Obesity as a medical problem

Nature

Volumn 404, Issue 6778, 2000, Pages 635-643

  Kopelman, Peter G ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; DNA; FATTY ACID; GENE PRODUCT; GLUCOSE; INSULIN; LEPTIN; OXYGEN; RECEPTOR;

BASAL METABOLIC RATE; BODY FAT; BODY MASS; BREATHING DISORDER; CALORIC INTAKE; CANCER; DIABETES MELLITUS; DISEASE ASSOCIATION; ENERGY EXPENDITURE; ENVIRONMENTAL FACTOR; GENE; GENETIC SUSCEPTIBILITY; HUMAN; IMPEDANCE; ISCHEMIC HEART DISEASE; MORBIDITY; MORTALITY; NONHUMAN; NUTRITION; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REVIEW; SKINFOLD THICKNESS; THERMOGENESIS;

EID: 0034611791     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35007508     Document Type: Review

References (69)

1. Kopelman, P.G. Causes and consequences of obesity. Med. Int. 22, 385-388 (1994).
2. Society of Actuaries. Build Study of 1979 (Recording and Statistical Corporation, 1980).
3. Lew, E. A. Mortality and weight: insured lives and the American Cancer Study. Annals of Intern. Med. 103, 1024-1029 (1985).
4. Hubert, H. B. The importance of obesity in the development of coronary risk factors and disease: the epidemiological evidence. Annu. Rev. Public Health 7, 493-502 (1986).
5. World Health Organization Expert Committee. Physical Status: The Use and Interpretation of Anthropometry, WHO Tech. Rep. Ser. no. 854 (World Health Organization, Geneva, 1995).
6. World Health Organization. Obesity: Preventing and Managing the Global Epidemic (World Health Organization, Geneva, 1997).
7. Manson, J. E. et al. Body weight and mortality among women. N. Engl. J. Med. 333, 677-683 (1995).
8. Willett, W. C. et al. Weight, weight change, and coronary heart disease in women: risk within the "normal" weight range. J. Am. Med. Assoc. 273, 461-465 (1995).
9. Willett, W. C., Dietz, W. H. & Colditz, G. A. Guidelines for healthy weight. N. Engl. J. Med. 341, 427-433 (1999).
10. Han, T. S., van Leer, E. M., Seidell, J. C. & Lean, M. E. J. Waist circumference action levels in the identification of cardiovascular risk factors: prevalence study in a random sample. Br. Med. J. 311, 1401-1405 (1995).
11. Seidell, J. C. The impact of obesity on health status: some implications for health care costs. Int. J. Obesity 19(Suppl. 6), S13-S16 (1996).
12. McKeigue, P. M., Shah, B. & Marmot, M. G. Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet 337, 382-386 (1991).
13. Kotani, K. et al. Two decades of annual medical examinations in Japanese obese children: do obese children grow into obese adults? Int. J. Obesity 21, 912-921 (1997).
14. Dietz, W. H. Critical periods in childhood for the development of obesity. Am. J. Clin. Nutr. 59, 829-840 (1994).
15. World Health Organization MONICA Project. Geographical variation in the major risk factors of coronary heart disease in men and women aged 35-64 years. World Health Stat. Quart. 41, 115-140 (1988).
16. Prescott-Garke, P. & Primatesta, P. Health Survey for England 1996 (HMSO, London, 1998).
17. Kuczmarski, R. J. et al. Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys 1960 to 1991. J. Am. Med. Assoc. 272, 205-211 (1994).
18. Forrester, T. et al. in The Origins and Consequences of Obesity (eds Chadwick, D. J. & Cardeau, G.) 17-31 (Wiley, Chichester, 1996).
19. Popkin, B. M. The nutrition transition in low-income countries - an emerging crisis. Nutr. Rev. 52, 285-298 (1994).
20. Hodge, A. M. et al. Prevalence and secular trends in obesity in Pacific and Indian Ocean island populations. Obesity Res. 3(Suppl. 2), 77s-87s (1995).
