Increased levels of calprotectin in obesity are related to macrophage content: Impact on inflammation and effect of weight loss

Molecular Medicine

Volumn 17, Issue 11, 2011, Pages 1157-1167

  Catalán, Victoria ^a,b   Gómez Ambrosi, Javier ^a,b   Rodrígue, Amaia ^a,b   Ramírez, Beatriz ^a,b   Rotellar, Fernando ^a,b   Valentí, Victor ^a,b   Silva, Camilo ^a,b   Gil, María J ^a,b   Fernández Real, José Manuel ^b,c   Salvador, Javier ^a,b   Frühbeck, Gema ^a,b  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c Institut d'Investigació Biomédica ^*  (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CALGRANULIN; CALGRANULIN A; CALGRANULIN B; CD11B ANTIGEN; CD68 ANTIGEN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN SUBUNIT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADULT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; INSULIN RESISTANCE; INTRAABDOMINAL FAT; MACROPHAGE; MAJOR CLINICAL STUDY; MONOCYTE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; ROUX Y ANASTOMOSIS; WEIGHT REDUCTION;

ADIPOCYTES; ADULT; ANTHROPOMETRY; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTRA-ABDOMINAL FAT; LEUKOCYTE L1 ANTIGEN COMPLEX; MACROPHAGES; OBESITY; PROTEIN SUBUNITS; RECEPTORS, IMMUNOLOGIC; RNA, MESSENGER; S100 PROTEINS; TUMOR NECROSIS FACTOR-ALPHA; WEIGHT LOSS;

EID: 82855168153     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2011.00144     Document Type: Article

References (54)

