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Volumn 418, Issue , 2015, Pages 184-190

Non-pharmacological and pharmacological strategies of brown adipose tissue recruitment in humans

Author keywords

Beige adipose tissue; Energy balance; FGF21; Irisin; Metabolism; Thermogenesis

Indexed keywords

CAPSAICIN DERIVATIVE; PIOGLITAZONE; ROSIGLITAZONE; ANTIOBESITY AGENT; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 21; FIBRONECTIN; FNDC5 PROTEIN, HUMAN;

EID: 84945221434     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2015.05.025     Document Type: Review
Times cited : (30)

References (76)
  • 1
    • 0029398395 scopus 로고
    • Pharmacological and clinical studies of ephedrine and other thermogenic agonists
    • Astrup A., Breum L., Toubro S. Pharmacological and clinical studies of ephedrine and other thermogenic agonists. Obes. Res 1995, 3(Suppl. 4):537S-540S.
    • (1995) Obes. Res , vol.3 , pp. 537S-540S
    • Astrup, A.1    Breum, L.2    Toubro, S.3
  • 4
    • 84924365670 scopus 로고    scopus 로고
    • Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
    • Berbee J.F., Boon M.R., Khedoe P.P., Bartelt A., Schlein C., Worthmann A., et al. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat. Commun 2015, 6:6356.
    • (2015) Nat. Commun , vol.6 , pp. 6356
    • Berbee, J.F.1    Boon, M.R.2    Khedoe, P.P.3    Bartelt, A.4    Schlein, C.5    Worthmann, A.6
  • 5
    • 70350230097 scopus 로고    scopus 로고
    • Effects of ambient temperature on the incidence of myocardial infarction
    • Bhaskaran K., Hajat S., Haines A., Herrett E., Wilkinson P., Smeeth L. Effects of ambient temperature on the incidence of myocardial infarction. Heart 2009, 95:1760-1769.
    • (2009) Heart , vol.95 , pp. 1760-1769
    • Bhaskaran, K.1    Hajat, S.2    Haines, A.3    Herrett, E.4    Wilkinson, P.5    Smeeth, L.6
  • 7
    • 84924969384 scopus 로고    scopus 로고
    • Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
    • Brestoff J.R., Kim B.S., Saenz S.A., Stine R.R., Monticelli L.A., Sonnenberg G.F., et al. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature 2015, 519:242-246.
    • (2015) Nature , vol.519 , pp. 242-246
    • Brestoff, J.R.1    Kim, B.S.2    Saenz, S.A.3    Stine, R.R.4    Monticelli, L.A.5    Sonnenberg, G.F.6
  • 8
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: function and physiological significance
    • Cannon B., Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol. Rev 2004, 84:277-359.
    • (2004) Physiol. Rev , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 10
    • 78649837895 scopus 로고    scopus 로고
    • Minimal changes in environmental temperature result in a significant increase in energy expenditure and changes in the hormonal homeostasis in healthy adults
    • Celi F.S., Brychta R.J., Linderman J.D., Butler P.W., Alberobello A.T., Smith S., et al. Minimal changes in environmental temperature result in a significant increase in energy expenditure and changes in the hormonal homeostasis in healthy adults. Eur. J. Endocrinol 2010, 163:863-872.
    • (2010) Eur. J. Endocrinol , vol.163 , pp. 863-872
    • Celi, F.S.1    Brychta, R.J.2    Linderman, J.D.3    Butler, P.W.4    Alberobello, A.T.5    Smith, S.6
  • 11
    • 70350443275 scopus 로고    scopus 로고
    • Transdifferentiation properties of adipocytes in the Adipose Organ
    • Cinti S. Transdifferentiation properties of adipocytes in the Adipose Organ. Am. J. Physiol. Endocrinol. Metab 2009, 297:E977-E986.
    • (2009) Am. J. Physiol. Endocrinol. Metab , vol.297 , pp. E977-E986
    • Cinti, S.1
  • 12
    • 0141781299 scopus 로고    scopus 로고
    • "USA-Fat": prevalence is related to ambient outdoor temperature-evaluation with 18F-FDG PET/CT
    • Cohade C., Mourtzikos K.A., Wahl R.L. "USA-Fat": prevalence is related to ambient outdoor temperature-evaluation with 18F-FDG PET/CT. J. Nucl. Med 2003, 44:1267-1270.