21. Musaiger, A. in Diet-Related Non-communicable Diseases in the Arab Countries of the Gulf. (eds Musaiger, A.O. & Miladi, S. S.) 99-117 (Food and Agriculture Organisation of the United Nations, Cairo, 1996).
22. Bouchard, C. et al. The response to long term overfeeding in identical twins. N. Engl. J. Med. 322, 1477-1482 (1990).
23. Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432 (1994).
24. Campfield, L. A., Smith, E. J., Guisez, Y., Devos, R. & Burn, P. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 280, 546-549 (1995).
25. Maffei, M. et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight reduced subjects. Nature Med. 11, 1155-1161 (1995).
26. Farooqi, I. S. et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N. Engl. J. Med. 341, 879-884 (1999).
27. Prentice, A. M., Black, A. E., Coward, W. A. & Cole, T. J. Energy expenditure in affluent societies: an analysis of 319 doubly-labelled water measurements. Eur. J. Clin. Nutr. 50, 93-97 (1996).
28. Ravussin, E. et al. Reduced rate of expenditure as a risk factor for body weight. N. Engl. J. Med. 318, 467-472 (1988).
29. Seidell, J., Muller, D., Sorkin, J. & Andres, R. Fasting respiratory exchange ratio and resting metabolic rates as predictors of weight gain: The Baltimore Longitudinal Study on Ageing. Int. J. Obesity 16, 667-674 (1992).
30. Ferro-Luzzi, A. & Martino, L. in The Origins and Consequences of Obesity (eds Chadwick, D. & Cardew, G.) 207-227 (Wiley, Chichester, 1996).
31. Rissanen, A. et al. Determinants of weight gain and overweight in adult Finns. Eur. J. Clin. Nutr. 45, 419-430 (1991).
32. Gormaker, S. et al. Television viewing as a cause of increasing obesity among children in the United States. Arch. Pediatr. Adolesc. Med. 150, 356-362 (1996).
33. Prentice, A. M. & Jebb, S. A. Obesity in Britain: gluttony or sloth? Br. Med. J. 311, 437-439 (1995).
34. Lichtman, S. et al. Discrepancy between self-reported and actual calorie intake and exercise in obese subjects. N. Engl. J. Med. 327, 1893-1898 (1993).
35. Poppitt, S. D., Swann, D., Black, A. E. & Prentice, A. M. Assessment of selective under-reporting of food intake by both obese and non-obese women in metabolic facility of Int. J. Obesity 22, 303-311 (1998).
36. Lawton, C., Burley, V., Wales, J. & Blundell, J. Dietary fat and appetite control in obese subjects: weak effects on satiation and satiety. Int. J. Obesity 17, 409-416 (1993).
37. Blundell J. E. & Macdiarmid, J. I. Passive overconsumption: fat intake and short term energy balance. Ann. NY Acad. Sci. 827, 392-107 (1997).
38. James, W. in The Origins and Consequences of obesity (eds Chadwick, D. & Cardew, G.) 1-16 (Wiley, Chichester, 1996).
39. Ravussin, E. Metabolic differences and the development of obesity. Metabolism 9(Suppl. 3), 12-14 (1995).
40. Wilks, R. et al. in The Origins and Consequences of Obesity (eds Chadwick, D. & Cardew, G.) 37-53 (Wiley, Chichester, 1996).
41. Bennett, N., Dodd, T., Flatley, J., Freeth, S. & Bolling, K. Health Survey for England 1993 (HMSO, London, 1995).
42. Barker, D. J. P. Fetal origins of coronary heart disease. Br. Med. J. 311, 171-174 (1995).
43. Barker, D. J. P. et al. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. Br. Med. J. 298, 654-657 (1989).
44. Hales, C. N. et al. Fetal and infant growth and impaired glucose tolerance at age 64. Br. Med. J. 303, 1019-1022 (1991).
45. Ravelli, J.-P., Stein, Z. A. & Susser, M. W. Obesity in young men after famine exposure in utero and early infancy. N. Engl. J. Med. 295, 349-353 (1976).
46. Kolterman, O. G., Insel, J., Sackow, M. & Olefsky, M. Mechanisms of insulin resistance in human obesity. J. Clin. Invest. 65, 1272-1284 (1980).
