, A. Salamian, K. Karbalaie, M. Emadi-Baygi, and S. Tanhaei et al. Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells Neuroscience 231 2013 296 304
    • (2013) Neuroscience , vol.231 , pp. 296-304
    • Hashemi, M.S.1    Ghaedi, K.2    Salamian, A.3    Karbalaie, K.4    Emadi-Baygi, M.5    Tanhaei, S.6
  • 29
    • 0015332110 scopus 로고
    • The distribution of brown adipose tissue in the human
    • J.M. Heaton The distribution of brown adipose tissue in the human J Anat 112 1972 35 39
    • (1972) J Anat , vol.112 , pp. 35-39
    • Heaton, J.M.1
  • 30
    • 84887069835 scopus 로고    scopus 로고
    • Irisin and exercise training in humans - Results from a randomized controlled training trial
    • A. Hecksteden, M. Wegmann, A. Steffen, J. Kraushaar, A. Morsch, and S. Ruppenthal et al. Irisin and exercise training in humans - results from a randomized controlled training trial BMC Med 11 2013 235
    • (2013) BMC Med , vol.11 , pp. 235
    • Hecksteden, A.1    Wegmann, M.2    Steffen, A.3    Kraushaar, J.4    Morsch, A.5    Ruppenthal, S.6
  • 33
  • 34
    • 77249099832 scopus 로고    scopus 로고
    • Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat
    • E. Hondares, M. Rosell, F.J. Gonzalez, M. Giralt, R. Iglesias, and F. Villarroya Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat Cell Metab 11 2010 206 212
    • (2010) Cell Metab , vol.11 , pp. 206-212
    • Hondares, E.1    Rosell, M.2    Gonzalez, F.J.3    Giralt, M.4    Iglesias, R.5    Villarroya, F.6
  • 35
    • 84869497609 scopus 로고    scopus 로고
    • FNDC5 and irisin in humans. I: Predictors of circulating concentrations in serum and plasma. II: MRNA expression and circulating concentrations in response to weight loss and exercise
    • J.Y. Huh, G. Panagiotou, V. Mougios, M. Brinkoetter, M.T. Vamvini, and B.E. Schneider et al. FNDC5 and irisin in humans. I: Predictors of circulating concentrations in serum and plasma. II: mRNA expression and circulating concentrations in response to weight loss and exercise Metabolism 61 2012 1725 1738
    • (2012) Metabolism , vol.61 , pp. 1725-1738
    • Huh, J.Y.1    Panagiotou, G.2    Mougios, V.3    Brinkoetter, M.4    Vamvini, M.T.5    Schneider, B.E.6
  • 36
    • 77953010087 scopus 로고    scopus 로고
    • Medicine Beige can be slimming
    • J. Ishibashi, and P. Seale Medicine Beige can be slimming Science 328 2010 1113 1114
    • (2010) Science , vol.328 , pp. 1113-1114
    • Ishibashi, J.1    Seale, P.2
  • 37
    • 0024394362 scopus 로고
    • Context effects and inefficient initiation at non-AUG codons in eucaryotic cell-free translation systems
    • M. Kozak Context effects and inefficient initiation at non-AUG codons in eucaryotic cell-free translation systems Mol Cell Biol 9 1989 5073 5080 (Pubitemid 19275978)
    • (1989) Molecular and Cellular Biology , vol.9 , Issue.11 , pp. 5073-5080
    • Kozak, M.1
  • 38
    • 84894264547 scopus 로고    scopus 로고
    • A transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women
    • R.R. Kraemer, P. Shockett, N.D. Webb, U. Shah, and V.D. Castracane A transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women Horm Metab Res 2013
    • (2013) Horm Metab Res
    • Kraemer, R.R.1    Shockett, P.2    Webb, N.D.3    Shah, U.4    Castracane, V.D.5
  • 39
    • 79959688288 scopus 로고    scopus 로고
    • Ghrelin modulates sympathetic nervous system activity and stress response in lean and overweight men
    • E. Lambert, G. Lambert, C. Ika-Sari, T. Dawood, K. Lee, and R. Chopra et al. Ghrelin modulates sympathetic nervous system activity and stress response in lean and overweight men Hypertension 58 2011 43 50
