ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism

Genes and Development

Volumn 10, Issue 9, 1996, Pages 1096-1107

  Kim, Jae B ^a   Spiegelman, Bruce M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

ADD1; adipocyte differentiation; bHLH LZ transcription factor; dominant negative ADD1

Indexed keywords

CELL PROTEIN; TRANSCRIPTION FACTOR;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; DNA TRANSFECTION; FATTY ACID METABOLISM; GENE EXPRESSION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION;

EID: 0030007427     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.10.9.1096     Document Type: Article

References (50)

1. Benezra, R., R.L. Davis, D. Lockshon, D.L. Turner, and H. Weintraub. 1990. The protein Id: A negative regulator of helixloop-helix DNA binding proteins. Cell 61: 49-59.
2. Bennett, M.K., J.M. Lopez, H.B. Sanchez, and T.F. Osborne. 1995. Sterol regulation of fatty acid synthase promoter. J. Biol Chem. 270: 20078-20083.
3. Birkenmeier, E.H., B. Gwynn, S. Howard, J. Jerry, J.I. Gordon, W.H. Landschulz, and S.L. McKnight. 1989. Tissue-specific expression and developmental and genetic mapping of the gene encoding C/EBP. Genes & Dev. 3: 1146-1156.
4. Braun, T., G. Buschhausen-Denker, E. Bober, E. Tannich, and H.H. Arnold. 1989. A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts. EMBO J. 8: 701-709.
5. Briggs, M.R., C. Yokoyama, X. Wang, M.S. Brown, and J.L. Goldstein. 1993. Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence. J. Biol. Chem. 268: 14490-14496.
6. Cao, Z., R.M. Umek, and S.L. McKnight. 1991. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes & Dev. 5: 1538-1552.
7. Caudy, M., H. Vassin, M. Brand, R. Tuma, L.Y. Jan, and Y.N. Jan. 1988. daughterless, a gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achate-scute complex. Cell 55: 1061-1067.
8. Cavailles, V., S. Dauvois, P.S. Danielian, and M.G. Parker. 1994. Interaction of proteins with transcriptionally active estrogen receptors. Proc. Natl. Acad. Sci. 59: 750-755.
9. Christy, R.J., V.W. Yang, J.M. Ntambi, D.E. Geiman, W.H. Landschulz, A.D. Friedman, Y. Nakabeppu, T.J. Kelly, and M.D. Lane. 1989. Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes & Dev. 3: 1323-1335.
10. Davis, R.L., H. Weintraub, and A.B. Lassar. 1987. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 51: 987-1000.
11. Davis, R.L., F.F. Cheng, A.B. Lassar, and H. Weintraub. 1990. The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation. Cell 60: 733-746.
12. 2 is a ligand for the adipocyte determination factor PPARγ. Cell 83: 803-812.
13. Freytag, S.O., D.L. Paielli, and J.D. Gilbert. 1994. Ectopic expression of the CCAAT/enhancer-binding protein α promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes &. Dev. 8: 1654-1663.
14. Friedman, A.D., W.H. Landschultz, and S.L. McKnight. 1989. CCAAT/enhancer binding activates the promoter of the serum albumin gene in cultured hepatoma cells. Genes & Dev. 3: 1314-1322.
15. Graves, R.A., P. Tontonoz, and B.M. Spiegelman. 1992. Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Mol. Cell Biol. 12: 1202-1208.
16. Green, H. and O. Kehinde. 1974. Sublines of mouse 3T3 cells that accumulate lipid. Cell 1: 113-116.
17. _. 1976. Spontaneous heritable changes leading to increase adipose conversion in 3T3 cells. Cell 7: 105-115.
18. Halachmi, S., E. Marden, G. Martin, H. MacKay, C. Abbondanza, and M. Brown. 1994. Estrogen receptor-associated proteins: Possible mediators of hormone-induced transcription. Science 264: 1455-1458.
19. Herrera, R., H.S. Ro, G.S. Robinson, K.G. Xanthopoulos, and B.M. Spiegelman. 1989. A direct role for C/EBP and the AP-1-binding site in gene expression linked to adipocyte differ-entiation. Mol. Cell. Biol. 9: 5331-5339.
20. Hua, X., C. Yokoyama, J. Wu, M.R. Briggs, M.S. Brown, J.L. Goldstein, and X. Wang. 1993. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc. Natl. Acad. Sci. 90: 11603-11607.
21. Kaestner, K.H., R.J. Christy, and M.D. Lane. 1990. Mouse insulin-responsive glucose transporter gene: Characterization of the gene and trans-activation by the CCAAT/enhancer binding protein. Proc. Natl. Acad. Sci. 87: 251-255.
22. Kim, I.E., G.D. Spotts, Y.D. Halvorsen, H.M. Shih, T. Ellenberger, H.C. Towle, and B.M. Spiegelman. 1995. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol. Cell. Biol. 15: 2582-2588.
23. 2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83: 813-819.