47. Reynisdottir, S., Ellerfeldt, K., Wahrenberg, H., Lithell, H. & Arner, P. Multiple lipolysis defects in insulin resistance [metabolic] syndrome. J. Clin. Invest. 93, 2590-2599 (1994).
48. 3-adrenoceptors in obesity. J. Clin. Invest. 95, 1109-1116 (1995).
49. Frayn, K. N., Williams, C. M. & Arner, P. Are increased plasma non-esterified fatty acid concentrations a risk marker for coronary heart disease and other chronic diseases? Clin. Sci. 90, 243-253 (1996).
50. Sniderman, A. & Cainflone, K. Metabolic disruptions in the adipocyte-hepatocyte fatty acid axis as the cause of hyperapoB. Int. J. Obesity 19(Suppl. 1), S27-S33 (1995).
51. Colditz, G. A., Willett, W. C., Rotnitsky, A. & Manson, J. E. Weight gain as a risk factor for clinical diabetes in women. Arch. Int. Med. 122, 481-486 (1995).
52. Chan, J. M. et al. Obesity, fat distribution and weight gain as riskfactors for clinical diabetes in men. Diabetes Care 17, 961-969 (1994).
53. Lean, M. E. J., Hans, T. S. & Seidell, J. C. Impairment of health and quality life in people with large waist circumference. Lancet 351, 853-856 (1998).
54. Masserli, F. H. et al. Borderline hypertension and obesity: two prehypertensive states with elevated cardiac output. Circulation 66, 55-60 (1982).
55. De Divitiis O. et al. Obesity and cardiac function. Circulation 64, 477-482 (1981).
56. Licata, G. et al. Effect of obesity on left ventricular function studied by radionuclide angiography. Int. J. Obesity 15, 295-302 (1991).
57. Lauer, M. S., Anderson, K. M., Kannel, W. B. & Levy, D. The impact of obesity on left ventricular mass and geometry. J. Am. Med. Assoc. 266, 231-236 (1991).
58. de la Maza, M. et al. Ventricular mass in hypertensive and normotensive obese subjects. Int. J. Obesity 18, 193-197 (1994).
59. Garavaglia, G. E. et al. Myocardial contractility and left ventricular function in obese patients with essential hypertension. Am. J. Cardiol. 62, 594-597 (1988).
60. Hubert, H. B., Feinleib, M., McNamara, P. M. & Castelli, W. P. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham heart study. Circulation 67, 968-977 (1983).
61. Willet, W. C. et al. Weight, weight change and coronary heart disease in women. J. Am. Med. Assoc. 273, 461-465 (1995).
62. Kopelman, P. G. Sleep apnoea and hypoventilation in obesity. Int. J. Obesity 16(Suppl. 2), S37-S42 (1992).
63. Grunstein, R. R. in Clinical Obesity (eds Kopelman, P. G. & Stock, M. J.) 248-289 (Blackwell Science, Oxford, 1998).
64. Kopelman, P. G., Apps, M. C. P., Cope, T. & Empey, D. W. Nocturnal hypoxia and sleep apnoea in asymptomatic men. Int. J. Obesity 10, 211-217 (1986).
65. Kopelman, P. G., Apps, M. C. P., Cope, T. & Empey, D. W. The influence of menstrual status, body weight and hypothalamic function on nocturnal respiration in women. J. R. Coll. Physicians Lond. 19, 243-247 (1985).
66. Rochester, D. F. & Eaton, Y. Current concepts in the pathogenesis of the obesity-hypoventilation syndrome. Mechanical and circulatory factors. Am. J. Med. 57, 402-420 (1974).
67. Grunstein, R. R., Stenlof, K., Hedner, J. & Sjostrom, L. Impact of obstructive apnoea and sleepiness on metabolic and cardiovascular risk factors in the Swedish Obese Subjects (SOS) Study. Int. J. Obesity 19, 410-418 (1995).
68. Palomaki, H., Partinen, M., Erkinjuntti, T. & Kaste, M. Snoring, sleep apnoea syndrome and stroke. Neurology 42(Suppl. 6), 75-81 (1992).
69. Rose, G. Population distribution of risk and disease. Nutr. Metabol. Cardiovascular Dis. 1, 37-40 (1991).