    • (2011) Hypertension , vol.58 , pp. 43-50
    • Lambert, E.1    Lambert, G.2    Ika-Sari, C.3    Dawood, T.4    Lee, K.5    Chopra, R.6
  • 40
    • 0024691070 scopus 로고
    • Brown adipose tissue in humans
    • M.E. Lean Brown adipose tissue in humans Proc Nutr Soc 48 1989 243 256
    • (1989) Proc Nutr Soc , vol.48 , pp. 243-256
    • Lean, M.E.1
  • 41
    • 84873512773 scopus 로고    scopus 로고
    • Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure
    • S.H. Lecker, A. Zavin, P. Cao, R. Arena, K. Allsup, and K.M. Daniels et al. Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure Circ Heart Fail 5 2012 812 818
    • (2012) Circ Heart Fail , vol.5 , pp. 812-818
    • Lecker, S.H.1    Zavin, A.2    Cao, P.3    Arena, R.4    Allsup, K.5    Daniels, K.M.6
  • 42
    • 84891814129 scopus 로고    scopus 로고
    • Functional thermogenic beige adipogenesis is inducible in human neck fat
    • P. Lee, C.D. Werner, E. Kebebew, and F.S. Celi Functional thermogenic beige adipogenesis is inducible in human neck fat Int J Obes (Lond) 2013
    • (2013) Int J Obes (Lond)
    • Lee, P.1    Werner, C.D.2    Kebebew, E.3    Celi, F.S.4
  • 43
    • 84861739378 scopus 로고    scopus 로고
    • Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice
    • S. Lim, J. Honek, Y. Xue, T. Seki, Z. Cao, and P. Andersson et al. Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice Nat Protocol 7 2012 606 615
    • (2012) Nat Protocol , vol.7 , pp. 606-615
    • Lim, S.1    Honek, J.2    Xue, Y.3    Seki, T.4    Cao, Z.5    Andersson, P.6
  • 44
    • 84894545399 scopus 로고    scopus 로고
    • Relationship between circulating irisin, renal function and body composition in type 2 diabetes
    • J.J. Liu, S. Liu, M.D. Wong, C.S. Tan, S. Tavintharan, and C.F. Sum et al. Relationship between circulating irisin, renal function and body composition in type 2 diabetes J Diabetes Complicat 2013
    • (2013) J Diabetes Complicat
    • Liu, J.J.1    Liu, S.2    Wong, M.D.3    Tan, C.S.4    Tavintharan, S.5    Sum, C.F.6
  • 45
    • 84879915581 scopus 로고    scopus 로고
    • Lower circulating irisin is associated with type 2 diabetes mellitus
    • J.J. Liu, M.D. Wong, W.C. Toy, C.S. Tan, S. Liu, and X.W. Ng et al. Lower circulating irisin is associated with type 2 diabetes mellitus J Diabetes Complicat 27 2013 365 369
    • (2013) J Diabetes Complicat , vol.27 , pp. 365-369
    • Liu, J.J.1    Wong, M.D.2    Toy, W.C.3    Tan, C.S.4    Liu, S.5    Ng, X.W.6
  • 46
    • 84865522177 scopus 로고    scopus 로고
    • Neural correlates of plasma acylated ghrelin level in individuals with major depressive disorder
    • K. Matsuo, M. Nakano, M. Nakashima, T. Watanuki, K. Egashira, and T. Matsubara et al. Neural correlates of plasma acylated ghrelin level in individuals with major depressive disorder Brain Res 1473 2012 185 192
    • (2012) Brain Res , vol.1473 , pp. 185-192
    • Matsuo, K.1    Nakano, M.2    Nakashima, M.3    Watanuki, T.4    Egashira, K.5    Matsubara, T.6
  • 47
    • 84880571772 scopus 로고    scopus 로고
    • Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines
    • H.S. Moon, F. Dincer, and C.S. Mantzoros Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines Metabolism 62 2013 1131 1136
    • (2013) Metabolism , vol.62 , pp. 1131-1136
    • Moon, H.S.1    Dincer, F.2    Mantzoros, C.S.3
  • 48
    • 84876222786 scopus 로고    scopus 로고
    • Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance
    • J.M. Moreno-Navarrete, F. Ortega, M. Serrano, E. Guerra, G. Pardo, and F. Tinahones et al. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance J Clin Endocrinol Metab 98 2013 E769 E778
