Six-transmembrane epithelial antigen of prostate 4 and neutrophil gelatinase-associated lipocalin expression in visceral adipose tissue is related to iron status and inflammation in human obesity

European Journal of Nutrition

Volumn 52, Issue 6, 2013, Pages 1587-1595

  Catalán, Victoria ^a,b   Gómez Ambrosi, Javier ^a,b   Rodríguez, Amaia ^a,b   Ramírez, Beatriz ^a,b   Rotellar, Fernando ^a,b   Valentí, Victor ^a,b   Silva, Camilo ^a,b   Gil, María J ^a,b   Salvador, Javier ^a,b   Frühbeck, Gema ^a,b  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

Author keywords

Ferritin; Inflammation; Iron homeostasis; Lipocalin 2; Obesity; STAMP2

Indexed keywords

EPITHELIAL MEMBRANE ANTIGEN; FERRITIN; IRON; MESSENGER RNA; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; SIX TRANSMEMBRANE EPITHELIAL ANTIGEN OF PROSTATE 4; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; GENE EXPRESSION; HUMAN; INFLAMMATION; INTRAABDOMINAL FAT; IRON BLOOD LEVEL; IRON METABOLISM; MALE; OBESITY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ACUTE-PHASE PROTEINS; ADIPOKINES; ADULT; ANTIGENS; BODY MASS INDEX; FEMALE; GENE EXPRESSION; HOMEOSTASIS; HUMANS; INFLAMMATION; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; IRON; LIPOCALINS; MALE; MEMBRANE PROTEINS; OBESITY; OXIDOREDUCTASES; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER;

EID: 84891831269     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-012-0464-8     Document Type: Article

References (50)