    • (2003) J. Nucl. Med , vol.44 , pp. 1267-1270
    • Cohade, C.1    Mourtzikos, K.A.2    Wahl, R.L.3
  • 13
    • 0020470426 scopus 로고
    • Body composition and resting metabolic rate: the myth of feminine metabolism
    • Cunningham J.J. Body composition and resting metabolic rate: the myth of feminine metabolism. Am. J. Clin. Nutr 1982, 36:721-726.
    • (1982) Am. J. Clin. Nutr , vol.36 , pp. 721-726
    • Cunningham, J.J.1
  • 16
    • 84877331455 scopus 로고    scopus 로고
    • Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
    • Cypess A.M., White A.P., Vernochet C., Schulz T.J., Xue R., Sass C.A., et al. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat. Med 2013, 19:635-639.
    • (2013) Nat. Med , vol.19 , pp. 635-639
    • Cypess, A.M.1    White, A.P.2    Vernochet, C.3    Schulz, T.J.4    Xue, R.5    Sass, C.A.6
  • 18
    • 84879846992 scopus 로고    scopus 로고
    • Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis
    • Dong M., Yang X., Lim S., Cao Z., Honek J., Lu H., et al. Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis. Cell Metab 2013, 18:118-129.
    • (2013) Cell Metab , vol.18 , pp. 118-129
    • Dong, M.1    Yang, X.2    Lim, S.3    Cao, Z.4    Honek, J.5    Lu, H.6
  • 19
    • 0015622413 scopus 로고
    • Association of pheochromocytomas with brown fat tumors
    • English J.T., Patel S.K., Flanagan M.J. Association of pheochromocytomas with brown fat tumors. Radiology 1973, 107:279-281.
    • (1973) Radiology , vol.107 , pp. 279-281
    • English, J.T.1    Patel, S.K.2    Flanagan, M.J.3
  • 21
    • 0031957513 scopus 로고    scopus 로고
    • Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus
    • Esterbauer H., Oberkofler H., Liu Y.M., Breban D., Hell E., Krempler F., et al. Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus. J. Lipid Res 1998, 39:834-844.
    • (1998) J. Lipid Res , vol.39 , pp. 834-844
    • Esterbauer, H.1    Oberkofler, H.2    Liu, Y.M.3    Breban, D.4    Hell, E.5    Krempler, F.6
  • 22
    • 0032452431 scopus 로고    scopus 로고
    • Additive effects of the mutations in the beta3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish women
    • Fogelholm M., Valve R., Kukkonen-Harjula K., Nenonen A., Hakkarainen V., Laakso M., et al. Additive effects of the mutations in the beta3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish women. J. Clin. Endocrinol. Metab 1998, 83:4246-4250.
    • (1998) J. Clin. Endocrinol. Metab , vol.83 , pp. 4246-4250
    • Fogelholm, M.1    Valve, R.2    Kukkonen-Harjula, K.3    Nenonen, A.4    Hakkarainen, V.5    Laakso, M.6
  • 24
    • 84922883000 scopus 로고    scopus 로고
    • An insulin-sensitizing thiazolidinedione, which minimally activates PPAR?, does not cause bone loss
    • Fukunaga T., Zou W., Rohatgi N., Colca J.R., Teitelbaum S.L. An insulin-sensitizing thiazolidinedione, which minimally activates PPAR?, does not cause bone loss. J. Bone Miner. Res 2014, 30:481-488.
    • (2014) J. Bone Miner. Res , vol.30 , pp. 481-488
    • Fukunaga, T.1    Zou, W.2    Rohatgi, N.3    Colca, J.R.4    Teitelbaum, S.L.5
  • 26
    • 38949185747 scopus 로고    scopus 로고
    • Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab)
    • Healy G.N., Wijndaele K., Dunstan D.W., Shaw J.E., Salmon J., Zimmet P.Z., et al. Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). Diabetes Care 2008, 31:369-371.
    • (2008) Diabetes Care , vol.31 , pp. 369-371
    • Healy, G.N.1    Wijndaele, K.2    Dunstan, D.W.3    Shaw, J.E.4    Salmon, J.5    Zimmet, P.Z.6
  • 27
    • 84877263632 scopus 로고    scopus 로고
    • A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans
    • Jespersen N.Z., Larsen T.J., Peijs L., Daugaard S., Homoe P., Loft A., et al. A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab 2013, 17:798-805.