24. Lehmann, J.M., L.B. Moore, T.A. Smith-Oliver, W.O. Wilkison, T.M. Willson, and S.A. Kliewer. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPAR γ). J. Biol. Chem. 270: 12953-12956.
25. Lin, F.T. and M.D. Lane. 1992. Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglycéride accumulation during differentiation of 3T3-L1 preadipocytes. Genes & Dev. 6: 533-544.
26. _. 1994. CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc. Natl. Acad. Sci. 91: 8757-8761.
27. Moller, D.E. and J. Flier. 1991. Insulin resistance-mechanism, syndromes, and implications. N. Engl. J. Med. 325: 938-948.
28. Murre, C., P.S. McCaw, and D. Baltimore. 1989. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56: 777-783.
29. Park, E.A., W.J. Roesler, J. Liu, D.J. Klemm, A.L. Gurrney, J.D. Thatcher, J. Shuman, and A. Friedman. 1990. The role of the CAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP). Mol Cell. Biol. 10: 6264-6272.
30. Pear, W.S., G.P. Nolan, M.L. Scotts, and D. Baltimore. 1993. Production of high titer, helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. 87: 9590-9594.
31. Ross, S.R., R.A. Graves, A. Greenstein, K.A. Platt, H.L. Shyu, B. Mellovitz, and B.M. Spiegelman. 1990. A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo. Proc. Natl. Acad. Sci. 87: 9590-9594.
32. Salvin, B.C. 1979. Fine structure studies on white adipocyte differentiation. Anat. Rec. 195: 63-72.
33. Samuelsson, L., K. Stromberg, K. Vikman, G. Bjursell, and S. Enerback. 1991. The CCAAT/enhancer binding protein and its role in adipocyte differentiation: Evidence for direct involvement in terminal adipocyte development. EMBO J. 10:3787-3793.
34. Sato, R., J. Yang, X. Wang, M.J. Evans, Y.K. Ho, J.L. Goldstein, and M.S. Brown. 1994. Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). J. Biol. Chem. 269: 17267-17273.
35. Smith, J.R., T.F. Osborne, J.L. Goldstein, and M.S. Brown. 1990. Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene. J. Biol. Chem. 265: 2306-2310.
36. Spiegelman, B.M., L. Choy, G.S. Hotamisligil, R.A. Graves, and P. Tontonoz. 1993. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. J. Biol. Chem. 268: 6823-6826.
37. Tapscott, S.J., R.L. Davis, M.J. Thayer, P.P. Cheng, H. Weintraub, and A.B. Lassar. 1988. MyoD: A nuclear phosphoprotein requring a Myc homology region to convert fibroblasts to myoblasts. Science 242: 405-411.
38. Tontonoz, P., J.B. Kim, R.A. Graves, and B.M. Spiegelman. 1993. ADD1: A novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol. Cell. Biol. 13: 4753-4759.
39. Tontonoz, P., R.A. Graves, A.I. Budavari, H. Erdjument-Bromage, M. Lui, E. Hu, P. Tempst, and B.M. Spiegelman. 1994a. Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPARγ and RXRα. Nucleic Acids Res. 22: 5628-5634.
40. Tontonoz, P., E. Hu, R.A. Graves, A.I. Budavari, and B.M. Spiegelman. 1994b. mPPARγ2: Tissue-specific regulator of an adipocyte enhancer. Genes &. Dev. 8: 1224-1234.
41. Tontonoz, P., E. Hu, and B.M. Spiegelman. 1994c. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79: 1147-1156.
42. Umek, R.M., A.D. Friedman, and S.L. McKnight. 1991. CCAAT-enhancer binding protein: A component of a differentiation switch. Science 251: 288-292.
43. Villares, R. and C.V. Cabrera. 1987. The achaete-scute gene complex of D. melanogaster: Conserved domains in a subset of genes required for neurogenesis and their homology to myc. Cell 50: 415-424.
44. Voronova, A. and D. Baltimore. 1990. Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains. Proc. Natl. Acad. Sci. 87: 4722-4726.
45. Wang, X., M.R. Briggs, X. Hua, C. Yokoyama, J.L. Goldstein, and M.S. Brown. 1993. Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization. J. Biol. Chem. 268: 14497-14504.
46. Wang, X., R. Sato, M.S. Brown, X. Hua, and J.L. Goldstein. 1994. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77: 53-62.
47. Wright, W.E., D.A. Sassoon, and V.K. Lin. 1989. Myogenin, a factor requring myogenesis, has a domain homologous to MyoD. Cell 56: 607-617.
48. Wu, Z., Y. Xie, N. Bucher, and S.R. Farmer. 1995. Conditional ectopic expression of C/EBPβ in NIH-3T3 cells induces PPARγ and stimulates adipogenesis. Genes &. Dev. 9: 2350-2363.
49. Yeh, W.C., Z. Cao, M. Classon, and S.L. McKnight. 1995. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes &. Dev. 9: 168-181.
50. Yokoyama, C., X. Wang, M.R. Briggs, A. Admon, J. Wu, X. Hua, J.L. Goldstein, and M.S. Brown. 1993. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell 75: 187-197.