1. Olefsky JM, Glass CK. (2010) Macrophages, inflammation, and insulin resistance. Annu. Rev. Physiol. 72:219-46.
2. Bouma G, Lam-Tse WK, Wierenga-Wolf AF, Drexhage HA, Versnel MA. (2004) Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin. Diabetes. 53:1979-86.
3. Mortensen OH, et al. (2009) Calprotectin: a novel marker of obesity. PLoS One. 4:e7419.
4. Odink K, et al. (1987) Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis. Nature. 330:80-2.
5. Zwadlo G, Bruggen J, Gerhards G, Schlegel R, Sorg C. (1988) Two calcium-binding proteins associated with specific stages of myeloid cell differentiation are expressed by subsets of macrophages in inflammatory tissues. Clin. Exp. Immunol. 72:510-5.
6. Ehrchen JM, Sunderkotter C, Foell D, Vogl T, Roth J. (2009) The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. J. Leukoc. Biol. 86:557-66.
7. Striz I, Trebichavsky I. (2004) Calprotectin: a pleiotropic molecule in acute and chronic inflammation. Physiol. Res. 53:245-53.
8. Frosch M, et al. (2004) Expression of MRP8 and MRP14 by macrophages is a marker for severe forms of glomerulonephritis. J. Leukoc. Biol. 75:198-206.
9. Foell D, et al. (2008) Phagocyte-specific S100 proteins are released from affected mucosa and promote immune responses during inflammatory bowel disease. J. Pathol. 216:183-92.
10. Spagnuolo MI, et al. (2010) Relationship between severe obesity and gut inflammation in children: what's next? Ital. J. Pediatr. 36:66.
11. Perera C, McNeil HP, Geczy CL. (2009) S100 Calgranulins in inflammatory arthritis. Immunol. Cell Biol. 88:41-9.
12. Rammes A, et al. (1997) Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J. Biol. Chem. 272:9496-502.
13. Yen T, et al. (1997) Induction of the S100 chemotactic protein, CP-10, in murine microvascular endothelial cells by proinflammatory stimuli. Blood. 90:4812-21.
14. Xu K, Geczy CL. (2000) IFN-γ and TNF regulate macrophage expression of the chemotactic S100 protein S100A8. J. Immunol. 164:4916-23.
15. Manitz MP, et al. (2003) Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro. Mol. Cell. Biol. 23:1034-43.
16. Lim SY, Raftery MJ, Goyette J, Hsu K, Geczy CL. (2009) Oxidative modifications of S100 proteins: functional regulation by redox. J. Leukoc. Biol. 86:577-87.
17. Leclerc E, Fritz G, Vetter SW, Heizmann CW. (2009) Binding of S100 proteins to RAGE: an update. Biochim. Biophys. Acta. 1793:993-1007.
18. Rodríguez A, Catalán V, Gómez-Ambrosi J, Frühbeck G. (2007) Visceral and subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome? Curr. Pharm. Des. 13:2169-75.
19. Roth J, Vogl T, Sorg C, Sunderkotter C. (2003) Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules. Trends Immunol. 24:155-8.
20. Ginde SR, et al. (2005) Air displacement plethysmography: validation in overweight and obese subjects. Obes. Res. 13:1232-7.
21. Genuth S, et al. (2003) Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care. 26:3160-7.
22. Gómez-Ambrosi J, Frühbeck G, Martínez JA. (1999) Leptin, but not a β3-adrenergic agonist, upregulates muscle uncoupling protein-3 messenger RNA expression: short-term thermogenic interactions. Cell Mol. Life Sci. 55:992-7.
23. Catalán V, et al. (2007) Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass. Obes. Surg. 17:1464-74.
24. Gómez-Ambrosi J, et al. (2007) Plasma osteopontin levels and expression in adipose tissue are increased in obesity. J. Clin. Endocrinol. Metab. 92:3719-27.
25. Catalán V, et al. (2007) Validation of endogenous control genes in human adipose tissue: relevance to obesity and obesity-associated type 2 diabetes mellitus. Horm. Metab. Res. 39:495-500.
26. Rodríguez A, et al. (2009) Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes. Int. J. Obes. 33:541-52.
27. Griendling KK. (2006) NADPH oxidases: new regulators of old functions. Antioxid. Redox. Signal. 8:1443-5.
28. Frühbeck G, Gómez-Ambrosi J. (2001) Rationale for the existence of additional adipostatic hormones. FASEB J. 15:1996-2006.
29. Nijhuis J, et al. (2009) Neutrophil activation in morbid obesity, chronic activation of acute inflammation. Obesity. 17:2014-8.
30. Sun X, et al. (2011) Analysis of plasma calprotectin and polymorphisms of S100A8 in patients with aggressive periodontitis. J. Periodontal. Res. 46:354-60.
31. Kim OY, et al. (2009) G allele at RAGE SNP82 is associated with proinflammatory markers in obese subjects. Nutr. Res. 29:106-13.
32. Basta G, et al. (2006) Circulating soluble receptor for advanced glycation end products is inversely associated with glycemic control and S100A12 protein. J. Clin. Endocrinol. Metab. 91:4628-34.
33. Geroldi D, et al. (2005) Decreased plasma levels of soluble receptor for advanced glycation endproducts in patients with essential hypertension. J. Hypertens. 23:1725-9.
34. Flyvbjerg A, et al. (2004) Long-term renal effects of a neutralizing RAGE antibody in obese type 2 diabetic mice. Diabetes. 53:166-72.
35. Park L, et al. (1998) Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts. Nat. Med. 4:1025-31.
36. Devangelio E, et al. (2007) Soluble RAGE in type 2 diabetes: association with oxidative stress. Free Radic. Biol. Med. 43:511-8.
37. Nin JW, et al. (2010) Higher plasma soluble receptor for advanced glycation end products (sRAGE) levels are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-year follow-up study. Diabetes. 59:2027-32.
38. Thomas MC, et al. (2011) Soluble receptor for AGE (RAGE) is a novel independent predictor of allcause and cardiovascular mortality in type 1 diabetes. Diabetologia. 54:2669-77.
39. Forsythe LK, Wallace JM, Livingstone MB. (2008) Obesity and inflammation: the effects of weight loss. Nutr. Res. Rev. 21:117-33.
40. Eue I, Pietz B, Storck J, Klempt M, Sorg C. (2000) Transendothelial migration of 27E10+ human monocytes. Int. Immunol. 12:1593-604.
41. Kanda H, et al. (2006) MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J. Clin. Invest. 116:1494-505.
42. Harrison CA, et al. (1999) Oxidation regulates the inflammatory properties of the murine S100 protein S100A8. J. Biol. Chem. 274:8561-9.
43. Lugering N, et al. (1995) The myeloic related protein MRP8/14 (27E10 antigen)-usefulness as a potential marker for disease activity in ulcerative colitis and putative biological function. Eur. J. Clin. Invest. 25:659-64.
44. Mortensen OH, et al. (2008) Calprotectin is released from human skeletal muscle tissue during exercise. J. Physiol. 586:3551-62.
45. Berntzen HB, Munthe E, Fagerhol MK. (1989) A longitudinal study of the leukocyte protein L1 as an indicator of disease activity in patients with rheumatoid arthritis. J. Rheumatol. 16:1416-20.
46. Hammer HB, et al. (2010) Calprotectin (a major S100 leucocyte protein) predicts 10-year radiographic progression in patients with rheumatoid arthritis. Ann. Rheum. Dis. 69:150-4.
47. Brun JG, Madland TM, Gran JT, Myklebust G. (2005) A longitudinal study of calprotectin in patients with polymyalgia rheumatica or temporal arteritis: relation to disease activity. Scand. J. Rheumatol. 34:125-8.
48. Furukawa S, et al. (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 114:1752-61.
49. Kerkhoff C, et al. (2005) The arachidonic acidbinding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2. FASEB J. 19:467-9.
50. Sunahori K, et al. (2006) The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor κB and p38 mitogen-activated protein kinase in rheumatoid arthritis. Arthritis Res. Ther. 8:R69.
51. Chen YS, Yan W, Geczy CL, Brown MA, Thomas R. (2009) Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis. Arthritis Res. Ther. 11:R39.
52. McNair ED, et al. (2010) Modulation of high sensitivity C-reactive protein by soluble receptor for advanced glycation end products. Mol. Cell. Biochem. 341:135-8.
53. Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. (1993) Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 75:263-74.
54. Yan SF, Ramasamy R, Schmidt AM. (2010) The RAGE axis: a fundamental mechanism signaling danger to the vulnerable vasculature. Circ. Res. 106:842-53.