    • (2013) Cell Metab , vol.17 , pp. 798-805
    • Jespersen, N.Z.1    Larsen, T.J.2    Peijs, L.3    Daugaard, S.4    Homoe, P.5    Loft, A.6
  • 28
    • 84916608284 scopus 로고    scopus 로고
    • The effects of temperature and seasons on subcutaneous white adipose tissue in humans: evidence for thermogenic gene induction
    • jc20142440
    • Kern P.A., Finlin B.S., Zhu B., Rasouli N., McGehee R.E., Westgate P.M., et al. The effects of temperature and seasons on subcutaneous white adipose tissue in humans: evidence for thermogenic gene induction. J. Clin. Endocrinol. Metab 2014, 99:E2772-E2779. jc20142440.
    • (2014) J. Clin. Endocrinol. Metab , vol.99 , pp. E2772-E2779
    • Kern, P.A.1    Finlin, B.S.2    Zhu, B.3    Rasouli, N.4    McGehee, R.E.5    Westgate, P.M.6
  • 29
    • 42149188744 scopus 로고    scopus 로고
    • Temporal relation between temperature change and FDG uptake in brown adipose tissue
    • Kim S., Krynyckyi B.R., Machac J., Kim C.K. Temporal relation between temperature change and FDG uptake in brown adipose tissue. Eur. J. Nucl. Med. Mol. Imaging 2008, 35:984-989.
    • (2008) Eur. J. Nucl. Med. Mol. Imaging , vol.35 , pp. 984-989
    • Kim, S.1    Krynyckyi, B.R.2    Machac, J.3    Kim, C.K.4
  • 30
    • 0028865142 scopus 로고
    • Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
    • Kopecky J., Clarke G., Enerback S., Spiegelman B., Kozak L.P. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J. Clin. Invest 1995, 96:2914-2923.
    • (1995) J. Clin. Invest , vol.96 , pp. 2914-2923
    • Kopecky, J.1    Clarke, G.2    Enerback, S.3    Spiegelman, B.4    Kozak, L.P.5
  • 31
    • 0022482362 scopus 로고
    • Brown adipose tissue in patients with phaeochromocytoma
    • Lean M.E., James W.P., Jennings G., Trayhurn P. Brown adipose tissue in patients with phaeochromocytoma. Int. J. Obes 1986, 10:219-227.
    • (1986) Int. J. Obes , vol.10 , pp. 219-227
    • Lean, M.E.1    James, W.P.2    Jennings, G.3    Trayhurn, P.4
  • 33
    • 77957577776 scopus 로고    scopus 로고
    • A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans
    • Lee P., Greenfield J.R., Ho K.K., Fulham M.J. A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans. Am. J. Physiol. Endocrinol. Metab 2010, 299:E601-E606.
    • (2010) Am. J. Physiol. Endocrinol. Metab , vol.299 , pp. E601-E606
    • Lee, P.1    Greenfield, J.R.2    Ho, K.K.3    Fulham, M.J.4
  • 34
    • 80053154065 scopus 로고    scopus 로고
    • Inducible brown adipogenesis of supraclavicular fat in adult humans
    • Lee P., Swarbrick M.M., Zhao J.T., Ho K.K. Inducible brown adipogenesis of supraclavicular fat in adult humans. Endocrinology 2011, 152:3597-3602.
    • (2011) Endocrinology , vol.152 , pp. 3597-3602
    • Lee, P.1    Swarbrick, M.M.2    Zhao, J.T.3    Ho, K.K.4
  • 36
    • 84872070199 scopus 로고    scopus 로고
    • Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis and cold-induced thermogenesis
    • Lee P., Brychta R., Linderman J., Smith S., Chen K.Y., Celi F.S. Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis and cold-induced thermogenesis. J. Clin. Endocrinol. Metab 2013, 98:E98-E102.
    • (2013) J. Clin. Endocrinol. Metab , vol.98 , pp. E98-E102
    • Lee, P.1    Brychta, R.2    Linderman, J.3    Smith, S.4    Chen, K.Y.5    Celi, F.S.6
  • 37
    • 84907973405 scopus 로고    scopus 로고
    • Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans
    • Lee P., Smith S., Linderman J., Courville A.B., Brychta R.J., Dieckmann W., et al. Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans. Diabetes 2014, 63:3686-3698.