    • (2013) J Clin Endocrinol Metab , vol.98
    • Moreno-Navarrete, J.M.1    Ortega, F.2    Serrano, M.3    Guerra, E.4    Pardo, G.5    Tinahones, F.6
  • 49
  • 51
    • 84893981352 scopus 로고    scopus 로고
    • The effects of acute and chronic exercise on PGC-1alpha, irisin and browning of subcutaneous adipose tissue in humans
    • F. Norheim, T.M. Langleite, M. Hjorth, T. Holen, A. Kielland, and H.K. Stadheim et al. The effects of acute and chronic exercise on PGC-1alpha, irisin and browning of subcutaneous adipose tissue in humans FEBS J 2013
    • (2013) FEBS J
    • Norheim, F.1    Langleite, T.M.2    Hjorth, M.3    Holen, T.4    Kielland, A.5    Stadheim, H.K.6
  • 52
    • 84886769757 scopus 로고    scopus 로고
    • Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health
    • S. Pekkala, P.K. Wiklund, J.J. Hulmi, J.P. Ahtiainen, M. Horttanainen, and E. Pollanen et al. Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health J Physiol 591 2013 5393 5400
    • (2013) J Physiol , vol.591 , pp. 5393-5400
    • Pekkala, S.1    Wiklund, P.K.2    Hulmi, J.J.3    Ahtiainen, J.P.4    Horttanainen, M.5    Pollanen, E.6
  • 53
    • 77950226740 scopus 로고    scopus 로고
    • Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes
    • N. Petrovic, T.B. Walden, I.G. Shabalina, J.A. Timmons, B. Cannon, and J. Nedergaard Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes J Biol Chem 285 2010 7153 7164
    • (2010) J Biol Chem , vol.285 , pp. 7153-7164
    • Petrovic, N.1    Walden, T.B.2    Shabalina, I.G.3    Timmons, J.A.4    Cannon, B.5    Nedergaard, J.6
  • 54
    • 84863141614 scopus 로고    scopus 로고
    • Resistance exercise training improves age-related declines in leg vascular conductance and rejuvenates acute leg blood flow responses to feeding and exercise
    • B. Phillips, J. Williams, P. Atherton, K. Smith, W. Hildebrandt, and D. Rankin et al. Resistance exercise training improves age-related declines in leg vascular conductance and rejuvenates acute leg blood flow responses to feeding and exercise J Appl Physiol (1985) 112 2012 347 353
    • (2012) J Appl Physiol (1985) , vol.112 , pp. 347-353
    • Phillips, B.1    Williams, J.2    Atherton, P.3    Smith, K.4    Hildebrandt, W.5    Rankin, D.6
  • 55
    • 0037322888 scopus 로고    scopus 로고
    • Exercise induces transient transcriptional activation of the PGC-1α gene in human skeletal muscle
    • DOI 10.1113/jphysiol.2002.034850
    • H. Pilegaard, B. Saltin, and P.D. Neufer Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle J Physiol 546 2003 851 858 (Pubitemid 36204518)
    • (2003) Journal of Physiology , vol.546 , Issue.3 , pp. 851-858
    • Pilegaard, H.1    Saltin, B.2    Neufer, D.P.3
  • 56
    • 84893901804 scopus 로고    scopus 로고
    • The identification of irisin in human cerebrospinal fluid: Influence of adiposity, metabolic markers and gestational diabetes
    • M.K. Piya, A.L. Harte, K. Sivakumar, G. Tripathi, P.D. Voyias, and S. James et al. The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers and gestational diabetes Am J Physiol Endocrinol Metab 2014
    • (2014) Am J Physiol Endocrinol Metab
    • Piya, M.K.1    Harte, A.L.2    Sivakumar, K.3    Tripathi, G.4    Voyias, P.D.5    James, S.6
  • 57
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • DOI 10.1016/S0092-8674(00)81410-5
    • P. Puigserver, Z. Wu, C.W. Park, R. Graves, M. Wright, and B.M. Spiegelman A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis Cell 92 1998 829 839 (Pubitemid 28155321)
