FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

Metabolism: Clinical and Experimental

Volumn 61, Issue 12, 2012, Pages 1725-1738

  Huh, Joo Young ^a   Panagiotou, Grigorios ^a   Mougios, Vassilis ^b   Brinkoetter, Mary ^a   Vamvini, Maria T ^a   Schneider, Benjamin E ^c   Mantzoros, Christos S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Exercise; FNDC5; Irisin; Weight loss

Indexed keywords

ADIPONECTIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HORMONE; INSULIN; IRISIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BARIATRIC SURGERY; BODY MASS; CROSS-SECTIONAL STUDY; DOWN REGULATION; EXERCISE; FEMALE; FNDC5 GENE; GENE; GENE EXPRESSION; GLYCOLYSIS; HUMAN; HUMAN TISSUE; LIPOLYSIS; MAJOR CLINICAL STUDY; METABOLIC REGULATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; WAIST HIP RATIO; WEIGHT REDUCTION;

ADENOSINE TRIPHOSPHATE; ADULT; ATHLETES; BARIATRIC SURGERY; BIOLOGICAL MARKERS; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; EXERCISE; FEMALE; FIBRONECTINS; GENE EXPRESSION REGULATION; GLYCOLYSIS; HORMONES; HUMANS; LIPOLYSIS; MALE; MIDDLE AGED; OBESITY, MORBID; RNA, MESSENGER; WEIGHT LOSS;

EID: 84869497609     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2012.09.002     Document Type: Article

References (30)

1. C.L. Ogden, M.D. Carroll, and B.K. Kit Prevalence of obesity in the United States, 2009-2010 NCHS Data Brief 82 2012 1 8
2. J. Tuomilehto, J. Lindstrom, and J.G. Eriksson Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance N Engl J Med 344 18 2001 1343 1350 (Pubitemid 32378388)
3. M. Nocon, T. Hiemann, and F. Muller-Riemenschneider Association of physical activity with all-cause and cardiovascular mortality: a systematic review and meta-analysis Eur J Cardiovasc Prev Rehabil 15 3 2008 239 246
4. D. Thompson, F. Karpe, and M. Lafontan Physical activity and exercise in the regulation of human adipose tissue physiology Physiol Rev 92 1 2012 157 191
5. A. Pinto, D. Di Raimondo, and A. Tuttolomondo Effects of physical exercise on inflammatory markers of atherosclerosis Curr Pharm Des 2012 [epub ahead of print]
6. B.K. Pedersen, and M.A. Febbraio Muscles, exercise and obesity: skeletal muscle as a secretory organ Nat Rev Endocrinol 8 8 2012 457 465
7. B.K. Pedersen The diseasome of physical inactivity - and the role of myokines in muscle-fat cross talk J Physiol 587 Pt 23 2009 5559 5568
8. M.A. Febbraio, N. Hiscock, and M. Sacchetti Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction Diabetes 53 7 2004 1643 1648 (Pubitemid 38864744)
9. C. Handschin, C.S. Choi, and S. Chin Abnormal glucose homeostasis in skeletal muscle-specific pgc-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk J Clin Invest 117 11 2007 3463 3474 (Pubitemid 350097002)
10. P. Bostrom, J. Wu, and M.P. Jedrychowski A pgc1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis Nature 481 7382 2012 463 468
11. P. Seale, H.M. Conroe, and J. Estall Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice J Clin Invest 121 1 2011 96 105
12. S. Enerback Human brown adipose tissue Cell Metab 11 4 2010 248 252
13. J.A. Timmons, K. Baar, and P.K. Davidsen Is irisin a human exercise gene? Nature 488 7413 2012 E9 E10 [discussion E-1]
14. J.H. Lee, J.L. Chan, and N. Yiannakouris Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects J Clin Endocrinol Metab 88 10 2003 4848 4856 (Pubitemid 37357535)
15. P. Saraslanidis, A. Petridou, and G.C. Bogdanis Muscle metabolism and performance improvement after two training programmes of sprint running differing in rest interval duration J Sports Sci 29 11 2011 1167 1174
16. M.T. Vamvini, K.N. Aronis, and J.P. Chamberland Energy deprivation alters in a leptin- and cortisol-independent manner circulating levels of activin a and follistatin but not myostatin in healthy males J Clin Endocrinol Metab 96 11 2011 3416 3423
17. V.A. Moragianni, K.N. Aronis, and J.P. Chamberland Short-term energy deprivation alters activin a and follistatin but not inhibin b levels of lean healthy women in a leptin-independent manner J Clin Endocrinol Metab 96 12 2011 3750 3758
18. J. Nijhuis, F.M. Van Dielen, and W.A. Buurman Ghrelin, leptin and insulin levels after restrictive surgery: a 2-year follow-up study Obes Surg 14 6 2004 783 787 (Pubitemid 38982263)
19. G.H. Ballantyne, A. Gumbs, and I.M. Modlin Changes in insulin resistance following bariatric surgery and the adipoinsular axis: role of the adipocytokines, leptin, adiponectin and resistin Obes Surg 15 5 2005 692 699 (Pubitemid 40847960)
20. F. Villarroya Irisin, turning up the heat Cell Metab 15 3 2012 277 278
21. K. Ruschke, L. Fishbein, and A. Dietrich Gene expression of ppargamma and pgc-1alpha in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial effects of physical training Eur J Endocrinol 162 3 2010 515 523
22. G.H. Vijgen, N.D. Bouvy, and G.J. Teule Increase in brown adipose tissue activity after weight loss in morbidly obese subjects J Clin Endocrinol Metab 97 7 2012 E1229 E1233
23. A.J. Van Der Lely, M. Tschop, and M.L. Heiman Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin Endocr Rev 25 3 2004 426 457 (Pubitemid 38780667)
24. R. Salvatori Growth hormone and igf-1 Rev Endocr Metab Disord 5 1 2004 15 23 (Pubitemid 38374695)
25. S. Welle Growth hormone and insulin-like growth factor-i as anabolic agents Curr Opin Clin Nutr Metab Care 1 3 1998 257 262 (Pubitemid 128539451)
26. S.M. Greising, R.S. Carey, and J.E. Blackford Estradiol treatment, physical activity, and muscle function in ovarian-senescent mice Exp Gerontol 46 8 2011 685 693
27. K.L. Herbst, and S. Bhasin Testosterone action on skeletal muscle Curr Opin Clin Nutr Metab Care 7 3 2004 271 277 (Pubitemid 40340664)
28. M. Brown Skeletal muscle and bone: effect of sex steroids and aging Adv Physiol Educ 32 2 2008 120 126
29. B.K. Pedersen, and M.A. Febbraio Muscle as an endocrine organ: focus on muscle-derived interleukin-6 Physiol Rev 88 4 2008 1379 1406
30. F. Sanchis-Gomar, G. Lippi, and S. Mayero Irisin: a new potential hormonal target for the treatment of obesity and type 2 diabetes J Diabetes 4 3 2012 196