    • (2014) Diabetes , vol.63 , pp. 3686-3698
    • Lee, P.1    Smith, S.2    Linderman, J.3    Courville, A.B.4    Brychta, R.J.5    Dieckmann, W.6
  • 38
    • 84896710569 scopus 로고    scopus 로고
    • Functional thermogenic beige adipogenesis is inducible in human neck fat
    • Lee P., Werner C.D., Kebebew E., Celi F.S. Functional thermogenic beige adipogenesis is inducible in human neck fat. Int. J. Obes. (Lond) 2014, 38:170-176.
    • (2014) Int. J. Obes. (Lond) , vol.38 , pp. 170-176
    • Lee, P.1    Werner, C.D.2    Kebebew, E.3    Celi, F.S.4
  • 39
    • 84893452569 scopus 로고    scopus 로고
    • Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans
    • Lee P., Linderman J.D., Smith S., Brychta R.J., Wang J., Idelson C., et al. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab 2014, 19:302-309.
    • (2014) Cell Metab , vol.19 , pp. 302-309
    • Lee, P.1    Linderman, J.D.2    Smith, S.3    Brychta, R.J.4    Wang, J.5    Idelson, C.6
  • 40
    • 84923640618 scopus 로고    scopus 로고
    • Formoterol, a highly beta2-selective agonist, induces gender-dimorphic whole body leucine metabolism in humans
    • Lee P., Birzniece V., Umpleby A.M., Poljak A., Ho K.K. Formoterol, a highly beta2-selective agonist, induces gender-dimorphic whole body leucine metabolism in humans. Metabolism 2015, 64:506-512.
    • (2015) Metabolism , vol.64 , pp. 506-512
    • Lee, P.1    Birzniece, V.2    Umpleby, A.M.3    Poljak, A.4    Ho, K.K.5
  • 41
    • 84930587228 scopus 로고    scopus 로고
    • The sum of all browning in FGF21 therapeutics
    • Lee P., Swarbrick M.M., Greenfield J.R. The sum of all browning in FGF21 therapeutics. Cell Metab 2015, 21:795-796.
    • (2015) Cell Metab , vol.21 , pp. 795-796
    • Lee, P.1    Swarbrick, M.M.2    Greenfield, J.R.3
  • 43
    • 0022536596 scopus 로고
    • Uptake of glucose and release of fatty acids and glycerol by rat brown adipose tissue in vivo
    • Ma S.W., Foster D.O. Uptake of glucose and release of fatty acids and glycerol by rat brown adipose tissue in vivo. Can. J. Physiol. Pharmacol 1986, 64:609-614.
    • (1986) Can. J. Physiol. Pharmacol , vol.64 , pp. 609-614
    • Ma, S.W.1    Foster, D.O.2
  • 44
    • 0017700708 scopus 로고
    • One hundred cases of pheochromocytoma (107 tumors) at the Columbia-Presbyterian Medical Center, 1926-1976: a clinicopathological analysis
    • Melicow M.M. One hundred cases of pheochromocytoma (107 tumors) at the Columbia-Presbyterian Medical Center, 1926-1976: a clinicopathological analysis. Cancer 1977, 40:1987-2004.
    • (1977) Cancer , vol.40 , pp. 1987-2004
    • Melicow, M.M.1
  • 45
    • 82555186955 scopus 로고    scopus 로고
    • Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
    • Nguyen K.D., Qiu Y., Cui X., Goh Y.P., Mwangi J., David T., et al. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 2011, 480:104-108.
    • (2011) Nature , vol.480 , pp. 104-108
    • Nguyen, K.D.1    Qiu, Y.2    Cui, X.3    Goh, Y.P.4    Mwangi, J.5    David, T.6
  • 46
    • 79960945989 scopus 로고    scopus 로고
    • Different metabolic responses of human brown adipose tissue to activation by cold and insulin
    • Orava J., Nuutila P., Lidell M.E., Oikonen V., Noponen T., Viljanen T., et al. Different metabolic responses of human brown adipose tissue to activation by cold and insulin. Cell Metab 2011, 14:272-279.
