Increased levels of chemerin and its receptor, chemokine-like receptor-1, in obesity are related to inflammation: Tumor necrosis factor-α stimulates mRNA levels of chemerin in visceral adipocytes from obese patients

Surgery for Obesity and Related Diseases

Volumn 9, Issue 2, 2013, Pages 306-314

  Catalán, Victoria ^a,b   Gómez Ambrosi, Javier ^a,b   Rodríguez, Amaia ^a,b   Ramírez, Beatriz ^b   Rotellar, Fernando ^b   Valentí, Víctor ^b   Silva, Camilo ^a   Gil, María J ^b   Salvador, Javier ^a   Frühbeck, Gema ^a,b  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

Author keywords

Chemerin; Chemokine like receptor 1; Inflammation; Obesity; Roux en Y gastric bypass; Visceral adipose tissue

Indexed keywords

CHEMERIN; CHEMOKINE RECEPTOR CCR1; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADULT; ARTICLE; CELL STIMULATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRAABDOMINAL FAT; MAJOR CLINICAL STUDY; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; STOMACH BYPASS; UPREGULATION; WEIGHT REDUCTION;

ADIPOCYTES; ADULT; CHEMOKINES; FEMALE; GASTRIC BYPASS; HUMANS; INFLAMMATION; INTRA-ABDOMINAL FAT; OBESITY; RECEPTORS, CHEMOKINE; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; WEIGHT LOSS;

EID: 84875519919     PISSN: 15507289     EISSN: 18787533     Source Type: Journal    
DOI: 10.1016/j.soard.2011.11.001     Document Type: Article

References (31)

1. M.F. Gregor, G.S. Hotamisligil Inflammatory mechanisms in obesity Annu Rev Immunol 29 2011 415 445
2. D. Mathis, S.E. Shoelson Immunometabolism: an emerging frontier Nat Rev Immunol 11 2011 81
3. A. Rodríguez, V. Catalán, J. Gómez-Ambrosi, G. Frühbeck Visceral and subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome? Curr Pharm Des 13 2007 2169 2175
4. J.M. Olefsky, C.K. Glass Macrophages, inflammation, and insulin resistance Annu Rev Physiol 72 2010 219 246
5. K. Meijer, M. de Vries, S. Al-Lahham Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages PLoS ONE 6 2011 e17154
6. M.C. Ernst, C.J. Sinal Chemerin: at the crossroads of inflammation and obesity Trends Endocrinol Metab 21 2010 660 667
7. V. Wittamer, J.D. Franssen, M. Vulcano Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids J Exp Med 198 2003 977 985
8. K. Bozaoglu, K. Bolton, J. McMillan Chemerin is a novel adipokine associated with obesity and metabolic syndrome Endocrinology 148 2007 4687 4694
9. K.B. Goralski, T.C. McCarthy, E.A. Hanniman Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism J Biol Chem 282 2007 28175 28188
10. M. Takahashi, Y. Takahashi, K. Takahashi Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes FEBS Lett 582 2008 573 578
11. H. Sell, A. Divoux, C. Poitou Chemerin correlates with markers for fatty liver in morbidly obese patients and strongly decreases after weight loss induced by bariatric surgery J Clin Endocrinol Metab 95 2010 2892 2896
12. N. Klöting, M. Fasshauer, A. Dietrich Insulin-sensitive obesity Am J Physiol Endocrinol Metab 299 2010 E506 E515
13. R. Hart, D.R. Greaves Chemerin contributes to inflammation by promoting macrophage adhesion to VCAM-1 and fibronectin through clustering of VLA-4 and VLA-5 J Immunol 185 2010 3728 3739
14. J.L. Cash, R. Hart, A. Russ Synthetic chemerin-derived peptides suppress inflammation through ChemR23 J Exp Med 205 2008 767 775
15. J.L. Cash, A.R. Christian, D.R. Greaves Chemerin peptides promote phagocytosis in a ChemR23- and Syk-dependent manner J Immunol 184 2010 5315 5324
16. J. Weigert, M. Neumeier, J. Wanninger Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes Clin Endocrinol 72 2010 342 348
17. S.D. Parlee, M.C. Ernst, S. Muruganandan, C.J. Sinal, K.B. Goralski Serum chemerin levels vary with time of day and are modified by obesity and tumor necrosis factor-α Endocrinology 151 2010 2590 2602
18. S. Kralisch, S. Weise, G. Sommer Interleukin-1β induces the novel adipokine chemerin in adipocytes in vitro Regul Pept 154 2009 102 106
19. J. Gómez-Ambrosi, C. Silva, J.C. Galofré Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity Int J Obes (Lond) 36 2012 286 294
20. J. Gómez-Ambrosi, C. Silva, J.C. Galofré Body adiposity and type 2 diabetes: increased risk with a high body fat percentage even having a normal BMI Obesity 19 2011 1439 1444
21. G. Frühbeck, J. Gómez-Ambrosi Rationale for the existence of additional adipostatic hormones FASEB J 15 2001 1996 2006
22. K. Bozaoglu, D. Segal, K.A. Shields Chemerin is associated with metabolic syndrome phenotypes in a Mexican-American population J Clin Endocrinol Metab 94 2009 3085 3088
23. Q. Qiao, R. Nyamdorj Is the association of type II diabetes with waist circumference or waist-to-hip ratio stronger than that with body mass index? Eur J Clin Nutr 64 2010 30 34
24. M. Lehrke, A. Becker, M. Greif Chemerin is associated with markers of inflammation and components of the metabolic syndrome but does not predict coronary atherosclerosis Eur J Endocrinol 161 2009 339 344
25. V. Catalán, J. Gómez-Ambrosi, B. Ramírez Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass Obes Surg 17 2007 1464 1474
26. C. Ress, A. Tschoner, J. Engl Effect of bariatric surgery on circulating chemerin levels Eur J Clin Invest 40 2010 277 280
27. S.G. Roh, S.H. Song, K.C. Choi Chemerin - a new adipokine that modulates adipogenesis via its own receptor Biochem Biophys Res Commun 362 2007 1013 1018
28. H. Sell, J. Laurencikiene, A. Taube Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells Diabetes 58 2009 2731 2740
29. B.A. Zabel, T. Ohyama, L. Zuniga Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-β and TLR ligands Exp Hematol 34 2006 1106 1114
30. S. Bauer, J. Wanninger, S. Schmidhofer Sterol regulatory element-binding protein 2 (SREBP2) activation after excess triglyceride storage induces chemerin in hypertrophic adipocytes Endocrinology 152 2011 26 35
31. J. Kaur, R. Adya, B.K. Tan, J. Chen, H.S. Randeva Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis Biochem Biophys Res Commun 391 2010 1762 1768