Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

Nature

Volumn 432, Issue 7019, 2004, Pages 917-921

  Flo, Trude H ^a,b   Smith, Kelly D ^a,c   Sato, Shintaro ^d,e   Rodriguez, David J ^a   Holmes, Margaret A ^f   Strong, Roland K ^f   Akira, Shizuo ^d,e   Aderem, Alan ^a  

^a INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c UNIVERSITY OF WASHINGTON   (United States)

^d OSAKA UNIVERSITY   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^f Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BINDING ENERGY; IMMUNOLOGY; IRON; PATHOLOGY; PROTEINS;

INNATE IMMUNE SYSTEM; IRON-BINDING PROTEINS; SIDEROPHORES;

METABOLISM;

BACTERIAL PROTEIN; ENTEROCHELIN; LIPOCALIN 2; SIDEROPHORE; TOLL LIKE RECEPTOR 1; UNCLASSIFIED DRUG;

MEDICINE;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IRON TRANSPORT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SECRETION; SYNTHESIS;

ACUTE-PHASE PROTEINS; ANIMALS; ENTEROBACTIN; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FEMALE; IMMUNITY, NATURAL; IRON; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; ONCOGENE PROTEINS; PROTEIN BINDING; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SUBSTRATE SPECIFICITY; TOLL-LIKE RECEPTORS;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 11144314814     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03104     Document Type: Article

References (24)

1. Weinberg, E. D. Iron withholding: a defense against infection and neoplasia. Physiol. Rev. 64, 65-102 (1984).
2. Andrews, N. C. Iron homeostasis: insights from genetics and animal models. Nature Rev. Genet. 1, 208-217 (2000).
3. Ratledge, C. & Dover, L. G. Iron metabolism in pathogenic bacteria. Annu. Rev. Microbiol. 54, 881-941 (2000).
4. Faraldo-Gomez, J. D. & Sansom, M. S. Acquisition of siderophores in gram-negative bacteria. Nature Rev. Mol. Cell Biol. 4, 105-116 (2003).
5. Goetz, D. H. et al. The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol. Cell 10, 1033-1043 (2002).
6. Takeda, K., Kaisho, T. & Akira, S. Toll-like receptors. Annu. Rev. Immunol. 21, 335-376 (2003).
7. Janeway, C. A. Jr & Medzhitov, R. Innate immune recognition. Annu. Rev. Immunol. 20, 197-216 (2002).
8. Kjeldsen, L., Cowland, J. B. & Borregaard, N. Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse. Biochim. Biophys. Acta 1482, 272-283 (2000).
9. Triebel, S., Blaser, J., Reinke, H. & Tschesche, H. A 25 kDa alpha 2-microglobulin-related protein is a component of the 125 kDa form of human gelatinase. FEBS Lett. 314, 386-388 (1992).
10. Kjeldsen, L., Johnsen, A. H., Sengelov, H. & Borregaard, N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J. Biol. Chem. 268, 10425-10432 (1993).
11. Flower, D. R., North, A. C. & Attwood, T. K. Mouse oncogene protein 24p3 is a member of the lipocalin protein family. Biochem. Biophys. Res. Commun. 180, 69-74 (1991).
12. Liu, Q., Ryon, J. & Nilsen-Hamilton, M. Uterocalin: a mouse acute phase protein expressed in the uterus around birth. Mol. Reprod. Dev. 46, 507-514 (1997).
13. Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085-2088 (1998).
14. Lien, E. et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J. Biol. Chem. 274, 33419-33425 (1999).
15. Ozinsky, A. et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc. Natl Acad. Sci. USA 97, 13766-13771 (2000).
16. Takeuchi, O. et al. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 169, 10-14 (2002).
17. Hayashi, F. et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410, 1099-1103 (2001).
18. Xu, S. & Venge, P. Lipocalins as biochemical markers of disease. Biochim. Biophys. Acta 1482, 298-307 (2000).
19. Liu, Q. & Nilsen-Hamilton, M. Identification of a new acute phase protein. J. Biol. Chem. 270, 22565-22570 (1995).
20. Winkelmann, G. Microbial siderophore-mediated transport. Biochem. Soc. Trans. 30, 691-696 (2002).
21. Yang, J. et al. An iron delivery pathway mediated by a lipocalin. Mol. Cell 10, 1045-1056 (2002).
22. Suire, S., Stewart, F., Beauchamp, J. & Kennedy, M. W. Uterocalin, a lipocalin provisioning the preattachment equine conceptus: fatty acid and retinol binding properties, and structural characterization. Biochem. J. 356, 369-376 (2001).
23. Devireddy, L. R., Teodoro, J. G., Richard, F. A. & Green, M. R. Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation. Science 293, 829-834 (2001).
24. Hou, Z., Stack, T. D. P., Sunderland, C. J. & Raymond, K. N. Enhanced iron (III) chelation through ligand predisposition: Syntheses, structures and stability of Tris-catecholate enterobactin analogs. Inorg. Chim. Acta 263, 341-355 (1997).