    • (2011) Cell Metab , vol.14 , pp. 272-279
    • Orava, J.1    Nuutila, P.2    Lidell, M.E.3    Oikonen, V.4    Noponen, T.5    Viljanen, T.6
  • 47
    • 78650098848 scopus 로고    scopus 로고
    • Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans
    • Ouellet V., Routhier-Labadie A., Bellemare W., Lakhal-Chaieb L., Turcotte E., Carpentier A.C., et al. Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans. J. Clin. Endocrinol. Metab 2011, 96:192-199.
    • (2011) J. Clin. Endocrinol. Metab , vol.96 , pp. 192-199
    • Ouellet, V.1    Routhier-Labadie, A.2    Bellemare, W.3    Lakhal-Chaieb, L.4    Turcotte, E.5    Carpentier, A.C.6
  • 48
    • 84856529575 scopus 로고    scopus 로고
    • Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans
    • Ouellet V., Labbe S.M., Blondin D.P., Phoenix S., Guerin B., Haman F., et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J. Clin. Invest 2012, 122:545-552.
    • (2012) J. Clin. Invest , vol.122 , pp. 545-552
    • Ouellet, V.1    Labbe, S.M.2    Blondin, D.P.3    Phoenix, S.4    Guerin, B.5    Haman, F.6
  • 49
    • 84902097377 scopus 로고    scopus 로고
    • Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis
    • Rao R.R., Long J.Z., White J.P., Svensson K.J., Lou J., Lokurkar I., et al. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 2014, 157:1279-1291.
    • (2014) Cell , vol.157 , pp. 1279-1291
    • Rao, R.R.1    Long, J.Z.2    White, J.P.3    Svensson, K.J.4    Lou, J.5    Lokurkar, I.6
  • 50
    • 0027717745 scopus 로고
    • Metabolic predictors of obesity: cross-sectional versus longitudinal data
    • discussion S41-2
    • Ravussin E., Swinburn B.A. Metabolic predictors of obesity: cross-sectional versus longitudinal data. Int. J. Obes. Relat. Metab. Disord 1993, 17(Suppl. 3):S28-S31. discussion S41-2.
    • (1993) Int. J. Obes. Relat. Metab. Disord , vol.17 , pp. S28-S31
    • Ravussin, E.1    Swinburn, B.A.2
  • 51
    • 0020466632 scopus 로고
    • Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma
    • Ricquier D., Nechad M., Mory G. Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma. J. Clin. Endocrinol. Metab 1982, 54:803-807.
    • (1982) J. Clin. Endocrinol. Metab , vol.54 , pp. 803-807
    • Ricquier, D.1    Nechad, M.2    Mory, G.3
  • 52
    • 67650242165 scopus 로고    scopus 로고
    • High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity
    • Saito M., Okamatsu-Ogura Y., Matsushita M., Watanabe K., Yoneshiro T., Nio-Kobayashi J., et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 2009, 58:1526-1531.
    • (2009) Diabetes , vol.58 , pp. 1526-1531
    • Saito, M.1    Okamatsu-Ogura, Y.2    Matsushita, M.3    Watanabe, K.4    Yoneshiro, T.5    Nio-Kobayashi, J.6
  • 53
    • 77958529709 scopus 로고    scopus 로고
    • Cardiovascular risk and thiazolidinediones-what do meta-analyses really tell us?
    • Schernthaner G., Chilton R.J. Cardiovascular risk and thiazolidinediones-what do meta-analyses really tell us?. Diabetes Obes. Metab 2010, 12:1023-1035.
    • (2010) Diabetes Obes. Metab , vol.12 , pp. 1023-1035
    • Schernthaner, G.1    Chilton, R.J.2
  • 54
    • 84890949863 scopus 로고    scopus 로고
    • Do we still need pioglitazone for the treatment of type 2 diabetes? A risk-benefit critique in 2013
    • Schernthaner G., Currie C.J., Schernthaner G.H. Do we still need pioglitazone for the treatment of type 2 diabetes? A risk-benefit critique in 2013. Diabetes Care 2013, 36(Suppl. 2):S155-S161.