    • (1998) Cell , vol.92 , Issue.6 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 62
    • 84888323854 scopus 로고    scopus 로고
    • The structure of irisin reveals a novel intersubunit beta-sheet fibronectin type III (FNIII) dimer: Implications for receptor activation
    • M.A. Schumacher, N. Chinnam, T. Ohashi, R.S. Shah, and H.P. Erickson The structure of irisin reveals a novel intersubunit beta-sheet fibronectin type III (FNIII) dimer: implications for receptor activation J Biol Chem 288 2013 33738 33744
    • (2013) J Biol Chem , vol.288 , pp. 33738-33744
    • Schumacher, M.A.1    Chinnam, N.2    Ohashi, T.3    Shah, R.S.4    Erickson, H.P.5
  • 63
    • 50049122271 scopus 로고    scopus 로고
    • PRDM16 controls a brown fat/skeletal muscle switch
    • P. Seale, B. Bjork, W. Yang, S. Kajimura, S. Chin, and S. Kuang et al. PRDM16 controls a brown fat/skeletal muscle switch Nature 454 2008 961 967
    • (2008) Nature , vol.454 , pp. 961-967
    • Seale, P.1    Bjork, B.2    Yang, W.3    Kajimura, S.4    Chin, S.5    Kuang, S.6
  • 64
    • 84877147751 scopus 로고    scopus 로고
    • Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1alpha-Fndc5 pathway in muscle
    • T. Shan, X. Liang, P. Bi, and S. Kuang Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1alpha-Fndc5 pathway in muscle FASEB J 27 2013 1981 1989
    • (2013) FASEB J , vol.27 , pp. 1981-1989
    • Shan, T.1    Liang, X.2    Bi, P.3    Kuang, S.4
  • 65
    • 84867346134 scopus 로고    scopus 로고
    • Greater insulin sensitivity in calorie restricted rats occurs with unaltered circulating levels of several important myokines and cytokines
    • N. Sharma, C.M. Castorena, and G.D. Cartee Greater insulin sensitivity in calorie restricted rats occurs with unaltered circulating levels of several important myokines and cytokines Nutr Metab (Lond) 9 2012 90
    • (2012) Nutr Metab (Lond) , vol.9 , pp. 90
    • Sharma, N.1    Castorena, C.M.2    Cartee, G.D.3
  • 68
    • 84876744461 scopus 로고    scopus 로고
    • Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity
    • H. Staiger, A. Böhm, M. Scheler, L. Berti, J. Machann, and F. Schick et al. Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity PLoS ONE 8 2013 e61903
    • (2013) PLoS ONE , vol.8 , pp. 61903
    • Staiger, H.1    Böhm, A.2    Scheler, M.3    Berti, L.4    Machann, J.5    Schick, F.6
  • 69
    • 84871587312 scopus 로고    scopus 로고
    • Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity - Correlation with body mass index
    • A. Stengel, T. Hofmann, M. Goebel-Stengel, U. Elbelt, P. Kobelt, and B.F. Klapp Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity - correlation with body mass index Peptides 39 2013 125 130
    • (2013) Peptides , vol.39 , pp. 125-130
    • Stengel, A.1    Hofmann, T.2    Goebel-Stengel, M.3    Elbelt, U.4    Kobelt, P.5    Klapp, B.F.6
  • 70
    • 84880570314 scopus 로고    scopus 로고
    • Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass
    • A.G. Swick, S. Orena, and A. O'Connor Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass Metabolism 62 2013 1070 1073
    • (2013) Metabolism , vol.62 , pp. 1070-1073
    • Swick, A.G.1    Orena, S.2    O'Connor, A.3
  • 71
    • 0037019815 scopus 로고    scopus 로고
    • Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes
    • DOI 10.1016/S0378-1119(02)00828-4, PII S0378111902008284
    • A. Teufel, N. Malik, M. Mukhopadhyay, and H. Westphal Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes Gene 297 2002 79 83 (Pubitemid 35217782)
    • (2002) Gene , vol.297 , Issue.1-2 , pp. 79-83
    • Teufel, A.1    Malik, N.2    Mukhopadhyay, M.3    Westphal, H.4