1. Frühbeck G, Gómez-Ambrosi J (2003) Control of body weight: a physiologic and transgenic perspective. Diabetologia 46:143-172
2. Haslam DW, James WP (2005) Obesity. Lancet 366:1197-1209
3. Fernández-Real JM, López-Bermejo A, Ricart W (2002) Crosstalk between iron metabolism and diabetes. Diabetes 51:2348-2354
4. Piperno A, Trombini P, Gelosa M, Mauri V, Pecci V, Vergani A, Salvioni A, Mariani R, Mancia G (2002) Increased serum ferritin is common in men with essential hypertension. J Hypertens 20:1513-1518
5. Menke A, Muntner P, Fernández-Real JM, Guallar E (2012) The association of biomarkers of iron status with mortality in US adults. Nutr Metab Cardiovasc Dis 22:734-740
6. Ford ES, Cogswell ME (1999) Diabetes and serum ferritin concentration among U.S. adults. Diabetes Care 22:1978-1983
7. Ferrannini E (2000) Insulin resistance, iron, and the liver. Lancet 355:2181-2182
8. Guillen C, McInnes IB, Kruger H, Brock JH (1998) Iron, lactoferrin and iron regulatory protein activity in the synovium; relative importance of iron loading and the inflammatory response. Ann Rheum Dis 57:309-314
9. Jehn M, Clark JM, Guallar E (2004) Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diabetes Care 27:2422-2428
10. Freixenet N, Remacha A, Berlanga E, Caixas A, Gimenez-Palop O, Blanco-Vaca F, Bach V, Baiget M, Sanchez Y, Felez J, Gonzalez-Clemente JM (2009) Serum soluble transferrin receptor concentrations are increased in central obesity. Results from a screening programme for hereditary hemochromatosis in men with hyperferritinemia. Clin Chim Acta 400:111-116
11. Finch C (1994) Regulators of iron balance in humans. Blood 84:1697-1702
12. Anderson GJ, Darshan D, Wilkins SJ, Frazer DM (2007) Regulation of systemic iron homeostasis: how the body responds to changes in iron demand. Biometals 20:665-674
13. Swaminathan S, Fonseca VA, Alam MG, Shah SV (2007) The role of iron in diabetes and its complications. Diabetes Care 30:1926-1933
14. Gkouvatsos K, Papanikolaou G, Pantopoulos K (2012) Regulation of iron transport and the role of transferrin. Biochim Biophys Acta 1820:188-202
15. Bao G, Clifton M, Hoette TM, Mori K, Deng SX, Qiu A, Viltard M, Williams D, Paragas N, Leete T, Kulkarni R, Li X, Lee B, Kalandadze A, Ratner AJ, Pizarro JC, Schmidt-Ott KM, Landry DW, Raymond KN, Strong RK, Barasch J (2010) Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. Nat Chem Biol 6:602-609
16. Wang Y, Lam KS, Kraegen EW, Sweeney G, Zhang J, Tso AW, Chow WS, Wat NM, Xu JY, Hoo RL, Xu A (2007) Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Clin Chem 53:34-41
17. Wellen KE, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, Hotamisligil GS (2007) Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell 129:537-548
18. Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem A (2004) Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432:917-921
19. Torti SV, Torti FM (2011) Ironing out cancer. Cancer Res 71:1511-1514
20. Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Silva C, Rotellar F, Gil MJ, Cienfuegos JA, Salvador J, Frühbeck G (2009) Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans. J Mol Med 87:803-813
21. Esteve E, Ricart W, Fernández-Real JM (2009) Adipocytokines and insulin resistance: the possible role of lipocalin-2, retinol binding protein-4, and adiponectin. Diabetes Care 32(Suppl 2):S362-367
22. Frühbeck G, Gómez-Ambrosi J (2001) Rationale for the existence of additional adipostatic hormones. FASEB J 15:1996-2006
23. Moldes M, Lasnier F, Gauthereau X, Klein C, Pairault J, Feve B, Chambaut-Guerin AM (2001) Tumor necrosis factor-α-induced adipose-related protein (TIARP), a cell-surface protein that is highly induced by tumor necrosis factor-α and adipose conversion. J Biol Chem 276:33938-33946
24. Ohgami RS, Campagna DR, McDonald A, Fleming MD (2006) The Steap proteins are metalloreductases. Blood 108:1388-1394
25. Arner P, Stenson BM, Dungner E, Naslund E, Hoffstedt J, Ryden M, Dahlman I (2008) Expression of six transmembrane protein of prostate 2 in human adipose tissue associates with adiposity and insulin resistance. J Clin Endocrinol Metab 93:2249-2254
26. De Domenico I, McVey Ward D, Kaplan J (2008) Regulation of iron acquisition and storage: consequences for iron-linked disorders. Nat Rev Mol Cell Biol 9:72-81
27. Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259:87-91
