Osteopontin as a means to cope with environmental insults: Regulation of inflammation, tissue remodeling, and cell survival

Journal of Clinical Investigation

Volumn 107, Issue 9, 2001, Pages 1055-1061

  Denhardt, David T ^a,e   Noda, Masaki ^b   O'Regan, Anthony W ^c   Pavlin, Dubravko ^d   Berman, Jeffrey S ^c  

^a RUTGERS UNIVERSITY   (United States)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^e RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN; NITRIC OXIDE SYNTHASE; OSTEOPONTIN; THROMBIN;

ANIMAL CELL; BONE REMODELING; CELL SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION REGULATION; IMMUNITY; INFLAMMATION; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0035021027     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI12980     Document Type: Review

References (40)

1. CD44 variants but not CD44s cooperate with betal-containing integrins to permit cells to bind to osteopontin in dependently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis
2. Structural requirements for α9β1-mediated adhesion and migration to thrombin-cleaved OPN
3. The integrin α9β1 binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin
4. Analysis of the α4β1 integrin-osteopontin interaction
5. 3 regulates platelet and lymphocyte adhesion to intact and thrombin-cleaved osteopontin
6. Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the αvβ3 integrin, osteopontin, and thrombin
7. Osteopontin: A key cytokine in cell-mediated and granulomatous inflammation
8. Osteopontin (OPN) function in pathology: Lessons from OPN-deficient mice
9. Osteopontin
10. CD44 occupancy prevents macrophage multinucleation
11. In vivo induction of insulin-like growth factor-1 receptor and CD44v6 confers homing and adhesion to murine multiple myeloma cells
12. Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7)
13. Coupling of osteopontin and its cell surface receptor CD44 to the cell survival response elicited by interleukin-3 or granulocyte-mactophage colony-stimulating factor
14. Osteopontin expression and function: Role in bone remodeling
15. Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine-like properties in vitto
16. Eta-1 (osteopontin): An early component of type-1 (cell-mediated) immunity
17. Osteopontin augments CD3-mediated interferon-γ and CD40 ligand expression by T cells, which results in IL-12 production from peripheral blood mononuclear cells
18. Regulation of NO synthesis induced by inflammatory mediators in RAW264.7 cells: Collagen prevents inhibition by osteopontin
19. Osteopontin inhibits inducible nitric oxide synthase activity in rat vascular tissues
20. Osteopontin is induced by nitric oxide in RAW264.7 cells
21. Expression of osteopontin mRNA and protein in rheumatoid arthritis
22. Osteopontin: An intrinsic inhibitor of inflammation in cartilage
23. Lack of in vivo function of osteopontin in experimental anti-GBM nephritis
24. Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin
25. Osteopontin expression correlates with clinical outcome in patients with mycobacterial infection
26. Altered wound healing in mice lacking a functional osteopontin gene (sppl)
27. Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease
28. Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification
29. Phosphate is a specific signal for induction of osteopontin gene expression
30. Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption
31. Osteopontin facilitates angiogenesis, accumulation of osteoclasts and resorption of ectopic bone
32. Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin
33. The molecular mechanisms of osteoclast dysfunction associated with osteopontin deficiency: The failure of Rho stimulation of mDial
34. Intracellular osteopontin is an integral component of the CD44-ERM complex involved in cell migration
35. Mechanical stimulation of osteopontin mRNA expression and synthesis in bone cell cultures
36. Mechanical loading stimulates differentiation of periodontal osteoblasts in a mouse osteoinduction model: Effect on type I collagen and alkaline phosphatase genes
37. Temporal pattern of stimulation of osteoblast-associated genes during mechanically-induced osteogenesis in vivo: Early responses of osteocalcin and type I collagen
38. Reciprocal regulation of osteopontin gene during mechanically induced bone formation and resorption
39. Role of osteopontin in bone remodeling caused by mechanical stress
40. Human osteoclasts, not osteoblasts, deposit osteopontin onto resorption surfaces: An in vitro and ex vivo study of remodeling bone