    • (2013) Diabetes Care , vol.36 , pp. S155-S161
    • Schernthaner, G.1    Currie, C.J.2    Schernthaner, G.H.3
  • 55
    • 0035023620 scopus 로고    scopus 로고
    • Beta(1)- and beta(2)-Adrenoceptor-mediated thermogenesis and lipid utilization in obese and lean men
    • Schiffelers S.L., Saris W.H., Boomsma F., van Baak M.A. beta(1)- and beta(2)-Adrenoceptor-mediated thermogenesis and lipid utilization in obese and lean men. J. Clin. Endocrinol. Metab 2001, 86:2191-2199.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 2191-2199
    • Schiffelers, S.L.1    Saris, W.H.2    Boomsma, F.3    van Baak, M.A.4
  • 56
    • 84869233588 scopus 로고    scopus 로고
    • Human BAT possesses molecular signatures that resemble beige/brite cells
    • Sharp L.Z., Shinoda K., Ohno H., Scheel D.W., Tomoda E., Ruiz L., et al. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS ONE 2012, 7:e49452.
    • (2012) PLoS ONE , vol.7 , pp. e49452
    • Sharp, L.Z.1    Shinoda, K.2    Ohno, H.3    Scheel, D.W.4    Tomoda, E.5    Ruiz, L.6
  • 57
    • 0034957329 scopus 로고    scopus 로고
    • Synergistic effect of polymorphisms of uncoupling protein 1 and beta3-adrenergic receptor genes on autonomic nervous system activity
    • Shihara N., Yasuda K., Moritani T., Ue H., Uno M., Adachi T., et al. Synergistic effect of polymorphisms of uncoupling protein 1 and beta3-adrenergic receptor genes on autonomic nervous system activity. Int. J. Obes. Relat. Metab. Disord 2001, 25:761-766.
    • (2001) Int. J. Obes. Relat. Metab. Disord , vol.25 , pp. 761-766
    • Shihara, N.1    Yasuda, K.2    Moritani, T.3    Ue, H.4    Uno, M.5    Adachi, T.6
  • 58
    • 84863178641 scopus 로고    scopus 로고
    • Activation of transient receptor potential A1 by a non-pungent capsaicin-like compound, capsiate
    • Shintaku K., Uchida K., Suzuki Y., Zhou Y., Fushiki T., Watanabe T., et al. Activation of transient receptor potential A1 by a non-pungent capsaicin-like compound, capsiate. Br. J. Pharmacol 2012, 165:1476-1486.
    • (2012) Br. J. Pharmacol , vol.165 , pp. 1476-1486
    • Shintaku, K.1    Uchida, K.2    Suzuki, Y.3    Zhou, Y.4    Fushiki, T.5    Watanabe, T.6
  • 59
    • 84876788350 scopus 로고    scopus 로고
    • Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men
    • Sugita J., Yoneshiro T., Hatano T., Aita S., Ikemoto T., Uchiwa H., et al. Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men. Br. J. Nutr 2013, 110:733-738.
    • (2013) Br. J. Nutr , vol.110 , pp. 733-738
    • Sugita, J.1    Yoneshiro, T.2    Hatano, T.3    Aita, S.4    Ikemoto, T.5    Uchiwa, H.6
  • 60
    • 84899410105 scopus 로고    scopus 로고
    • Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans
    • Sugita J., Yoneshiro T., Sugishima Y., Ikemoto T., Uchiwa H., Suzuki I., et al. Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans. J. Nutr. Sci. Vitaminol. (Tokyo) 2014, 60:22-27.
    • (2014) J. Nutr. Sci. Vitaminol. (Tokyo) , vol.60 , pp. 22-27
    • Sugita, J.1    Yoneshiro, T.2    Sugishima, Y.3    Ikemoto, T.4    Uchiwa, H.5    Suzuki, I.6
  • 64
    • 0031802431 scopus 로고    scopus 로고
    • Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns
    • Valve R., Heikkinen S., Rissanen A., Laakso M., Uusitupa M. Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns. Diabetologia 1998, 41:357-361.
    • (1998) Diabetologia , vol.41 , pp. 357-361
    • Valve, R.1    Heikkinen, S.2    Rissanen, A.3    Laakso, M.4    Uusitupa, M.5
  • 66
    • 84868206600 scopus 로고    scopus 로고
    • Systemic beta-adrenergic stimulation of thermogenesis is not accompanied by brown adipose tissue activity in humans
    • Vosselman M.J., van der Lans A.A., Brans B., Wierts R., van Baak M.A., Schrauwen P., et al. Systemic beta-adrenergic stimulation of thermogenesis is not accompanied by brown adipose tissue activity in humans. Diabetes 2012, 61:3106-3113.