28. Catalán V, Gómez-Ambrosi J, Rodríguez A, Salvador J, Frühbeck G (2009) Adipokines in the treatment of diabetes mellitus and obesity. Expert Opin Pharmacother 10:239-254
29. Catalán V, Gómez-Ambrosi J, Rodríguez A, Frühbeck G (2012) Role of extracellular matrix remodelling in adipose tissue pathophysiology. Relevance in the development of obesity. Histol Histopathol 27:1515-1528
30. Gómez-Ambrosi J, Catalán V, Ramírez B, Rodríguez A, Colina I, Silva C, Rotellar F, Mugueta C, Gil MJ, Cienfuegos JA, Salvador J, Frühbeck G (2007) Plasma osteopontin levels and expression in adipose tissue are increased in obesity. J Clin Endocrinol Metab 92:3719-3727
31. Gómez-Ambrosi J, Silva C, Galofré JC, Escalada J, Santos S, Millán D, Vila N, Ibañez P, Gil MJ, Valentí V, Rotellar F, Ramírez B, Salvador J, Frühbeck G (2012) Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity. Int J Obes 36:286-294
32. Ginde SR, Geliebter A, Rubiano F, Silva AM, Wang J, Heshka S, Heymsfield SB (2005) Air displacement plethysmography: validation in overweight and obese subjects. Obes Res 13:1232-1237
33. 3-adrenergic agonist, upregulates muscle uncoupling protein-3 messenger RNA expression: short-term thermogenic interactions. Cell Mol Life Sci 55:992-997
34. Gómez-Ambrosi J, Salvador J, Rotellar F, Silva C, Catalán V, Rodríguez A, Gil MJ, Frühbeck G (2006) Increased serum amyloid A concentrations in morbid obesity decrease after gastric bypass. Obes Surg 16:262-269
35. Catalán V, Gómez-Ambrosi J, Ramírez B, Rotellar F, Pastor C, Silva C, Rodríguez A, Gil MJ, Cienfuegos JA, Frühbeck G (2007) Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass. Obes Surg 17:1464-1474
36. Muruzábal FJ, Frühbeck G, Gómez-Ambrosi J, Archanco M, Burrell MA (2002) Immunocytochemical detection of leptin in non-mammalian vertebrate stomach. Gen Comp Endocrinol 128:149-152
37. Catalán V, Gómez-Ambrosi J, Rotellar F, Silva C, Rodríguez A, Salvador J, Gil MJ, Cienfuegos JA, Frühbeck G (2007) Validation of endogenous control genes in human adipose tissue: relevance to obesity and obesity-associated type 2 diabetes mellitus. Horm Metab Res 39:495-500
38. Gygi SP, Rochon Y, Franza BR, Aebersold R (1999) Correlation between protein and mRNA abundance in yeast. Mol Cell Biol 19:1720-1730
39. Guo Y, Xiao P, Lei S, Deng F, Xiao GG, Liu Y, Chen X, Li L, Wu S, Chen Y, Jiang H, Tan L, Xie J, Zhu X, Liang S, Deng H (2008) How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes. Acta Biochim Biophys Sin 40:426-436
40. Zhang CM, Chi X, Wang B, Zhang M, Ni YH, Chen RH, Li XN, Guo XR (2008) Downregulation of STEAP4, a highly-expressed TNF-α-inducible gene in adipose tissue, is associated with obesity in humans. Acta Pharmacol Sin 29:587-592
41. Moreno-Navarrete JM, Ortega F, Serrano M, Pérez-Pérez R, Sabater M, Ricart W, Tinahones F, Peral B, Fernández-Real JM (2011) Decreased STAMP2 expression in association with visceral adipose tissue dysfunction. J Clin Endocrinol Metab 2011:E1816-1825
42. Zhang J, Wu Y, Zhang Y, Leroith D, Bernlohr DA, Chen X (2008) The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Mol Endocrinol 22:1416-1426
43. Cheng HL, Bryant C, Cook R, O'Connor H, Rooney K, Steinbeck K (2012) The relationship between obesity and hypoferraemia in adults: a systematic review. Obes Rev 13:150-161
44. Harrison PM, Arosio P (1996) The ferritins: molecular properties, iron storage function and cellular regulation. Biochim Biophys Acta 1275:161-203
45. Knutson MD (2007) Steap proteins: implications for iron and copper metabolism. Nutr Rev 65:335-340
46. Anderson GJ, Vulpe CD (2009) Mammalian iron transport. Cell Mol Life Sci 66:3241-3261
47. Theil EC, Goss DJ (2009) Living with iron (and oxygen): questions and answers about iron homeostasis. Chem Rev 109:4568-4579
48. ten Freyhaus H, Calay ES, Yalcin A, Vallerie SN, Yang L, Calay ZZ, Saatcioglu F, Hotamisligil GS (2012) Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis. Cell Metab 16:81-89
49. Guo H, Jin D, Zhang Y, Wright W, Bazuine M, Brockman DA, Bernlohr DA, Chen X (2010) Lipocalin-2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice. Diabetes 59:1376-1385
50. Law IK, Xu A, Lam KS, Berger T, Mak TW, Vanhoutte PM, Liu JT, Sweeney G, Zhou M, Yang B, Wang Y (2010) Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes 59:872-882