  • 75
    • 84875676983 scopus 로고    scopus 로고
    • Nesfatin-1/NUCB2 as a potential new element of sleep regulation in rats
    • S. Vas, C. Adori, K. Konczol, Z. Katai, D. Pap, and R.S. Papp et al. Nesfatin-1/NUCB2 as a potential new element of sleep regulation in rats PLoS ONE 8 2013 e59809
    • (2013) PLoS ONE , vol.8 , pp. 59809
    • Vas, S.1    Adori, C.2    Konczol, K.3    Katai, Z.4    Pap, D.5    Papp, R.S.6
  • 76
    • 81355132716 scopus 로고    scopus 로고
    • Resistance exercise enhances the molecular signaling of mitochondrial biogenesis induced by endurance exercise in human skeletal muscle
    • L. Wang, H. Mascher, N. Psilander, E. Blomstrand, and K. Sahlin Resistance exercise enhances the molecular signaling of mitochondrial biogenesis induced by endurance exercise in human skeletal muscle J Appl Physiol (1985) 111 2011 1335 1344
    • (2011) J Appl Physiol (1985) , vol.111 , pp. 1335-1344
    • Wang, L.1    Mascher, H.2    Psilander, N.3    Blomstrand, E.4    Sahlin, K.5
  • 77
    • 84877129604 scopus 로고    scopus 로고
    • Decrease in irisin in patients with chronic kidney disease
    • M.S. Wen, C.Y. Wang, S.L. Lin, and K.C. Hung Decrease in irisin in patients with chronic kidney disease PLoS ONE 8 2013 e64025
    • (2013) PLoS ONE , vol.8 , pp. 64025
    • Wen, M.S.1    Wang, C.Y.2    Lin, S.L.3    Hung, K.C.4
  • 78
    • 73949099327 scopus 로고    scopus 로고
    • Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging
    • T. Wenz, S.G. Rossi, R.L. Rotundo, B.M. Spiegelman, and C.T. Moraes Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging Proc Natl Acad Sci U S A 106 2009 20405 20410
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 20405-20410
    • Wenz, T.1    Rossi, S.G.2    Rotundo, R.L.3    Spiegelman, B.M.4    Moraes, C.T.5
  • 81
    • 84864287504 scopus 로고    scopus 로고
    • Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
    • J. Wu, P. Bostrom, L.M. Sparks, L. Ye, J.H. Choi, and A.H. Giang et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human Cell 150 2012 366 376
    • (2012) Cell , vol.150 , pp. 366-376
    • Wu, J.1    Bostrom, P.2    Sparks, L.M.3    Ye, L.4    Choi, J.H.5    Giang, A.H.6
  • 82
    • 84856725443 scopus 로고    scopus 로고
    • Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice
    • C. Zhang, C. McFarlane, S. Lokireddy, S. Masuda, X. Ge, and P.D. Gluckman et al. Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice Diabetologia 55 2012 183 193
    • (2012) Diabetologia , vol.55 , pp. 183-193
    • Zhang, C.1    McFarlane, C.2    Lokireddy, S.3    Masuda, S.4    Ge, X.5    Gluckman, P.D.6
  • 83
    • 84882890178 scopus 로고    scopus 로고
    • Irisin is inversely associated with intrahepatic triglyceride contents in obese adults
    • H.J. Zhang, X.F. Zhang, Z.M. Ma, L.L. Pan, Z. Chen, and H.W. Han et al. Irisin is inversely associated with intrahepatic triglyceride contents in obese adults J Hepatol 59 2013 557 562
    • (2013) J Hepatol , vol.59 , pp. 557-562
    • Zhang, H.J.1    Zhang, X.F.2    Ma, Z.M.3    Pan, L.L.4    Chen, Z.5    Han, H.W.6
  • 84
    • 84893064752 scopus 로고    scopus 로고
    • Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP Kinase and ERK MAP kinase signaling
    • Y. Zhang, R. Li, Y. Meng, S. Li, W. Donelan, and Y. Zhao et al. Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP Kinase and ERK MAP kinase signaling Diabetes 63 2 2013 Feb 514 525
    • (2013) Diabetes , vol.63 , Issue.2 , pp. 514-525
    • Zhang, Y.1    Li, R.2    Meng, Y.3    Li, S.4    Donelan, W.5    Zhao, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.