    • (2012) Diabetes , vol.61 , pp. 3106-3113
    • Vosselman, M.J.1    van der Lans, A.A.2    Brans, B.3    Wierts, R.4    van Baak, M.A.5    Schrauwen, P.6
  • 68
    • 79959305513 scopus 로고    scopus 로고
    • Brown adipose tissue in humans is activated by elevated plasma catecholamines levels and is inversely related to central obesity
    • Wang Q., Zhang M., Ning G., Gu W., Su T., Xu M., et al. Brown adipose tissue in humans is activated by elevated plasma catecholamines levels and is inversely related to central obesity. PLoS ONE 2011, 6:e21006.
    • (2011) PLoS ONE , vol.6 , pp. e21006
    • Wang, Q.1    Zhang, M.2    Ning, G.3    Gu, W.4    Su, T.5    Xu, M.6
  • 69
    • 84864287504 scopus 로고    scopus 로고
    • Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
    • Wu J., Bostrom P., Sparks L.M., Ye L., Choi J.H., Giang A.H., et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012, 150:366-376.
    • (2012) Cell , vol.150 , pp. 366-376
    • Wu, J.1    Bostrom, P.2    Sparks, L.M.3    Ye, L.4    Choi, J.H.5    Giang, A.H.6
  • 70
    • 84864287504 scopus 로고    scopus 로고
    • Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
    • Wu J., Bostrom P., Sparks L.M., Ye L., Choi J.H., Giang A.H., et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012, 150:366-376.
    • (2012) Cell , vol.150 , pp. 366-376
    • Wu, J.1    Bostrom, P.2    Sparks, L.M.3    Ye, L.4    Choi, J.H.5    Giang, A.H.6
  • 71
    • 84873518501 scopus 로고    scopus 로고
    • Adaptive thermogenesis in adipocytes: is beige the new brown?
    • Wu J., Cohen P., Spiegelman B.M. Adaptive thermogenesis in adipocytes: is beige the new brown?. Genes Dev 2013, 27:234-250.
    • (2013) Genes Dev , vol.27 , pp. 234-250
    • Wu, J.1    Cohen, P.2    Spiegelman, B.M.3
  • 72
    • 80052139636 scopus 로고    scopus 로고
    • Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans
    • Yoneshiro T., Aita S., Matsushita M., Okamatsu-Ogura Y., Kameya T., Kawai Y., et al. Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans. Obesity (Silver Spring) 2011, 19:1755-1760.
    • (2011) Obesity (Silver Spring) , vol.19 , pp. 1755-1760
    • Yoneshiro, T.1    Aita, S.2    Matsushita, M.3    Okamatsu-Ogura, Y.4    Kameya, T.5    Kawai, Y.6
  • 73
    • 84880272552 scopus 로고    scopus 로고
    • Impact of UCP1 and beta3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans
    • Yoneshiro T., Ogawa T., Okamoto N., Matsushita M., Aita S., Kameya T., et al. Impact of UCP1 and beta3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans. Int. J. Obes. (Lond) 2012, 37:993-998.
    • (2012) Int. J. Obes. (Lond) , vol.37 , pp. 993-998
    • Yoneshiro, T.1    Ogawa, T.2    Okamoto, N.3    Matsushita, M.4    Aita, S.5    Kameya, T.6
  • 75
    • 84880689343 scopus 로고    scopus 로고
    • Eosinophil inversely associates with type 2 diabetes and insulin resistance in Chinese adults
    • Zhu L., Su T., Xu M., Xu Y., Li M., Wang T., et al. Eosinophil inversely associates with type 2 diabetes and insulin resistance in Chinese adults. PLoS ONE 2013, 8:e67613.
    • (2013) PLoS ONE , vol.8 , pp. e67613
    • Zhu, L.1    Su, T.2    Xu, M.3    Xu, Y.4    Li, M.5    Wang, T.6
  • 76
    • 84908564226 scopus 로고    scopus 로고
    • Risk of fracture with thiazolidinediones: an updated meta-analysis of randomized clinical trials
    • Zhu Z.N., Jiang Y.F., Ding T. Risk of fracture with thiazolidinediones: an updated meta-analysis of randomized clinical trials. Bone 2014, 68:115-123.
    • (2014) Bone , vol.68 , pp. 115-123
    • Zhu, Z.N.1    Jiang, Y.F.2    Ding, T.3


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